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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SHQ1-SRSF11

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SHQ1-SRSF11
FusionPDB ID: 81753
FusionGDB2.0 ID: 81753
HgeneTgene
Gene symbol

SHQ1

SRSF11

Gene ID

55164

9295

Gene nameSHQ1, H/ACA ribonucleoprotein assembly factorserine and arginine rich splicing factor 11
SynonymsGRIM-1|Shq1pNET2|SFRS11|dJ677H15.2|p54
Cytomap

3p13

1p31.1

Type of geneprotein-codingprotein-coding
Descriptionprotein SHQ1 homologSHQ1 homologgene associated with retinoid and interferon-induced mortality 1serine/arginine-rich splicing factor 11SR splicing factor 11arginine-rich 54 kDa nuclear proteinsplicing factor p54splicing factor, arginine/serine-rich 11
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000325599, ENST00000463369, 
ENST00000468371, 
ENST00000370949, 
ENST00000484162, ENST00000370950, 
ENST00000370951, ENST00000405432, 
ENST00000436161, ENST00000454435, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 10 X 4=32015 X 16 X 5=1200
# samples 1118
** MAII scorelog2(11/320*10)=-1.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/1200*10)=-2.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SHQ1 [Title/Abstract] AND SRSF11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SHQ1(72842067)-SRSF11(70694105), # samples:1
Anticipated loss of major functional domain due to fusion event.SHQ1-SRSF11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SHQ1-SRSF11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SHQ1-SRSF11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SHQ1-SRSF11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSHQ1

GO:0022618

ribonucleoprotein complex assembly

19383767

HgeneSHQ1

GO:0043065

positive regulation of apoptotic process

20663920

HgeneSHQ1

GO:2000233

negative regulation of rRNA processing

20663920


check buttonFusion gene breakpoints across SHQ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SRSF11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8366-01ASHQ1chr3

72842067

-SRSF11chr1

70694105

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000325599SHQ1chr372842067-ENST00000370951SRSF11chr170694105+338213211402569809
ENST00000325599SHQ1chr372842067-ENST00000405432SRSF11chr170694105+257313211402572811
ENST00000325599SHQ1chr372842067-ENST00000370950SRSF11chr170694105+482013211402572810
ENST00000325599SHQ1chr372842067-ENST00000454435SRSF11chr170694105+199313211401513457
ENST00000325599SHQ1chr372842067-ENST00000436161SRSF11chr170694105+195713211401504454
ENST00000463369SHQ1chr372842067-ENST00000370951SRSF11chr170694105+32481187242435803
ENST00000463369SHQ1chr372842067-ENST00000405432SRSF11chr170694105+24391187242438804
ENST00000463369SHQ1chr372842067-ENST00000370950SRSF11chr170694105+46861187242438804
ENST00000463369SHQ1chr372842067-ENST00000454435SRSF11chr170694105+18591187241379451
ENST00000463369SHQ1chr372842067-ENST00000436161SRSF11chr170694105+18231187241370448

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000325599ENST00000370951SHQ1chr372842067-SRSF11chr170694105+0.0007340680.99926597
ENST00000325599ENST00000405432SHQ1chr372842067-SRSF11chr170694105+0.0020774750.9979226
ENST00000325599ENST00000370950SHQ1chr372842067-SRSF11chr170694105+0.0002435420.9997565
ENST00000325599ENST00000454435SHQ1chr372842067-SRSF11chr170694105+0.0003799910.99961996
ENST00000325599ENST00000436161SHQ1chr372842067-SRSF11chr170694105+0.0007796720.9992204
ENST00000463369ENST00000370951SHQ1chr372842067-SRSF11chr170694105+0.000775360.99922466
ENST00000463369ENST00000405432SHQ1chr372842067-SRSF11chr170694105+0.002303360.9976966
ENST00000463369ENST00000370950SHQ1chr372842067-SRSF11chr170694105+0.000255690.99974436
ENST00000463369ENST00000454435SHQ1chr372842067-SRSF11chr170694105+0.0005489060.9994511
ENST00000463369ENST00000436161SHQ1chr372842067-SRSF11chr170694105+0.0013154370.9986846

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81753_81753_1_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000325599_SRSF11_chr1_70694105_ENST00000370950_length(amino acids)=810AA_BP=394
MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNM
LTALLAPRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAA
ERRQKRLAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQ
VCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLK
CLLDIHKIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSL
LAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDT
SSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRS
RSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERS
TSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD

--------------------------------------------------------------

>81753_81753_2_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000325599_SRSF11_chr1_70694105_ENST00000370951_length(amino acids)=809AA_BP=394
MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNM
LTALLAPRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAA
ERRQKRLAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQ
VCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLK
CLLDIHKIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSL
LAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDT
SSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRS
RSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERS

--------------------------------------------------------------

>81753_81753_3_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000325599_SRSF11_chr1_70694105_ENST00000405432_length(amino acids)=811AA_BP=394
MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNM
LTALLAPRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAA
ERRQKRLAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQ
VCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLK
CLLDIHKIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSL
LAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDT
SSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRS
RSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERS
TSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD

--------------------------------------------------------------

>81753_81753_4_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000325599_SRSF11_chr1_70694105_ENST00000436161_length(amino acids)=454AA_BP=394
MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNM
LTALLAPRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAA
ERRQKRLAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQ
VCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLK
CLLDIHKIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEVKQPTRVVVHKT

--------------------------------------------------------------

>81753_81753_5_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000325599_SRSF11_chr1_70694105_ENST00000454435_length(amino acids)=457AA_BP=394
MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNM
LTALLAPRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAA
ERRQKRLAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQ
VCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLK
CLLDIHKIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEVFHGSIKAAVKK

--------------------------------------------------------------

>81753_81753_6_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000463369_SRSF11_chr1_70694105_ENST00000370950_length(amino acids)=804AA_BP=388
MSNRARLSKKKKKKNIQFAIPRMNKTWSLSLKNGDCSCGGPILTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLA
PRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAAERRQKR
LAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYSLI
DILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLKCLLDIH
KIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANA
VAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIE
EAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKT
RDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKK

--------------------------------------------------------------

>81753_81753_7_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000463369_SRSF11_chr1_70694105_ENST00000370951_length(amino acids)=803AA_BP=388
MSNRARLSKKKKKKNIQFAIPRMNKTWSLSLKNGDCSCGGPILTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLA
PRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAAERRQKR
LAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYSLI
DILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLKCLLDIH
KIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANA
VAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIE
EAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKT
RDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKK

--------------------------------------------------------------

>81753_81753_8_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000463369_SRSF11_chr1_70694105_ENST00000405432_length(amino acids)=804AA_BP=388
MSNRARLSKKKKKKNIQFAIPRMNKTWSLSLKNGDCSCGGPILTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLA
PRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAAERRQKR
LAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYSLI
DILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLKCLLDIH
KIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANA
VAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIE
EAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKT
RDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKK

--------------------------------------------------------------

>81753_81753_9_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000463369_SRSF11_chr1_70694105_ENST00000436161_length(amino acids)=448AA_BP=388
MSNRARLSKKKKKKNIQFAIPRMNKTWSLSLKNGDCSCGGPILTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLA
PRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAAERRQKR
LAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYSLI
DILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLKCLLDIH

--------------------------------------------------------------

>81753_81753_10_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000463369_SRSF11_chr1_70694105_ENST00000454435_length(amino acids)=451AA_BP=388
MSNRARLSKKKKKKNIQFAIPRMNKTWSLSLKNGDCSCGGPILTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLA
PRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAAERRQKR
LAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYSLI
DILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLKCLLDIH
KIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEVFHGSIKAAVKKILLTHE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:72842067/chr1:70694105)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHQ1chr3:72842067chr1:70694105ENST00000325599-10111_89393.6666666666667578.0DomainCS
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113252_25967.66666666666667485.0Compositional biasNote=Poly-Arg
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113291_29467.66666666666667485.0Compositional biasNote=Poly-Arg
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113341_34967.66666666666667485.0Compositional biasNote=Poly-Arg
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113397_40467.66666666666667485.0Compositional biasNote=Poly-Lys
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113252_25967.66666666666667484.0Compositional biasNote=Poly-Arg
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113291_29467.66666666666667484.0Compositional biasNote=Poly-Arg
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113341_34967.66666666666667484.0Compositional biasNote=Poly-Arg
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113397_40467.66666666666667484.0Compositional biasNote=Poly-Lys
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113252_25967.66666666666667485.0Compositional biasNote=Poly-Arg
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113291_29467.66666666666667485.0Compositional biasNote=Poly-Arg
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113341_34967.66666666666667485.0Compositional biasNote=Poly-Arg
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113397_40467.66666666666667485.0Compositional biasNote=Poly-Lys
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113247_35367.66666666666667485.0RegionNote=10 X 8 AA approximate repeats of R-R-S-R-S-R-S-R
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113247_35367.66666666666667484.0RegionNote=10 X 8 AA approximate repeats of R-R-S-R-S-R-S-R
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113247_35367.66666666666667485.0RegionNote=10 X 8 AA approximate repeats of R-R-S-R-S-R-S-R
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113247_25567.66666666666667485.0RepeatNote=1
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113258_26567.66666666666667485.0RepeatNote=2
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113267_27467.66666666666667485.0RepeatNote=3
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113275_28267.66666666666667485.0RepeatNote=4
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113285_29267.66666666666667485.0RepeatNote=5
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113293_30067.66666666666667485.0RepeatNote=6
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113302_30967.66666666666667485.0RepeatNote=7
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113321_32867.66666666666667485.0RepeatNote=8
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113334_34167.66666666666667485.0RepeatNote=9
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370950113346_35367.66666666666667485.0RepeatNote=10
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113247_25567.66666666666667484.0RepeatNote=1
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113258_26567.66666666666667484.0RepeatNote=2
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113267_27467.66666666666667484.0RepeatNote=3
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113275_28267.66666666666667484.0RepeatNote=4
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113285_29267.66666666666667484.0RepeatNote=5
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113293_30067.66666666666667484.0RepeatNote=6
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113302_30967.66666666666667484.0RepeatNote=7
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113321_32867.66666666666667484.0RepeatNote=8
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113334_34167.66666666666667484.0RepeatNote=9
TgeneSRSF11chr3:72842067chr1:70694105ENST00000370951113346_35367.66666666666667484.0RepeatNote=10
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113247_25567.66666666666667485.0RepeatNote=1
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113258_26567.66666666666667485.0RepeatNote=2
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113267_27467.66666666666667485.0RepeatNote=3
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113275_28267.66666666666667485.0RepeatNote=4
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113285_29267.66666666666667485.0RepeatNote=5
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113293_30067.66666666666667485.0RepeatNote=6
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113302_30967.66666666666667485.0RepeatNote=7
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113321_32867.66666666666667485.0RepeatNote=8
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113334_34167.66666666666667485.0RepeatNote=9
TgeneSRSF11chr3:72842067chr1:70694105ENST00000405432113346_35367.66666666666667485.0RepeatNote=10

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHQ1chr3:72842067chr1:70694105ENST00000325599-1011441_490393.6666666666667578.0Compositional biasNote=Ser-rich
TgeneSRSF11chr3:72842067chr1:70694105ENST0000037095011317_3167.66666666666667485.0Compositional biasNote=Poly-Gly
TgeneSRSF11chr3:72842067chr1:70694105ENST0000037095111317_3167.66666666666667484.0Compositional biasNote=Poly-Gly
TgeneSRSF11chr3:72842067chr1:70694105ENST0000040543211317_3167.66666666666667485.0Compositional biasNote=Poly-Gly
TgeneSRSF11chr3:72842067chr1:70694105ENST0000037095011333_11367.66666666666667485.0DomainRRM
TgeneSRSF11chr3:72842067chr1:70694105ENST0000037095111333_11367.66666666666667484.0DomainRRM
TgeneSRSF11chr3:72842067chr1:70694105ENST0000040543211333_11367.66666666666667485.0DomainRRM


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SHQ1
SRSF11


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SHQ1-SRSF11


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SHQ1-SRSF11


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource