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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SFPQ-TFE3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SFPQ-TFE3
FusionPDB ID: 81142
FusionGDB2.0 ID: 81142
HgeneTgene
Gene symbol

SFPQ

TFE3

Gene ID

654780

7030

Gene namesplicing factor proline/glutamine-richtranscription factor binding to IGHM enhancer 3
SynonymsSFPQRCCP2|RCCX1|TFEA|bHLHe33
Cytomap

16q24.1

Xp11.23

Type of genencRNAprotein-coding
Description-transcription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3
Modification date2020030320200327
UniProtAcc

P23246

P19532

Ensembl transtripts involved in fusion geneENST idsENST00000357214, ENST00000468598, 
ENST00000487451, ENST00000315869, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 16 X 8=179214 X 15 X 6=1260
# samples 1915
** MAII scorelog2(19/1792*10)=-3.23749931372666
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1260*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SFPQ [Title/Abstract] AND TFE3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SFPQ(35654604)-TFE3(48898095), # samples:14
TFE3(48900637)-SFPQ(35653691), # samples:3
Anticipated loss of major functional domain due to fusion event.SFPQ-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SFPQ-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SFPQ-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SFPQ-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SFPQ-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SFPQ-TFE3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SFPQ-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SFPQ-TFE3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SFPQ-TFE3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SFPQ-TFE3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
TFE3-SFPQ seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TFE3-SFPQ seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TFE3-SFPQ seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TFE3-SFPQ seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TFE3-SFPQ seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TFE3-SFPQ seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SFPQ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TFE3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-AK-3456-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRCTCGA-B0-5705-01ASFPQchr1

35652602

-TFE3chrX

48891766

-
ChimerDB4KIRCTCGA-B8-5546-01ASFPQchr1

35652602

-TFE3chrX

48891766

-
ChimerDB4KIRCTCGA-BP-4756-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRCTCGA-BP-4758-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-G7-7501-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-G7-7501SFPQchr1

35654603

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-G7-7501SFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-SX-A7SO-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-SX-A7SOSFPQchr1

35654603

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-SX-A7SOSFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerKB3..SFPQchr1

35652602

-TFE3chrX

48891766

-
ChimerKB3..SFPQchr1

35654603

-TFE3chrX

48891055

-
ChimerKB3..SFPQchr1

35654604

-TFE3chrX

48898095

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357214SFPQchr135652602-ENST00000315869TFE3chrX48891766-43552085872927946
ENST00000357214SFPQchr135654604-ENST00000315869TFE3chrX48898095-483517968734071106
ENST00000357214SFPQchr135654604-ENST00000315869TFE3chrX48898095-483517968734071106
ENST00000357214SFPQchr135652602-ENST00000315869TFE3chrX48891766-43552085872927946
ENST00000357214SFPQchr135654603-ENST00000315869TFE3chrX48898095-483517968734071106

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357214ENST00000315869SFPQchr135654604-TFE3chrX48898095-0.0053817270.99461836
ENST00000357214ENST00000315869SFPQchr135652602-TFE3chrX48891766-0.0079983310.99200165
ENST00000357214ENST00000315869SFPQchr135654603-TFE3chrX48898095-0.0053817270.99461836

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81142_81142_1_SFPQ-TFE3_SFPQ_chr1_35652602_ENST00000357214_TFE3_chrX_48891766_ENST00000315869_length(amino acids)=946AA_BP=666
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGAMNMGDPYGS
GGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGSDMLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKD
NHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGL
PVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEE

--------------------------------------------------------------

>81142_81142_2_SFPQ-TFE3_SFPQ_chr1_35654603_ENST00000357214_TFE3_chrX_48898095_ENST00000315869_length(amino acids)=1106AA_BP=568
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAG
GSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRY
HLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEM
LSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKEL
GTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSL
KPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASD

--------------------------------------------------------------

>81142_81142_3_SFPQ-TFE3_SFPQ_chr1_35654604_ENST00000357214_TFE3_chrX_48898095_ENST00000315869_length(amino acids)=1106AA_BP=568
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAG
GSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRY
HLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEM
LSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKEL
GTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSL
KPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:35654604/chrX:48898095)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SFPQ

P23246

TFE3

P19532

FUNCTION: DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}.FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:29146937, PubMed:30733432, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:31672913). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:31672913). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910497_596662.0708.0Coiled coilOntology_term=ECO:0000255,ECO:0000269
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91010_15662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91010_266662.0708.0Compositional biasNote=Gln/Glu/Pro-rich
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910184_188662.0708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91020_27662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91056_65662.0708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910571_574662.0708.0Compositional biasNote=Poly-Arg
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910613_616662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910635_641662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91067_71662.0708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91095_98662.0708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91099_103662.0708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61010_15565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61010_266565.6666666666666708.0Compositional biasNote=Gln/Glu/Pro-rich
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610184_188565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61020_27565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61056_65565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61067_71565.6666666666666708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61095_98565.6666666666666708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61099_103565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61010_15565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61010_266565.6666666666666708.0Compositional biasNote=Gln/Glu/Pro-rich
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610184_188565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61020_27565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61056_65565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61067_71565.6666666666666708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61095_98565.6666666666666708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61099_103565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910297_369662.0708.0DomainRRM 1
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910371_452662.0708.0DomainRRM 2
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610297_369565.6666666666666708.0DomainRRM 1
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610371_452565.6666666666666708.0DomainRRM 2
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610297_369565.6666666666666708.0DomainRRM 1
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610371_452565.6666666666666708.0DomainRRM 2
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-9109_27662.0708.0RegionNote=3 X 3 AA repeats of R-G-G
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-6109_27565.6666666666666708.0RegionNote=3 X 3 AA repeats of R-G-G
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-6109_27565.6666666666666708.0RegionNote=3 X 3 AA repeats of R-G-G
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91019_21662.0708.0RepeatNote=2
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91025_27662.0708.0RepeatNote=3
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-9109_11662.0708.0RepeatNote=1
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61019_21565.6666666666666708.0RepeatNote=2
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61025_27565.6666666666666708.0RepeatNote=3
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-6109_11565.6666666666666708.0RepeatNote=1
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61019_21565.6666666666666708.0RepeatNote=2
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61025_27565.6666666666666708.0RepeatNote=3
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-6109_11565.6666666666666708.0RepeatNote=1
TgeneTFE3chr1:35652602chrX:48891766ENST00000315869410346_399295.0576.0DomainbHLH
TgeneTFE3chr1:35654603chrX:48898095ENST00000315869010346_39938.666666666666664576.0DomainbHLH
TgeneTFE3chr1:35654604chrX:48898095ENST00000315869010346_39938.666666666666664576.0DomainbHLH
TgeneTFE3chr1:35652602chrX:48891766ENST00000315869410409_430295.0576.0RegionNote=Leucine-zipper
TgeneTFE3chr1:35654603chrX:48898095ENST00000315869010260_27138.666666666666664576.0RegionStrong transcription activation domain
TgeneTFE3chr1:35654603chrX:48898095ENST00000315869010409_43038.666666666666664576.0RegionNote=Leucine-zipper
TgeneTFE3chr1:35654604chrX:48898095ENST00000315869010260_27138.666666666666664576.0RegionStrong transcription activation domain
TgeneTFE3chr1:35654604chrX:48898095ENST00000315869010409_43038.666666666666664576.0RegionNote=Leucine-zipper

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610497_596565.6666666666666708.0Coiled coilOntology_term=ECO:0000255,ECO:0000269
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610497_596565.6666666666666708.0Coiled coilOntology_term=ECO:0000255,ECO:0000269
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610571_574565.6666666666666708.0Compositional biasNote=Poly-Arg
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610613_616565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610635_641565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610571_574565.6666666666666708.0Compositional biasNote=Poly-Arg
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610613_616565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610635_641565.6666666666666708.0Compositional biasNote=Poly-Gly
TgeneTFE3chr1:35652602chrX:48891766ENST00000315869410260_271295.0576.0RegionStrong transcription activation domain


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (726) >>>726.pdbFusion protein BP residue: 666
CIF file (726) >>>726.cif		SFPQchr135652602-TFE3chrX48891766-
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGP
MGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQ
QQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSG
PGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGP
GPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQ
HHPPYHQQHHQGPPPGGPGGRSEEKISDSEGFKANLSLLRRPGEKTYTQR
CRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAE
IAKAELDDTPMRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGP
IERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKS
LDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLRQDLMRRQEEL
RRMEELHNQEMQKRKEMQLRQEEERRRREEEMMIRQREMEEQMRRQREES
YSRMGYMDPRERDMRMGGGGAMNMGDPYGSGGQKFPPLGGGGGIGYEANP
GVPPATMSGSMMGSDMLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNI
KREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDP
EMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQE
LELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHV
GGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEE
946
3D view using mol* of 726 (AA BP:666)
PDB file (803) >>>803.pdbFusion protein BP residue: 568
CIF file (803) >>>803.cif		SFPQchr135654604-TFE3chrX48898095-
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGP
MGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQ
QQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSG
PGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGP
GPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQ
HHPPYHQQHHQGPPPGGPGGRSEEKISDSEGFKANLSLLRRPGEKTYTQR
CRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAE
IAKAELDDTPMRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGP
IERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKS
LDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLRQDLMRRQEEL
RRMEELHNQEMQKRKEMQLSLNSLLPESGIVADIELENVLDPDSFYELKS
QPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQ
LMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPP
AQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPP
PGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEII
SLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVS
NSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKEL
GTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQA
NRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEE
GRPGAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHL
GLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSF
1106
3D view using mol* of 803 (AA BP:568)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SFPQ_pLDDT.png
all structure
all structure
TFE3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SFPQ_TFE3_726_pLDDT.png (AA BP:666)
all structure
SFPQ_TFE3_726_pLDDT_and_active_sites.png (AA BP:666)
all structure
SFPQ_TFE3_726_violinplot.png (AA BP:666)
all structure
SFPQ_TFE3_803_pLDDT.png (AA BP:568)
all structure
SFPQ_TFE3_803_pLDDT_and_active_sites.png (AA BP:568)
all structure
SFPQ_TFE3_803_violinplot.png (AA BP:568)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
SFPQ_TFE3_726.png
all structure
SFPQ_TFE3_803.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
7261.044971.121219.1770.5080.6560.8781.6260.612.6661.663Chain A: 381,444,445,446,447,448,520,523,524,527,5
28,531
8031.0163991.0876259.9940.64640.62470.79341.05540.68251.54631.0894Chain A: 380,381,383,384,385,415,416,417,443,444,4
45,446,447,448,450,520,521,523,524,527,528,531

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
726ZINC000029571072DB06636Isavuconazonium-6.7164-7.1484
726ZINC000014210876DB09272Eluxadoline-6.40576-7.13336
726ZINC000053084692DB06654Safinamide-6.28281-7.06091
726ZINC000001550477DB01259Lapatinib-6.88388-6.97268
726ZINC000000403079DB00211Midodrine-6.72239-6.83039
726ZINC000000000507DB00211Midodrine-6.66343-6.77143
726ZINC000049637509DB06636Isavuconazonium-6.27401-6.70601
726ZINC000150588351DB11574Elbasvir-5.36251-6.60611
726ZINC000003991624DB09082Vilanterol-6.53987-6.54517
726ZINC000001996784DB08893Mirabegron-5.52811-6.37911
726ZINC000022059926DB01155Gemifloxacin-6.33436-6.37526
726ZINC000000001979DB00794Primidone-6.23425-6.23425
726ZINC000003812863DB00722Lisinopril-5.99641-6.11831
726ZINC000004099200DB00213Pantoprazole-5.77344-6.07514
726ZINC000000968255DB01193Acebutolol-6.0237-6.0254
726ZINC000003776633DB09488Acrivastine-5.98057-5.98637
726ZINC000002568036DB01219Dantrolene-5.88917-5.96157
726ZINC000252679615DB01219Dantrolene-5.88917-5.96157
726ZINC000019702309DB00697Tizanidine-5.12326-5.96026
726ZINC000013537284DB00969Alosetron-5.66257-5.95767

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000014210876DB09272EluxadolineSmall moleculeCOC1=CC=C(CN([C@@H](C)C2=NC(=CN2)C2=CC=CC=C2)C(=O)[C@@H](N)CC2=C(C)C=C(C=C2C)C(N)=O)C=C1C(O)=OApproved|Investigational
ZINC000053084692DB06654SafinamideSmall moleculeC[C@H](NCC1=CC=C(OCC2=CC(F)=CC=C2)C=C1)C(N)=OApproved|Investigational
ZINC000001550477DB01259LapatinibSmall moleculeCS(=O)(=O)CCNCC1=CC=C(O1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(OCC2=CC(F)=CC=C2)C=C1Approved|Investigational
ZINC000000403079DB00211MidodrineSmall moleculeCOC1=CC(C(O)CNC(=O)CN)=C(OC)C=C1Approved
ZINC000049637509DB06636IsavuconazoniumSmall molecule[H]C(C)(OC(=O)N(C)C1=C(COC(=O)CNC)C=CC=N1)[N+]1=CN(C[C@](O)(C2=C(F)C=CC(F)=C2)[C@@]([H])(C)C2=NC(=CS2)C2=CC=C(C=C2)C#N)N=C1Approved|Investigational
ZINC000150588351DB11574ElbasvirSmall molecule[H][C@]1(CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C)C1=NC=C(N1)C1=CC2=C(C=C1)N1[C@@H](OC3=C(C=CC(=C3)C3=CN=C(N3)[C@]3([H])CCCN3C(=O)[C@@H](NC(=O)OC)C(C)C)C1=C2)C1=CC=CC=C1Approved
ZINC000003991624DB09082VilanterolSmall moleculeOCC1=C(O)C=CC(=C1)[C@@H](O)CNCCCCCCOCCOCC1=C(Cl)C=CC=C1ClApproved
ZINC000001996784DB08893MirabegronSmall moleculeNC1=NC(CC(=O)NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=CS1Approved
ZINC000000001979DB00794PrimidoneSmall moleculeCCC1(C(=O)NCNC1=O)C1=CC=CC=C1Approved|Vet_approved
ZINC000003812863DB00722LisinoprilSmall moleculeNCCCC[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=OApproved|Investigational
ZINC000000968255DB01193AcebutololSmall moleculeCCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(=C1)C(C)=OApproved|Investigational
ZINC000003776633DB09488AcrivastineSmall molecule[H]C(CN1CCCC1)=C(C1=CC=C(C)C=C1)C1=CC=CC(=N1)C([H])=C(/[H])C(O)=OApproved
ZINC000019702309DB00697TizanidineSmall moleculeClC1=C(NC2=NCCN2)C2=NSN=C2C=C1Approved|Investigational
ZINC000013537284DB00969AlosetronSmall moleculeCN1C2=C(C3=CC=CC=C13)C(=O)N(CC1=C(C)NC=N1)CC2Approved|Withdrawn

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000014210876569.6597.127866.349287.048259.904319.39701681.617610.758.68917.53822
ZINC000014210876569.6593.679901.19287.315271.102342.77301718.172610.758.88816.54622
ZINC000014210876569.6596.683902.919270.324282.937349.65801740.575610.758.9214.83122
ZINC000014210876569.6596.148862.573279.279281.556301.73701689.73610.758.98413.05322
ZINC000014210876569.65914.843858.111275.061269.062313.98801679.1610.759.13316.01322
ZINC000014210876569.65914.363896.983280.954265.963350.06601717.668610.759.0117.35222
ZINC000053084692302.3486.36612.581156.033105.388304.28646.8741036.21834.759.083376.96100
ZINC000053084692302.3483.053603.233143.432120.534292.3746.8971022.59734.759.137372.68300
ZINC000001550477581.068.763984.429219.392136.563520.447108.0271738.43918.258.353175.11221
ZINC000001550477581.068.228914.704239.85389.107476.75108.9941676.88418.258.025182.62721
ZINC000000403079254.2858.222508.117287.098138.59782.4220861.92446.78.952258.56701
ZINC000000403079254.2858.241520.317283.5144.0392.7870868.5846.78.838257.05201
ZINC000000000507254.2854.725473.576261.82136.95374.8030834.49146.78.718258.58701
ZINC000000000507254.2854.114523.523284.58146.4492.5030869.50546.78.676256.59801
ZINC000150588351882.036.5721345.74717.517186.345441.87802635.9722.513.258.001168.97331
ZINC000150588351882.0315.5811298.014670.728196.39430.89602598.6552.513.258.107165.89131
ZINC000150588351882.037.6941389.327750.107173.462465.75802673.8482.513.258.124173.08531
ZINC000150588351882.032.2191373.023721.483195.055456.48502655.1922.513.258.091168.49731
ZINC000150588351882.0313.7611347.364706.26205.501435.60302635.2572.513.258.253164.82431
ZINC000150588351882.036.9221403.807740.212182.531481.06402678.7442.513.258.307171.99131
ZINC000150588351882.0313.991367.982729.766188.685449.53102678.6732.513.257.973170.20832
ZINC000150588351882.0310.6561391.126719.587194.166477.37302673.6242.513.257.937169.24432
ZINC000150588351882.038.2331375.056718.117197.908459.03202655.632.513.257.962167.78732
ZINC000003991624486.4343.258903.903422.215140.111234.063107.5151590.87849.058.965188.14701
ZINC000001996784396.5065.759766.121167.737163.909381.05653.421313.34757.78.494375.07100
ZINC000001996784396.5065.465768.333168.285165.496381.31553.2371317.85557.78.411374.8900
ZINC000022059926389.3855.386675.076333.398232.63867.9641.081199.52228.79.053236.53501
ZINC000022059926389.3854.357656.741321.575225.55768.44141.1671178.17628.79.183237.34601
ZINC000000001979218.2556.424430.487152.039113.7164.7480724.718259.834270.0900
ZINC000003812863405.4935.463730.208302.892230.979196.33601324.77459.59.56315.84902
ZINC000003812863405.4933.617663.455286.232239.361137.86201260.91659.59.30116.6402
ZINC000004099200383.3698.318623.128213.24477.412222.302110.171084.47189.124376.69200
ZINC000004099200383.3698.299620.121215.6578.983216.916108.5731082.558189.183376.22100
ZINC000004099200383.3698.355619.5212.86177.163219.295110.1821080.981189.019376.60300
ZINC000004099200383.3698.428625.396215.33578.49221.055110.5161084.724189.007376.45900
ZINC000000968255336.438.487719.214492.156136.66990.38901228.68638.458.852374.51200
ZINC000003776633348.4444.003710.695326.718122.5261.47701233.641158.89270.80500
ZINC000002568036314.2573.867548.75854.323243.185251.250924.46159.205367.05800
ZINC000002568036314.2574.186547.354.729241.127251.4440922.097159.191367.40800
ZINC000252679615314.2573.867548.75854.323243.185251.250924.46159.205367.05800
ZINC000252679615314.2572.557527.99664.383238.233225.380905.494159.686367.50600
ZINC000252679615314.2574.186547.354.729241.127251.4440922.097159.191367.40800
ZINC000252679615314.2572.845525.88465.15235.939224.7950902.055159.671367.87500
ZINC000019702309253.7096.047452.2124.06498.774104.993124.368734.09124.58.136392.42100
ZINC000019702309253.7094.762447.533119.519104.091101.452122.471730.551248.555392.15500
ZINC000013537284294.35511.018558.659261.63964.423232.5970975.98514.58.467310000
ZINC000013537284294.3552.688556.854260.96665.507230.3810971.56114.58.221310000
ZINC000013537284294.35511.062555.086259.10266.238229.7460970.70114.58.471310000


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000029571072CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c10.0254160270.235213823
ZINC000014210876COc1ccc(CN(C(=O)[C@@H](N)Cc2c(C)cc(C(N)=O)cc2C)[C@@H](C)c2nc(-c3ccccc3)c[nH]2)cc1C(=O)O0.0678197430.140534867
ZINC000053084692C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O0.2799554790.265373208
ZINC000001550477CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o10.187595690.281219747
ZINC000000403079COc1ccc(OC)c([C@@H](O)CNC(=O)CN)c10.2299587370.301481614
ZINC000000000507COc1ccc(OC)c([C@H](O)CNC(=O)CN)c10.2299587370.301481614
ZINC000049637509CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c10.0254160270.235213823
ZINC000150588351COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc3c(c2)O[C@@H](c2ccccc2)n2c-3cc3cc(-c4c[nH]c([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)n4)ccc32)c[nH]1)C(C)C0.0158759170.217012798
ZINC000003991624OCc1cc([C@@H](O)CNCCCCCCOCCOCc2c(Cl)cccc2Cl)ccc1O0.1381093360.274850695
ZINC000001996784Nc1nc(CC(=O)Nc2ccc(CCNC[C@H](O)c3ccccc3)cc2)cs10.205681060.138337618
ZINC000022059926CO/N=C1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@@H]1CN0.0776115140.258972331
ZINC000000001979CCC1(c2ccccc2)C(=O)NCNC1=O0.1702668320.409145584
ZINC000003812863NCCCC[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N1CCC[C@H]1C(=O)O0.1139036130.150945123
ZINC000004099200COc1ccnc(C[S@](=O)c2nc3ccc(OC(F)F)cc3[nH]2)c1OC0.1146673540.321842622
ZINC000000968255CCCC(=O)Nc1ccc(OC[C@H](O)CNC(C)C)c(C(C)=O)c10.2084012030.251834481
ZINC000003776633Cc1ccc(/C(=CCN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc10.222375690.247350052
ZINC000002568036O=C1CN(/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(=O)N10.2040708230.461176527
ZINC000252679615O=C1CN(N=Cc2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(O)=N10.1491321090.500589886
ZINC000019702309Clc1ccc2nsnc2c1N=C1NCCN10.0701726770.465014194
ZINC000013537284Cc1nc[nH]c1CN1CCc2c(c3ccccc3n2C)C1=O0.1673991990.254688426


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SFPQNONO, FHL2, EXOSC5, HN1, SFPQ, UBC, PTBP1, TOP1, CDC5L, ZMYM2, SP1, SP3, HDAC1, HDAC2, SIN3A, NR3C1, PITX3, NR4A2, RAC1, SRRM1, SRRM2, Rxra, Nono, Sin3a, Thra, SMARCD1, SMARCA2, AR, TOPORS, MAPK1, PRKCI, TADA2A, POT1, SMN1, SNW1, Mapk13, STAT6, HDAC5, AI837181, Mki67, EBNA-LP, PPP1CA, SNRPA, U2AF2, SREK1, RAD21, CEBPA, ELAVL1, ARRB2, SIRT7, HNRNPA1, TSG101, NR2C1, CBLL1, CDK2, COPS5, AP2M1, PARK7, PPARGC1A, U2AF1, SF3B1, EFTUD2, TCERG1, HNRNPR, HNRNPC, SNRPA1, SRSF5, HNRNPM, SRSF7, SF3B3, SRSF3, SRSF4, SNRPD2, SF3A1, DDX21, PHF5A, SART1, HTATSF1, ILF3, TOP2B, HNRNPL, SLTM, SSR4, DNAJC19, TIMM10, TPR, STAG2, SON, THRAP3, SMC3, UTP14A, SMARCA5, TXN, ZC3HAV1, VTN, APEX1, UQCRFS1P1, TOMM40, TIMM9, TIMM23B, BTK, FN1, VCAM1, RNF43, CSNK2A1, SMAD5, ITGA4, PAN2, CD81, PARK2, PRPF40A, WBP4, APBB1, GAS7, PIN1, WWOX, rev, RPA3, RPA2, RPA1, ERG, ASB3, ASB12, ASB18, STAU1, MDM2, HUWE1, FUS, MOV10, NXF1, PPARG, HIST3H3, CUL7, OBSL1, CCDC8, UBE2I, EED, ESR1, ORC6, RPS6KB2, UNK, ACAT1, CARS, COX5A, DPH5, HNRNPA2B1, HNRNPA3, HNRNPD, IMMT, KHDRBS1, LMO7, NDUFS3, NUP210, PFKM, SERBP1, DDX17, PGK1, TARS, WBP11, UQCRC2, YTHDF2, SFN, NTRK1, SCARNA22, KRAS, MUS81, AHSA1, Lin7c, Tsc1, Rpl35, Cxxc1, CRY1, MCM2, MCM5, EGFR, RC3H1, ZNF746, RBMXL1, PSPC1, DIDO1, MMADHC, PRRC2A, EWSR1, LSM14A, FAM98A, DHPS, SYNCRIP, SMARCC1, PRMT5, SMARCC2, NCOA5, PRRC2C, ALYREF, SF1, RBM27, HIP1R, CYLD, CD2BP2, TRIM25, UBE2A, BRCA1, LMNA, PAWR, CTNNB1, PCBP1, CUL4B, UBE2M, PRPF8, AAR2, PIH1D1, TNIP2, YLPM1, NKX2-1, RNF4, CHD3, CHD4, TNF, RIOK1, BPLF1, FGF11, HEXIM1, MEPCE, LARP7, RUNX1, RNF123, AGR2, RECQL4, DCPS, TNRC6A, PIK3R1, RNF144A, REST, ZFP36L2, MYC, CDK9, TP53BP1, MDC1, KIAA1429, METTL3, METTL14, PSMA3, ACTC1, RAD51D, PHB, ARMC12, CHEK2, USP14, NR2C2, ZFYVE21, XRCC6, ATXN3, VRK1, SND1, HIST1H4A, DYRK1A, MAB21L2, SCARB2, SNRNP70, Dppa3, TAF15, MATR3, GSK3B, BIRC3, WWP2, ERCC6, PPIA, PLEKHA4, PINK1, FANCD2, HCVgp1, LINC01554, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, VIM, NFKB1, ZC3H18, PRKD1, MTHFS, UTP20, WDR7, SLC12A2, ATP11C, IGFBP3, PRKDC, WAPAL, MAU2, LAMTOR5, CELF1, NEK4, DUX4, DUX4L9, CIT, CHMP4B, CHMP4C, KIF14, KIF20A, KIF23, PRC1, C8orf82, HNRNPH1, INS, NDN, BIN1, DHX9, HULC, ZNF263, BRD4, NUPR1, RBM45, CIC, Apc2, TARDBP, RBM39, FBP1, LGALS9, YWHAE, IFI16, WDR76, EIF3F, NEAT1, LOC100506753, vpr, EIF5A, RPL23A, NUDT21, NUFIP2, RPS19, NDC80, PPIL4, DDX42, TSPYL5, METTL17, CPSF7, PPP1R10, SP100, FAM76B, MKRN1, KDF1, DDX58, OGT, CD274, SPOP, UFL1, DDRGK1, TP53, TRIM37, ATG10, FZR1, FMR1, FXR1, FXR2, WDR5, NAA40, BGLT3, PTP4A3, ANKRD50, TMEM14B, TRIM68, LONP1, CYCS, BTF3, SLFN11, EP300, FBXW7, CTTN, CTBP1, DMRTB1, TFIP11, EXOSC8, CEP55, KRT31, SF3B4, Ewsr1, Rbm14, Pspc1, Cpsf6, Cstf2t, CCNF, HECTD1, nsp14, PER2, PEG10,
TFE3AKR1B1, CLTC, PHB2, ACLY, CUL2, EPRS, PFAS, VARS, NEDD8, RPL38, TRIM28, EIF3A, RPA3, E2F3, SMARCE1, MITF, TFE3, SMAD3, SMAD4, TFEC, EWSR1, XPO1, TFEB, Arrb2, TARDBP, HIST1H4A, LAMTOR3, nsp2, nsp7, AIM2, NR3C1, DDX58, YWHAG, YWHAQ, HDAC5, BTF3, nsp16, IRF8, KLF12, KLF16, KLF3, KLF5, KLF8, SOX2, TLX3, VSX1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SFPQall structure
TFE3all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SFPQ-TFE3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SFPQ-TFE3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
SFPQTFE3PecomaMyCancerGenome
SFPQTFE3Translocation-Associated Renal Cell CarcinomaMyCancerGenome
SFPQTFE3Large Cell Neuroendocrine CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSFPQC4518356MiT family translocation renal cell carcinoma2ORPHANET
HgeneSFPQC0019693HIV Infections1CTD_human
HgeneSFPQC0037274Dermatologic disorders1CTD_human
HgeneSFPQC0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneSFPQC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneSFPQC0311375Arsenic Poisoning1CTD_human
HgeneSFPQC0751851Arsenic Encephalopathy1CTD_human
HgeneSFPQC0751852Arsenic Induced Polyneuropathy1CTD_human
HgeneSFPQC4505456HIV Coinfection1CTD_human
TgeneTFE3C4518356MiT family translocation renal cell carcinoma2ORPHANET
TgeneTFE3C0206657Alveolar Soft Part Sarcoma1ORPHANET
TgeneTFE3C0206732Epithelioid hemangioendothelioma1ORPHANET