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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SHB-PAX5

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SHB-PAX5
	FusionPDB ID: 81628
	FusionGDB2.0 ID: 81628
		Hgene	Tgene
	Gene symbol	SHB	PAX5
	Gene ID	6461	5079
	Gene name	SH2 domain containing adaptor protein B	paired box 5
	Synonyms	bA3J10.2	ALL3\|BSAP
	Cytomap	9p13.1	9p13.2
	Type of gene	protein-coding	protein-coding
	Description	SH2 domain-containing adapter protein BSHB (Src homology 2 domain containing) adaptor protein BSHB adaptor protein (a Src homology 2 protein)Src homology 2 domain containing adaptor protein B	paired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5
	Modification date	20200313	20200313
	UniProtAcc	.	Q02548
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000377700, ENST00000377707,	ENST00000377847, ENST00000414447, ENST00000446742, ENST00000520281, ENST00000522003, ENST00000523145, ENST00000358127, ENST00000377852, ENST00000377853, ENST00000520154, ENST00000523241,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 10 X 8=1200	8 X 7 X 6=336
	# samples	19	9
	** MAII score	log2(19/1200*10)=-2.65896308216493 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SHB [Title/Abstract] AND PAX5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SHB(38016008)-PAX5(37020798), # samples:2
Anticipated loss of major functional domain due to fusion event.	SHB-PAX5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SHB-PAX5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SHB-PAX5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SHB-PAX5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SHB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PAX5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-22-4609-01A	SHB	chr9	38016007	-	PAX5	chr9	37020797	-
ChimerDB4	LUSC	TCGA-22-4609-01A	SHB	chr9	38016008	-	PAX5	chr9	37020798	-
ChimerDB4	LUSC	TCGA-22-4609	SHB	chr9	38016007	-	PAX5	chr9	37020798	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000377707	SHB	chr9	38016008	-	ENST00000358127	PAX5	chr9	37020798	-	9819	1404	500	2533	677
ENST00000377707	SHB	chr9	38016008	-	ENST00000523241	PAX5	chr9	37020798	-	2690	1404	500	2332	610
ENST00000377707	SHB	chr9	38016008	-	ENST00000520154	PAX5	chr9	37020798	-	2603	1404	500	2245	581
ENST00000377707	SHB	chr9	38016008	-	ENST00000377852	PAX5	chr9	37020798	-	2820	1404	500	2431	643
ENST00000377707	SHB	chr9	38016008	-	ENST00000377853	PAX5	chr9	37020798	-	2835	1404	500	2446	648
ENST00000377700	SHB	chr9	38016008	-	ENST00000358127	PAX5	chr9	37020798	-	9821	1406	502	2535	677
ENST00000377700	SHB	chr9	38016008	-	ENST00000523241	PAX5	chr9	37020798	-	2692	1406	502	2334	610
ENST00000377700	SHB	chr9	38016008	-	ENST00000520154	PAX5	chr9	37020798	-	2605	1406	502	2247	581
ENST00000377700	SHB	chr9	38016008	-	ENST00000377852	PAX5	chr9	37020798	-	2822	1406	502	2433	643
ENST00000377700	SHB	chr9	38016008	-	ENST00000377853	PAX5	chr9	37020798	-	2837	1406	502	2448	648
ENST00000377707	SHB	chr9	38016007	-	ENST00000358127	PAX5	chr9	37020798	-	9819	1404	500	2533	677
ENST00000377707	SHB	chr9	38016007	-	ENST00000523241	PAX5	chr9	37020798	-	2690	1404	500	2332	610
ENST00000377707	SHB	chr9	38016007	-	ENST00000520154	PAX5	chr9	37020798	-	2603	1404	500	2245	581
ENST00000377707	SHB	chr9	38016007	-	ENST00000377852	PAX5	chr9	37020798	-	2820	1404	500	2431	643
ENST00000377707	SHB	chr9	38016007	-	ENST00000377853	PAX5	chr9	37020798	-	2835	1404	500	2446	648
ENST00000377700	SHB	chr9	38016007	-	ENST00000358127	PAX5	chr9	37020798	-	9821	1406	502	2535	677
ENST00000377700	SHB	chr9	38016007	-	ENST00000523241	PAX5	chr9	37020798	-	2692	1406	502	2334	610
ENST00000377700	SHB	chr9	38016007	-	ENST00000520154	PAX5	chr9	37020798	-	2605	1406	502	2247	581
ENST00000377700	SHB	chr9	38016007	-	ENST00000377852	PAX5	chr9	37020798	-	2822	1406	502	2433	643
ENST00000377700	SHB	chr9	38016007	-	ENST00000377853	PAX5	chr9	37020798	-	2837	1406	502	2448	648
ENST00000377707	SHB	chr9	38016007	-	ENST00000358127	PAX5	chr9	37020797	-	9819	1404	500	2533	677
ENST00000377707	SHB	chr9	38016007	-	ENST00000523241	PAX5	chr9	37020797	-	2690	1404	500	2332	610
ENST00000377707	SHB	chr9	38016007	-	ENST00000520154	PAX5	chr9	37020797	-	2603	1404	500	2245	581
ENST00000377707	SHB	chr9	38016007	-	ENST00000377852	PAX5	chr9	37020797	-	2820	1404	500	2431	643
ENST00000377707	SHB	chr9	38016007	-	ENST00000377853	PAX5	chr9	37020797	-	2835	1404	500	2446	648
ENST00000377700	SHB	chr9	38016007	-	ENST00000358127	PAX5	chr9	37020797	-	9821	1406	502	2535	677
ENST00000377700	SHB	chr9	38016007	-	ENST00000523241	PAX5	chr9	37020797	-	2692	1406	502	2334	610
ENST00000377700	SHB	chr9	38016007	-	ENST00000520154	PAX5	chr9	37020797	-	2605	1406	502	2247	581
ENST00000377700	SHB	chr9	38016007	-	ENST00000377852	PAX5	chr9	37020797	-	2822	1406	502	2433	643
ENST00000377700	SHB	chr9	38016007	-	ENST00000377853	PAX5	chr9	37020797	-	2837	1406	502	2448	648

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000377707	ENST00000358127	SHB	chr9	38016008	-	PAX5	chr9	37020798	-	0.010063536	0.9899365
ENST00000377707	ENST00000523241	SHB	chr9	38016008	-	PAX5	chr9	37020798	-	0.044950802	0.9550492
ENST00000377707	ENST00000520154	SHB	chr9	38016008	-	PAX5	chr9	37020798	-	0.03920476	0.9607952
ENST00000377707	ENST00000377852	SHB	chr9	38016008	-	PAX5	chr9	37020798	-	0.031273987	0.968726
ENST00000377707	ENST00000377853	SHB	chr9	38016008	-	PAX5	chr9	37020798	-	0.03394013	0.96605986
ENST00000377700	ENST00000358127	SHB	chr9	38016008	-	PAX5	chr9	37020798	-	0.010044418	0.98995554
ENST00000377700	ENST00000523241	SHB	chr9	38016008	-	PAX5	chr9	37020798	-	0.044698033	0.955302
ENST00000377700	ENST00000520154	SHB	chr9	38016008	-	PAX5	chr9	37020798	-	0.03907097	0.96092904
ENST00000377700	ENST00000377852	SHB	chr9	38016008	-	PAX5	chr9	37020798	-	0.031119756	0.9688803
ENST00000377700	ENST00000377853	SHB	chr9	38016008	-	PAX5	chr9	37020798	-	0.03377101	0.966229
ENST00000377707	ENST00000358127	SHB	chr9	38016007	-	PAX5	chr9	37020798	-	0.010063536	0.9899365
ENST00000377707	ENST00000523241	SHB	chr9	38016007	-	PAX5	chr9	37020798	-	0.044950802	0.9550492
ENST00000377707	ENST00000520154	SHB	chr9	38016007	-	PAX5	chr9	37020798	-	0.03920476	0.9607952
ENST00000377707	ENST00000377852	SHB	chr9	38016007	-	PAX5	chr9	37020798	-	0.031273987	0.968726
ENST00000377707	ENST00000377853	SHB	chr9	38016007	-	PAX5	chr9	37020798	-	0.03394013	0.96605986
ENST00000377700	ENST00000358127	SHB	chr9	38016007	-	PAX5	chr9	37020798	-	0.010044418	0.98995554
ENST00000377700	ENST00000523241	SHB	chr9	38016007	-	PAX5	chr9	37020798	-	0.044698033	0.955302
ENST00000377700	ENST00000520154	SHB	chr9	38016007	-	PAX5	chr9	37020798	-	0.03907097	0.96092904
ENST00000377700	ENST00000377852	SHB	chr9	38016007	-	PAX5	chr9	37020798	-	0.031119756	0.9688803
ENST00000377700	ENST00000377853	SHB	chr9	38016007	-	PAX5	chr9	37020798	-	0.03377101	0.966229
ENST00000377707	ENST00000358127	SHB	chr9	38016007	-	PAX5	chr9	37020797	-	0.010063536	0.9899365
ENST00000377707	ENST00000523241	SHB	chr9	38016007	-	PAX5	chr9	37020797	-	0.044950802	0.9550492
ENST00000377707	ENST00000520154	SHB	chr9	38016007	-	PAX5	chr9	37020797	-	0.03920476	0.9607952
ENST00000377707	ENST00000377852	SHB	chr9	38016007	-	PAX5	chr9	37020797	-	0.031273987	0.968726
ENST00000377707	ENST00000377853	SHB	chr9	38016007	-	PAX5	chr9	37020797	-	0.03394013	0.96605986
ENST00000377700	ENST00000358127	SHB	chr9	38016007	-	PAX5	chr9	37020797	-	0.010044418	0.98995554
ENST00000377700	ENST00000523241	SHB	chr9	38016007	-	PAX5	chr9	37020797	-	0.044698033	0.955302
ENST00000377700	ENST00000520154	SHB	chr9	38016007	-	PAX5	chr9	37020797	-	0.03907097	0.96092904
ENST00000377700	ENST00000377852	SHB	chr9	38016007	-	PAX5	chr9	37020797	-	0.031119756	0.9688803
ENST00000377700	ENST00000377853	SHB	chr9	38016007	-	PAX5	chr9	37020797	-	0.03377101	0.966229

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81628_81628_1_SHB-PAX5_SHB_chr9_38016007_ENST00000377700_PAX5_chr9_37020797_ENST00000358127_length(amino acids)=677AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGS

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>81628_81628_2_SHB-PAX5_SHB_chr9_38016007_ENST00000377700_PAX5_chr9_37020797_ENST00000377852_length(amino acids)=643AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARG

--------------------------------------------------------------

>81628_81628_3_SHB-PAX5_SHB_chr9_38016007_ENST00000377700_PAX5_chr9_37020797_ENST00000377853_length(amino acids)=648AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSPYYYS

--------------------------------------------------------------

>81628_81628_4_SHB-PAX5_SHB_chr9_38016007_ENST00000377700_PAX5_chr9_37020797_ENST00000520154_length(amino acids)=581AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

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>81628_81628_5_SHB-PAX5_SHB_chr9_38016007_ENST00000377700_PAX5_chr9_37020797_ENST00000523241_length(amino acids)=610AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

--------------------------------------------------------------

>81628_81628_6_SHB-PAX5_SHB_chr9_38016007_ENST00000377700_PAX5_chr9_37020798_ENST00000358127_length(amino acids)=677AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGS

--------------------------------------------------------------

>81628_81628_7_SHB-PAX5_SHB_chr9_38016007_ENST00000377700_PAX5_chr9_37020798_ENST00000377852_length(amino acids)=643AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARG

--------------------------------------------------------------

>81628_81628_8_SHB-PAX5_SHB_chr9_38016007_ENST00000377700_PAX5_chr9_37020798_ENST00000377853_length(amino acids)=648AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSPYYYS

--------------------------------------------------------------

>81628_81628_9_SHB-PAX5_SHB_chr9_38016007_ENST00000377700_PAX5_chr9_37020798_ENST00000520154_length(amino acids)=581AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

--------------------------------------------------------------

>81628_81628_10_SHB-PAX5_SHB_chr9_38016007_ENST00000377700_PAX5_chr9_37020798_ENST00000523241_length(amino acids)=610AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

--------------------------------------------------------------

>81628_81628_11_SHB-PAX5_SHB_chr9_38016007_ENST00000377707_PAX5_chr9_37020797_ENST00000358127_length(amino acids)=677AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGS

--------------------------------------------------------------

>81628_81628_12_SHB-PAX5_SHB_chr9_38016007_ENST00000377707_PAX5_chr9_37020797_ENST00000377852_length(amino acids)=643AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARG

--------------------------------------------------------------

>81628_81628_13_SHB-PAX5_SHB_chr9_38016007_ENST00000377707_PAX5_chr9_37020797_ENST00000377853_length(amino acids)=648AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSPYYYS

--------------------------------------------------------------

>81628_81628_14_SHB-PAX5_SHB_chr9_38016007_ENST00000377707_PAX5_chr9_37020797_ENST00000520154_length(amino acids)=581AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

--------------------------------------------------------------

>81628_81628_15_SHB-PAX5_SHB_chr9_38016007_ENST00000377707_PAX5_chr9_37020797_ENST00000523241_length(amino acids)=610AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

--------------------------------------------------------------

>81628_81628_16_SHB-PAX5_SHB_chr9_38016007_ENST00000377707_PAX5_chr9_37020798_ENST00000358127_length(amino acids)=677AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGS

--------------------------------------------------------------

>81628_81628_17_SHB-PAX5_SHB_chr9_38016007_ENST00000377707_PAX5_chr9_37020798_ENST00000377852_length(amino acids)=643AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARG

--------------------------------------------------------------

>81628_81628_18_SHB-PAX5_SHB_chr9_38016007_ENST00000377707_PAX5_chr9_37020798_ENST00000377853_length(amino acids)=648AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSPYYYS

--------------------------------------------------------------

>81628_81628_19_SHB-PAX5_SHB_chr9_38016007_ENST00000377707_PAX5_chr9_37020798_ENST00000520154_length(amino acids)=581AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

--------------------------------------------------------------

>81628_81628_20_SHB-PAX5_SHB_chr9_38016007_ENST00000377707_PAX5_chr9_37020798_ENST00000523241_length(amino acids)=610AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

--------------------------------------------------------------

>81628_81628_21_SHB-PAX5_SHB_chr9_38016008_ENST00000377700_PAX5_chr9_37020798_ENST00000358127_length(amino acids)=677AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGS

--------------------------------------------------------------

>81628_81628_22_SHB-PAX5_SHB_chr9_38016008_ENST00000377700_PAX5_chr9_37020798_ENST00000377852_length(amino acids)=643AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARG

--------------------------------------------------------------

>81628_81628_23_SHB-PAX5_SHB_chr9_38016008_ENST00000377700_PAX5_chr9_37020798_ENST00000377853_length(amino acids)=648AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSPYYYS

--------------------------------------------------------------

>81628_81628_24_SHB-PAX5_SHB_chr9_38016008_ENST00000377700_PAX5_chr9_37020798_ENST00000520154_length(amino acids)=581AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

--------------------------------------------------------------

>81628_81628_25_SHB-PAX5_SHB_chr9_38016008_ENST00000377700_PAX5_chr9_37020798_ENST00000523241_length(amino acids)=610AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

--------------------------------------------------------------

>81628_81628_26_SHB-PAX5_SHB_chr9_38016008_ENST00000377707_PAX5_chr9_37020798_ENST00000358127_length(amino acids)=677AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGS

--------------------------------------------------------------

>81628_81628_27_SHB-PAX5_SHB_chr9_38016008_ENST00000377707_PAX5_chr9_37020798_ENST00000377852_length(amino acids)=643AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARG

--------------------------------------------------------------

>81628_81628_28_SHB-PAX5_SHB_chr9_38016008_ENST00000377707_PAX5_chr9_37020798_ENST00000377853_length(amino acids)=648AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE
PIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSPYYYS

--------------------------------------------------------------

>81628_81628_29_SHB-PAX5_SHB_chr9_38016008_ENST00000377707_PAX5_chr9_37020798_ENST00000520154_length(amino acids)=581AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

--------------------------------------------------------------

>81628_81628_30_SHB-PAX5_SHB_chr9_38016008_ENST00000377707_PAX5_chr9_37020798_ENST00000523241_length(amino acids)=610AA_BP=1
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSD
PFDAKNDLKSKAGKGESAGYMEPYEAQRIMTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE
TGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSV
TQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTE

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:38016008/chr9:37020798)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	PAX5 Q02548
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). {ECO:0000269\|PubMed:10811620, ECO:0000269\|PubMed:27181361, ECO:0000269\|PubMed:32612238}.; FUNCTION: (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172). {ECO:0000269\|PubMed:23678172, ECO:0000269\|PubMed:31941781}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000358127

16_142

15.333333333333334

392.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000377847

16_142

15.333333333333334

329.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000377852

16_142

15.333333333333334

358.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000377853

16_142

15.333333333333334

363.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000414447

16_142

15.333333333333334

349.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000446742

16_142

15.333333333333334

292.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000520281

16_142

15.333333333333334

320.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000358127

16_142

15.333333333333334

392.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000377847

16_142

15.333333333333334

329.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000377852

16_142

15.333333333333334

358.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000377853

16_142

15.333333333333334

363.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000414447

16_142

15.333333333333334

349.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000446742

16_142

15.333333333333334

292.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000520281

16_142

15.333333333333334

320.0

DNA binding

Paired

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000358127

16_142

15.333333333333334

392.0

DNA binding

Paired

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000377847

16_142

15.333333333333334

329.0

DNA binding

Paired

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000377852

16_142

15.333333333333334

358.0

DNA binding

Paired

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000377853

16_142

15.333333333333334

363.0

DNA binding

Paired

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000414447

16_142

15.333333333333334

349.0

DNA binding

Paired

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000446742

16_142

15.333333333333334

292.0

DNA binding

Paired

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000520281

16_142

15.333333333333334

320.0

DNA binding

Paired

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000358127

19_75

15.333333333333334

392.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000358127

94_142

15.333333333333334

392.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000377847

19_75

15.333333333333334

329.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000377847

94_142

15.333333333333334

329.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000377852

19_75

15.333333333333334

358.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000377852

94_142

15.333333333333334

358.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000377853

19_75

15.333333333333334

363.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000377853

94_142

15.333333333333334

363.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000414447

19_75

15.333333333333334

349.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000414447

94_142

15.333333333333334

349.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000446742

19_75

15.333333333333334

292.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000446742

94_142

15.333333333333334

292.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000520281

19_75

15.333333333333334

320.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020797

ENST00000520281

94_142

15.333333333333334

320.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000358127

19_75

15.333333333333334

392.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000358127

94_142

15.333333333333334

392.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000377847

19_75

15.333333333333334

329.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000377847

94_142

15.333333333333334

329.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000377852

19_75

15.333333333333334

358.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000377852

94_142

15.333333333333334

358.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000377853

19_75

15.333333333333334

363.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000377853

94_142

15.333333333333334

363.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000414447

19_75

15.333333333333334

349.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000414447

94_142

15.333333333333334

349.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000446742

19_75

15.333333333333334

292.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000446742

94_142

15.333333333333334

292.0

Region

RED subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000520281

19_75

15.333333333333334

320.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016007

chr9:37020798

ENST00000520281

94_142

15.333333333333334

320.0

Region

RED subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000358127

19_75

15.333333333333334

392.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000358127

94_142

15.333333333333334

392.0

Region

RED subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000377847

19_75

15.333333333333334

329.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000377847

94_142

15.333333333333334

329.0

Region

RED subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000377852

19_75

15.333333333333334

358.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000377852

94_142

15.333333333333334

358.0

Region

RED subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000377853

19_75

15.333333333333334

363.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000377853

94_142

15.333333333333334

363.0

Region

RED subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000414447

19_75

15.333333333333334

349.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000414447

94_142

15.333333333333334

349.0

Region

RED subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000446742

19_75

15.333333333333334

292.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000446742

94_142

15.333333333333334

292.0

Region

RED subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000520281

19_75

15.333333333333334

320.0

Region

PAI subdomain

Tgene

PAX5

chr9:38016008

chr9:37020798

ENST00000520281

94_142

15.333333333333334

320.0

Region

RED subdomain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SHB

chr9:38016007

chr9:37020797

ENST00000377700

410_504

279.3333333333333

298.0

Domain

SH2

Hgene

SHB

chr9:38016007

chr9:37020797

ENST00000377707

410_504

279.3333333333333

510.0

Domain

SH2

Hgene

SHB

chr9:38016007

chr9:37020798

ENST00000377700

410_504

279.3333333333333

298.0

Domain

SH2

Hgene

SHB

chr9:38016007

chr9:37020798

ENST00000377707

410_504

279.3333333333333

510.0

Domain

SH2

Hgene

SHB

chr9:38016008

chr9:37020798

ENST00000377700

410_504

279.3333333333333

298.0

Domain

SH2

Hgene

SHB

chr9:38016008

chr9:37020798

ENST00000377707

410_504

279.3333333333333

510.0

Domain

SH2

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
PAX5	TLE4, DAXX, RUNX1, MYB, ID3, EP300, TBP, RB1, MAPK1, KAT2B, CDKN1B, UBE3A, RAD52, HMGB3, HOXC8, MAPK9, NFYC, FBLN1, GRHL2, DTX2, CSNK2A1, UBE2I, CCNC, BCAS2, C1orf109, GNG13, ZMYM5, SEC14L4, RNF144B, OSGIN1, CIB3, SAE1, STAC, TLK2, HMBOX1, NGLY1, NEIL2, LONRF1, LDLRAP1, LARP4, UBXN7, ACOT12, CKS1B, KLHL38, HGS, CXorf38, KRTAP10-8, PNMA5, KRTAP9-3, UBXN2B, CDK3, BKRF1, HIST1H3A, PAX8, KLHL14,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SHB
PAX5

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to SHB-PAX5

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SHB-PAX5

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	PAX5	C0006413	Burkitt Lymphoma	4	ORPHANET
Tgene	PAX5	C1292769	Precursor B-cell lymphoblastic leukemia	4	ORPHANET
Tgene	PAX5	C0023485	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2	CTD_human
Tgene	PAX5	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	CGI;CTD_human;UNIPROT
Tgene	PAX5	C0023452	Childhood Acute Lymphoblastic Leukemia	1	CTD_human
Tgene	PAX5	C0023453	L2 Acute Lymphoblastic Leukemia	1	CTD_human
Tgene	PAX5	C1535926	Neurodevelopmental Disorders	1	CTD_human