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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SEMA3F-RBM6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SEMA3F-RBM6
FusionPDB ID: 80297
FusionGDB2.0 ID: 80297
HgeneTgene
Gene symbol

SEMA3F

RBM6

Gene ID

6405

10180

Gene namesemaphorin 3FRNA binding motif protein 6
SynonymsSEMA-IV|SEMA4|SEMAK3G2|DEF-3|DEF3|HLC-11|NY-LU-12|g16
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionsemaphorin-3Fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, 3Fsemaphorin III/Fsemaphorin IVRNA-binding protein 6RNA-binding protein DEF-3lung cancer antigen NY-LU-12lung cancer protooncogene 11
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000002829, ENST00000413852, 
ENST00000434342, 		ENST00000422955, 
ENST00000441115, ENST00000266022, 
ENST00000442092, ENST00000443081, 
ENST00000539992, ENST00000421682, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 9 X 6=32422 X 21 X 10=4620
# samples 1230
** MAII scorelog2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/4620*10)=-3.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SEMA3F [Title/Abstract] AND RBM6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SEMA3F(50212621)-RBM6(50085678), # samples:2
SEMA3F(50197167)-RBM6(50085678), # samples:2
Anticipated loss of major functional domain due to fusion event.SEMA3F-RBM6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SEMA3F-RBM6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SEMA3F-RBM6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SEMA3F-RBM6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEMA3F

GO:0007411

axon guidance

15814794


check buttonFusion gene breakpoints across SEMA3F (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBM6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6969-01ASEMA3Fchr3

50211783

+RBM6chr3

50085678

+
ChimerDB4LUADTCGA-55-6969-01ASEMA3Fchr3

50212621

-RBM6chr3

50085678

+
ChimerDB4LUADTCGA-55-6969-01ASEMA3Fchr3

50212621

+RBM6chr3

50085678

+
ChimerDB4LUADTCGA-55-6969-01ASEMA3Fchr3

50214294

+RBM6chr3

50036873

+
ChimerDB4LUADTCGA-55-6969-01ASEMA3Fchr3

50214294

+RBM6chr3

50085678

+
ChimerDB4LUADTCGA-55-6969SEMA3Fchr3

50211783

+RBM6chr3

50085677

+
ChimerDB4LUSCTCGA-37-4135-01ASEMA3Fchr3

50197167

-RBM6chr3

50085678

+
ChimerDB4LUSCTCGA-37-4135SEMA3Fchr3

50197167

+RBM6chr3

50085677

+
ChimerDB4LUSCTCGA-37-4135SEMA3Fchr3

50197167

+RBM6chr3

50085678

+
ChimerDB4OVTCGA-13-1511-01ASEMA3Fchr3

50197167

+RBM6chr3

50000009

+
ChimerDB4OVTCGA-13-1511SEMA3Fchr3

50197167

+RBM6chr3

50000008

+
ChimerDB4UCSTCGA-N5-A4RO-01ASEMA3Fchr3

50214294

-RBM6chr3

50095161

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000413852SEMA3Fchr350214294-ENST00000442092RBM6chr350095161+23335381022216704
ENST00000413852SEMA3Fchr350214294-ENST00000266022RBM6chr350095161+23345381022216704
ENST00000413852SEMA3Fchr350214294-ENST00000443081RBM6chr350095161+23325381022216704
ENST00000002829SEMA3Fchr350214294-ENST00000442092RBM6chr350095161+292211274842805773
ENST00000002829SEMA3Fchr350214294-ENST00000266022RBM6chr350095161+292311274842805773
ENST00000002829SEMA3Fchr350214294-ENST00000443081RBM6chr350095161+292111274842805773
ENST00000434342SEMA3Fchr350214294-ENST00000442092RBM6chr350095161+26638683182546742
ENST00000434342SEMA3Fchr350214294-ENST00000266022RBM6chr350095161+26648683182546742
ENST00000434342SEMA3Fchr350214294-ENST00000443081RBM6chr350095161+26628683182546742

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000413852ENST00000442092SEMA3Fchr350214294-RBM6chr350095161+0.0051912910.9948087
ENST00000413852ENST00000266022SEMA3Fchr350214294-RBM6chr350095161+0.0051682650.9948317
ENST00000413852ENST00000443081SEMA3Fchr350214294-RBM6chr350095161+0.0051312650.99486876
ENST00000002829ENST00000442092SEMA3Fchr350214294-RBM6chr350095161+0.0033344790.99666554
ENST00000002829ENST00000266022SEMA3Fchr350214294-RBM6chr350095161+0.0033218510.9966781
ENST00000002829ENST00000443081SEMA3Fchr350214294-RBM6chr350095161+0.0033184990.9966815
ENST00000434342ENST00000442092SEMA3Fchr350214294-RBM6chr350095161+0.0016665430.9983335
ENST00000434342ENST00000266022SEMA3Fchr350214294-RBM6chr350095161+0.0016623470.9983376
ENST00000434342ENST00000443081SEMA3Fchr350214294-RBM6chr350095161+0.0016607580.9983392

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>80297_80297_1_SEMA3F-RBM6_SEMA3F_chr3_50214294_ENST00000002829_RBM6_chr3_50095161_ENST00000266022_length(amino acids)=773AA_BP=215
MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPL
IIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTA
PRQDYIFYLEPERLESGKGKCPYDPKLDTASALIMTEAKQELITYPQPQKTSIPAPLEKQPNQPLRPADKEPEPRKREEGQESRLGHQKR
EAERYLPPSRREGPTFRRDRERESWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANVRIIKNRTGPMGHTYGFIDLDSHA
EALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTNRQGQQSSSDCYIYDSATGYYY
DPLAGTYYDPNTQQEVYVPQDPGLPEEEEIKEKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASEGKAPAEDVFKKPLPPTVKKEE
SPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLH
KQNLEIHRKIKQSEQELAYLERREREGKFKGRGNDRREKLQSFDSPERKRIKYSRETDSDRKLVDKEDIDTSSKGGCVQQATGWRKGTGL

--------------------------------------------------------------

>80297_80297_2_SEMA3F-RBM6_SEMA3F_chr3_50214294_ENST00000002829_RBM6_chr3_50095161_ENST00000442092_length(amino acids)=773AA_BP=215
MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPL
IIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTA
PRQDYIFYLEPERLESGKGKCPYDPKLDTASALIMTEAKQELITYPQPQKTSIPAPLEKQPNQPLRPADKEPEPRKREEGQESRLGHQKR
EAERYLPPSRREGPTFRRDRERESWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANVRIIKNRTGPMGHTYGFIDLDSHA
EALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTNRQGQQSSSDCYIYDSATGYYY
DPLAGTYYDPNTQQEVYVPQDPGLPEEEEIKEKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASEGKAPAEDVFKKPLPPTVKKEE
SPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLH
KQNLEIHRKIKQSEQELAYLERREREGKFKGRGNDRREKLQSFDSPERKRIKYSRETDSDRKLVDKEDIDTSSKGGCVQQATGWRKGTGL

--------------------------------------------------------------

>80297_80297_3_SEMA3F-RBM6_SEMA3F_chr3_50214294_ENST00000002829_RBM6_chr3_50095161_ENST00000443081_length(amino acids)=773AA_BP=215
MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPL
IIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTA
PRQDYIFYLEPERLESGKGKCPYDPKLDTASALIMTEAKQELITYPQPQKTSIPAPLEKQPNQPLRPADKEPEPRKREEGQESRLGHQKR
EAERYLPPSRREGPTFRRDRERESWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANVRIIKNRTGPMGHTYGFIDLDSHA
EALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTNRQGQQSSSDCYIYDSATGYYY
DPLAGTYYDPNTQQEVYVPQDPGLPEEEEIKEKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASEGKAPAEDVFKKPLPPTVKKEE
SPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLH
KQNLEIHRKIKQSEQELAYLERREREGKFKGRGNDRREKLQSFDSPERKRIKYSRETDSDRKLVDKEDIDTSSKGGCVQQATGWRKGTGL

--------------------------------------------------------------

>80297_80297_4_SEMA3F-RBM6_SEMA3F_chr3_50214294_ENST00000413852_RBM6_chr3_50095161_ENST00000266022_length(amino acids)=704AA_BP=146
MKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRT
HLYVCGTGAYNPMCTYVNRGRRAQDYIFYLEPERLESGKGKCPYDPKLDTASALIMTEAKQELITYPQPQKTSIPAPLEKQPNQPLRPAD
KEPEPRKREEGQESRLGHQKREAERYLPPSRREGPTFRRDRERESWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANVRI
IKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTN
RQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPGLPEEEEIKEKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASE
GKAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLL
CRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGKFKGRGNDRREKLQSFDSPERKRIKYSRETDSDRKLVDKEDI

--------------------------------------------------------------

>80297_80297_5_SEMA3F-RBM6_SEMA3F_chr3_50214294_ENST00000413852_RBM6_chr3_50095161_ENST00000442092_length(amino acids)=704AA_BP=146
MKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRT
HLYVCGTGAYNPMCTYVNRGRRAQDYIFYLEPERLESGKGKCPYDPKLDTASALIMTEAKQELITYPQPQKTSIPAPLEKQPNQPLRPAD
KEPEPRKREEGQESRLGHQKREAERYLPPSRREGPTFRRDRERESWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANVRI
IKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTN
RQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPGLPEEEEIKEKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASE
GKAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLL
CRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGKFKGRGNDRREKLQSFDSPERKRIKYSRETDSDRKLVDKEDI

--------------------------------------------------------------

>80297_80297_6_SEMA3F-RBM6_SEMA3F_chr3_50214294_ENST00000413852_RBM6_chr3_50095161_ENST00000443081_length(amino acids)=704AA_BP=146
MKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRT
HLYVCGTGAYNPMCTYVNRGRRAQDYIFYLEPERLESGKGKCPYDPKLDTASALIMTEAKQELITYPQPQKTSIPAPLEKQPNQPLRPAD
KEPEPRKREEGQESRLGHQKREAERYLPPSRREGPTFRRDRERESWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANVRI
IKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTN
RQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPGLPEEEEIKEKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASE
GKAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLL
CRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGKFKGRGNDRREKLQSFDSPERKRIKYSRETDSDRKLVDKEDI

--------------------------------------------------------------

>80297_80297_7_SEMA3F-RBM6_SEMA3F_chr3_50214294_ENST00000434342_RBM6_chr3_50095161_ENST00000266022_length(amino acids)=742AA_BP=184
MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPL
IIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQDYIFYLEPERLESGKGKCPYDPKLDTAS
ALIMTEAKQELITYPQPQKTSIPAPLEKQPNQPLRPADKEPEPRKREEGQESRLGHQKREAERYLPPSRREGPTFRRDRERESWSGETRQ
DGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANVRIIKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGK
RRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTNRQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPGLPEEEEIK
EKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASEGKAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEE
QTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGKFKG
RGNDRREKLQSFDSPERKRIKYSRETDSDRKLVDKEDIDTSSKGGCVQQATGWRKGTGLGYGHPGLASSEEAEGRMRGPSVGASGRTSKR

--------------------------------------------------------------

>80297_80297_8_SEMA3F-RBM6_SEMA3F_chr3_50214294_ENST00000434342_RBM6_chr3_50095161_ENST00000442092_length(amino acids)=742AA_BP=184
MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPL
IIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQDYIFYLEPERLESGKGKCPYDPKLDTAS
ALIMTEAKQELITYPQPQKTSIPAPLEKQPNQPLRPADKEPEPRKREEGQESRLGHQKREAERYLPPSRREGPTFRRDRERESWSGETRQ
DGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANVRIIKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGK
RRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTNRQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPGLPEEEEIK
EKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASEGKAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEE
QTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGKFKG
RGNDRREKLQSFDSPERKRIKYSRETDSDRKLVDKEDIDTSSKGGCVQQATGWRKGTGLGYGHPGLASSEEAEGRMRGPSVGASGRTSKR

--------------------------------------------------------------

>80297_80297_9_SEMA3F-RBM6_SEMA3F_chr3_50214294_ENST00000434342_RBM6_chr3_50095161_ENST00000443081_length(amino acids)=742AA_BP=184
MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPL
IIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQDYIFYLEPERLESGKGKCPYDPKLDTAS
ALIMTEAKQELITYPQPQKTSIPAPLEKQPNQPLRPADKEPEPRKREEGQESRLGHQKREAERYLPPSRREGPTFRRDRERESWSGETRQ
DGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANVRIIKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGK
RRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTNRQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPGLPEEEEIK
EKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASEGKAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEE
QTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGKFKG
RGNDRREKLQSFDSPERKRIKYSRETDSDRKLVDKEDIDTSSKGGCVQQATGWRKGTGLGYGHPGLASSEEAEGRMRGPSVGASGRTSKR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:50212621/chr3:50085678)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRBM6chr3:50214294chr3:50095161ENST00000266022721826_829564.33333333333341124.0Compositional biasNote=Poly-Glu
TgeneRBM6chr3:50214294chr3:50095161ENST00000266022721892_895564.33333333333341124.0Compositional biasNote=Poly-Pro
TgeneRBM6chr3:50214294chr3:50095161ENST00000266022721915_921564.33333333333341124.0Compositional biasNote=Poly-Glu
TgeneRBM6chr3:50214294chr3:50095161ENST00000422955519826_82942.333333333333336602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr3:50214294chr3:50095161ENST00000422955519892_89542.333333333333336602.0Compositional biasNote=Poly-Pro
TgeneRBM6chr3:50214294chr3:50095161ENST00000422955519915_92142.333333333333336602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr3:50214294chr3:50095161ENST00000442092317826_82942.333333333333336602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr3:50214294chr3:50095161ENST00000442092317892_89542.333333333333336602.0Compositional biasNote=Poly-Pro
TgeneRBM6chr3:50214294chr3:50095161ENST00000442092317915_92142.333333333333336602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr3:50214294chr3:50095161ENST000002660227211051_1097564.33333333333341124.0DomainG-patch
TgeneRBM6chr3:50214294chr3:50095161ENST000004229555191051_109742.333333333333336602.0DomainG-patch
TgeneRBM6chr3:50214294chr3:50095161ENST00000422955519456_53642.333333333333336602.0DomainRRM
TgeneRBM6chr3:50214294chr3:50095161ENST000004420923171051_109742.333333333333336602.0DomainG-patch
TgeneRBM6chr3:50214294chr3:50095161ENST00000442092317456_53642.333333333333336602.0DomainRRM

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEMA3Fchr3:50214294chr3:50095161ENST00000002829-719758_779214.33333333333334786.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneSEMA3Fchr3:50214294chr3:50095161ENST00000434342-618758_779183.33333333333334755.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneSEMA3Fchr3:50214294chr3:50095161ENST00000002829-71931_545214.33333333333334786.0DomainSema
HgeneSEMA3Fchr3:50214294chr3:50095161ENST00000002829-719605_690214.33333333333334786.0DomainNote=Ig-like C2-type
HgeneSEMA3Fchr3:50214294chr3:50095161ENST00000434342-61831_545183.33333333333334755.0DomainSema
HgeneSEMA3Fchr3:50214294chr3:50095161ENST00000434342-618605_690183.33333333333334755.0DomainNote=Ig-like C2-type
TgeneRBM6chr3:50214294chr3:50095161ENST00000266022721456_536564.33333333333341124.0DomainRRM


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SEMA3F
RBM6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SEMA3F-RBM6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SEMA3F-RBM6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource