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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SECISBP2-NEDD4L

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SECISBP2-NEDD4L
FusionPDB ID: 80187
FusionGDB2.0 ID: 80187
HgeneTgene
Gene symbol

SECISBP2

NEDD4L

Gene ID

79048

23327

Gene nameSECIS binding protein 2NEDD4 like E3 ubiquitin protein ligase
SynonymsSBP2NEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2
Cytomap

9q22.2

18q21.31

Type of geneprotein-codingprotein-coding
Descriptionselenocysteine insertion sequence-binding protein 2Sec insertion sequence-binding protein 2E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseubiquitin-protein ligase Rsp5
Modification date2020031320200329
UniProtAcc.

Q96PU5

Ensembl transtripts involved in fusion geneENST idsENST00000339901, ENST00000375807, 
ENST00000534113, ENST00000470305, 
ENST00000357895, ENST00000431212, 
ENST00000435432, ENST00000456173, 
ENST00000456986, ENST00000586263, 
ENST00000588516, ENST00000256830, 
ENST00000256832, ENST00000400345, 
ENST00000589054, ENST00000356462, 
ENST00000382850, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 8 X 7=67227 X 28 X 6=4536
# samples 1432
** MAII scorelog2(14/672*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(32/4536*10)=-3.82527683005487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SECISBP2 [Title/Abstract] AND NEDD4L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SECISBP2(91956394)-NEDD4L(56063399), # samples:3
Anticipated loss of major functional domain due to fusion event.SECISBP2-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SECISBP2-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SECISBP2-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SECISBP2-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SECISBP2-NEDD4L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SECISBP2-NEDD4L seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNEDD4L

GO:0003254

regulation of membrane depolarization

15217910

TgeneNEDD4L

GO:0006511

ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0010038

response to metal ion

11244092

TgeneNEDD4L

GO:0016567

protein ubiquitination

15217910|25631046

TgeneNEDD4L

GO:0034765

regulation of ion transmembrane transport

17289006

TgeneNEDD4L

GO:0042391

regulation of membrane potential

17289006

TgeneNEDD4L

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0060306

regulation of membrane repolarization

21463633

TgeneNEDD4L

GO:0070936

protein K48-linked ubiquitination

21463633

TgeneNEDD4L

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

TgeneNEDD4L

GO:1901017

negative regulation of potassium ion transmembrane transporter activity

21463633

TgeneNEDD4L

GO:1901380

negative regulation of potassium ion transmembrane transport

21463633

TgeneNEDD4L

GO:1902306

negative regulation of sodium ion transmembrane transport

15217910

TgeneNEDD4L

GO:1903861

positive regulation of dendrite extension

23999003

TgeneNEDD4L

GO:2000009

negative regulation of protein localization to cell surface

21463633

TgeneNEDD4L

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

15217910


check buttonFusion gene breakpoints across SECISBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NEDD4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-8075-01ASECISBP2chr9

91956394

-NEDD4Lchr18

56063399

+
ChimerDB4LUADTCGA-86-8075-01ASECISBP2chr9

91956394

+NEDD4Lchr18

56063399

+
ChimerDB4LUADTCGA-86-8075SECISBP2chr9

91956394

+NEDD4Lchr18

56063398

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000375807SECISBP2chr991956394+ENST00000356462NEDD4Lchr1856063399+19141506711894607
ENST00000375807SECISBP2chr991956394+ENST00000382850NEDD4Lchr1856063399+68791506711894607
ENST00000339901SECISBP2chr991956394+ENST00000356462NEDD4Lchr1856063399+178013721561760534
ENST00000339901SECISBP2chr991956394+ENST00000382850NEDD4Lchr1856063399+674513721561760534
ENST00000534113SECISBP2chr991956394+ENST00000356462NEDD4Lchr1856063399+20241616582004648
ENST00000534113SECISBP2chr991956394+ENST00000382850NEDD4Lchr1856063399+69891616582004648
ENST00000375807SECISBP2chr991956394+ENST00000356462NEDD4Lchr1856063398+19141506711894607
ENST00000375807SECISBP2chr991956394+ENST00000382850NEDD4Lchr1856063398+68791506711894607
ENST00000339901SECISBP2chr991956394+ENST00000356462NEDD4Lchr1856063398+178013721561760534
ENST00000339901SECISBP2chr991956394+ENST00000382850NEDD4Lchr1856063398+674513721561760534
ENST00000534113SECISBP2chr991956394+ENST00000356462NEDD4Lchr1856063398+20241616582004648
ENST00000534113SECISBP2chr991956394+ENST00000382850NEDD4Lchr1856063398+69891616582004648

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375807ENST00000356462SECISBP2chr991956394+NEDD4Lchr1856063399+0.0029268470.9970732
ENST00000375807ENST00000382850SECISBP2chr991956394+NEDD4Lchr1856063399+0.0005569810.999443
ENST00000339901ENST00000356462SECISBP2chr991956394+NEDD4Lchr1856063399+0.0011088670.9988912
ENST00000339901ENST00000382850SECISBP2chr991956394+NEDD4Lchr1856063399+0.0001325970.99986744
ENST00000534113ENST00000356462SECISBP2chr991956394+NEDD4Lchr1856063399+0.0021439550.9978561
ENST00000534113ENST00000382850SECISBP2chr991956394+NEDD4Lchr1856063399+0.0002690740.9997309
ENST00000375807ENST00000356462SECISBP2chr991956394+NEDD4Lchr1856063398+0.0029268470.9970732
ENST00000375807ENST00000382850SECISBP2chr991956394+NEDD4Lchr1856063398+0.0005569810.999443
ENST00000339901ENST00000356462SECISBP2chr991956394+NEDD4Lchr1856063398+0.0011088670.9988912
ENST00000339901ENST00000382850SECISBP2chr991956394+NEDD4Lchr1856063398+0.0001325970.99986744
ENST00000534113ENST00000356462SECISBP2chr991956394+NEDD4Lchr1856063398+0.0021439550.9978561
ENST00000534113ENST00000382850SECISBP2chr991956394+NEDD4Lchr1856063398+0.0002690740.9997309

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>80187_80187_1_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000339901_NEDD4L_chr18_56063398_ENST00000356462_length(amino acids)=534AA_BP=405
MVRVLRSMCLPQLCSHILSVCSGTTSDRNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSER
ADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDIS
LLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSE
ALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQP
QDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFSWPWKMLKDLKGWIKHPVPRGWLFF

--------------------------------------------------------------

>80187_80187_2_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000339901_NEDD4L_chr18_56063398_ENST00000382850_length(amino acids)=534AA_BP=405
MVRVLRSMCLPQLCSHILSVCSGTTSDRNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSER
ADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDIS
LLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSE
ALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQP
QDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFSWPWKMLKDLKGWIKHPVPRGWLFF

--------------------------------------------------------------

>80187_80187_3_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000339901_NEDD4L_chr18_56063399_ENST00000356462_length(amino acids)=534AA_BP=405
MVRVLRSMCLPQLCSHILSVCSGTTSDRNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSER
ADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDIS
LLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSE
ALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQP
QDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFSWPWKMLKDLKGWIKHPVPRGWLFF

--------------------------------------------------------------

>80187_80187_4_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000339901_NEDD4L_chr18_56063399_ENST00000382850_length(amino acids)=534AA_BP=405
MVRVLRSMCLPQLCSHILSVCSGTTSDRNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSER
ADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDIS
LLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSE
ALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQP
QDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFSWPWKMLKDLKGWIKHPVPRGWLFF

--------------------------------------------------------------

>80187_80187_5_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000375807_NEDD4L_chr18_56063398_ENST00000356462_length(amino acids)=607AA_BP=478
MASEGPREPESEGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAATYYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPY
AYSPYTLDSTQNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHH
LSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEI
VVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHP
TQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQL
DLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFSWPWKMLKDLKGWIKHPVPRGWLFFKQVLLALLHLPNRLLQR

--------------------------------------------------------------

>80187_80187_6_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000375807_NEDD4L_chr18_56063398_ENST00000382850_length(amino acids)=607AA_BP=478
MASEGPREPESEGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAATYYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPY
AYSPYTLDSTQNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHH
LSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEI
VVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHP
TQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQL
DLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFSWPWKMLKDLKGWIKHPVPRGWLFFKQVLLALLHLPNRLLQR

--------------------------------------------------------------

>80187_80187_7_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000375807_NEDD4L_chr18_56063399_ENST00000356462_length(amino acids)=607AA_BP=478
MASEGPREPESEGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAATYYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPY
AYSPYTLDSTQNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHH
LSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEI
VVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHP
TQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQL
DLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFSWPWKMLKDLKGWIKHPVPRGWLFFKQVLLALLHLPNRLLQR

--------------------------------------------------------------

>80187_80187_8_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000375807_NEDD4L_chr18_56063399_ENST00000382850_length(amino acids)=607AA_BP=478
MASEGPREPESEGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAATYYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPY
AYSPYTLDSTQNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHH
LSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEI
VVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHP
TQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQL
DLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFSWPWKMLKDLKGWIKHPVPRGWLFFKQVLLALLHLPNRLLQR

--------------------------------------------------------------

>80187_80187_9_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000534113_NEDD4L_chr18_56063398_ENST00000356462_length(amino acids)=648AA_BP=519
MASFPRSWERIDCFKGSCVFLNVILRSTYSALPLDGALAIACIIFRPIKFSVKGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAAT
YYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPYAYSPYTLDSTQNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEM
KALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGA
ENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNV
TSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEF
PNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFS
WPWKMLKDLKGWIKHPVPRGWLFFKQVLLALLHLPNRLLQRRWQRAAAGMVPGAEPSPRTRPSSDAGTWSQLEFLPFPPQIINWLMCTLI

--------------------------------------------------------------

>80187_80187_10_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000534113_NEDD4L_chr18_56063398_ENST00000382850_length(amino acids)=648AA_BP=519
MASFPRSWERIDCFKGSCVFLNVILRSTYSALPLDGALAIACIIFRPIKFSVKGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAAT
YYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPYAYSPYTLDSTQNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEM
KALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGA
ENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNV
TSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEF
PNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFS
WPWKMLKDLKGWIKHPVPRGWLFFKQVLLALLHLPNRLLQRRWQRAAAGMVPGAEPSPRTRPSSDAGTWSQLEFLPFPPQIINWLMCTLI

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>80187_80187_11_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000534113_NEDD4L_chr18_56063399_ENST00000356462_length(amino acids)=648AA_BP=519
MASFPRSWERIDCFKGSCVFLNVILRSTYSALPLDGALAIACIIFRPIKFSVKGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAAT
YYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPYAYSPYTLDSTQNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEM
KALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGA
ENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNV
TSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEF
PNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFS
WPWKMLKDLKGWIKHPVPRGWLFFKQVLLALLHLPNRLLQRRWQRAAAGMVPGAEPSPRTRPSSDAGTWSQLEFLPFPPQIINWLMCTLI

--------------------------------------------------------------

>80187_80187_12_SECISBP2-NEDD4L_SECISBP2_chr9_91956394_ENST00000534113_NEDD4L_chr18_56063399_ENST00000382850_length(amino acids)=648AA_BP=519
MASFPRSWERIDCFKGSCVFLNVILRSTYSALPLDGALAIACIIFRPIKFSVKGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAAT
YYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPYAYSPYTLDSTQNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEM
KALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGA
ENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNV
TSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEF
PNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSALIALTYLHMKPLKIYERNFS
WPWKMLKDLKGWIKHPVPRGWLFFKQVLLALLHLPNRLLQRRWQRAAAGMVPGAEPSPRTRPSSDAGTWSQLEFLPFPPQIINWLMCTLI

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:91956394/chr18:56063399)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NEDD4L

Q96PU5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSECISBP2chr9:91956394chr18:56063398ENST00000339901+1017380_387405.3333333333333782.0Compositional biasNote=Poly-Lys
HgeneSECISBP2chr9:91956394chr18:56063398ENST00000375807+1017380_387478.3333333333333855.0Compositional biasNote=Poly-Lys
HgeneSECISBP2chr9:91956394chr18:56063399ENST00000339901+1017380_387405.3333333333333782.0Compositional biasNote=Poly-Lys
HgeneSECISBP2chr9:91956394chr18:56063399ENST00000375807+1017380_387478.3333333333333855.0Compositional biasNote=Poly-Lys

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSECISBP2chr9:91956394chr18:56063398ENST00000339901+1017673_694405.3333333333333782.0RegionRNA-binding
HgeneSECISBP2chr9:91956394chr18:56063398ENST00000375807+1017673_694478.3333333333333855.0RegionRNA-binding
HgeneSECISBP2chr9:91956394chr18:56063399ENST00000339901+1017673_694405.3333333333333782.0RegionRNA-binding
HgeneSECISBP2chr9:91956394chr18:56063399ENST00000375807+1017673_694478.3333333333333855.0RegionRNA-binding
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000002568302628193_226837.6666666666666872.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000002568302628385_418837.6666666666666872.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000002568302628497_530837.6666666666666872.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063398ENST0000025683026284_126837.6666666666666872.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000002568302628548_581837.6666666666666872.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000002568302628640_974837.6666666666666872.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003564622729193_226877.6666666666666912.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003564622729385_418877.6666666666666912.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003564622729497_530877.6666666666666912.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063398ENST0000035646227294_126877.6666666666666912.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003564622729548_581877.6666666666666912.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003564622729640_974877.6666666666666912.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003578952931193_226933.6666666666666968.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003578952931385_418933.6666666666666968.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003578952931497_530933.6666666666666968.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063398ENST0000035789529314_126933.6666666666666968.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003578952931548_581933.6666666666666968.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003578952931640_974933.6666666666666968.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003828502830193_226921.6666666666666956.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003828502830385_418921.6666666666666956.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003828502830497_530921.6666666666666956.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063398ENST0000038285028304_126921.6666666666666956.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003828502830548_581921.6666666666666956.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000003828502830640_974921.6666666666666956.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004003452931193_226941.6666666666666976.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004003452931385_418941.6666666666666976.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004003452931497_530941.6666666666666976.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063398ENST0000040034529314_126941.6666666666666976.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004003452931548_581941.6666666666666976.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004003452931640_974941.6666666666666976.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004312122830193_226820.6666666666666855.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004312122830385_418820.6666666666666855.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004312122830497_530820.6666666666666855.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063398ENST0000043121228304_126820.6666666666666855.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004312122830548_581820.6666666666666855.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004312122830640_974820.6666666666666855.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004354322931193_226800.6666666666666835.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004354322931385_418800.6666666666666835.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004354322931497_530800.6666666666666835.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063398ENST0000043543229314_126800.6666666666666835.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004354322931548_581800.6666666666666835.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004354322931640_974800.6666666666666835.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004561732729193_226800.6666666666666835.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004561732729385_418800.6666666666666835.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004561732729497_530800.6666666666666835.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063398ENST0000045617327294_126800.6666666666666835.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004561732729548_581800.6666666666666835.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004561732729640_974800.6666666666666835.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004569862931193_226820.6666666666666855.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004569862931385_418820.6666666666666855.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004569862931497_530820.6666666666666855.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063398ENST0000045698629314_126820.6666666666666855.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004569862931548_581820.6666666666666855.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000004569862931640_974820.6666666666666855.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000005862632830193_226913.6666666666666948.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000005862632830385_418913.6666666666666948.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000005862632830497_530913.6666666666666948.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063398ENST0000058626328304_126913.6666666666666948.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000005862632830548_581913.6666666666666948.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063398ENST000005862632830640_974913.6666666666666948.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000002568302628193_226837.6666666666666872.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000002568302628385_418837.6666666666666872.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000002568302628497_530837.6666666666666872.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063399ENST0000025683026284_126837.6666666666666872.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000002568302628548_581837.6666666666666872.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000002568302628640_974837.6666666666666872.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003564622729193_226877.6666666666666912.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003564622729385_418877.6666666666666912.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003564622729497_530877.6666666666666912.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063399ENST0000035646227294_126877.6666666666666912.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003564622729548_581877.6666666666666912.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003564622729640_974877.6666666666666912.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003578952931193_226933.6666666666666968.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003578952931385_418933.6666666666666968.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003578952931497_530933.6666666666666968.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063399ENST0000035789529314_126933.6666666666666968.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003578952931548_581933.6666666666666968.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003578952931640_974933.6666666666666968.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003828502830193_226921.6666666666666956.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003828502830385_418921.6666666666666956.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003828502830497_530921.6666666666666956.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063399ENST0000038285028304_126921.6666666666666956.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003828502830548_581921.6666666666666956.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000003828502830640_974921.6666666666666956.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004003452931193_226941.6666666666666976.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004003452931385_418941.6666666666666976.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004003452931497_530941.6666666666666976.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063399ENST0000040034529314_126941.6666666666666976.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004003452931548_581941.6666666666666976.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004003452931640_974941.6666666666666976.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004312122830193_226820.6666666666666855.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004312122830385_418820.6666666666666855.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004312122830497_530820.6666666666666855.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063399ENST0000043121228304_126820.6666666666666855.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004312122830548_581820.6666666666666855.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004312122830640_974820.6666666666666855.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004354322931193_226800.6666666666666835.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004354322931385_418800.6666666666666835.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004354322931497_530800.6666666666666835.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063399ENST0000043543229314_126800.6666666666666835.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004354322931548_581800.6666666666666835.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004354322931640_974800.6666666666666835.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004561732729193_226800.6666666666666835.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004561732729385_418800.6666666666666835.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004561732729497_530800.6666666666666835.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063399ENST0000045617327294_126800.6666666666666835.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004561732729548_581800.6666666666666835.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004561732729640_974800.6666666666666835.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004569862931193_226820.6666666666666855.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004569862931385_418820.6666666666666855.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004569862931497_530820.6666666666666855.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063399ENST0000045698629314_126820.6666666666666855.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004569862931548_581820.6666666666666855.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000004569862931640_974820.6666666666666855.0DomainHECT
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000005862632830193_226913.6666666666666948.0DomainWW 1
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000005862632830385_418913.6666666666666948.0DomainWW 2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000005862632830497_530913.6666666666666948.0DomainWW 3
TgeneNEDD4Lchr9:91956394chr18:56063399ENST0000058626328304_126913.6666666666666948.0DomainC2
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000005862632830548_581913.6666666666666948.0DomainWW 4
TgeneNEDD4Lchr9:91956394chr18:56063399ENST000005862632830640_974913.6666666666666948.0DomainHECT


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SECISBP2
NEDD4L


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SECISBP2-NEDD4L


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SECISBP2-NEDD4L


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource