UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:SEMA4B-ARID1B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SEMA4B-ARID1B
FusionPDB ID: 80306
FusionGDB2.0 ID: 80306
HgeneTgene
Gene symbol

SEMA4B

ARID1B

Gene ID

10509

57492

Gene namesemaphorin 4BAT-rich interaction domain 1B
SynonymsSEMAC|SemC6A3-5|BAF250B|BRIGHT|CSS1|DAN15|ELD/OSA1|MRD12|OSA2|P250R
Cytomap

15q26.1

6q25.3

Type of geneprotein-codingprotein-coding
Descriptionsemaphorin-4Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4Bsemaphorin-CAT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA protein
Modification date2020031320200320
UniProtAcc.

Q8NFD5

Ensembl transtripts involved in fusion geneENST idsENST00000332496, ENST00000379122, 
ENST00000411539, ENST00000560263, 
ENST00000478761, ENST00000275248, 
ENST00000346085, ENST00000350026, 
ENST00000367148, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 9 X 11=158410 X 12 X 6=720
# samples 2112
** MAII scorelog2(21/1584*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SEMA4B [Title/Abstract] AND ARID1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SEMA4B(90744967)-ARID1B(157495141), # samples:2
Anticipated loss of major functional domain due to fusion event.SEMA4B-ARID1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SEMA4B-ARID1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SEMA4B-ARID1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SEMA4B-ARID1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SEMA4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARID1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L7-A6VZSEMA4Bchr15

90744967

+ARID1Bchr6

157495141

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379122SEMA4Bchr1590744967+ENST00000350026ARID1Bchr6157495141+542444014241641340
ENST00000379122SEMA4Bchr1590744967+ENST00000346085ARID1Bchr6157495141+705344014241641340
ENST00000379122SEMA4Bchr1590744967+ENST00000367148ARID1Bchr6157495141+570044014243231393
ENST00000379122SEMA4Bchr1590744967+ENST00000275248ARID1Bchr6157495141+570044014243231393
ENST00000332496SEMA4Bchr1590744967+ENST00000350026ARID1Bchr6157495141+53813979941211340
ENST00000332496SEMA4Bchr1590744967+ENST00000346085ARID1Bchr6157495141+70103979941211340
ENST00000332496SEMA4Bchr1590744967+ENST00000367148ARID1Bchr6157495141+56573979942801393
ENST00000332496SEMA4Bchr1590744967+ENST00000275248ARID1Bchr6157495141+56573979942801393
ENST00000411539SEMA4Bchr1590744967+ENST00000350026ARID1Bchr6157495141+540141719141411316
ENST00000411539SEMA4Bchr1590744967+ENST00000346085ARID1Bchr6157495141+703041719141411316
ENST00000411539SEMA4Bchr1590744967+ENST00000367148ARID1Bchr6157495141+567741719143001369
ENST00000411539SEMA4Bchr1590744967+ENST00000275248ARID1Bchr6157495141+567741719143001369

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379122ENST00000350026SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0017856630.99821436
ENST00000379122ENST00000346085SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0005406570.9994593
ENST00000379122ENST00000367148SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0016595880.99834037
ENST00000379122ENST00000275248SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0016595880.99834037
ENST00000332496ENST00000350026SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0017085210.99829143
ENST00000332496ENST00000346085SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0005137190.9994862
ENST00000332496ENST00000367148SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0015903450.9984097
ENST00000332496ENST00000275248SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0015903450.9984097
ENST00000411539ENST00000350026SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0017738410.9982261
ENST00000411539ENST00000346085SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0005342780.99946576
ENST00000411539ENST00000367148SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0016445440.99835545
ENST00000411539ENST00000275248SEMA4Bchr1590744967+ARID1Bchr6157495141+0.0016445440.99835545

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>80306_80306_1_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000332496_ARID1B_chr6_157495141_ENST00000275248_length(amino acids)=1393AA_BP=98
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELA
TNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSM
QDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQ
APPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDS
TVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRP
PPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLV
TLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMA

--------------------------------------------------------------

>80306_80306_2_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000332496_ARID1B_chr6_157495141_ENST00000346085_length(amino acids)=1340AA_BP=98
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSS
LPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQ
PPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDV
MGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYG
GHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMG
GPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPS
YQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSK
DIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKD
DSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRV
QEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTE
SSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERK
RAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQ
RLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTM

--------------------------------------------------------------

>80306_80306_3_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000332496_ARID1B_chr6_157495141_ENST00000350026_length(amino acids)=1340AA_BP=98
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSS
LPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQ
PPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDV
MGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYG
GHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMG
GPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPS
YQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSK
DIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKD
DSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRV
QEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTE
SSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERK
RAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQ
RLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTM

--------------------------------------------------------------

>80306_80306_4_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000332496_ARID1B_chr6_157495141_ENST00000367148_length(amino acids)=1393AA_BP=98
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELA
TNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSM
QDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQ
APPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDS
TVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRP
PPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLV
TLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMA

--------------------------------------------------------------

>80306_80306_5_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000379122_ARID1B_chr6_157495141_ENST00000275248_length(amino acids)=1393AA_BP=98
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELA
TNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSM
QDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQ
APPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDS
TVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRP
PPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLV
TLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMA

--------------------------------------------------------------

>80306_80306_6_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000379122_ARID1B_chr6_157495141_ENST00000346085_length(amino acids)=1340AA_BP=98
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSS
LPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQ
PPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDV
MGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYG
GHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMG
GPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPS
YQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSK
DIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKD
DSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRV
QEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTE
SSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERK
RAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQ
RLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTM

--------------------------------------------------------------

>80306_80306_7_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000379122_ARID1B_chr6_157495141_ENST00000350026_length(amino acids)=1340AA_BP=98
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSS
LPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQ
PPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDV
MGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYG
GHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMG
GPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPS
YQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSK
DIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKD
DSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRV
QEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTE
SSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERK
RAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQ
RLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTM

--------------------------------------------------------------

>80306_80306_8_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000379122_ARID1B_chr6_157495141_ENST00000367148_length(amino acids)=1393AA_BP=98
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELA
TNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSM
QDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQ
APPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDS
TVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRP
PPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLV
TLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMA

--------------------------------------------------------------

>80306_80306_9_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000411539_ARID1B_chr6_157495141_ENST00000275248_length(amino acids)=1369AA_BP=74
MPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLASVGLADMMSPGESK
LPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKV
YELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLF
AFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPF
SDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFP
YGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQ
GQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHES
QWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPP
PIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKC
LIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQ
ASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQE
KSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPG
NDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILD
GLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQ
GDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAV

--------------------------------------------------------------

>80306_80306_10_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000411539_ARID1B_chr6_157495141_ENST00000346085_length(amino acids)=1316AA_BP=74
MPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLASVGLADMMSPGESK
LPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGL
AQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSM
AEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSE
PFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPP
AKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPY
PYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSL
ENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTW
ALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEE
DEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTH
FESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEP
RSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWW
WDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATP
PFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVD

--------------------------------------------------------------

>80306_80306_11_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000411539_ARID1B_chr6_157495141_ENST00000350026_length(amino acids)=1316AA_BP=74
MPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLASVGLADMMSPGESK
LPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGL
AQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSM
AEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSE
PFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPP
AKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPY
PYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSL
ENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTW
ALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEE
DEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTH
FESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEP
RSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWW
WDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATP
PFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVD

--------------------------------------------------------------

>80306_80306_12_SEMA4B-ARID1B_SEMA4B_chr15_90744967_ENST00000411539_ARID1B_chr6_157495141_ENST00000367148_length(amino acids)=1369AA_BP=74
MPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLASVGLADMMSPGESK
LPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKV
YELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLF
AFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPF
SDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFP
YGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQ
GQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHES
QWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPP
PIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKC
LIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQ
ASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQE
KSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPG
NDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILD
GLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQ
GDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAV

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:90744967/chr6:157495141)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARID1B

Q8NFD5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7, ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARID1Bchr15:90744967chr6:157495141ENST000003460859201034_10371008.33333333333342250.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr15:90744967chr6:157495141ENST000003460859201441_14441008.33333333333342250.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr15:90744967chr6:157495141ENST000003460859201459_15971008.33333333333342250.0Compositional biasNote=Pro-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST000003460859201833_18361008.33333333333342250.0Compositional biasNote=Poly-Pro
TgeneARID1Bchr15:90744967chr6:157495141ENST000003500268191034_1037995.33333333333342237.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr15:90744967chr6:157495141ENST000003500268191441_1444995.33333333333342237.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr15:90744967chr6:157495141ENST000003500268191459_1597995.33333333333342237.0Compositional biasNote=Pro-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST000003500268191833_1836995.33333333333342237.0Compositional biasNote=Poly-Pro
TgeneARID1Bchr15:90744967chr6:157495141ENST000003671488201034_1037995.33333333333342290.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr15:90744967chr6:157495141ENST000003671488201441_1444995.33333333333342290.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr15:90744967chr6:157495141ENST000003671488201459_1597995.33333333333342290.0Compositional biasNote=Pro-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST000003671488201833_1836995.33333333333342290.0Compositional biasNote=Poly-Pro
TgeneARID1Bchr15:90744967chr6:157495141ENST000003460859201053_11441008.33333333333342250.0DomainARID
TgeneARID1Bchr15:90744967chr6:157495141ENST000003500268191053_1144995.33333333333342237.0DomainARID
TgeneARID1Bchr15:90744967chr6:157495141ENST000003671488201053_1144995.33333333333342290.0DomainARID
TgeneARID1Bchr15:90744967chr6:157495141ENST000003460859201358_13771008.33333333333342250.0MotifNuclear localization signal
TgeneARID1Bchr15:90744967chr6:157495141ENST000003460859202036_20401008.33333333333342250.0MotifNote=LXXLL
TgeneARID1Bchr15:90744967chr6:157495141ENST000003500268191358_1377995.33333333333342237.0MotifNuclear localization signal
TgeneARID1Bchr15:90744967chr6:157495141ENST000003500268192036_2040995.33333333333342237.0MotifNote=LXXLL
TgeneARID1Bchr15:90744967chr6:157495141ENST000003671488201358_1377995.33333333333342290.0MotifNuclear localization signal
TgeneARID1Bchr15:90744967chr6:157495141ENST000003671488202036_2040995.33333333333342290.0MotifNote=LXXLL

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEMA4Bchr15:90744967chr6:157495141ENST00000379122+216758_78147.333333333333336738.0Compositional biasNote=Pro-rich
HgeneSEMA4Bchr15:90744967chr6:157495141ENST00000379122+21647_52347.333333333333336738.0DomainSema
HgeneSEMA4Bchr15:90744967chr6:157495141ENST00000379122+216525_57947.333333333333336738.0DomainNote=PSI
HgeneSEMA4Bchr15:90744967chr6:157495141ENST00000379122+216604_66347.333333333333336738.0DomainNote=Ig-like C2-type
HgeneSEMA4Bchr15:90744967chr6:157495141ENST00000379122+21644_71747.333333333333336738.0Topological domainExtracellular
HgeneSEMA4Bchr15:90744967chr6:157495141ENST00000379122+216739_83747.333333333333336738.0Topological domainCytoplasmic
HgeneSEMA4Bchr15:90744967chr6:157495141ENST00000379122+216718_73847.333333333333336738.0TransmembraneHelical
TgeneARID1Bchr15:90744967chr6:157495141ENST00000346085920107_1311008.33333333333342250.0Compositional biasNote=Gln-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000346085920114_1311008.33333333333342250.0Compositional biasNote=Poly-Gln
TgeneARID1Bchr15:90744967chr6:157495141ENST00000346085920141_4011008.33333333333342250.0Compositional biasNote=Gly-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST000003460859202_471008.33333333333342250.0Compositional biasNote=Ala-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000346085920329_4931008.33333333333342250.0Compositional biasNote=Ala-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST0000034608592035_571008.33333333333342250.0Compositional biasNote=Ser-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000346085920574_6331008.33333333333342250.0Compositional biasNote=Gln-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000346085920684_7711008.33333333333342250.0Compositional biasNote=Ser-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST0000034608592081_1041008.33333333333342250.0Compositional biasNote=His-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000346085920932_9351008.33333333333342250.0Compositional biasNote=Poly-Ala
TgeneARID1Bchr15:90744967chr6:157495141ENST00000350026819107_131995.33333333333342237.0Compositional biasNote=Gln-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000350026819114_131995.33333333333342237.0Compositional biasNote=Poly-Gln
TgeneARID1Bchr15:90744967chr6:157495141ENST00000350026819141_401995.33333333333342237.0Compositional biasNote=Gly-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST000003500268192_47995.33333333333342237.0Compositional biasNote=Ala-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000350026819329_493995.33333333333342237.0Compositional biasNote=Ala-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST0000035002681935_57995.33333333333342237.0Compositional biasNote=Ser-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000350026819574_633995.33333333333342237.0Compositional biasNote=Gln-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000350026819684_771995.33333333333342237.0Compositional biasNote=Ser-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST0000035002681981_104995.33333333333342237.0Compositional biasNote=His-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000350026819932_935995.33333333333342237.0Compositional biasNote=Poly-Ala
TgeneARID1Bchr15:90744967chr6:157495141ENST00000367148820107_131995.33333333333342290.0Compositional biasNote=Gln-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000367148820114_131995.33333333333342290.0Compositional biasNote=Poly-Gln
TgeneARID1Bchr15:90744967chr6:157495141ENST00000367148820141_401995.33333333333342290.0Compositional biasNote=Gly-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST000003671488202_47995.33333333333342290.0Compositional biasNote=Ala-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000367148820329_493995.33333333333342290.0Compositional biasNote=Ala-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST0000036714882035_57995.33333333333342290.0Compositional biasNote=Ser-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000367148820574_633995.33333333333342290.0Compositional biasNote=Gln-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000367148820684_771995.33333333333342290.0Compositional biasNote=Ser-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST0000036714882081_104995.33333333333342290.0Compositional biasNote=His-rich
TgeneARID1Bchr15:90744967chr6:157495141ENST00000367148820932_935995.33333333333342290.0Compositional biasNote=Poly-Ala
TgeneARID1Bchr15:90744967chr6:157495141ENST00000346085920419_4231008.33333333333342250.0MotifNote=LXXLL
TgeneARID1Bchr15:90744967chr6:157495141ENST00000350026819419_423995.33333333333342237.0MotifNote=LXXLL
TgeneARID1Bchr15:90744967chr6:157495141ENST00000367148820419_423995.33333333333342290.0MotifNote=LXXLL


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SEMA4B
ARID1B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to SEMA4B-ARID1B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to SEMA4B-ARID1B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource