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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SEC23B-ZCCHC7

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SEC23B-ZCCHC7
	FusionPDB ID: 80067
	FusionGDB2.0 ID: 80067
		Hgene	Tgene
	Gene symbol	SEC23B	ZCCHC7
	Gene ID	10483	84186
	Gene name	SEC23 homolog B, COPII coat complex component	zinc finger CCHC-type containing 7
	Synonyms	CDA-II\|CDAII\|CDAN2\|CWS7\|HEMPAS\|hSec23B	AIR1\|HSPC086
	Cytomap	20p11.23	9p13.2
	Type of gene	protein-coding	protein-coding
	Description	protein transport protein Sec23BSEC23 homolog B, coat complex II componentSEC23-like protein BSEC23-related protein Btransport protein SEC23B	zinc finger CCHC domain-containing protein 7TRAMP-like complex RNA-binding factor ZCCHC7zinc finger, CCHC domain containing 7
	Modification date	20200313	20200320
	UniProtAcc	.	Q8N3Z6
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000262544, ENST00000336714, ENST00000377465, ENST00000377475, ENST00000494645,	ENST00000461038, ENST00000322831, ENST00000336755, ENST00000534928,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 12 X 9=1296	20 X 16 X 8=2560
	# samples	15	22
	** MAII score	log2(15/1296*10)=-3.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/2560*10)=-3.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SEC23B [Title/Abstract] AND ZCCHC7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SEC23B(18506576)-ZCCHC7(37349354), # samples:3 ZCCHC7(37327831)-SEC23B(18522940), # samples:1
Anticipated loss of major functional domain due to fusion event.	SEC23B-ZCCHC7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SEC23B-ZCCHC7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SEC23B-ZCCHC7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SEC23B-ZCCHC7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ZCCHC7-SEC23B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZCCHC7-SEC23B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SEC23B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZCCHC7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-A45T-01A	SEC23B	chr20	18506576	-	ZCCHC7	chr9	37349354	+
ChimerDB4	HNSC	TCGA-CV-A45T-01A	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349354	+
ChimerDB4	HNSC	TCGA-CV-A45T	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349353	+
ChimerDB4	HNSC	TCGA-CV-A45T	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349354	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262544	SEC23B	chr20	18506576	+	ENST00000336755	ZCCHC7	chr9	37349354	+	2850	1324	490	1968	492
ENST00000262544	SEC23B	chr20	18506576	+	ENST00000534928	ZCCHC7	chr9	37349354	+	2267	1324	490	1968	492
ENST00000336714	SEC23B	chr20	18506576	+	ENST00000336755	ZCCHC7	chr9	37349354	+	2792	1266	432	1910	492
ENST00000336714	SEC23B	chr20	18506576	+	ENST00000534928	ZCCHC7	chr9	37349354	+	2209	1266	432	1910	492
ENST00000377475	SEC23B	chr20	18506576	+	ENST00000336755	ZCCHC7	chr9	37349354	+	2786	1260	426	1904	492
ENST00000377475	SEC23B	chr20	18506576	+	ENST00000534928	ZCCHC7	chr9	37349354	+	2203	1260	426	1904	492
ENST00000377465	SEC23B	chr20	18506576	+	ENST00000336755	ZCCHC7	chr9	37349354	+	2610	1084	250	1728	492
ENST00000377465	SEC23B	chr20	18506576	+	ENST00000534928	ZCCHC7	chr9	37349354	+	2027	1084	250	1728	492
ENST00000262544	SEC23B	chr20	18506576	+	ENST00000336755	ZCCHC7	chr9	37349353	+	2850	1324	490	1968	492
ENST00000262544	SEC23B	chr20	18506576	+	ENST00000534928	ZCCHC7	chr9	37349353	+	2267	1324	490	1968	492
ENST00000336714	SEC23B	chr20	18506576	+	ENST00000336755	ZCCHC7	chr9	37349353	+	2792	1266	432	1910	492
ENST00000336714	SEC23B	chr20	18506576	+	ENST00000534928	ZCCHC7	chr9	37349353	+	2209	1266	432	1910	492
ENST00000377475	SEC23B	chr20	18506576	+	ENST00000336755	ZCCHC7	chr9	37349353	+	2786	1260	426	1904	492
ENST00000377475	SEC23B	chr20	18506576	+	ENST00000534928	ZCCHC7	chr9	37349353	+	2203	1260	426	1904	492
ENST00000377465	SEC23B	chr20	18506576	+	ENST00000336755	ZCCHC7	chr9	37349353	+	2610	1084	250	1728	492
ENST00000377465	SEC23B	chr20	18506576	+	ENST00000534928	ZCCHC7	chr9	37349353	+	2027	1084	250	1728	492

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262544	ENST00000336755	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349354	+	0.001218781	0.99878126
ENST00000262544	ENST00000534928	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349354	+	0.00213394	0.9978661
ENST00000336714	ENST00000336755	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349354	+	0.001140641	0.9988594
ENST00000336714	ENST00000534928	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349354	+	0.001964972	0.998035
ENST00000377475	ENST00000336755	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349354	+	0.001284658	0.9987154
ENST00000377475	ENST00000534928	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349354	+	0.002199003	0.997801
ENST00000377465	ENST00000336755	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349354	+	0.00099467	0.9990054
ENST00000377465	ENST00000534928	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349354	+	0.001690383	0.9983096
ENST00000262544	ENST00000336755	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349353	+	0.001218781	0.99878126
ENST00000262544	ENST00000534928	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349353	+	0.00213394	0.9978661
ENST00000336714	ENST00000336755	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349353	+	0.001140641	0.9988594
ENST00000336714	ENST00000534928	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349353	+	0.001964972	0.998035
ENST00000377475	ENST00000336755	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349353	+	0.001284658	0.9987154
ENST00000377475	ENST00000534928	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349353	+	0.002199003	0.997801
ENST00000377465	ENST00000336755	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349353	+	0.00099467	0.9990054
ENST00000377465	ENST00000534928	SEC23B	chr20	18506576	+	ZCCHC7	chr9	37349353	+	0.001690383	0.9983096

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>80067_80067_1_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000262544_ZCCHC7_chr9_37349353_ENST00000336755_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_2_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000262544_ZCCHC7_chr9_37349353_ENST00000534928_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_3_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000262544_ZCCHC7_chr9_37349354_ENST00000336755_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_4_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000262544_ZCCHC7_chr9_37349354_ENST00000534928_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_5_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000336714_ZCCHC7_chr9_37349353_ENST00000336755_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_6_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000336714_ZCCHC7_chr9_37349353_ENST00000534928_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_7_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000336714_ZCCHC7_chr9_37349354_ENST00000336755_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_8_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000336714_ZCCHC7_chr9_37349354_ENST00000534928_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_9_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000377465_ZCCHC7_chr9_37349353_ENST00000336755_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_10_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000377465_ZCCHC7_chr9_37349353_ENST00000534928_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_11_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000377465_ZCCHC7_chr9_37349354_ENST00000336755_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_12_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000377465_ZCCHC7_chr9_37349354_ENST00000534928_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_13_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000377475_ZCCHC7_chr9_37349353_ENST00000336755_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_14_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000377475_ZCCHC7_chr9_37349353_ENST00000534928_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_15_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000377475_ZCCHC7_chr9_37349354_ENST00000336755_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

--------------------------------------------------------------

>80067_80067_16_SEC23B-ZCCHC7_SEC23B_chr20_18506576_ENST00000377475_ZCCHC7_chr9_37349354_ENST00000534928_length(amino acids)=492AA_BP=250
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS
KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:18506576/chr9:37349354)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ZCCHC7 Q8N3Z6
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ZCCHC7

chr20:18506576

chr9:37349353

ENST00000336755

348_365

329.0

544.0

Zinc finger

CCHC-type 4

Tgene

ZCCHC7

chr20:18506576

chr9:37349354

ENST00000336755

348_365

329.0

544.0

Zinc finger

CCHC-type 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SEC23B

chr20:18506576

chr9:37349353

ENST00000262544

634_720

278.0

768.0

Repeat

Gelsolin-like

Hgene

SEC23B

chr20:18506576

chr9:37349353

ENST00000336714

634_720

278.0

768.0

Repeat

Gelsolin-like

Hgene

SEC23B

chr20:18506576

chr9:37349353

ENST00000377465

634_720

278.0

768.0

Repeat

Gelsolin-like

Hgene

SEC23B

chr20:18506576

chr9:37349353

ENST00000377475

634_720

278.0

768.0

Repeat

Gelsolin-like

Hgene

SEC23B

chr20:18506576

chr9:37349354

ENST00000262544

634_720

278.0

768.0

Repeat

Gelsolin-like

Hgene

SEC23B

chr20:18506576

chr9:37349354

ENST00000336714

634_720

278.0

768.0

Repeat

Gelsolin-like

Hgene

SEC23B

chr20:18506576

chr9:37349354

ENST00000377465

634_720

278.0

768.0

Repeat

Gelsolin-like

Hgene

SEC23B

chr20:18506576

chr9:37349354

ENST00000377475

634_720

278.0

768.0

Repeat

Gelsolin-like

Tgene

ZCCHC7

chr20:18506576

chr9:37349353

ENST00000336755

241_258

329.0

544.0

Zinc finger

CCHC-type 1

Tgene

ZCCHC7

chr20:18506576

chr9:37349353

ENST00000336755

263_280

329.0

544.0

Zinc finger

CCHC-type 2

Tgene

ZCCHC7

chr20:18506576

chr9:37349353

ENST00000336755

304_321

329.0

544.0

Zinc finger

CCHC-type 3

Tgene

ZCCHC7

chr20:18506576

chr9:37349354

ENST00000336755

241_258

329.0

544.0

Zinc finger

CCHC-type 1

Tgene

ZCCHC7

chr20:18506576

chr9:37349354

ENST00000336755

263_280

329.0

544.0

Zinc finger

CCHC-type 2

Tgene

ZCCHC7

chr20:18506576

chr9:37349354

ENST00000336755

304_321

329.0

544.0

Zinc finger

CCHC-type 3

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1037_SEC23B_18506576_ZCCHC7_37349354_1037_SEC23B_18506576_ZCCHC7_37349354_ranked_0.pdb	SEC23B	18506576	18506576	ENST00000534928	ZCCHC7	chr9	37349354	+	MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL SIAVGLLETKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPS KLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHY	492

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

SEC23B_pLDDT.png

ZCCHC7_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

ZCCHC7

PAPD5, PAPD7, ELAVL1, LYN, SUMO1, SUMO2, PHC1, UBE2I, CARD9, RPL10A, RPL14, PDLIM7, HDLBP, SENP5, EIF2S2, HDGFRP2, ZNHIT6, FAM208A, PPAN, HIST1H1T, KIAA0020, NOL12, DGCR8, RPL28, ZKSCAN1, RNF4, CREBBP, HIST1H4A, KIF9, NEK6, GIPC2, TRIM41, LCE1E, ZNF250, NPM1, MKI67, PRKRA, NEIL1, RPL13, RPL3, RPL36, SART1, CCDC137, RPL11, ZBTB47, SRP14, RPL8, MPHOSPH6, ZNF467, ZC3H10, CPNE2, RPL7A, RPL4, RBM4B, RPLP0,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SEC23B
ZCCHC7

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to SEC23B-ZCCHC7

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SEC23B-ZCCHC7

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source