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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SH3GL1-ANKRD24

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SH3GL1-ANKRD24
FusionPDB ID: 81447
FusionGDB2.0 ID: 81447
HgeneTgene
Gene symbol

SH3GL1

ANKRD24

Gene ID

6455

170961

Gene nameSH3 domain containing GRB2 like 1, endophilin A2ankyrin repeat domain 24
SynonymsCNSA1|EEN|SH3D2B|SH3P8-
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionendophilin-A2EEN fusion partner of MLLSH3 domain protein 2BSH3 domain-containing GRB2-like protein 1SH3-containing Grb-2-like 1 proteinSH3-domain GRB2-like 1endophilin-2extra 11-19 leukemia fusionextra eleven-nineteen leukemia fusion gene proteinankyrin repeat domain-containing protein 24
Modification date2020031320200313
UniProtAcc

Q99961

Q8TF21

Ensembl transtripts involved in fusion geneENST idsENST00000269886, ENST00000417295, 
ENST00000598564, 		ENST00000595096, 
ENST00000262970, ENST00000318934, 
ENST00000600132, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 9 X 12=19447 X 7 X 7=343
# samples 229
** MAII scorelog2(22/1944*10)=-3.14345279008112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/343*10)=-1.93021166984314
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SH3GL1 [Title/Abstract] AND ANKRD24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SH3GL1(4400321)-ANKRD24(4219588), # samples:3
Anticipated loss of major functional domain due to fusion event.SH3GL1-ANKRD24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SH3GL1-ANKRD24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SH3GL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANKRD24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-GM-A2DC-01ASH3GL1chr19

4400321

-ANKRD24chr19

4219588

+
ChimerDB4BRCATCGA-GM-A2DCSH3GL1chr19

4400320

-ANKRD24chr19

4219587

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000269886SH3GL1chr194400321-ENST00000600132ANKRD24chr194219588+971224179661160
ENST00000269886SH3GL1chr194400321-ENST00000318934ANKRD24chr194219588+971224179661160
ENST00000269886SH3GL1chr194400321-ENST00000262970ANKRD24chr194219588+662224179661161
ENST00000598564SH3GL1chr194400321-ENST00000600132ANKRD24chr194219588+8429550532160
ENST00000598564SH3GL1chr194400321-ENST00000318934ANKRD24chr194219588+8429550532160
ENST00000598564SH3GL1chr194400321-ENST00000262970ANKRD24chr194219588+5339550532161
ENST00000417295SH3GL1chr194400321-ENST00000600132ANKRD24chr194219588+949202157639160
ENST00000417295SH3GL1chr194400321-ENST00000318934ANKRD24chr194219588+949202157639160
ENST00000417295SH3GL1chr194400321-ENST00000262970ANKRD24chr194219588+640202157639161
ENST00000269886SH3GL1chr194400320-ENST00000600132ANKRD24chr194219587+971224179661160
ENST00000269886SH3GL1chr194400320-ENST00000318934ANKRD24chr194219587+971224179661160
ENST00000269886SH3GL1chr194400320-ENST00000262970ANKRD24chr194219587+662224179661161
ENST00000598564SH3GL1chr194400320-ENST00000600132ANKRD24chr194219587+8429550532160
ENST00000598564SH3GL1chr194400320-ENST00000318934ANKRD24chr194219587+8429550532160
ENST00000598564SH3GL1chr194400320-ENST00000262970ANKRD24chr194219587+5339550532161
ENST00000417295SH3GL1chr194400320-ENST00000600132ANKRD24chr194219587+949202157639160
ENST00000417295SH3GL1chr194400320-ENST00000318934ANKRD24chr194219587+949202157639160
ENST00000417295SH3GL1chr194400320-ENST00000262970ANKRD24chr194219587+640202157639161

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000269886ENST00000600132SH3GL1chr194400321-ANKRD24chr194219588+0.0022508570.99774915
ENST00000269886ENST00000318934SH3GL1chr194400321-ANKRD24chr194219588+0.0022508570.99774915
ENST00000269886ENST00000262970SH3GL1chr194400321-ANKRD24chr194219588+0.0010318080.99896824
ENST00000598564ENST00000600132SH3GL1chr194400321-ANKRD24chr194219588+0.0020286820.99797136
ENST00000598564ENST00000318934SH3GL1chr194400321-ANKRD24chr194219588+0.0020286820.99797136
ENST00000598564ENST00000262970SH3GL1chr194400321-ANKRD24chr194219588+0.0007639480.9992361
ENST00000417295ENST00000600132SH3GL1chr194400321-ANKRD24chr194219588+0.002636770.99736327
ENST00000417295ENST00000318934SH3GL1chr194400321-ANKRD24chr194219588+0.002636770.99736327
ENST00000417295ENST00000262970SH3GL1chr194400321-ANKRD24chr194219588+0.0011891570.9988109
ENST00000269886ENST00000600132SH3GL1chr194400320-ANKRD24chr194219587+0.0022508570.99774915
ENST00000269886ENST00000318934SH3GL1chr194400320-ANKRD24chr194219587+0.0022508570.99774915
ENST00000269886ENST00000262970SH3GL1chr194400320-ANKRD24chr194219587+0.0010318080.99896824
ENST00000598564ENST00000600132SH3GL1chr194400320-ANKRD24chr194219587+0.0020286820.99797136
ENST00000598564ENST00000318934SH3GL1chr194400320-ANKRD24chr194219587+0.0020286820.99797136
ENST00000598564ENST00000262970SH3GL1chr194400320-ANKRD24chr194219587+0.0007639480.9992361
ENST00000417295ENST00000600132SH3GL1chr194400320-ANKRD24chr194219587+0.002636770.99736327
ENST00000417295ENST00000318934SH3GL1chr194400320-ANKRD24chr194219587+0.002636770.99736327
ENST00000417295ENST00000262970SH3GL1chr194400320-ANKRD24chr194219587+0.0011891570.9988109

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81447_81447_1_SH3GL1-ANKRD24_SH3GL1_chr19_4400320_ENST00000269886_ANKRD24_chr19_4219587_ENST00000262970_length(amino acids)=161AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_2_SH3GL1-ANKRD24_SH3GL1_chr19_4400320_ENST00000269886_ANKRD24_chr19_4219587_ENST00000318934_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_3_SH3GL1-ANKRD24_SH3GL1_chr19_4400320_ENST00000269886_ANKRD24_chr19_4219587_ENST00000600132_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_4_SH3GL1-ANKRD24_SH3GL1_chr19_4400320_ENST00000417295_ANKRD24_chr19_4219587_ENST00000262970_length(amino acids)=161AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_5_SH3GL1-ANKRD24_SH3GL1_chr19_4400320_ENST00000417295_ANKRD24_chr19_4219587_ENST00000318934_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_6_SH3GL1-ANKRD24_SH3GL1_chr19_4400320_ENST00000417295_ANKRD24_chr19_4219587_ENST00000600132_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_7_SH3GL1-ANKRD24_SH3GL1_chr19_4400320_ENST00000598564_ANKRD24_chr19_4219587_ENST00000262970_length(amino acids)=161AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_8_SH3GL1-ANKRD24_SH3GL1_chr19_4400320_ENST00000598564_ANKRD24_chr19_4219587_ENST00000318934_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_9_SH3GL1-ANKRD24_SH3GL1_chr19_4400320_ENST00000598564_ANKRD24_chr19_4219587_ENST00000600132_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_10_SH3GL1-ANKRD24_SH3GL1_chr19_4400321_ENST00000269886_ANKRD24_chr19_4219588_ENST00000262970_length(amino acids)=161AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_11_SH3GL1-ANKRD24_SH3GL1_chr19_4400321_ENST00000269886_ANKRD24_chr19_4219588_ENST00000318934_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_12_SH3GL1-ANKRD24_SH3GL1_chr19_4400321_ENST00000269886_ANKRD24_chr19_4219588_ENST00000600132_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_13_SH3GL1-ANKRD24_SH3GL1_chr19_4400321_ENST00000417295_ANKRD24_chr19_4219588_ENST00000262970_length(amino acids)=161AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_14_SH3GL1-ANKRD24_SH3GL1_chr19_4400321_ENST00000417295_ANKRD24_chr19_4219588_ENST00000318934_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_15_SH3GL1-ANKRD24_SH3GL1_chr19_4400321_ENST00000417295_ANKRD24_chr19_4219588_ENST00000600132_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_16_SH3GL1-ANKRD24_SH3GL1_chr19_4400321_ENST00000598564_ANKRD24_chr19_4219588_ENST00000262970_length(amino acids)=161AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_17_SH3GL1-ANKRD24_SH3GL1_chr19_4400321_ENST00000598564_ANKRD24_chr19_4219588_ENST00000318934_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

>81447_81447_18_SH3GL1-ANKRD24_SH3GL1_chr19_4400321_ENST00000598564_ANKRD24_chr19_4219588_ENST00000600132_length(amino acids)=160AA_BP=14
MSVAGLKKQFYKASQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:4400321/chr19:4219588)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SH3GL1

Q99961

ANKRD24

Q8TF21

FUNCTION: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000269886-110145_25015.0369.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000417295-19145_25015.0321.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000598564-110145_25015.0305.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000269886-110145_25015.0369.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000417295-19145_25015.0321.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000598564-110145_25015.0305.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000269886-11018_24915.0369.0DomainBAR
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000269886-110306_36515.0369.0DomainSH3
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000417295-1918_24915.0321.0DomainBAR
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000417295-19306_36515.0321.0DomainSH3
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000598564-11018_24915.0305.0DomainBAR
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000598564-110306_36515.0305.0DomainSH3
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000269886-11018_24915.0369.0DomainBAR
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000269886-110306_36515.0369.0DomainSH3
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000417295-1918_24915.0321.0DomainBAR
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000417295-19306_36515.0321.0DomainSH3
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000598564-11018_24915.0305.0DomainBAR
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000598564-110306_36515.0305.0DomainSH3
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000269886-1101_2115.0369.0RegionMembrane-binding amphipathic helix
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000269886-11060_8715.0369.0RegionRequired for dimerization upon membrane association
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000417295-191_2115.0321.0RegionMembrane-binding amphipathic helix
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000417295-1960_8715.0321.0RegionRequired for dimerization upon membrane association
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000598564-1101_2115.0305.0RegionMembrane-binding amphipathic helix
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000598564-11060_8715.0305.0RegionRequired for dimerization upon membrane association
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000269886-1101_2115.0369.0RegionMembrane-binding amphipathic helix
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000269886-11060_8715.0369.0RegionRequired for dimerization upon membrane association
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000417295-191_2115.0321.0RegionMembrane-binding amphipathic helix
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000417295-1960_8715.0321.0RegionRequired for dimerization upon membrane association
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000598564-1101_2115.0305.0RegionMembrane-binding amphipathic helix
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000598564-11060_8715.0305.0RegionRequired for dimerization upon membrane association
TgeneANKRD24chr19:4400320chr19:4219587ENST000002629701520320_5171091.01237.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400320chr19:4219587ENST000002629701520714_11101091.01237.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400320chr19:4219587ENST000003189341621320_5171001.01147.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400320chr19:4219587ENST000003189341621714_11101001.01147.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400320chr19:4219587ENST000006001321722320_5171001.01147.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400320chr19:4219587ENST000006001321722714_11101001.01147.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400321chr19:4219588ENST000002629701520320_5171091.01237.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400321chr19:4219588ENST000002629701520714_11101091.01237.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400321chr19:4219588ENST000003189341621320_5171001.01147.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400321chr19:4219588ENST000003189341621714_11101001.01147.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400321chr19:4219588ENST000006001321722320_5171001.01147.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400321chr19:4219588ENST000006001321722714_11101001.01147.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD24chr19:4400320chr19:4219587ENST000002629701520308_3111091.01237.0Compositional biasNote=Poly-Pro
TgeneANKRD24chr19:4400320chr19:4219587ENST000003189341621308_3111001.01147.0Compositional biasNote=Poly-Pro
TgeneANKRD24chr19:4400320chr19:4219587ENST000006001321722308_3111001.01147.0Compositional biasNote=Poly-Pro
TgeneANKRD24chr19:4400321chr19:4219588ENST000002629701520308_3111091.01237.0Compositional biasNote=Poly-Pro
TgeneANKRD24chr19:4400321chr19:4219588ENST000003189341621308_3111001.01147.0Compositional biasNote=Poly-Pro
TgeneANKRD24chr19:4400321chr19:4219588ENST000006001321722308_3111001.01147.0Compositional biasNote=Poly-Pro
TgeneANKRD24chr19:4400320chr19:4219587ENST000002629701520114_1431091.01237.0RepeatNote=ANK 2
TgeneANKRD24chr19:4400320chr19:4219587ENST000002629701520147_1761091.01237.0RepeatNote=ANK 3
TgeneANKRD24chr19:4400320chr19:4219587ENST000002629701520180_2091091.01237.0RepeatNote=ANK 4
TgeneANKRD24chr19:4400320chr19:4219587ENST000002629701520213_2421091.01237.0RepeatNote=ANK 5
TgeneANKRD24chr19:4400320chr19:4219587ENST00000262970152081_1101091.01237.0RepeatNote=ANK 1
TgeneANKRD24chr19:4400320chr19:4219587ENST000003189341621114_1431001.01147.0RepeatNote=ANK 2
TgeneANKRD24chr19:4400320chr19:4219587ENST000003189341621147_1761001.01147.0RepeatNote=ANK 3
TgeneANKRD24chr19:4400320chr19:4219587ENST000003189341621180_2091001.01147.0RepeatNote=ANK 4
TgeneANKRD24chr19:4400320chr19:4219587ENST000003189341621213_2421001.01147.0RepeatNote=ANK 5
TgeneANKRD24chr19:4400320chr19:4219587ENST00000318934162181_1101001.01147.0RepeatNote=ANK 1
TgeneANKRD24chr19:4400320chr19:4219587ENST000006001321722114_1431001.01147.0RepeatNote=ANK 2
TgeneANKRD24chr19:4400320chr19:4219587ENST000006001321722147_1761001.01147.0RepeatNote=ANK 3
TgeneANKRD24chr19:4400320chr19:4219587ENST000006001321722180_2091001.01147.0RepeatNote=ANK 4
TgeneANKRD24chr19:4400320chr19:4219587ENST000006001321722213_2421001.01147.0RepeatNote=ANK 5
TgeneANKRD24chr19:4400320chr19:4219587ENST00000600132172281_1101001.01147.0RepeatNote=ANK 1
TgeneANKRD24chr19:4400321chr19:4219588ENST000002629701520114_1431091.01237.0RepeatNote=ANK 2
TgeneANKRD24chr19:4400321chr19:4219588ENST000002629701520147_1761091.01237.0RepeatNote=ANK 3
TgeneANKRD24chr19:4400321chr19:4219588ENST000002629701520180_2091091.01237.0RepeatNote=ANK 4
TgeneANKRD24chr19:4400321chr19:4219588ENST000002629701520213_2421091.01237.0RepeatNote=ANK 5
TgeneANKRD24chr19:4400321chr19:4219588ENST00000262970152081_1101091.01237.0RepeatNote=ANK 1
TgeneANKRD24chr19:4400321chr19:4219588ENST000003189341621114_1431001.01147.0RepeatNote=ANK 2
TgeneANKRD24chr19:4400321chr19:4219588ENST000003189341621147_1761001.01147.0RepeatNote=ANK 3
TgeneANKRD24chr19:4400321chr19:4219588ENST000003189341621180_2091001.01147.0RepeatNote=ANK 4
TgeneANKRD24chr19:4400321chr19:4219588ENST000003189341621213_2421001.01147.0RepeatNote=ANK 5
TgeneANKRD24chr19:4400321chr19:4219588ENST00000318934162181_1101001.01147.0RepeatNote=ANK 1
TgeneANKRD24chr19:4400321chr19:4219588ENST000006001321722114_1431001.01147.0RepeatNote=ANK 2
TgeneANKRD24chr19:4400321chr19:4219588ENST000006001321722147_1761001.01147.0RepeatNote=ANK 3
TgeneANKRD24chr19:4400321chr19:4219588ENST000006001321722180_2091001.01147.0RepeatNote=ANK 4
TgeneANKRD24chr19:4400321chr19:4219588ENST000006001321722213_2421001.01147.0RepeatNote=ANK 5
TgeneANKRD24chr19:4400321chr19:4219588ENST00000600132172281_1101001.01147.0RepeatNote=ANK 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SH3GL1all structure
ANKRD24


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000269886-110218_25415.0369.0ARC
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000417295-19218_25415.0321.0ARC
HgeneSH3GL1chr19:4400320chr19:4219587ENST00000598564-110218_25415.0305.0ARC
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000269886-110218_25415.0369.0ARC
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000417295-19218_25415.0321.0ARC
HgeneSH3GL1chr19:4400321chr19:4219588ENST00000598564-110218_25415.0305.0ARC


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Related Drugs to SH3GL1-ANKRD24


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SH3GL1-ANKRD24


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource