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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SETD2-RNF216

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SETD2-RNF216
FusionPDB ID: 80884
FusionGDB2.0 ID: 80884
HgeneTgene
Gene symbol

SETD2

RNF216

Gene ID

29072

54476

Gene nameSET domain containing 2, histone lysine methyltransferasering finger protein 216
SynonymsHBP231|HIF-1|HIP-1|HSPC069|HYPB|KMT3A|LLS|SET2|p231HBPCAHH|TRIAD3|U7I1|UBCE7IP1|ZIN
Cytomap

3p21.31

7p22.1

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase SETD2SET domain containing 2huntingtin interacting protein 1huntingtin yeast partner Bhuntingtin-interacting protein Blysine N-methyltransferase 3Aprotein-lysine N-methyltransferase SETD2E3 ubiquitin-protein ligase RNF216RING-type E3 ubiquitin transferase RNF216triad domain-containing protein 3ubiquitin-conjugating enzyme 7-interacting protein 1zinc finger protein inhibiting NF-kappa-B
Modification date2020031520200313
UniProtAcc

Q9BYW2

Q9NWF9

Ensembl transtripts involved in fusion geneENST idsENST00000409792, ENST00000492397, 
ENST00000469375, ENST00000389902, 
ENST00000425013, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 19 X 16=820817 X 18 X 11=3366
# samples 4133
** MAII scorelog2(41/8208*10)=-4.32333491610161
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/3366*10)=-3.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SETD2 [Title/Abstract] AND RNF216 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SETD2(47125209)-RNF216(5756397), # samples:1
SETD2(47125210)-RNF216(5756397), # samples:1
Anticipated loss of major functional domain due to fusion event.SETD2-RNF216 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SETD2-RNF216 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SETD2-RNF216 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SETD2-RNF216 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSETD2

GO:0010569

regulation of double-strand break repair via homologous recombination

24843002

HgeneSETD2

GO:0018023

peptidyl-lysine trimethylation

27518565

HgeneSETD2

GO:0018026

peptidyl-lysine monomethylation

28753426

HgeneSETD2

GO:0032465

regulation of cytokinesis

27518565

HgeneSETD2

GO:0032727

positive regulation of interferon-alpha production

28753426

HgeneSETD2

GO:0034340

response to type I interferon

28753426

HgeneSETD2

GO:0051607

defense response to virus

28753426

HgeneSETD2

GO:0097198

histone H3-K36 trimethylation

23043551|24843002|26002201|27474439|28753426

HgeneSETD2

GO:0097676

histone H3-K36 dimethylation

26002201

HgeneSETD2

GO:1902850

microtubule cytoskeleton organization involved in mitosis

27518565

HgeneSETD2

GO:1905634

regulation of protein localization to chromatin

24843002

TgeneRNF216

GO:0032648

regulation of interferon-beta production

19893624

TgeneRNF216

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

19893624

TgeneRNF216

GO:0050691

regulation of defense response to virus by host

19893624

TgeneRNF216

GO:0070936

protein K48-linked ubiquitination

19893624


check buttonFusion gene breakpoints across SETD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RNF216 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8210-01ASETD2chr3

47125210

-RNF216chr7

5756397

-
ChimerDB4STADTCGA-FP-8210SETD2chr3

47125209

-RNF216chr7

5756397

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409792SETD2chr347125209-ENST00000425013RNF216chr75756397-100446103172302409
ENST00000409792SETD2chr347125209-ENST00000389902RNF216chr75756397-74846103172302409
ENST00000409792SETD2chr347125210-ENST00000425013RNF216chr75756397-100446103172302409
ENST00000409792SETD2chr347125210-ENST00000389902RNF216chr75756397-74846103172302409

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409792ENST00000425013SETD2chr347125209-RNF216chr75756397-0.0003706480.9996294
ENST00000409792ENST00000389902SETD2chr347125209-RNF216chr75756397-0.0002686610.99973136
ENST00000409792ENST00000425013SETD2chr347125210-RNF216chr75756397-0.0003706480.9996294
ENST00000409792ENST00000389902SETD2chr347125210-RNF216chr75756397-0.0002686610.99973136

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>80884_80884_1_SETD2-RNF216_SETD2_chr3_47125209_ENST00000409792_RNF216_chr7_5756397_ENST00000389902_length(amino acids)=2409AA_BP=2032
LRGGGSRRRLQPLPMKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFS
FSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASP
PTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQ
DTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIE
KERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHR
SSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEA
IKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPA
PSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSE
LSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCT
LNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSL
PPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGR
PEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRL
QSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNR
LPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHV
DGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDRE
EEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKK
VRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIAC
GEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYF
MALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVS
IRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAEL
GDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKL
MFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESN
GTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEEL
TQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSD
VKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSI
NGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQRVEALPRPVPQNLPQPQM

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>80884_80884_2_SETD2-RNF216_SETD2_chr3_47125209_ENST00000409792_RNF216_chr7_5756397_ENST00000425013_length(amino acids)=2409AA_BP=2032
LRGGGSRRRLQPLPMKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFS
FSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASP
PTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQ
DTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIE
KERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHR
SSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEA
IKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPA
PSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSE
LSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCT
LNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSL
PPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGR
PEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRL
QSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNR
LPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHV
DGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDRE
EEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKK
VRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIAC
GEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYF
MALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVS
IRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAEL
GDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKL
MFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESN
GTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEEL
TQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSD
VKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSI
NGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQRVEALPRPVPQNLPQPQM

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>80884_80884_3_SETD2-RNF216_SETD2_chr3_47125210_ENST00000409792_RNF216_chr7_5756397_ENST00000389902_length(amino acids)=2409AA_BP=2032
LRGGGSRRRLQPLPMKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFS
FSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASP
PTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQ
DTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIE
KERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHR
SSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEA
IKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPA
PSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSE
LSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCT
LNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSL
PPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGR
PEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRL
QSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNR
LPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHV
DGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDRE
EEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKK
VRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIAC
GEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYF
MALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVS
IRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAEL
GDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKL
MFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESN
GTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEEL
TQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSD
VKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSI
NGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQRVEALPRPVPQNLPQPQM

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>80884_80884_4_SETD2-RNF216_SETD2_chr3_47125210_ENST00000409792_RNF216_chr7_5756397_ENST00000425013_length(amino acids)=2409AA_BP=2032
LRGGGSRRRLQPLPMKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFS
FSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASP
PTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQ
DTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIE
KERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHR
SSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEA
IKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPA
PSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSE
LSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCT
LNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSL
PPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGR
PEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRL
QSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNR
LPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHV
DGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDRE
EEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKK
VRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIAC
GEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYF
MALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVS
IRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAEL
GDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKL
MFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESN
GTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEEL
TQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSD
VKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSI
NGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQRVEALPRPVPQNLPQPQM

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:47125209/chr7:5756397)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SETD2

Q9BYW2

RNF216

Q9NWF9

FUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.FUNCTION: Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. {ECO:0000269|PubMed:15107846, ECO:0000269|PubMed:19893624}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-1221166_2472020.02565.0Compositional biasNote=Pro-rich
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-1221385_4562020.02565.0Compositional biasNote=Arg-rich
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-1221166_2472020.02565.0Compositional biasNote=Pro-rich
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-1221385_4562020.02565.0Compositional biasNote=Arg-rich
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211494_15482020.02565.0DomainAWS
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211550_16672020.02565.0DomainSET
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211674_16902020.02565.0DomainPost-SET
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211494_15482020.02565.0DomainAWS
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211550_16672020.02565.0DomainSET
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211674_16902020.02565.0DomainPost-SET
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211560_15622020.02565.0RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211603_16052020.02565.0RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211628_16292020.02565.0RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211560_15622020.02565.0RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211603_16052020.02565.0RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211628_16292020.02565.0RegionS-adenosyl-L-methionine binding
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817737_763548.0924.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817737_763491.0867.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817737_763548.0924.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817737_763491.0867.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817769_862548.0924.0Compositional biasNote=Pro-rich
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817769_862491.0867.0Compositional biasNote=Pro-rich
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817769_862548.0924.0Compositional biasNote=Pro-rich
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817769_862491.0867.0Compositional biasNote=Pro-rich
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817511_728491.0867.0RegionTRIAD supradomain
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817511_728491.0867.0RegionTRIAD supradomain
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817583_648548.0924.0Zinc fingerIBR-type
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817675_703548.0924.0Zinc fingerRING-type 2%3B atypical
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817515_564491.0867.0Zinc fingerRING-type 1
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817583_648491.0867.0Zinc fingerIBR-type
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817675_703491.0867.0Zinc fingerRING-type 2%3B atypical
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817583_648548.0924.0Zinc fingerIBR-type
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817675_703548.0924.0Zinc fingerRING-type 2%3B atypical
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817515_564491.0867.0Zinc fingerRING-type 1
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817583_648491.0867.0Zinc fingerIBR-type
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817675_703491.0867.0Zinc fingerRING-type 2%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212117_21462020.02565.0Coiled coilOntology_term=ECO:0000255
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212117_21462020.02565.0Coiled coilOntology_term=ECO:0000255
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212149_22322020.02565.0Compositional biasNote=Pro-rich
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212266_23652020.02565.0Compositional biasNote=Gln-rich
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212149_22322020.02565.0Compositional biasNote=Pro-rich
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212266_23652020.02565.0Compositional biasNote=Gln-rich
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212389_24222020.02565.0DomainWW
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212389_24222020.02565.0DomainWW
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212137_23662020.02565.0RegionLow charge region
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212137_23662020.02565.0RegionLow charge region
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817475_491548.0924.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817475_491491.0867.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817475_491548.0924.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817475_491491.0867.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817511_728548.0924.0RegionTRIAD supradomain
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817511_728548.0924.0RegionTRIAD supradomain
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817515_564548.0924.0Zinc fingerRING-type 1
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817515_564548.0924.0Zinc fingerRING-type 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SETD2HTT, IWS1, TP53, HIST1H3A, SETD2, POLR2A, ELAVL1, ATXN1, CIC, HCVgp1, CBX8, SOX2, SMAD3, SIAH2, CLK2, HIST3H3, WDR37, ARHGEF10, LUC7L, SCARA3, AURKA, EIF3I, XPO1, RASSF8, Ttll7, Soga1, GAN, ATM, HNRNPLL, NXF2, HSPB8, RSBN1, F9, CPNE7, PIP4K2A, TRPC4AP, JMJD6, TRIM25, SPOP, PCGF1, ESR2, FGFR2, MDC1, KIAA1429, RPA1, RAD51, HIST1H4A, DCAF4, CUL7, nsp9ab, nsp9, NPM1, CENPF, ORF14, ESR1, MYCN, RNGTT, AURKB, BRPF3, CECR2, SP110, TRIM66, C12orf49, BRD4, DDX58, APEX1, DDX23, DHX40, DHX8, TERF2IP, ARX, SHANK3, NAA40, SCRIB, PSD2, STK11, CTCFL, KIAA0408, ABTB2, ARAF, RNF145, RNPS1, ZBTB44, RNH1, OR10H1, SRSF6, C2CD4B, CCDC96, COQ3, SLC35G1, FGF12, RAMP1, FTSJ3, VDR, SAP18, CCDC71, LRRTM4, ZNF10, CSNK2B, PIGF, SRPK2, FGF11, SLU7, CXCL6, NFKBIL1, SLFN11, SIRT6, ATRX,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SETD2all structure
RNF216all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212457_25642020.02565.0POLR2A
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212457_25642020.02565.0POLR2A


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Related Drugs to SETD2-RNF216


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SETD2-RNF216


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSETD2C0279702Conventional (Clear Cell) Renal Cell Carcinoma6CGI;CTD_human;UNIPROT
HgeneSETD2C4085873LUSCAN-LUMISH SYNDROME4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneSETD2C0007134Renal Cell Carcinoma2CTD_human
HgeneSETD2C0023467Leukemia, Myelocytic, Acute2UNIPROT
HgeneSETD2C1266042Chromophobe Renal Cell Carcinoma2CTD_human
HgeneSETD2C1266043Sarcomatoid Renal Cell Carcinoma2CTD_human
HgeneSETD2C1266044Collecting Duct Carcinoma of the Kidney2CTD_human
HgeneSETD2C1306837Papillary Renal Cell Carcinoma2CTD_human
HgeneSETD2C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2UNIPROT
HgeneSETD2C0006142Malignant neoplasm of breast1CTD_human
HgeneSETD2C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneSETD2C0010701Phyllodes Tumor1CTD_human
HgeneSETD2C0023418leukemia1CTD_human
HgeneSETD2C0033578Prostatic Neoplasms1CTD_human
HgeneSETD2C0175695Sotos' syndrome1ORPHANET
HgeneSETD2C0206656Embryonal Rhabdomyosarcoma1CTD_human
HgeneSETD2C0345967Malignant mesothelioma1CTD_human
HgeneSETD2C0376358Malignant neoplasm of prostate1CTD_human
HgeneSETD2C0600066Malignant Cystosarcoma Phyllodes1CTD_human
HgeneSETD2C0678222Breast Carcinoma1CTD_human
HgeneSETD2C0920269Microsatellite Instability1CTD_human
HgeneSETD2C1257931Mammary Neoplasms, Human1CTD_human
HgeneSETD2C1458155Mammary Neoplasms1CTD_human
HgeneSETD2C1535926Neurodevelopmental Disorders1CTD_human
HgeneSETD2C1721098Replication Error Phenotype1CTD_human
HgeneSETD2C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneSETD2C4704874Mammary Carcinoma, Human1CTD_human
TgeneRNF216C1859305Cerebellar Ataxia and Hypogonadotropic Hypogonadism2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT