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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SIPA1-FRMD8

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SIPA1-FRMD8
	FusionPDB ID: 81933
	FusionGDB2.0 ID: 81933
		Hgene	Tgene
	Gene symbol	SIPA1	FRMD8
	Gene ID	6494	83786
	Gene name	signal-induced proliferation-associated 1	FERM domain containing 8
	Synonyms	SPA1	FKSG44\|iTAP
	Cytomap	11q13.1	11q13.1
	Type of gene	protein-coding	protein-coding
	Description	signal-induced proliferation-associated protein 1GTPase-activating protein Spa-1p130 SPA-1signal-induced proliferation-associated gene 1sipa-1	FERM domain-containing protein 8band4.1 inhibitor LRP interactorbiliiRhom Tail-Associated Protein
	Modification date	20200313	20200313
	UniProtAcc	.	Q9BZ67
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000394224, ENST00000394227, ENST00000527525, ENST00000534313,	ENST00000355991, ENST00000416776, ENST00000531296, ENST00000317568,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 4=64	10 X 11 X 10=1100
	# samples	5	18
	** MAII score	log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1100*10)=-2.61143471208235 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SIPA1 [Title/Abstract] AND FRMD8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SIPA1(65412600)-FRMD8(65178713), # samples:3
Anticipated loss of major functional domain due to fusion event.	SIPA1-FRMD8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SIPA1-FRMD8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FRMD8	GO:1904469	positive regulation of tumor necrosis factor secretion	29897333

Fusion gene breakpoints across SIPA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FRMD8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-DS-A1O9-01A	SIPA1	chr11	65412600	-	FRMD8	chr11	65178713	+
ChimerDB4	CESC	TCGA-DS-A1O9-01A	SIPA1	chr11	65412600	+	FRMD8	chr11	65178713	+
ChimerDB4	CESC	TCGA-DS-A1O9	SIPA1	chr11	65412600	+	FRMD8	chr11	65178713	+
ChimerDB4	SKCM	TCGA-FR-A3YO-06A	SIPA1	chr11	65410110	+	FRMD8	chr11	65172335	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000534313	SIPA1	chr11	65412600	+	ENST00000317568	FRMD8	chr11	65178713	+	3620	1336	177	1454	425
ENST00000527525	SIPA1	chr11	65412600	+	ENST00000317568	FRMD8	chr11	65178713	+	3690	1406	247	1524	425
ENST00000394224	SIPA1	chr11	65412600	+	ENST00000317568	FRMD8	chr11	65178713	+	3739	1455	296	1573	425
ENST00000394227	SIPA1	chr11	65412600	+	ENST00000317568	FRMD8	chr11	65178713	+	3537	1253	94	1371	425
ENST00000534313	SIPA1	chr11	65410110	+	ENST00000317568	FRMD8	chr11	65172335	+	3650	1161	177	1484	435
ENST00000527525	SIPA1	chr11	65410110	+	ENST00000317568	FRMD8	chr11	65172335	+	3720	1231	247	1554	435
ENST00000394224	SIPA1	chr11	65410110	+	ENST00000317568	FRMD8	chr11	65172335	+	3769	1280	296	1603	435
ENST00000394227	SIPA1	chr11	65410110	+	ENST00000317568	FRMD8	chr11	65172335	+	3567	1078	94	1401	435

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000534313	ENST00000317568	SIPA1	chr11	65412600	+	FRMD8	chr11	65178713	+	0.13719428	0.8628057
ENST00000527525	ENST00000317568	SIPA1	chr11	65412600	+	FRMD8	chr11	65178713	+	0.14396358	0.8560364
ENST00000394224	ENST00000317568	SIPA1	chr11	65412600	+	FRMD8	chr11	65178713	+	0.13312648	0.86687356
ENST00000394227	ENST00000317568	SIPA1	chr11	65412600	+	FRMD8	chr11	65178713	+	0.1355961	0.86440396
ENST00000534313	ENST00000317568	SIPA1	chr11	65410110	+	FRMD8	chr11	65172335	+	0.1516846	0.8483154
ENST00000527525	ENST00000317568	SIPA1	chr11	65410110	+	FRMD8	chr11	65172335	+	0.16208725	0.8379128
ENST00000394224	ENST00000317568	SIPA1	chr11	65410110	+	FRMD8	chr11	65172335	+	0.14916837	0.8508317
ENST00000394227	ENST00000317568	SIPA1	chr11	65410110	+	FRMD8	chr11	65172335	+	0.15203948	0.84796053

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81933_81933_1_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000394224_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=435AA_BP=303
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVAELMSSLIEYCIELSQAAEPAGPQDSATGSPS

--------------------------------------------------------------

>81933_81933_2_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000394227_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=435AA_BP=303
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVAELMSSLIEYCIELSQAAEPAGPQDSATGSPS

--------------------------------------------------------------

>81933_81933_3_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000527525_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=435AA_BP=303
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVAELMSSLIEYCIELSQAAEPAGPQDSATGSPS

--------------------------------------------------------------

>81933_81933_4_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000534313_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=435AA_BP=303
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVAELMSSLIEYCIELSQAAEPAGPQDSATGSPS

--------------------------------------------------------------

>81933_81933_5_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000394224_FRMD8_chr11_65178713_ENST00000317568_length(amino acids)=425AA_BP=387
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF

--------------------------------------------------------------

>81933_81933_6_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000394227_FRMD8_chr11_65178713_ENST00000317568_length(amino acids)=425AA_BP=387
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF

--------------------------------------------------------------

>81933_81933_7_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000527525_FRMD8_chr11_65178713_ENST00000317568_length(amino acids)=425AA_BP=387
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF

--------------------------------------------------------------

>81933_81933_8_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000534313_FRMD8_chr11_65178713_ENST00000317568_length(amino acids)=425AA_BP=387
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65412600/chr11:65178713)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FRMD8 Q9BZ67
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269\|PubMed:19572019, ECO:0000269\|PubMed:29897333, ECO:0000269\|PubMed:29897336}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SIPA1

chr11:65410110

chr11:65172335

ENST00000394224

972_1034

328.0

1043.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SIPA1

chr11:65410110

chr11:65172335

ENST00000534313

972_1034

328.0

1043.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SIPA1

chr11:65412600

chr11:65178713

ENST00000394224

972_1034

386.3333333333333

1043.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SIPA1

chr11:65412600

chr11:65178713

ENST00000534313

972_1034

386.3333333333333

1043.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SIPA1

chr11:65410110

chr11:65172335

ENST00000394224

321_539

328.0

1043.0

Domain

Rap-GAP

Hgene

SIPA1

chr11:65410110

chr11:65172335

ENST00000394224

687_763

328.0

1043.0

Domain

PDZ

Hgene

SIPA1

chr11:65410110

chr11:65172335

ENST00000534313

321_539

328.0

1043.0

Domain

Rap-GAP

Hgene

SIPA1

chr11:65410110

chr11:65172335

ENST00000534313

687_763

328.0

1043.0

Domain

PDZ

Hgene

SIPA1

chr11:65412600

chr11:65178713

ENST00000394224

321_539

386.3333333333333

1043.0

Domain

Rap-GAP

Hgene

SIPA1

chr11:65412600

chr11:65178713

ENST00000394224

687_763

386.3333333333333

1043.0

Domain

PDZ

Hgene

SIPA1

chr11:65412600

chr11:65178713

ENST00000534313

321_539

386.3333333333333

1043.0

Domain

Rap-GAP

Hgene

SIPA1

chr11:65412600

chr11:65178713

ENST00000534313

687_763

386.3333333333333

1043.0

Domain

PDZ

Tgene

FRMD8

chr11:65410110

chr11:65172335

ENST00000317568

30_376

357.0

465.0

Domain

FERM

Tgene

FRMD8

chr11:65410110

chr11:65172335

ENST00000355991

30_376

301.0

409.0

Domain

FERM

Tgene

FRMD8

chr11:65412600

chr11:65178713

ENST00000317568

30_376

425.3333333333333

465.0

Domain

FERM

Tgene

FRMD8

chr11:65412600

chr11:65178713

ENST00000355991

30_376

369.3333333333333

409.0

Domain

FERM

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>887_SIPA1_65412600_FRMD8_65178713_887_SIPA1_65412600_FRMD8_65178713_ranked_0.pdb	SIPA1	65410110	65412600	ENST00000317568	FRMD8	chr11	65178713	+	MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF	425

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

SIPA1_pLDDT.png

FRMD8_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SIPA1
FRMD8

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to SIPA1-FRMD8

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SIPA1-FRMD8

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source