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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SHQ1-SRSF11

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SHQ1-SRSF11
	FusionPDB ID: 81753
	FusionGDB2.0 ID: 81753
		Hgene	Tgene
	Gene symbol	SHQ1	SRSF11
	Gene ID	55164	9295
	Gene name	SHQ1, H/ACA ribonucleoprotein assembly factor	serine and arginine rich splicing factor 11
	Synonyms	GRIM-1\|Shq1p	NET2\|SFRS11\|dJ677H15.2\|p54
	Cytomap	3p13	1p31.1
	Type of gene	protein-coding	protein-coding
	Description	protein SHQ1 homologSHQ1 homologgene associated with retinoid and interferon-induced mortality 1	serine/arginine-rich splicing factor 11SR splicing factor 11arginine-rich 54 kDa nuclear proteinsplicing factor p54splicing factor, arginine/serine-rich 11
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000325599, ENST00000463369, ENST00000468371,	ENST00000370949, ENST00000484162, ENST00000370950, ENST00000370951, ENST00000405432, ENST00000436161, ENST00000454435,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 10 X 4=320	15 X 16 X 5=1200
	# samples	11	18
	** MAII score	log2(11/320*10)=-1.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1200*10)=-2.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SHQ1 [Title/Abstract] AND SRSF11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SHQ1(72842067)-SRSF11(70694105), # samples:1
Anticipated loss of major functional domain due to fusion event.	SHQ1-SRSF11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SHQ1-SRSF11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SHQ1-SRSF11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SHQ1-SRSF11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SHQ1	GO:0022618	ribonucleoprotein complex assembly	19383767
Hgene	SHQ1	GO:0043065	positive regulation of apoptotic process	20663920
Hgene	SHQ1	GO:2000233	negative regulation of rRNA processing	20663920

Fusion gene breakpoints across SHQ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SRSF11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8366-01A	SHQ1	chr3	72842067	-	SRSF11	chr1	70694105	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000325599	SHQ1	chr3	72842067	-	ENST00000370951	SRSF11	chr1	70694105	+	3382	1321	140	2569	809
ENST00000325599	SHQ1	chr3	72842067	-	ENST00000405432	SRSF11	chr1	70694105	+	2573	1321	140	2572	811
ENST00000325599	SHQ1	chr3	72842067	-	ENST00000370950	SRSF11	chr1	70694105	+	4820	1321	140	2572	810
ENST00000325599	SHQ1	chr3	72842067	-	ENST00000454435	SRSF11	chr1	70694105	+	1993	1321	140	1513	457
ENST00000325599	SHQ1	chr3	72842067	-	ENST00000436161	SRSF11	chr1	70694105	+	1957	1321	140	1504	454
ENST00000463369	SHQ1	chr3	72842067	-	ENST00000370951	SRSF11	chr1	70694105	+	3248	1187	24	2435	803
ENST00000463369	SHQ1	chr3	72842067	-	ENST00000405432	SRSF11	chr1	70694105	+	2439	1187	24	2438	804
ENST00000463369	SHQ1	chr3	72842067	-	ENST00000370950	SRSF11	chr1	70694105	+	4686	1187	24	2438	804
ENST00000463369	SHQ1	chr3	72842067	-	ENST00000454435	SRSF11	chr1	70694105	+	1859	1187	24	1379	451
ENST00000463369	SHQ1	chr3	72842067	-	ENST00000436161	SRSF11	chr1	70694105	+	1823	1187	24	1370	448

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000325599	ENST00000370951	SHQ1	chr3	72842067	-	SRSF11	chr1	70694105	+	0.000734068	0.99926597
ENST00000325599	ENST00000405432	SHQ1	chr3	72842067	-	SRSF11	chr1	70694105	+	0.002077475	0.9979226
ENST00000325599	ENST00000370950	SHQ1	chr3	72842067	-	SRSF11	chr1	70694105	+	0.000243542	0.9997565
ENST00000325599	ENST00000454435	SHQ1	chr3	72842067	-	SRSF11	chr1	70694105	+	0.000379991	0.99961996
ENST00000325599	ENST00000436161	SHQ1	chr3	72842067	-	SRSF11	chr1	70694105	+	0.000779672	0.9992204
ENST00000463369	ENST00000370951	SHQ1	chr3	72842067	-	SRSF11	chr1	70694105	+	0.00077536	0.99922466
ENST00000463369	ENST00000405432	SHQ1	chr3	72842067	-	SRSF11	chr1	70694105	+	0.00230336	0.9976966
ENST00000463369	ENST00000370950	SHQ1	chr3	72842067	-	SRSF11	chr1	70694105	+	0.00025569	0.99974436
ENST00000463369	ENST00000454435	SHQ1	chr3	72842067	-	SRSF11	chr1	70694105	+	0.000548906	0.9994511
ENST00000463369	ENST00000436161	SHQ1	chr3	72842067	-	SRSF11	chr1	70694105	+	0.001315437	0.9986846

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81753_81753_1_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000325599_SRSF11_chr1_70694105_ENST00000370950_length(amino acids)=810AA_BP=394
MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNM
LTALLAPRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAA
ERRQKRLAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQ
VCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLK
CLLDIHKIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSL
LAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDT
SSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRS
RSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERS
TSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD

--------------------------------------------------------------

>81753_81753_2_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000325599_SRSF11_chr1_70694105_ENST00000370951_length(amino acids)=809AA_BP=394
MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNM
LTALLAPRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAA
ERRQKRLAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQ
VCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLK
CLLDIHKIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSL
LAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDT
SSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRS
RSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERS

--------------------------------------------------------------

>81753_81753_3_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000325599_SRSF11_chr1_70694105_ENST00000405432_length(amino acids)=811AA_BP=394
MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNM
LTALLAPRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAA
ERRQKRLAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQ
VCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLK
CLLDIHKIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSL
LAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDT
SSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRS
RSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERS
TSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD

--------------------------------------------------------------

>81753_81753_4_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000325599_SRSF11_chr1_70694105_ENST00000436161_length(amino acids)=454AA_BP=394
MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNM
LTALLAPRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAA
ERRQKRLAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQ
VCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLK
CLLDIHKIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEVKQPTRVVVHKT

--------------------------------------------------------------

>81753_81753_5_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000325599_SRSF11_chr1_70694105_ENST00000454435_length(amino acids)=457AA_BP=394
MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNM
LTALLAPRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAA
ERRQKRLAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQ
VCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLK
CLLDIHKIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEVFHGSIKAAVKK

--------------------------------------------------------------

>81753_81753_6_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000463369_SRSF11_chr1_70694105_ENST00000370950_length(amino acids)=804AA_BP=388
MSNRARLSKKKKKKNIQFAIPRMNKTWSLSLKNGDCSCGGPILTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLA
PRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAAERRQKR
LAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYSLI
DILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLKCLLDIH
KIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANA
VAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIE
EAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKT
RDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKK

--------------------------------------------------------------

>81753_81753_7_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000463369_SRSF11_chr1_70694105_ENST00000370951_length(amino acids)=803AA_BP=388
MSNRARLSKKKKKKNIQFAIPRMNKTWSLSLKNGDCSCGGPILTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLA
PRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAAERRQKR
LAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYSLI
DILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLKCLLDIH
KIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANA
VAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIE
EAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKT
RDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKK

--------------------------------------------------------------

>81753_81753_8_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000463369_SRSF11_chr1_70694105_ENST00000405432_length(amino acids)=804AA_BP=388
MSNRARLSKKKKKKNIQFAIPRMNKTWSLSLKNGDCSCGGPILTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLA
PRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAAERRQKR
LAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYSLI
DILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLKCLLDIH
KIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANA
VAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIE
EAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKT
RDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKK

--------------------------------------------------------------

>81753_81753_9_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000463369_SRSF11_chr1_70694105_ENST00000436161_length(amino acids)=448AA_BP=388
MSNRARLSKKKKKKNIQFAIPRMNKTWSLSLKNGDCSCGGPILTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLA
PRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAAERRQKR
LAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYSLI
DILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLKCLLDIH

--------------------------------------------------------------

>81753_81753_10_SHQ1-SRSF11_SHQ1_chr3_72842067_ENST00000463369_SRSF11_chr1_70694105_ENST00000454435_length(amino acids)=451AA_BP=388
MSNRARLSKKKKKKNIQFAIPRMNKTWSLSLKNGDCSCGGPILTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLA
PRKSRTAKPLVEEIGASEIPEEVVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGVLQRLQDELSDVIDIKDPDFTPAAERRQKR
LAAELAKFDPDHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQEQENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYSLI
DILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFETWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLKCLLDIH
KIFQENDPAYILNDLYISDYCVWIQKVNDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEVFHGSIKAAVKKILLTHE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:72842067/chr1:70694105)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SHQ1

chr3:72842067

chr1:70694105

ENST00000325599

1_89

393.6666666666667

578.0

Domain

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

252_259

67.66666666666667

485.0

Compositional bias

Note=Poly-Arg

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

291_294

67.66666666666667

485.0

Compositional bias

Note=Poly-Arg

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

341_349

67.66666666666667

485.0

Compositional bias

Note=Poly-Arg

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

397_404

67.66666666666667

485.0

Compositional bias

Note=Poly-Lys

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

252_259

67.66666666666667

484.0

Compositional bias

Note=Poly-Arg

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

291_294

67.66666666666667

484.0

Compositional bias

Note=Poly-Arg

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

341_349

67.66666666666667

484.0

Compositional bias

Note=Poly-Arg

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

397_404

67.66666666666667

484.0

Compositional bias

Note=Poly-Lys

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

252_259

67.66666666666667

485.0

Compositional bias

Note=Poly-Arg

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

291_294

67.66666666666667

485.0

Compositional bias

Note=Poly-Arg

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

341_349

67.66666666666667

485.0

Compositional bias

Note=Poly-Arg

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

397_404

67.66666666666667

485.0

Compositional bias

Note=Poly-Lys

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

247_353

67.66666666666667

485.0

Region

Note=10 X 8 AA approximate repeats of R-R-S-R-S-R-S-R

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

247_353

67.66666666666667

484.0

Region

Note=10 X 8 AA approximate repeats of R-R-S-R-S-R-S-R

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

247_353

67.66666666666667

485.0

Region

Note=10 X 8 AA approximate repeats of R-R-S-R-S-R-S-R

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

247_255

67.66666666666667

485.0

Repeat

Note=1

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

258_265

67.66666666666667

485.0

Repeat

Note=2

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

267_274

67.66666666666667

485.0

Repeat

Note=3

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

275_282

67.66666666666667

485.0

Repeat

Note=4

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

285_292

67.66666666666667

485.0

Repeat

Note=5

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

293_300

67.66666666666667

485.0

Repeat

Note=6

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

302_309

67.66666666666667

485.0

Repeat

Note=7

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

321_328

67.66666666666667

485.0

Repeat

Note=8

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

334_341

67.66666666666667

485.0

Repeat

Note=9

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

346_353

67.66666666666667

485.0

Repeat

Note=10

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

247_255

67.66666666666667

484.0

Repeat

Note=1

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

258_265

67.66666666666667

484.0

Repeat

Note=2

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

267_274

67.66666666666667

484.0

Repeat

Note=3

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

275_282

67.66666666666667

484.0

Repeat

Note=4

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

285_292

67.66666666666667

484.0

Repeat

Note=5

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

293_300

67.66666666666667

484.0

Repeat

Note=6

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

302_309

67.66666666666667

484.0

Repeat

Note=7

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

321_328

67.66666666666667

484.0

Repeat

Note=8

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

334_341

67.66666666666667

484.0

Repeat

Note=9

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

346_353

67.66666666666667

484.0

Repeat

Note=10

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

247_255

67.66666666666667

485.0

Repeat

Note=1

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

258_265

67.66666666666667

485.0

Repeat

Note=2

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

267_274

67.66666666666667

485.0

Repeat

Note=3

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

275_282

67.66666666666667

485.0

Repeat

Note=4

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

285_292

67.66666666666667

485.0

Repeat

Note=5

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

293_300

67.66666666666667

485.0

Repeat

Note=6

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

302_309

67.66666666666667

485.0

Repeat

Note=7

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

321_328

67.66666666666667

485.0

Repeat

Note=8

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

334_341

67.66666666666667

485.0

Repeat

Note=9

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

346_353

67.66666666666667

485.0

Repeat

Note=10

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SHQ1

chr3:72842067

chr1:70694105

ENST00000325599

441_490

393.6666666666667

578.0

Compositional bias

Note=Ser-rich

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

17_31

67.66666666666667

485.0

Compositional bias

Note=Poly-Gly

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

17_31

67.66666666666667

484.0

Compositional bias

Note=Poly-Gly

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

17_31

67.66666666666667

485.0

Compositional bias

Note=Poly-Gly

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370950

33_113

67.66666666666667

485.0

Domain

RRM

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000370951

33_113

67.66666666666667

484.0

Domain

RRM

Tgene

SRSF11

chr3:72842067

chr1:70694105

ENST00000405432

33_113

67.66666666666667

485.0

Domain

RRM

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SHQ1
SRSF11

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to SHQ1-SRSF11

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SHQ1-SRSF11

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source