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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SDC4-NRG1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SDC4-NRG1
FusionPDB ID: 79822
FusionGDB2.0 ID: 79822
HgeneTgene
Gene symbol

SDC4

NRG1

Gene ID

6385

3084

Gene namesyndecan 4neuregulin 1
SynonymsSYND4ARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDF
Cytomap

20q13.12

8p12

Type of geneprotein-codingprotein-coding
Descriptionsyndecan-4amphiglycanryudocan amphiglycanryudocan core proteinsyndecan 4 (amphiglycan, ryudocan)syndecan proteoglycan 4pro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factor
Modification date2020031320200320
UniProtAcc

P31431

Q02297

Ensembl transtripts involved in fusion geneENST idsENST00000372733, ENST00000537976, 
ENST00000523681, ENST00000287842, 
ENST00000287845, ENST00000338921, 
ENST00000341377, ENST00000356819, 
ENST00000405005, ENST00000519301, 
ENST00000520407, ENST00000520502, 
ENST00000521670, ENST00000523079, 
ENST00000539990, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 12 X 10=144025 X 17 X 14=5950
# samples 2127
** MAII scorelog2(21/1440*10)=-2.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/5950*10)=-4.46185835603184
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SDC4 [Title/Abstract] AND NRG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SDC4(43959006)-NRG1(32585467), # samples:4
Anticipated loss of major functional domain due to fusion event.SDC4-NRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SDC4-NRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SDC4-NRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SDC4-NRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNRG1

GO:0003222

ventricular trabecula myocardium morphogenesis

17336907

TgeneNRG1

GO:0031334

positive regulation of protein complex assembly

10559227

TgeneNRG1

GO:0038127

ERBB signaling pathway

11389077

TgeneNRG1

GO:0038129

ERBB3 signaling pathway

27353365

TgeneNRG1

GO:0045892

negative regulation of transcription, DNA-templated

15073182

TgeneNRG1

GO:0051048

negative regulation of secretion

10559227

TgeneNRG1

GO:0060379

cardiac muscle cell myoblast differentiation

17336907

TgeneNRG1

GO:0060956

endocardial cell differentiation

17336907


check buttonFusion gene breakpoints across SDC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NRG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-7954-01ASDC4chr20

43959006

-NRG1chr8

32585467

+
ChimerDB4LUADTCGA-86-7954SDC4chr20

43959005

-NRG1chr8

32585466

+
ChimerDB4LUSCTCGA-85-7950-01ASDC4chr20

43959006

-NRG1chr8

32585467

+
ChimerKB4..SDC4chr20

43964560

-NRG1chr8

43964560

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372733SDC4chr2043959006-ENST00000519301NRG1chr832585467+1924485401920626
ENST00000372733SDC4chr2043959006-ENST00000520407NRG1chr832585467+116548540708222
ENST00000372733SDC4chr2043959006-ENST00000523079NRG1chr832585467+1825485401245401
ENST00000372733SDC4chr2043959006-ENST00000338921NRG1chr832585467+2558485401929629
ENST00000372733SDC4chr2043959006-ENST00000356819NRG1chr832585467+2549485401920626
ENST00000372733SDC4chr2043959006-ENST00000287845NRG1chr832585467+2549485401920626
ENST00000372733SDC4chr2043959006-ENST00000341377NRG1chr832585467+25934857261964412
ENST00000372733SDC4chr2043959006-ENST00000287842NRG1chr832585467+2006485401896618
ENST00000372733SDC4chr2043959006-ENST00000521670NRG1chr832585467+1644485401371443
ENST00000372733SDC4chr2043959006-ENST00000405005NRG1chr832585467+1975485401905621
ENST00000372733SDC4chr2043959006-ENST00000520502NRG1chr832585467+114848540708222
ENST00000372733SDC4chr2043959006-ENST00000539990NRG1chr832585467+2003485401896618
ENST00000537976SDC4chr2043959006-ENST00000519301NRG1chr832585467+1785346121781589
ENST00000537976SDC4chr2043959006-ENST00000520407NRG1chr832585467+102634612569185
ENST00000537976SDC4chr2043959006-ENST00000523079NRG1chr832585467+1686346121106364
ENST00000537976SDC4chr2043959006-ENST00000338921NRG1chr832585467+2419346121790592
ENST00000537976SDC4chr2043959006-ENST00000356819NRG1chr832585467+2410346121781589
ENST00000537976SDC4chr2043959006-ENST00000287845NRG1chr832585467+2410346121781589
ENST00000537976SDC4chr2043959006-ENST00000341377NRG1chr832585467+24543465871825412
ENST00000537976SDC4chr2043959006-ENST00000287842NRG1chr832585467+1867346121757581
ENST00000537976SDC4chr2043959006-ENST00000521670NRG1chr832585467+1505346121232406
ENST00000537976SDC4chr2043959006-ENST00000405005NRG1chr832585467+1836346121766584
ENST00000537976SDC4chr2043959006-ENST00000520502NRG1chr832585467+100934612569185
ENST00000537976SDC4chr2043959006-ENST00000539990NRG1chr832585467+1864346121757581
ENST00000372733SDC4chr2043959005-ENST00000519301NRG1chr832585466+1924485401920626
ENST00000372733SDC4chr2043959005-ENST00000520407NRG1chr832585466+116548540708222
ENST00000372733SDC4chr2043959005-ENST00000523079NRG1chr832585466+1825485401245401
ENST00000372733SDC4chr2043959005-ENST00000338921NRG1chr832585466+2558485401929629
ENST00000372733SDC4chr2043959005-ENST00000356819NRG1chr832585466+2549485401920626
ENST00000372733SDC4chr2043959005-ENST00000287845NRG1chr832585466+2549485401920626
ENST00000372733SDC4chr2043959005-ENST00000341377NRG1chr832585466+25934857261964412
ENST00000372733SDC4chr2043959005-ENST00000287842NRG1chr832585466+2006485401896618
ENST00000372733SDC4chr2043959005-ENST00000521670NRG1chr832585466+1644485401371443
ENST00000372733SDC4chr2043959005-ENST00000405005NRG1chr832585466+1975485401905621
ENST00000372733SDC4chr2043959005-ENST00000520502NRG1chr832585466+114848540708222
ENST00000372733SDC4chr2043959005-ENST00000539990NRG1chr832585466+2003485401896618
ENST00000537976SDC4chr2043959005-ENST00000519301NRG1chr832585466+1785346121781589
ENST00000537976SDC4chr2043959005-ENST00000520407NRG1chr832585466+102634612569185
ENST00000537976SDC4chr2043959005-ENST00000523079NRG1chr832585466+1686346121106364
ENST00000537976SDC4chr2043959005-ENST00000338921NRG1chr832585466+2419346121790592
ENST00000537976SDC4chr2043959005-ENST00000356819NRG1chr832585466+2410346121781589
ENST00000537976SDC4chr2043959005-ENST00000287845NRG1chr832585466+2410346121781589
ENST00000537976SDC4chr2043959005-ENST00000341377NRG1chr832585466+24543465871825412
ENST00000537976SDC4chr2043959005-ENST00000287842NRG1chr832585466+1867346121757581
ENST00000537976SDC4chr2043959005-ENST00000521670NRG1chr832585466+1505346121232406
ENST00000537976SDC4chr2043959005-ENST00000405005NRG1chr832585466+1836346121766584
ENST00000537976SDC4chr2043959005-ENST00000520502NRG1chr832585466+100934612569185
ENST00000537976SDC4chr2043959005-ENST00000539990NRG1chr832585466+1864346121757581

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372733ENST00000519301SDC4chr2043959006-NRG1chr832585467+0.0026930560.99730694
ENST00000372733ENST00000520407SDC4chr2043959006-NRG1chr832585467+0.0005660860.99943393
ENST00000372733ENST00000523079SDC4chr2043959006-NRG1chr832585467+0.0010028070.99899715
ENST00000372733ENST00000338921SDC4chr2043959006-NRG1chr832585467+0.0009275180.99907243
ENST00000372733ENST00000356819SDC4chr2043959006-NRG1chr832585467+0.0008945420.9991054
ENST00000372733ENST00000287845SDC4chr2043959006-NRG1chr832585467+0.0008945420.9991054
ENST00000372733ENST00000341377SDC4chr2043959006-NRG1chr832585467+0.0039223320.9960777
ENST00000372733ENST00000287842SDC4chr2043959006-NRG1chr832585467+0.0017619180.9982381
ENST00000372733ENST00000521670SDC4chr2043959006-NRG1chr832585467+0.0038312410.9961688
ENST00000372733ENST00000405005SDC4chr2043959006-NRG1chr832585467+0.0022740640.9977259
ENST00000372733ENST00000520502SDC4chr2043959006-NRG1chr832585467+0.0005925470.9994074
ENST00000372733ENST00000539990SDC4chr2043959006-NRG1chr832585467+0.0017914210.99820864
ENST00000537976ENST00000519301SDC4chr2043959006-NRG1chr832585467+0.0048563480.99514365
ENST00000537976ENST00000520407SDC4chr2043959006-NRG1chr832585467+0.0101070180.989893
ENST00000537976ENST00000523079SDC4chr2043959006-NRG1chr832585467+0.0028411140.9971589
ENST00000537976ENST00000338921SDC4chr2043959006-NRG1chr832585467+0.0017722110.9982278
ENST00000537976ENST00000356819SDC4chr2043959006-NRG1chr832585467+0.0013811630.99861884
ENST00000537976ENST00000287845SDC4chr2043959006-NRG1chr832585467+0.0013811630.99861884
ENST00000537976ENST00000341377SDC4chr2043959006-NRG1chr832585467+0.004130660.99586934
ENST00000537976ENST00000287842SDC4chr2043959006-NRG1chr832585467+0.0036057080.99639434
ENST00000537976ENST00000521670SDC4chr2043959006-NRG1chr832585467+0.026281620.97371835
ENST00000537976ENST00000405005SDC4chr2043959006-NRG1chr832585467+0.0048813830.9951186
ENST00000537976ENST00000520502SDC4chr2043959006-NRG1chr832585467+0.0095488670.99045116
ENST00000537976ENST00000539990SDC4chr2043959006-NRG1chr832585467+0.0036589110.99634105
ENST00000372733ENST00000519301SDC4chr2043959005-NRG1chr832585466+0.0026930560.99730694
ENST00000372733ENST00000520407SDC4chr2043959005-NRG1chr832585466+0.0005660860.99943393
ENST00000372733ENST00000523079SDC4chr2043959005-NRG1chr832585466+0.0010028070.99899715
ENST00000372733ENST00000338921SDC4chr2043959005-NRG1chr832585466+0.0009275180.99907243
ENST00000372733ENST00000356819SDC4chr2043959005-NRG1chr832585466+0.0008945420.9991054
ENST00000372733ENST00000287845SDC4chr2043959005-NRG1chr832585466+0.0008945420.9991054
ENST00000372733ENST00000341377SDC4chr2043959005-NRG1chr832585466+0.0039223320.9960777
ENST00000372733ENST00000287842SDC4chr2043959005-NRG1chr832585466+0.0017619180.9982381
ENST00000372733ENST00000521670SDC4chr2043959005-NRG1chr832585466+0.0038312410.9961688
ENST00000372733ENST00000405005SDC4chr2043959005-NRG1chr832585466+0.0022740640.9977259
ENST00000372733ENST00000520502SDC4chr2043959005-NRG1chr832585466+0.0005925470.9994074
ENST00000372733ENST00000539990SDC4chr2043959005-NRG1chr832585466+0.0017914210.99820864
ENST00000537976ENST00000519301SDC4chr2043959005-NRG1chr832585466+0.0048563480.99514365
ENST00000537976ENST00000520407SDC4chr2043959005-NRG1chr832585466+0.0101070180.989893
ENST00000537976ENST00000523079SDC4chr2043959005-NRG1chr832585466+0.0028411140.9971589
ENST00000537976ENST00000338921SDC4chr2043959005-NRG1chr832585466+0.0017722110.9982278
ENST00000537976ENST00000356819SDC4chr2043959005-NRG1chr832585466+0.0013811630.99861884
ENST00000537976ENST00000287845SDC4chr2043959005-NRG1chr832585466+0.0013811630.99861884
ENST00000537976ENST00000341377SDC4chr2043959005-NRG1chr832585466+0.004130660.99586934
ENST00000537976ENST00000287842SDC4chr2043959005-NRG1chr832585466+0.0036057080.99639434
ENST00000537976ENST00000521670SDC4chr2043959005-NRG1chr832585466+0.026281620.97371835
ENST00000537976ENST00000405005SDC4chr2043959005-NRG1chr832585466+0.0048813830.9951186
ENST00000537976ENST00000520502SDC4chr2043959005-NRG1chr832585466+0.0095488670.99045116
ENST00000537976ENST00000539990SDC4chr2043959005-NRG1chr832585466+0.0036589110.99634105

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>79822_79822_1_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000287842_length(amino acids)=618AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNI
ANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHS
SPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFM
EEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEV

--------------------------------------------------------------

>79822_79822_2_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000287845_length(amino acids)=626AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRS
ERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMS
SVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMP
SMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNG

--------------------------------------------------------------

>79822_79822_3_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000338921_length(amino acids)=629AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS
LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVI
VMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTV
SMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTK

--------------------------------------------------------------

>79822_79822_4_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>79822_79822_5_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000356819_length(amino acids)=626AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRS
ERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMS
SVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMP
SMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNG

--------------------------------------------------------------

>79822_79822_6_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000405005_length(amino acids)=621AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNM
MNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENS
RHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVS
PFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANR

--------------------------------------------------------------

>79822_79822_7_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000519301_length(amino acids)=626AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRS
ERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMS
SVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMP
SMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNG

--------------------------------------------------------------

>79822_79822_8_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000520407_length(amino acids)=222AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV

--------------------------------------------------------------

>79822_79822_9_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000520502_length(amino acids)=222AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV

--------------------------------------------------------------

>79822_79822_10_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000521670_length(amino acids)=443AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNM
MNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENS

--------------------------------------------------------------

>79822_79822_11_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000523079_length(amino acids)=401AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNI
ANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHS

--------------------------------------------------------------

>79822_79822_12_SDC4-NRG1_SDC4_chr20_43959005_ENST00000372733_NRG1_chr8_32585466_ENST00000539990_length(amino acids)=618AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNI
ANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHS
SPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFM
EEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEV

--------------------------------------------------------------

>79822_79822_13_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000287842_length(amino acids)=581AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELY
QKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAE
TSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSP
HSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDS
NSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASL

--------------------------------------------------------------

>79822_79822_14_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000287845_length(amino acids)=589AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIE
FMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSE
HIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARET
PDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSF
HHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGI

--------------------------------------------------------------

>79822_79822_15_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000338921_length(amino acids)=592AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHS
GEPFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>79822_79822_16_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>79822_79822_17_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000356819_length(amino acids)=589AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIE
FMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSE
HIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARET
PDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSF
HHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGI

--------------------------------------------------------------

>79822_79822_18_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000405005_length(amino acids)=584AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAE
ELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVER
EAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYR
DSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPA
HDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLA

--------------------------------------------------------------

>79822_79822_19_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000519301_length(amino acids)=589AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIE
FMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSE
HIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARET
PDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSF
HHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGI

--------------------------------------------------------------

>79822_79822_20_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000520407_length(amino acids)=185AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPF

--------------------------------------------------------------

>79822_79822_21_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000520502_length(amino acids)=185AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPF

--------------------------------------------------------------

>79822_79822_22_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000521670_length(amino acids)=406AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAE
ELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVER
EAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYR

--------------------------------------------------------------

>79822_79822_23_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000523079_length(amino acids)=364AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELY
QKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAE
TSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSP

--------------------------------------------------------------

>79822_79822_24_SDC4-NRG1_SDC4_chr20_43959005_ENST00000537976_NRG1_chr8_32585466_ENST00000539990_length(amino acids)=581AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELY
QKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAE
TSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSP
HSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDS
NSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASL

--------------------------------------------------------------

>79822_79822_25_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000287842_length(amino acids)=618AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNI
ANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHS
SPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFM
EEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEV

--------------------------------------------------------------

>79822_79822_26_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000287845_length(amino acids)=626AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRS
ERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMS
SVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMP
SMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNG

--------------------------------------------------------------

>79822_79822_27_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000338921_length(amino acids)=629AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS
LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVI
VMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTV
SMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTK

--------------------------------------------------------------

>79822_79822_28_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>79822_79822_29_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000356819_length(amino acids)=626AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRS
ERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMS
SVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMP
SMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNG

--------------------------------------------------------------

>79822_79822_30_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000405005_length(amino acids)=621AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNM
MNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENS
RHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVS
PFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANR

--------------------------------------------------------------

>79822_79822_31_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000519301_length(amino acids)=626AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRS
ERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMS
SVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMP
SMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNG

--------------------------------------------------------------

>79822_79822_32_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000520407_length(amino acids)=222AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV

--------------------------------------------------------------

>79822_79822_33_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000520502_length(amino acids)=222AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV

--------------------------------------------------------------

>79822_79822_34_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000521670_length(amino acids)=443AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNM
MNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENS

--------------------------------------------------------------

>79822_79822_35_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000523079_length(amino acids)=401AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNI
ANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHS

--------------------------------------------------------------

>79822_79822_36_SDC4-NRG1_SDC4_chr20_43959006_ENST00000372733_NRG1_chr8_32585467_ENST00000539990_length(amino acids)=618AA_BP=148
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNI
ANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHS
SPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFM
EEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEV

--------------------------------------------------------------

>79822_79822_37_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000287842_length(amino acids)=581AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELY
QKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAE
TSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSP
HSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDS
NSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASL

--------------------------------------------------------------

>79822_79822_38_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000287845_length(amino acids)=589AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIE
FMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSE
HIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARET
PDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSF
HHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGI

--------------------------------------------------------------

>79822_79822_39_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000338921_length(amino acids)=592AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHS
GEPFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>79822_79822_40_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>79822_79822_41_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000356819_length(amino acids)=589AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIE
FMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSE
HIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARET
PDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSF
HHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGI

--------------------------------------------------------------

>79822_79822_42_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000405005_length(amino acids)=584AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAE
ELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVER
EAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYR
DSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPA
HDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLA

--------------------------------------------------------------

>79822_79822_43_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000519301_length(amino acids)=589AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIE
FMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSE
HIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARET
PDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSF
HHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGI

--------------------------------------------------------------

>79822_79822_44_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000520407_length(amino acids)=185AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPF

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>79822_79822_45_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000520502_length(amino acids)=185AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPF

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>79822_79822_46_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000521670_length(amino acids)=406AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAE
ELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVER
EAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYR

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>79822_79822_47_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000523079_length(amino acids)=364AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELY
QKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAE
TSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSP

--------------------------------------------------------------

>79822_79822_48_SDC4-NRG1_SDC4_chr20_43959006_ENST00000537976_NRG1_chr8_32585467_ENST00000539990_length(amino acids)=581AA_BP=111
MRAFSSPRCHGPRPSVRAAAVLRRRSRRVDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSN
KVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELY
QKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAE
TSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSP
HSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDS
NSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:43959006/chr8:32585467)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDC4

P31431

NRG1

Q02297

FUNCTION: Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). {ECO:0000269|PubMed:22660413}.FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSDC4chr20:43959005chr8:32585466ENST00000372733-4519_145148.33333333333334199.0Topological domainExtracellular
HgeneSDC4chr20:43959006chr8:32585467ENST00000372733-4519_145148.33333333333334199.0Topological domainExtracellular
TgeneNRG1chr20:43959005chr8:32585466ENST00000287842412165_177167.33333333333334638.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959005chr8:32585466ENST00000341377413165_177167.33333333333334525.3333333333334Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959005chr8:32585466ENST00000356819413165_177167.33333333333334646.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959005chr8:32585466ENST00000405005412165_177167.33333333333334641.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959005chr8:32585466ENST00000519301211165_177112.33333333333333591.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959005chr8:32585466ENST00000521670413165_177167.33333333333334477.3333333333333Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959005chr8:32585466ENST00000523079411165_177167.33333333333334421.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959006chr8:32585467ENST00000287842412165_177167.33333333333334638.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959006chr8:32585467ENST00000341377413165_177167.33333333333334525.3333333333334Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959006chr8:32585467ENST00000356819413165_177167.33333333333334646.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959006chr8:32585467ENST00000405005412165_177167.33333333333334641.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959006chr8:32585467ENST00000519301211165_177112.33333333333333591.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959006chr8:32585467ENST00000521670413165_177167.33333333333334477.3333333333333Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959006chr8:32585467ENST00000523079411165_177167.33333333333334421.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959005chr8:32585466ENST00000287842412178_222167.33333333333334638.0DomainEGF-like
TgeneNRG1chr20:43959005chr8:32585466ENST00000341377413178_222167.33333333333334525.3333333333334DomainEGF-like
TgeneNRG1chr20:43959005chr8:32585466ENST00000356819413178_222167.33333333333334646.0DomainEGF-like
TgeneNRG1chr20:43959005chr8:32585466ENST00000405005412178_222167.33333333333334641.0DomainEGF-like
TgeneNRG1chr20:43959005chr8:32585466ENST00000519301211178_222112.33333333333333591.0DomainEGF-like
TgeneNRG1chr20:43959005chr8:32585466ENST00000521670413178_222167.33333333333334477.3333333333333DomainEGF-like
TgeneNRG1chr20:43959005chr8:32585466ENST00000523079411178_222167.33333333333334421.0DomainEGF-like
TgeneNRG1chr20:43959006chr8:32585467ENST00000287842412178_222167.33333333333334638.0DomainEGF-like
TgeneNRG1chr20:43959006chr8:32585467ENST00000341377413178_222167.33333333333334525.3333333333334DomainEGF-like
TgeneNRG1chr20:43959006chr8:32585467ENST00000356819413178_222167.33333333333334646.0DomainEGF-like
TgeneNRG1chr20:43959006chr8:32585467ENST00000405005412178_222167.33333333333334641.0DomainEGF-like
TgeneNRG1chr20:43959006chr8:32585467ENST00000519301211178_222112.33333333333333591.0DomainEGF-like
TgeneNRG1chr20:43959006chr8:32585467ENST00000521670413178_222167.33333333333334477.3333333333333DomainEGF-like
TgeneNRG1chr20:43959006chr8:32585467ENST00000523079411178_222167.33333333333334421.0DomainEGF-like
TgeneNRG1chr20:43959005chr8:32585466ENST00000287842412266_640167.33333333333334638.0Topological domainCytoplasmic
TgeneNRG1chr20:43959005chr8:32585466ENST00000341377413266_640167.33333333333334525.3333333333334Topological domainCytoplasmic
TgeneNRG1chr20:43959005chr8:32585466ENST00000356819413266_640167.33333333333334646.0Topological domainCytoplasmic
TgeneNRG1chr20:43959005chr8:32585466ENST00000405005412266_640167.33333333333334641.0Topological domainCytoplasmic
TgeneNRG1chr20:43959005chr8:32585466ENST00000519301211266_640112.33333333333333591.0Topological domainCytoplasmic
TgeneNRG1chr20:43959005chr8:32585466ENST0000052050203266_640222.33333333333334297.0Topological domainCytoplasmic
TgeneNRG1chr20:43959005chr8:32585466ENST00000521670413266_640167.33333333333334477.3333333333333Topological domainCytoplasmic
TgeneNRG1chr20:43959005chr8:32585466ENST00000523079411266_640167.33333333333334421.0Topological domainCytoplasmic
TgeneNRG1chr20:43959006chr8:32585467ENST00000287842412266_640167.33333333333334638.0Topological domainCytoplasmic
TgeneNRG1chr20:43959006chr8:32585467ENST00000341377413266_640167.33333333333334525.3333333333334Topological domainCytoplasmic
TgeneNRG1chr20:43959006chr8:32585467ENST00000356819413266_640167.33333333333334646.0Topological domainCytoplasmic
TgeneNRG1chr20:43959006chr8:32585467ENST00000405005412266_640167.33333333333334641.0Topological domainCytoplasmic
TgeneNRG1chr20:43959006chr8:32585467ENST00000519301211266_640112.33333333333333591.0Topological domainCytoplasmic
TgeneNRG1chr20:43959006chr8:32585467ENST0000052050203266_640222.33333333333334297.0Topological domainCytoplasmic
TgeneNRG1chr20:43959006chr8:32585467ENST00000521670413266_640167.33333333333334477.3333333333333Topological domainCytoplasmic
TgeneNRG1chr20:43959006chr8:32585467ENST00000523079411266_640167.33333333333334421.0Topological domainCytoplasmic
TgeneNRG1chr20:43959005chr8:32585466ENST00000287842412243_265167.33333333333334638.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959005chr8:32585466ENST00000341377413243_265167.33333333333334525.3333333333334TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959005chr8:32585466ENST00000356819413243_265167.33333333333334646.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959005chr8:32585466ENST00000405005412243_265167.33333333333334641.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959005chr8:32585466ENST00000519301211243_265112.33333333333333591.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959005chr8:32585466ENST0000052050203243_265222.33333333333334297.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959005chr8:32585466ENST00000521670413243_265167.33333333333334477.3333333333333TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959005chr8:32585466ENST00000523079411243_265167.33333333333334421.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959006chr8:32585467ENST00000287842412243_265167.33333333333334638.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959006chr8:32585467ENST00000341377413243_265167.33333333333334525.3333333333334TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959006chr8:32585467ENST00000356819413243_265167.33333333333334646.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959006chr8:32585467ENST00000405005412243_265167.33333333333334641.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959006chr8:32585467ENST00000519301211243_265112.33333333333333591.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959006chr8:32585467ENST0000052050203243_265222.33333333333334297.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959006chr8:32585467ENST00000521670413243_265167.33333333333334477.3333333333333TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959006chr8:32585467ENST00000523079411243_265167.33333333333334421.0TransmembraneHelical%3B Note%3DInternal signal sequence

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSDC4chr20:43959005chr8:32585466ENST00000372733-45171_198148.33333333333334199.0Topological domainCytoplasmic
HgeneSDC4chr20:43959006chr8:32585467ENST00000372733-45171_198148.33333333333334199.0Topological domainCytoplasmic
HgeneSDC4chr20:43959005chr8:32585466ENST00000372733-45146_170148.33333333333334199.0TransmembraneHelical
HgeneSDC4chr20:43959006chr8:32585467ENST00000372733-45146_170148.33333333333334199.0TransmembraneHelical
TgeneNRG1chr20:43959005chr8:32585466ENST0000052040725165_177348.3333333333333423.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959005chr8:32585466ENST0000052050203165_177222.33333333333334297.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959006chr8:32585467ENST0000052040725165_177348.3333333333333423.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959006chr8:32585467ENST0000052050203165_177222.33333333333334297.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr20:43959005chr8:32585466ENST0000028784241237_128167.33333333333334638.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959005chr8:32585466ENST0000034137741337_128167.33333333333334525.3333333333334DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959005chr8:32585466ENST0000035681941337_128167.33333333333334646.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959005chr8:32585466ENST0000040500541237_128167.33333333333334641.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959005chr8:32585466ENST0000051930121137_128112.33333333333333591.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959005chr8:32585466ENST0000052040725178_222348.3333333333333423.0DomainEGF-like
TgeneNRG1chr20:43959005chr8:32585466ENST000005204072537_128348.3333333333333423.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959005chr8:32585466ENST0000052050203178_222222.33333333333334297.0DomainEGF-like
TgeneNRG1chr20:43959005chr8:32585466ENST000005205020337_128222.33333333333334297.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959005chr8:32585466ENST0000052167041337_128167.33333333333334477.3333333333333DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959005chr8:32585466ENST0000052307941137_128167.33333333333334421.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959006chr8:32585467ENST0000028784241237_128167.33333333333334638.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959006chr8:32585467ENST0000034137741337_128167.33333333333334525.3333333333334DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959006chr8:32585467ENST0000035681941337_128167.33333333333334646.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959006chr8:32585467ENST0000040500541237_128167.33333333333334641.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959006chr8:32585467ENST0000051930121137_128112.33333333333333591.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959006chr8:32585467ENST0000052040725178_222348.3333333333333423.0DomainEGF-like
TgeneNRG1chr20:43959006chr8:32585467ENST000005204072537_128348.3333333333333423.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959006chr8:32585467ENST0000052050203178_222222.33333333333334297.0DomainEGF-like
TgeneNRG1chr20:43959006chr8:32585467ENST000005205020337_128222.33333333333334297.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959006chr8:32585467ENST0000052167041337_128167.33333333333334477.3333333333333DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959006chr8:32585467ENST0000052307941137_128167.33333333333334421.0DomainNote=Ig-like C2-type
TgeneNRG1chr20:43959005chr8:32585466ENST0000028784241220_242167.33333333333334638.0Topological domainExtracellular
TgeneNRG1chr20:43959005chr8:32585466ENST0000034137741320_242167.33333333333334525.3333333333334Topological domainExtracellular
TgeneNRG1chr20:43959005chr8:32585466ENST0000035681941320_242167.33333333333334646.0Topological domainExtracellular
TgeneNRG1chr20:43959005chr8:32585466ENST0000040500541220_242167.33333333333334641.0Topological domainExtracellular
TgeneNRG1chr20:43959005chr8:32585466ENST0000051930121120_242112.33333333333333591.0Topological domainExtracellular
TgeneNRG1chr20:43959005chr8:32585466ENST000005204072520_242348.3333333333333423.0Topological domainExtracellular
TgeneNRG1chr20:43959005chr8:32585466ENST0000052040725266_640348.3333333333333423.0Topological domainCytoplasmic
TgeneNRG1chr20:43959005chr8:32585466ENST000005205020320_242222.33333333333334297.0Topological domainExtracellular
TgeneNRG1chr20:43959005chr8:32585466ENST0000052167041320_242167.33333333333334477.3333333333333Topological domainExtracellular
TgeneNRG1chr20:43959005chr8:32585466ENST0000052307941120_242167.33333333333334421.0Topological domainExtracellular
TgeneNRG1chr20:43959006chr8:32585467ENST0000028784241220_242167.33333333333334638.0Topological domainExtracellular
TgeneNRG1chr20:43959006chr8:32585467ENST0000034137741320_242167.33333333333334525.3333333333334Topological domainExtracellular
TgeneNRG1chr20:43959006chr8:32585467ENST0000035681941320_242167.33333333333334646.0Topological domainExtracellular
TgeneNRG1chr20:43959006chr8:32585467ENST0000040500541220_242167.33333333333334641.0Topological domainExtracellular
TgeneNRG1chr20:43959006chr8:32585467ENST0000051930121120_242112.33333333333333591.0Topological domainExtracellular
TgeneNRG1chr20:43959006chr8:32585467ENST000005204072520_242348.3333333333333423.0Topological domainExtracellular
TgeneNRG1chr20:43959006chr8:32585467ENST0000052040725266_640348.3333333333333423.0Topological domainCytoplasmic
TgeneNRG1chr20:43959006chr8:32585467ENST000005205020320_242222.33333333333334297.0Topological domainExtracellular
TgeneNRG1chr20:43959006chr8:32585467ENST0000052167041320_242167.33333333333334477.3333333333333Topological domainExtracellular
TgeneNRG1chr20:43959006chr8:32585467ENST0000052307941120_242167.33333333333334421.0Topological domainExtracellular
TgeneNRG1chr20:43959005chr8:32585466ENST0000052040725243_265348.3333333333333423.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr20:43959006chr8:32585467ENST0000052040725243_265348.3333333333333423.0TransmembraneHelical%3B Note%3DInternal signal sequence


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1324_SDC4_43959006_NRG1_32585467_1324_SDC4_43959006_NRG1_32585467_ranked_0.pdbSDC44395900543959006ENST00000539990NRG1chr832585467+
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIP
ERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAATSTSTTGTSHLVKCAEKEKTFCVNGGECFMV
KDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS
LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVI
VMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTV
SMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTK
629


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SDC4_pLDDT.png
all structure
all structure
NRG1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SDC4FGF2, CCL5, GIPC1, DVL1, ELAVL1, MYC, TGFB3, TANK, SGTA, FGF1, PTEN, DBN1, Lima1, RARRES3, CYLD, GPR183, UBC, RIPK4, PYHIN1, MB21D1, PMP22, IL7R, MAL, SGTB, E6, PDPK1, ORF7b, ESR1, HNRNPH1, ABCB10, GTF3C1, FGF4, EVA1B, SDC2, PRDM10, VANGL2, TMEM192, CAMKV, METTL8, VANGL1, HADHB, GMEB1, C17orf80, ZBTB48, GMEB2, DHRS2, GTF3C2, GALNT2, PARP2, KRT35, ZNF92, TGFBR3, HADHA, FGFR3, TMEM186, LRRC16A, ZBTB1, AMPD2, FGFR2, DAXX, ADORA2B, H2AFZ, SULF2, NBR1, CALCOCO2, OPTN, SQSTM1, TAX1BP1, TOLLIP,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SDC4all structure
NRG1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SDC4-NRG1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SDC4-NRG1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSDC4C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneNRG1C0036341Schizophrenia7CTD_human
TgeneNRG1C0005586Bipolar Disorder5PSYGENET
TgeneNRG1C0024809Marijuana Abuse3PSYGENET
TgeneNRG1C0011570Mental Depression2PSYGENET
TgeneNRG1C0011581Depressive disorder2PSYGENET
TgeneNRG1C0006142Malignant neoplasm of breast1CTD_human
TgeneNRG1C0006870Cannabis Dependence1PSYGENET
TgeneNRG1C0007621Neoplastic Cell Transformation1CTD_human
TgeneNRG1C0011616Contact Dermatitis1CTD_human
TgeneNRG1C0018801Heart failure1CTD_human
TgeneNRG1C0018802Congestive heart failure1CTD_human
TgeneNRG1C0019569Hirschsprung Disease1CTD_human
TgeneNRG1C0023212Left-Sided Heart Failure1CTD_human
TgeneNRG1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNRG1C0024121Lung Neoplasms1CTD_human
TgeneNRG1C0026650Movement Disorders1CTD_human
TgeneNRG1C0027626Neoplasm Invasiveness1CTD_human
TgeneNRG1C0030193Pain1CTD_human
TgeneNRG1C0032460Polycystic Ovary Syndrome1CTD_human
TgeneNRG1C0038358Gastric ulcer1CTD_human
TgeneNRG1C0085758Aganglionosis, Colonic1CTD_human
TgeneNRG1C0087031Juvenile-Onset Still Disease1CTD_human
TgeneNRG1C0162351Contact hypersensitivity1CTD_human
TgeneNRG1C0234230Pain, Burning1CTD_human
TgeneNRG1C0234238Ache1CTD_human
TgeneNRG1C0234254Radiating pain1CTD_human
TgeneNRG1C0235527Heart Failure, Right-Sided1CTD_human
TgeneNRG1C0236733Amphetamine-Related Disorders1CTD_human
TgeneNRG1C0236804Amphetamine Addiction1CTD_human
TgeneNRG1C0236807Amphetamine Abuse1CTD_human
TgeneNRG1C0242379Malignant neoplasm of lung1CTD_human
TgeneNRG1C0266487Etat Marbre1CTD_human
TgeneNRG1C0458257Pain, Splitting1CTD_human
TgeneNRG1C0458259Pain, Crushing1CTD_human
TgeneNRG1C0678222Breast Carcinoma1CTD_human
TgeneNRG1C0751407Pain, Migratory1CTD_human
TgeneNRG1C0751408Suffering, Physical1CTD_human
TgeneNRG1C0876994Cardiotoxicity1CTD_human
TgeneNRG1C1136382Sclerocystic Ovaries1CTD_human
TgeneNRG1C1257840Aganglionosis, Rectosigmoid Colon1CTD_human
TgeneNRG1C1257931Mammary Neoplasms, Human1CTD_human
TgeneNRG1C1458155Mammary Neoplasms1CTD_human
TgeneNRG1C1959583Myocardial Failure1CTD_human
TgeneNRG1C1961112Heart Decompensation1CTD_human
TgeneNRG1C3495559Juvenile arthritis1CTD_human
TgeneNRG1C3661523Congenital Intestinal Aganglionosis1CTD_human
TgeneNRG1C3714758Juvenile psoriatic arthritis1CTD_human
TgeneNRG1C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneNRG1C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneNRG1C4704874Mammary Carcinoma, Human1CTD_human