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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SEL1L3-CCKAR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SEL1L3-CCKAR
FusionPDB ID: 80204
FusionGDB2.0 ID: 80204
HgeneTgene
Gene symbol

SEL1L3

CCKAR

Gene ID

23231

886

Gene nameSEL1L family member 3cholecystokinin A receptor
SynonymsSel-1L3CCK-A|CCK1-R|CCK1R|CCKRA
Cytomap

4p15.2

4p15.2

Type of geneprotein-codingprotein-coding
Descriptionprotein sel-1 homolog 3sel-1 suppressor of lin-12-like 3suppressor of lin-12-like protein 3cholecystokinin receptor type ACCK-A receptorCCK-ARcholecystokinin type-A receptorcholecystokinin-1 receptor
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000264868, ENST00000399878, 
ENST00000502949, ENST00000513364, 
ENST00000295589, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 12 X 7=9241 X 1 X 1=1
# samples 122
** MAII scorelog2(12/924*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/1*10)=4.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: SEL1L3 [Title/Abstract] AND CCKAR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SEL1L3(25759156)-CCKAR(26484905), # samples:3
Anticipated loss of major functional domain due to fusion event.SEL1L3-CCKAR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCKAR

GO:0038188

cholecystokinin signaling pathway

8503909


check buttonFusion gene breakpoints across SEL1L3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCKAR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A925-01ASEL1L3chr4

25759156

-CCKARchr4

26484905

-
ChimerDB4STADTCGA-VQ-A925SEL1L3chr4

25759155

-CCKARchr4

26484905

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000502949SEL1L3chr425759156-ENST00000295589CCKARchr426484905-410032011732471076
ENST00000502949SEL1L3chr425759155-ENST00000295589CCKARchr426484905-410032011732471076

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000502949ENST00000295589SEL1L3chr425759156-CCKARchr426484905-0.0013016960.99869823
ENST00000502949ENST00000295589SEL1L3chr425759155-CCKARchr426484905-0.0013016960.99869823

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>80204_80204_1_SEL1L3-CCKAR_SEL1L3_chr4_25759155_ENST00000502949_CCKAR_chr4_26484905_ENST00000295589_length(amino acids)=1076AA_BP=1061
MREWRPGQKSNQTKTHCTGGNWSVRPAKGNVVPSLGRQTSLTTSVIPKAEQSVAYKDFIYFTVFEGNVRNVSEVSVEYLCSQPCVVNLEA
VVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHSISVSAVIVRAWITHKYSGRDWNVKWEENLLHAVAKNYTLL
QTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYASSGENTGIVKKFPRFRNRELEATRRQRMDYPVFTVSLWLY
LLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQIVVTTSIGQDLKSYHNQTI
SFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEIVSVYASAAKHGGERQEAC
HLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSSIDGLHQISSIVPFLTDSS
CCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNIATKTPLDQHTLQGDQAYV
ETIRLKDDEILKVQTKEDGDVFMWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKK
NRRLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIFPGVPGRNQTLAGEYFHKAAQGGHM
EGTLWCSLYYITGNLETFPRDPEKAVVWAKHVAEKNGYLGHVIRKGLNAYLEGSWHEALLYYVLAAETGIEVSQTNLAHICEERPDLARR
YLGVNCVWRYYNFSVFQIDAPSFAYLKMGDLYYYGHQNQSQDLELSVQMYAQAALDGDSQGFFNLALLIEEGTIIPHHILDFLEIDSTLH

--------------------------------------------------------------

>80204_80204_2_SEL1L3-CCKAR_SEL1L3_chr4_25759156_ENST00000502949_CCKAR_chr4_26484905_ENST00000295589_length(amino acids)=1076AA_BP=1061
MREWRPGQKSNQTKTHCTGGNWSVRPAKGNVVPSLGRQTSLTTSVIPKAEQSVAYKDFIYFTVFEGNVRNVSEVSVEYLCSQPCVVNLEA
VVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHSISVSAVIVRAWITHKYSGRDWNVKWEENLLHAVAKNYTLL
QTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYASSGENTGIVKKFPRFRNRELEATRRQRMDYPVFTVSLWLY
LLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQIVVTTSIGQDLKSYHNQTI
SFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEIVSVYASAAKHGGERQEAC
HLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSSIDGLHQISSIVPFLTDSS
CCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNIATKTPLDQHTLQGDQAYV
ETIRLKDDEILKVQTKEDGDVFMWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKK
NRRLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIFPGVPGRNQTLAGEYFHKAAQGGHM
EGTLWCSLYYITGNLETFPRDPEKAVVWAKHVAEKNGYLGHVIRKGLNAYLEGSWHEALLYYVLAAETGIEVSQTNLAHICEERPDLARR
YLGVNCVWRYYNFSVFQIDAPSFAYLKMGDLYYYGHQNQSQDLELSVQMYAQAALDGDSQGFFNLALLIEEGTIIPHHILDFLEIDSTLH

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:25759156/chr4:26484905)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324575_6091051.33333333333331098.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324611_6471051.33333333333331098.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324694_7301051.33333333333331098.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324732_7671051.33333333333331098.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324768_8001051.33333333333331098.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324801_8391051.33333333333331098.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324840_8771051.33333333333331098.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324952_9881051.33333333333331098.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324575_6091086.33333333333331133.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324611_6471086.33333333333331133.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324694_7301086.33333333333331133.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324732_7671086.33333333333331133.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324768_8001086.33333333333331133.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324801_8391086.33333333333331133.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324840_8771086.33333333333331133.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324952_9881086.33333333333331133.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324575_609933.3333333333334980.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324611_647933.3333333333334980.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324694_730933.3333333333334980.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324732_767933.3333333333334980.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324768_800933.3333333333334980.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324801_839933.3333333333334980.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324840_877933.3333333333334980.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324575_6091051.33333333333331098.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324611_6471051.33333333333331098.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324694_7301051.33333333333331098.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324732_7671051.33333333333331098.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324768_8001051.33333333333331098.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324801_8391051.33333333333331098.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324840_8771051.33333333333331098.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324952_9881051.33333333333331098.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324575_6091086.33333333333331133.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324611_6471086.33333333333331133.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324694_7301086.33333333333331133.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324732_7671086.33333333333331133.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324768_8001086.33333333333331133.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324801_8391086.33333333333331133.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324840_8771086.33333333333331133.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324952_9881086.33333333333331133.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324575_609933.3333333333334980.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324611_647933.3333333333334980.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324694_730933.3333333333334980.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324732_767933.3333333333334980.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324768_800933.3333333333334980.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324801_839933.3333333333334980.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324840_877933.3333333333334980.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-23241057_10771086.33333333333331133.0TransmembraneHelical
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-23241057_10771086.33333333333331133.0TransmembraneHelical
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925235_313208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925335_349208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925374_428208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925235_313208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925335_349208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925374_428208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925211_234208.66666666666666429.0TransmembraneHelical%3B Name%3D5
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925314_334208.66666666666666429.0TransmembraneHelical%3B Name%3D6
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925350_373208.66666666666666429.0TransmembraneHelical%3B Name%3D7
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925211_234208.66666666666666429.0TransmembraneHelical%3B Name%3D5
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925314_334208.66666666666666429.0TransmembraneHelical%3B Name%3D6
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925350_373208.66666666666666429.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324952_988933.3333333333334980.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324952_988933.3333333333334980.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-23241057_10771051.33333333333331098.0TransmembraneHelical
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-23241057_1077933.3333333333334980.0TransmembraneHelical
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-23241057_10771051.33333333333331098.0TransmembraneHelical
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-23241057_1077933.3333333333334980.0TransmembraneHelical
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925105_115208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925138_157208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925179_210208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759155chr4:26484905ENST00000295589251_41208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759155chr4:26484905ENST000002955892568_77208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925105_115208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925138_157208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925179_210208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759156chr4:26484905ENST00000295589251_41208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759156chr4:26484905ENST000002955892568_77208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925116_137208.66666666666666429.0TransmembraneHelical%3B Name%3D3
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925158_178208.66666666666666429.0TransmembraneHelical%3B Name%3D4
TgeneCCKARchr4:25759155chr4:26484905ENST000002955892542_67208.66666666666666429.0TransmembraneHelical%3B Name%3D1
TgeneCCKARchr4:25759155chr4:26484905ENST000002955892578_104208.66666666666666429.0TransmembraneHelical%3B Name%3D2
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925116_137208.66666666666666429.0TransmembraneHelical%3B Name%3D3
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925158_178208.66666666666666429.0TransmembraneHelical%3B Name%3D4
TgeneCCKARchr4:25759156chr4:26484905ENST000002955892542_67208.66666666666666429.0TransmembraneHelical%3B Name%3D1
TgeneCCKARchr4:25759156chr4:26484905ENST000002955892578_104208.66666666666666429.0TransmembraneHelical%3B Name%3D2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SEL1L3
CCKAR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SEL1L3-CCKAR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SEL1L3-CCKAR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource