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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SEL1L3-FIP1L1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SEL1L3-FIP1L1
FusionPDB ID: 80206
FusionGDB2.0 ID: 80206
HgeneTgene
Gene symbol

SEL1L3

FIP1L1

Gene ID

23231

81608

Gene nameSEL1L family member 3factor interacting with PAPOLA and CPSF1
SynonymsSel-1L3FIP1|Rhe|hFip1
Cytomap

4p15.2

4q12

Type of geneprotein-codingprotein-coding
Descriptionprotein sel-1 homolog 3sel-1 suppressor of lin-12-like 3suppressor of lin-12-like protein 3pre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia
Modification date2020031320200313
UniProtAcc.

Q6UN15

Ensembl transtripts involved in fusion geneENST idsENST00000264868, ENST00000399878, 
ENST00000502949, ENST00000513364, 
ENST00000510668, ENST00000306932, 
ENST00000337488, ENST00000358575, 
ENST00000507166, ENST00000507922, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 12 X 7=92417 X 15 X 11=2805
# samples 1223
** MAII scorelog2(12/924*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2805*10)=-3.60829500455178
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SEL1L3 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SEL1L3(25803904)-FIP1L1(54265896), # samples:1
Anticipated loss of major functional domain due to fusion event.SEL1L3-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SEL1L3-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SEL1L3-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SEL1L3-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SEL1L3-FIP1L1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SEL1L3-FIP1L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SEL1L3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FIP1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer5381NSEL1L3chr4

25803904

-FIP1L1chr4

54265896

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399878SEL1L3chr425803904-ENST00000507166FIP1L1chr454265896+392420797839231281
ENST00000399878SEL1L3chr425803904-ENST00000358575FIP1L1chr454265896+340520797831851035
ENST00000399878SEL1L3chr425803904-ENST00000337488FIP1L1chr454265896+337820797831581026
ENST00000399878SEL1L3chr425803904-ENST00000507922FIP1L1chr454265896+25862079782555825
ENST00000399878SEL1L3chr425803904-ENST00000306932FIP1L1chr454265896+32232079783050990
ENST00000264868SEL1L3chr425803904-ENST00000507166FIP1L1chr454265896+377919342037781253
ENST00000264868SEL1L3chr425803904-ENST00000358575FIP1L1chr454265896+326019342030401006
ENST00000264868SEL1L3chr425803904-ENST00000337488FIP1L1chr454265896+32331934203013997
ENST00000264868SEL1L3chr425803904-ENST00000507922FIP1L1chr454265896+24411934202410796
ENST00000264868SEL1L3chr425803904-ENST00000306932FIP1L1chr454265896+30781934202905961

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399878ENST00000507166SEL1L3chr425803904-FIP1L1chr454265896+0.0006070840.99939287
ENST00000399878ENST00000358575SEL1L3chr425803904-FIP1L1chr454265896+0.0004004430.9995995
ENST00000399878ENST00000337488SEL1L3chr425803904-FIP1L1chr454265896+0.0006884740.99931157
ENST00000399878ENST00000507922SEL1L3chr425803904-FIP1L1chr454265896+0.0039180810.9960819
ENST00000399878ENST00000306932SEL1L3chr425803904-FIP1L1chr454265896+0.0007678320.9992322
ENST00000264868ENST00000507166SEL1L3chr425803904-FIP1L1chr454265896+0.0005489320.9994511
ENST00000264868ENST00000358575SEL1L3chr425803904-FIP1L1chr454265896+0.0004548020.99954516
ENST00000264868ENST00000337488SEL1L3chr425803904-FIP1L1chr454265896+0.0004715630.9995284
ENST00000264868ENST00000507922SEL1L3chr425803904-FIP1L1chr454265896+0.0023091030.9976909
ENST00000264868ENST00000306932SEL1L3chr425803904-FIP1L1chr454265896+0.0006031890.9993968

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>80206_80206_1_SEL1L3-FIP1L1_SEL1L3_chr4_25803904_ENST00000264868_FIP1L1_chr4_54265896_ENST00000306932_length(amino acids)=961AA_BP=638
MGAGQLRGTTPGGTLALRPAGMAPRPKKQPDKNPLHGRELNVVPSLGRQTSLTTSVIPKAEQSVAYKDFIYFTVFEGNVRNVSEVSVEYL
CSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHSISVSAVIVRAWITHKYSGRDWNVKWEENL
LHAVAKNYTLLQTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYASSGENTGIVKKFPRFRNRELEATRRQRMD
YPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQIVVTTSIG
QDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEIVSVYASA
AKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSSIDGLHQI
SSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNIATKTPLD
QHTLQGDQVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNF
SKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPS
LVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRH

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>80206_80206_2_SEL1L3-FIP1L1_SEL1L3_chr4_25803904_ENST00000264868_FIP1L1_chr4_54265896_ENST00000337488_length(amino acids)=997AA_BP=638
MGAGQLRGTTPGGTLALRPAGMAPRPKKQPDKNPLHGRELNVVPSLGRQTSLTTSVIPKAEQSVAYKDFIYFTVFEGNVRNVSEVSVEYL
CSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHSISVSAVIVRAWITHKYSGRDWNVKWEENL
LHAVAKNYTLLQTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYASSGENTGIVKKFPRFRNRELEATRRQRMD
YPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQIVVTTSIG
QDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEIVSVYASA
AKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSSIDGLHQI
SSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNIATKTPLD
QHTLQGDQVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLRRLPGAIDVI
GQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPT
IESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSV
FNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQES

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>80206_80206_3_SEL1L3-FIP1L1_SEL1L3_chr4_25803904_ENST00000264868_FIP1L1_chr4_54265896_ENST00000358575_length(amino acids)=1006AA_BP=638
MGAGQLRGTTPGGTLALRPAGMAPRPKKQPDKNPLHGRELNVVPSLGRQTSLTTSVIPKAEQSVAYKDFIYFTVFEGNVRNVSEVSVEYL
CSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHSISVSAVIVRAWITHKYSGRDWNVKWEENL
LHAVAKNYTLLQTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYASSGENTGIVKKFPRFRNRELEATRRQRMD
YPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQIVVTTSIG
QDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEIVSVYASA
AKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSSIDGLHQI
SSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNIATKTPLD
QHTLQGDQVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLRRLPGAIDVI
GQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGIPITVPPPGFPPPPG
APPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERE
RDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAG

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>80206_80206_4_SEL1L3-FIP1L1_SEL1L3_chr4_25803904_ENST00000264868_FIP1L1_chr4_54265896_ENST00000507166_length(amino acids)=1253AA_BP=638
MGAGQLRGTTPGGTLALRPAGMAPRPKKQPDKNPLHGRELNVVPSLGRQTSLTTSVIPKAEQSVAYKDFIYFTVFEGNVRNVSEVSVEYL
CSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHSISVSAVIVRAWITHKYSGRDWNVKWEENL
LHAVAKNYTLLQTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYASSGENTGIVKKFPRFRNRELEATRRQRMD
YPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQIVVTTSIG
QDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEIVSVYASA
AKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSSIDGLHQI
SSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNIATKTPLD
QHTLQGDQVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLRRLPGAIDVI
GQTITISRVEGRRRANENSNIQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKI
MTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA
DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA
QGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAK
PDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGL

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>80206_80206_5_SEL1L3-FIP1L1_SEL1L3_chr4_25803904_ENST00000264868_FIP1L1_chr4_54265896_ENST00000507922_length(amino acids)=796AA_BP=638
MGAGQLRGTTPGGTLALRPAGMAPRPKKQPDKNPLHGRELNVVPSLGRQTSLTTSVIPKAEQSVAYKDFIYFTVFEGNVRNVSEVSVEYL
CSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHSISVSAVIVRAWITHKYSGRDWNVKWEENL
LHAVAKNYTLLQTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYASSGENTGIVKKFPRFRNRELEATRRQRMD
YPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQIVVTTSIG
QDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEIVSVYASA
AKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSSIDGLHQI
SSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNIATKTPLD
QHTLQGDQVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLRRLPGAIDVI

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>80206_80206_6_SEL1L3-FIP1L1_SEL1L3_chr4_25803904_ENST00000399878_FIP1L1_chr4_54265896_ENST00000306932_length(amino acids)=990AA_BP=667
MHQVTCSGPDPGGLAMQRRGAGLGWPRQQQQQPPPLAVGPRAAAMVPSGGVPQGLGGRSACALLLLCYLNVVPSLGRQTSLTTSVIPKAE
QSVAYKDFIYFTVFEGNVRNVSEVSVEYLCSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHS
ISVSAVIVRAWITHKYSGRDWNVKWEENLLHAVAKNYTLLQTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYA
SSGENTGIVKKFPRFRNRELEATRRQRMDYPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVK
TKFIIPLKEWFRLDISFNGGQIVVTTSIGQDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPL
LEKQLAEQIKLYYERCAEVQEIVSVYASAAKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRN
QNESVSEIGGKIFEKAVKRLSSIDGLHQISSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYK
HYQGIDNYPLDWELSYAYYSNIATKTPLDQHTLQGDQVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITIS
RVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSS
GYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEER
YRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE

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>80206_80206_7_SEL1L3-FIP1L1_SEL1L3_chr4_25803904_ENST00000399878_FIP1L1_chr4_54265896_ENST00000337488_length(amino acids)=1026AA_BP=667
MHQVTCSGPDPGGLAMQRRGAGLGWPRQQQQQPPPLAVGPRAAAMVPSGGVPQGLGGRSACALLLLCYLNVVPSLGRQTSLTTSVIPKAE
QSVAYKDFIYFTVFEGNVRNVSEVSVEYLCSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHS
ISVSAVIVRAWITHKYSGRDWNVKWEENLLHAVAKNYTLLQTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYA
SSGENTGIVKKFPRFRNRELEATRRQRMDYPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVK
TKFIIPLKEWFRLDISFNGGQIVVTTSIGQDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPL
LEKQLAEQIKLYYERCAEVQEIVSVYASAAKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRN
QNESVSEIGGKIFEKAVKRLSSIDGLHQISSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYK
HYQGIDNYPLDWELSYAYYSNIATKTPLDQHTLQGDQVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKA
NSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPP
PTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRD
RERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGD

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>80206_80206_8_SEL1L3-FIP1L1_SEL1L3_chr4_25803904_ENST00000399878_FIP1L1_chr4_54265896_ENST00000358575_length(amino acids)=1035AA_BP=667
MHQVTCSGPDPGGLAMQRRGAGLGWPRQQQQQPPPLAVGPRAAAMVPSGGVPQGLGGRSACALLLLCYLNVVPSLGRQTSLTTSVIPKAE
QSVAYKDFIYFTVFEGNVRNVSEVSVEYLCSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHS
ISVSAVIVRAWITHKYSGRDWNVKWEENLLHAVAKNYTLLQTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYA
SSGENTGIVKKFPRFRNRELEATRRQRMDYPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVK
TKFIIPLKEWFRLDISFNGGQIVVTTSIGQDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPL
LEKQLAEQIKLYYERCAEVQEIVSVYASAAKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRN
QNESVSEIGGKIFEKAVKRLSSIDGLHQISSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYK
HYQGIDNYPLDWELSYAYYSNIATKTPLDQHTLQGDQVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKA
NSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPP
PTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREK
DRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSR

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>80206_80206_9_SEL1L3-FIP1L1_SEL1L3_chr4_25803904_ENST00000399878_FIP1L1_chr4_54265896_ENST00000507166_length(amino acids)=1281AA_BP=667
MHQVTCSGPDPGGLAMQRRGAGLGWPRQQQQQPPPLAVGPRAAAMVPSGGVPQGLGGRSACALLLLCYLNVVPSLGRQTSLTTSVIPKAE
QSVAYKDFIYFTVFEGNVRNVSEVSVEYLCSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHS
ISVSAVIVRAWITHKYSGRDWNVKWEENLLHAVAKNYTLLQTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYA
SSGENTGIVKKFPRFRNRELEATRRQRMDYPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVK
TKFIIPLKEWFRLDISFNGGQIVVTTSIGQDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPL
LEKQLAEQIKLYYERCAEVQEIVSVYASAAKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRN
QNESVSEIGGKIFEKAVKRLSSIDGLHQISSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYK
HYQGIDNYPLDWELSYAYYSNIATKTPLDQHTLQGDQVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKA
NSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRS
QPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIF
GLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSF
TYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEI
FSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVA
RMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIE

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>80206_80206_10_SEL1L3-FIP1L1_SEL1L3_chr4_25803904_ENST00000399878_FIP1L1_chr4_54265896_ENST00000507922_length(amino acids)=825AA_BP=667
MHQVTCSGPDPGGLAMQRRGAGLGWPRQQQQQPPPLAVGPRAAAMVPSGGVPQGLGGRSACALLLLCYLNVVPSLGRQTSLTTSVIPKAE
QSVAYKDFIYFTVFEGNVRNVSEVSVEYLCSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHS
ISVSAVIVRAWITHKYSGRDWNVKWEENLLHAVAKNYTLLQTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYA
SSGENTGIVKKFPRFRNRELEATRRQRMDYPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVK
TKFIIPLKEWFRLDISFNGGQIVVTTSIGQDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPL
LEKQLAEQIKLYYERCAEVQEIVSVYASAAKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRN
QNESVSEIGGKIFEKAVKRLSSIDGLHQISSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYK
HYQGIDNYPLDWELSYAYYSNIATKTPLDQHTLQGDQVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKA
NSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPP

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:25803904/chr4:54265896)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FIP1L1

Q6UN15

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000264868-1124575_609617.01098.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000399878-1124575_609652.01133.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000399878-1124611_647652.01133.0RepeatNote=Sel1-like 2
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000306932615356_406197.0521.0Compositional biasNote=Pro-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000306932615456_562197.0521.0Compositional biasNote=Arg-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000306932615478_594197.0521.0Compositional biasNote=Glu-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000337488818356_406235.0595.0Compositional biasNote=Pro-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000337488818456_562235.0595.0Compositional biasNote=Arg-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000337488818478_594235.0595.0Compositional biasNote=Glu-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000358575718356_406220.0589.0Compositional biasNote=Pro-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000358575718456_562220.0589.0Compositional biasNote=Arg-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000358575718478_594220.0589.0Compositional biasNote=Glu-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000507166824356_406235.0850.0Compositional biasNote=Pro-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000507166824456_562235.0850.0Compositional biasNote=Arg-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000507166824478_594235.0850.0Compositional biasNote=Glu-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000507922712356_406220.0379.0Compositional biasNote=Pro-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000507922712456_562220.0379.0Compositional biasNote=Arg-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000507922712478_594220.0379.0Compositional biasNote=Glu-rich
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000306932615457_490197.0521.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000337488818457_490235.0595.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000358575718457_490220.0589.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000507166824457_490235.0850.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chr4:25803904chr4:54265896ENST00000507922712457_490220.0379.0RegionArg/Asp/Glu-rich domain

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000264868-1124611_647617.01098.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000264868-1124694_730617.01098.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000264868-1124732_767617.01098.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000264868-1124768_800617.01098.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000264868-1124801_839617.01098.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000264868-1124840_877617.01098.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000264868-1124952_988617.01098.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000399878-1124694_730652.01133.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000399878-1124732_767652.01133.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000399878-1124768_800652.01133.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000399878-1124801_839652.01133.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000399878-1124840_877652.01133.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000399878-1124952_988652.01133.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000502949-1124575_609499.0980.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000502949-1124611_647499.0980.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000502949-1124694_730499.0980.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000502949-1124732_767499.0980.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000502949-1124768_800499.0980.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000502949-1124801_839499.0980.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000502949-1124840_877499.0980.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000502949-1124952_988499.0980.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000264868-11241057_1077617.01098.0TransmembraneHelical
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000399878-11241057_1077652.01133.0TransmembraneHelical
HgeneSEL1L3chr4:25803904chr4:54265896ENST00000502949-11241057_1077499.0980.0TransmembraneHelical
TgeneFIP1L1chr4:25803904chr4:54265896ENST000003069326151_356197.0521.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chr4:25803904chr4:54265896ENST000003374888181_356235.0595.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chr4:25803904chr4:54265896ENST000003585757181_356220.0589.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chr4:25803904chr4:54265896ENST000005071668241_356235.0850.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chr4:25803904chr4:54265896ENST000005079227121_356220.0379.0RegionNote=Necessary for stimulating PAPOLA activity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SEL1L3
FIP1L1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SEL1L3-FIP1L1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SEL1L3-FIP1L1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource