UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:SFPQ-HSD17B4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SFPQ-HSD17B4
FusionPDB ID: 81133
FusionGDB2.0 ID: 81133
HgeneTgene
Gene symbol

SFPQ

HSD17B4

Gene ID

654780

3295

Gene namesplicing factor proline/glutamine-richhydroxysteroid 17-beta dehydrogenase 4
SynonymsSFPQDBP|MFE-2|MPF-2|PRLTS1|SDR8C1
Cytomap

16q24.1

5q23.1

Type of genencRNAprotein-coding
Description-peroxisomal multifunctional enzyme type 217-beta-HSD 417-beta-HSD IV17-beta-hydroxysteroid dehydrogenase 417beta-estradiol dehydrogenase type IV3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydrataseD-3-hydroxyacyl-CoA dehydratase
Modification date2020030320200327
UniProtAcc

P23246

P51659

Ensembl transtripts involved in fusion geneENST idsENST00000357214, ENST00000468598, 
ENST00000522415, ENST00000256216, 
ENST00000414835, ENST00000504811, 
ENST00000509514, ENST00000510025, 
ENST00000513628, ENST00000515320, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 16 X 8=179216 X 15 X 12=2880
# samples 1919
** MAII scorelog2(19/1792*10)=-3.23749931372666
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2880*10)=-3.92199748799873
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SFPQ [Title/Abstract] AND HSD17B4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SFPQ(35652602)-HSD17B4(118860911), # samples:1
Anticipated loss of major functional domain due to fusion event.SFPQ-HSD17B4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SFPQ-HSD17B4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SFPQ-HSD17B4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SFPQ-HSD17B4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHSD17B4

GO:0006635

fatty acid beta-oxidation

10400999

TgeneHSD17B4

GO:0008209

androgen metabolic process

7487879

TgeneHSD17B4

GO:0008210

estrogen metabolic process

7487879

TgeneHSD17B4

GO:0036111

very long-chain fatty-acyl-CoA metabolic process

9482850

TgeneHSD17B4

GO:0036112

medium-chain fatty-acyl-CoA metabolic process

9089413


check buttonFusion gene breakpoints across SFPQ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HSD17B4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-76-4925-01ASFPQchr1

35652602

-HSD17B4chr5

118860911

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357214SFPQchr135652602-ENST00000256216HSD17B4chr5118860911+31322085872792901
ENST00000357214SFPQchr135652602-ENST00000515320HSD17B4chr5118860911+30512085872792901
ENST00000357214SFPQchr135652602-ENST00000510025HSD17B4chr5118860911+30682085872792901
ENST00000357214SFPQchr135652602-ENST00000504811HSD17B4chr5118860911+30632085872792901
ENST00000357214SFPQchr135652602-ENST00000414835HSD17B4chr5118860911+31312085872792901
ENST00000357214SFPQchr135652602-ENST00000513628HSD17B4chr5118860911+29732085872792901
ENST00000357214SFPQchr135652602-ENST00000509514HSD17B4chr5118860911+30512085872792901

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357214ENST00000256216SFPQchr135652602-HSD17B4chr5118860911+0.0059805990.9940194
ENST00000357214ENST00000515320SFPQchr135652602-HSD17B4chr5118860911+0.0066672690.9933327
ENST00000357214ENST00000510025SFPQchr135652602-HSD17B4chr5118860911+0.0064576750.9935423
ENST00000357214ENST00000504811SFPQchr135652602-HSD17B4chr5118860911+0.0065712030.99342877
ENST00000357214ENST00000414835SFPQchr135652602-HSD17B4chr5118860911+0.0059938940.99400604
ENST00000357214ENST00000513628SFPQchr135652602-HSD17B4chr5118860911+0.007368430.99263155
ENST00000357214ENST00000509514SFPQchr135652602-HSD17B4chr5118860911+0.0066672690.9933327

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81133_81133_1_SFPQ-HSD17B4_SFPQ_chr1_35652602_ENST00000357214_HSD17B4_chr5_118860911_ENST00000256216_length(amino acids)=901AA_BP=661
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGAMNMGDPYGS
GGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGSDMAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSR
FKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKK
VNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAK

--------------------------------------------------------------

>81133_81133_2_SFPQ-HSD17B4_SFPQ_chr1_35652602_ENST00000357214_HSD17B4_chr5_118860911_ENST00000414835_length(amino acids)=901AA_BP=661
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGAMNMGDPYGS
GGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGSDMAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSR
FKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKK
VNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAK

--------------------------------------------------------------

>81133_81133_3_SFPQ-HSD17B4_SFPQ_chr1_35652602_ENST00000357214_HSD17B4_chr5_118860911_ENST00000504811_length(amino acids)=901AA_BP=661
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGAMNMGDPYGS
GGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGSDMAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSR
FKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKK
VNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAK

--------------------------------------------------------------

>81133_81133_4_SFPQ-HSD17B4_SFPQ_chr1_35652602_ENST00000357214_HSD17B4_chr5_118860911_ENST00000509514_length(amino acids)=901AA_BP=661
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGAMNMGDPYGS
GGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGSDMAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSR
FKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKK
VNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAK

--------------------------------------------------------------

>81133_81133_5_SFPQ-HSD17B4_SFPQ_chr1_35652602_ENST00000357214_HSD17B4_chr5_118860911_ENST00000510025_length(amino acids)=901AA_BP=661
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGAMNMGDPYGS
GGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGSDMAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSR
FKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKK
VNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAK

--------------------------------------------------------------

>81133_81133_6_SFPQ-HSD17B4_SFPQ_chr1_35652602_ENST00000357214_HSD17B4_chr5_118860911_ENST00000513628_length(amino acids)=901AA_BP=661
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGAMNMGDPYGS
GGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGSDMAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSR
FKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKK
VNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAK

--------------------------------------------------------------

>81133_81133_7_SFPQ-HSD17B4_SFPQ_chr1_35652602_ENST00000357214_HSD17B4_chr5_118860911_ENST00000515320_length(amino acids)=901AA_BP=661
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGAMNMGDPYGS
GGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGSDMAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSR
FKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKK
VNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAK

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:35652602/chr5:118860911)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SFPQ

P23246

HSD17B4

P51659

FUNCTION: DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}.FUNCTION: Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed:10671535). {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-910497_596662.0708.0Coiled coilOntology_term=ECO:0000255,ECO:0000269
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-91010_15662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-91010_266662.0708.0Compositional biasNote=Gln/Glu/Pro-rich
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-910184_188662.0708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-91020_27662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-91056_65662.0708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-910571_574662.0708.0Compositional biasNote=Poly-Arg
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-910613_616662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-910635_641662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-91067_71662.0708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-91095_98662.0708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-91099_103662.0708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-910297_369662.0708.0DomainRRM 1
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-910371_452662.0708.0DomainRRM 2
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-9109_27662.0708.0RegionNote=3 X 3 AA repeats of R-G-G
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-91019_21662.0708.0RepeatNote=2
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-91025_27662.0708.0RepeatNote=3
HgeneSFPQchr1:35652602chr5:118860911ENST00000357214-9109_11662.0708.0RepeatNote=1
TgeneHSD17B4chr1:35652602chr5:118860911ENST000002562161624624_736501.0737.0DomainNote=SCP2
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005048111725624_736526.0762.0DomainNote=SCP2
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005153201523484_600483.0719.0DomainNote=MaoC-like
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005153201523624_736483.0719.0DomainNote=SCP2
TgeneHSD17B4chr1:35652602chr5:118860911ENST000002562161624734_736501.0737.0MotifMicrobody targeting signal
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005048111725734_736526.0762.0MotifMicrobody targeting signal
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005153201523734_736483.0719.0MotifMicrobody targeting signal
TgeneHSD17B4chr1:35652602chr5:118860911ENST000002562161624510_515501.0737.0Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005153201523510_515483.0719.0Region(3R)-3-hydroxydecanoyl-CoA binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHSD17B4chr1:35652602chr5:118860911ENST000002562161624484_600501.0737.0DomainNote=MaoC-like
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005048111725484_600526.0762.0DomainNote=MaoC-like
TgeneHSD17B4chr1:35652602chr5:118860911ENST00000256216162413_37501.0737.0Nucleotide bindingNAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST000002562161624164_168501.0737.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST000002562161624196_199501.0737.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST00000256216162475_76501.0737.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST00000504811172513_37526.0762.0Nucleotide bindingNAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005048111725164_168526.0762.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005048111725196_199526.0762.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST00000504811172575_76526.0762.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST00000515320152313_37483.0719.0Nucleotide bindingNAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005153201523164_168483.0719.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005153201523196_199483.0719.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST00000515320152375_76483.0719.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr1:35652602chr5:118860911ENST0000025621616241_305501.0737.0RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase
TgeneHSD17B4chr1:35652602chr5:118860911ENST000002562161624322_622501.0737.0RegionNote=Enoyl-CoA hydratase 2
TgeneHSD17B4chr1:35652602chr5:118860911ENST000002562161624406_407501.0737.0Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr1:35652602chr5:118860911ENST0000050481117251_305526.0762.0RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005048111725322_622526.0762.0RegionNote=Enoyl-CoA hydratase 2
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005048111725406_407526.0762.0Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005048111725510_515526.0762.0Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr1:35652602chr5:118860911ENST0000051532015231_305483.0719.0RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005153201523322_622483.0719.0RegionNote=Enoyl-CoA hydratase 2
TgeneHSD17B4chr1:35652602chr5:118860911ENST000005153201523406_407483.0719.0Region(3R)-3-hydroxydecanoyl-CoA binding


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SFPQNONO, FHL2, EXOSC5, HN1, SFPQ, UBC, PTBP1, TOP1, CDC5L, ZMYM2, SP1, SP3, HDAC1, HDAC2, SIN3A, NR3C1, PITX3, NR4A2, RAC1, SRRM1, SRRM2, Rxra, Nono, Sin3a, Thra, SMARCD1, SMARCA2, AR, TOPORS, MAPK1, PRKCI, TADA2A, POT1, SMN1, SNW1, Mapk13, STAT6, HDAC5, AI837181, Mki67, EBNA-LP, PPP1CA, SNRPA, U2AF2, SREK1, RAD21, CEBPA, ELAVL1, ARRB2, SIRT7, HNRNPA1, TSG101, NR2C1, CBLL1, CDK2, COPS5, AP2M1, PARK7, PPARGC1A, U2AF1, SF3B1, EFTUD2, TCERG1, HNRNPR, HNRNPC, SNRPA1, SRSF5, HNRNPM, SRSF7, SF3B3, SRSF3, SRSF4, SNRPD2, SF3A1, DDX21, PHF5A, SART1, HTATSF1, ILF3, TOP2B, HNRNPL, SLTM, SSR4, DNAJC19, TIMM10, TPR, STAG2, SON, THRAP3, SMC3, UTP14A, SMARCA5, TXN, ZC3HAV1, VTN, APEX1, UQCRFS1P1, TOMM40, TIMM9, TIMM23B, BTK, FN1, VCAM1, RNF43, CSNK2A1, SMAD5, ITGA4, PAN2, CD81, PARK2, PRPF40A, WBP4, APBB1, GAS7, PIN1, WWOX, rev, RPA3, RPA2, RPA1, ERG, ASB3, ASB12, ASB18, STAU1, MDM2, HUWE1, FUS, MOV10, NXF1, PPARG, HIST3H3, CUL7, OBSL1, CCDC8, UBE2I, EED, ESR1, ORC6, RPS6KB2, UNK, ACAT1, CARS, COX5A, DPH5, HNRNPA2B1, HNRNPA3, HNRNPD, IMMT, KHDRBS1, LMO7, NDUFS3, NUP210, PFKM, SERBP1, DDX17, PGK1, TARS, WBP11, UQCRC2, YTHDF2, SFN, NTRK1, SCARNA22, KRAS, MUS81, AHSA1, Lin7c, Tsc1, Rpl35, Cxxc1, CRY1, MCM2, MCM5, EGFR, RC3H1, ZNF746, RBMXL1, PSPC1, DIDO1, MMADHC, PRRC2A, EWSR1, LSM14A, FAM98A, DHPS, SYNCRIP, SMARCC1, PRMT5, SMARCC2, NCOA5, PRRC2C, ALYREF, SF1, RBM27, HIP1R, CYLD, CD2BP2, TRIM25, UBE2A, BRCA1, LMNA, PAWR, CTNNB1, PCBP1, CUL4B, UBE2M, PRPF8, AAR2, PIH1D1, TNIP2, YLPM1, NKX2-1, RNF4, CHD3, CHD4, TNF, RIOK1, BPLF1, FGF11, HEXIM1, MEPCE, LARP7, RUNX1, RNF123, AGR2, RECQL4, DCPS, TNRC6A, PIK3R1, RNF144A, REST, ZFP36L2, MYC, CDK9, TP53BP1, MDC1, KIAA1429, METTL3, METTL14, PSMA3, ACTC1, RAD51D, PHB, ARMC12, CHEK2, USP14, NR2C2, ZFYVE21, XRCC6, ATXN3, VRK1, SND1, HIST1H4A, DYRK1A, MAB21L2, SCARB2, SNRNP70, Dppa3, TAF15, MATR3, GSK3B, BIRC3, WWP2, ERCC6, PPIA, PLEKHA4, PINK1, FANCD2, HCVgp1, LINC01554, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, VIM, NFKB1, ZC3H18, PRKD1, MTHFS, UTP20, WDR7, SLC12A2, ATP11C, IGFBP3, PRKDC, WAPAL, MAU2, LAMTOR5, CELF1, NEK4, DUX4, DUX4L9, CIT, CHMP4B, CHMP4C, KIF14, KIF20A, KIF23, PRC1, C8orf82, HNRNPH1, INS, NDN, BIN1, DHX9, HULC, ZNF263, BRD4, NUPR1, RBM45, CIC, Apc2, TARDBP, RBM39, FBP1, LGALS9, YWHAE, IFI16, WDR76, EIF3F, NEAT1, LOC100506753, vpr, EIF5A, RPL23A, NUDT21, NUFIP2, RPS19, NDC80, PPIL4, DDX42, TSPYL5, METTL17, CPSF7, PPP1R10, SP100, FAM76B, MKRN1, KDF1, DDX58, OGT, CD274, SPOP, UFL1, DDRGK1, TP53, TRIM37, ATG10, FZR1, FMR1, FXR1, FXR2, WDR5, NAA40, BGLT3, PTP4A3, ANKRD50, TMEM14B, TRIM68, LONP1, CYCS, BTF3, SLFN11, EP300, FBXW7, CTTN, CTBP1, DMRTB1, TFIP11, EXOSC8, CEP55, KRT31, SF3B4, Ewsr1, Rbm14, Pspc1, Cpsf6, Cstf2t, CCNF, HECTD1, nsp14, PER2, PEG10,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SFPQall structure
HSD17B4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to SFPQ-HSD17B4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to SFPQ-HSD17B4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSFPQC4518356MiT family translocation renal cell carcinoma2ORPHANET
HgeneSFPQC0019693HIV Infections1CTD_human
HgeneSFPQC0037274Dermatologic disorders1CTD_human
HgeneSFPQC0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneSFPQC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneSFPQC0311375Arsenic Poisoning1CTD_human
HgeneSFPQC0751851Arsenic Encephalopathy1CTD_human
HgeneSFPQC0751852Arsenic Induced Polyneuropathy1CTD_human
HgeneSFPQC4505456HIV Coinfection1CTD_human