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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLC19A2-KDM4C

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC19A2-KDM4C
FusionPDB ID: 82375
FusionGDB2.0 ID: 82375
HgeneTgene
Gene symbol

SLC19A2

KDM4C

Gene ID

10560

23081

Gene namesolute carrier family 19 member 2lysine demethylase 4C
SynonymsTC1|THMD1|THT1|THTR1|TRMAGASC1|JHDM3C|JMJD2C|TDRD14C
Cytomap

1q24.2

9p24.1

Type of geneprotein-codingprotein-coding
Descriptionthiamine transporter 1high affinity thiamine transporterreduced folate carrier protein (RFC) likesolute carrier family 19 (thiamine transporter), member 2thTr-1lysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14C
Modification date2020031320200329
UniProtAcc.

Q9H3R0

Ensembl transtripts involved in fusion geneENST idsENST00000236137, ENST00000367804, 
ENST00000401787, ENST00000428870, 
ENST00000489243, ENST00000536108, 
ENST00000381306, ENST00000381309, 
ENST00000442236, ENST00000535193, 
ENST00000543771, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 2=3222 X 22 X 7=3388
# samples 426
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(26/3388*10)=-3.70385034630374
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLC19A2 [Title/Abstract] AND KDM4C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLC19A2(169446393)-KDM4C(7046862), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC19A2-KDM4C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC19A2-KDM4C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC19A2-KDM4C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC19A2-KDM4C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKDM4C

GO:0006357

regulation of transcription by RNA polymerase II

17277772

TgeneKDM4C

GO:0033169

histone H3-K9 demethylation

18066052|21914792

TgeneKDM4C

GO:0070544

histone H3-K36 demethylation

21914792


check buttonFusion gene breakpoints across SLC19A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KDM4C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0E1-01ASLC19A2chr1

169446393

-KDM4Cchr9

7046862

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000236137SLC19A2chr1169446393-ENST00000535193KDM4Cchr97046862+203810441231226367
ENST00000236137SLC19A2chr1169446393-ENST00000543771KDM4Cchr97046862+203810441231226367
ENST00000236137SLC19A2chr1169446393-ENST00000381306KDM4Cchr97046862+282110441231928601
ENST00000236137SLC19A2chr1169446393-ENST00000381309KDM4Cchr97046862+287510441231955610
ENST00000236137SLC19A2chr1169446393-ENST00000442236KDM4Cchr97046862+205110441231955610

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000236137ENST00000535193SLC19A2chr1169446393-KDM4Cchr97046862+0.0010510010.998949
ENST00000236137ENST00000543771SLC19A2chr1169446393-KDM4Cchr97046862+0.0010510010.998949
ENST00000236137ENST00000381306SLC19A2chr1169446393-KDM4Cchr97046862+0.000399060.99960095
ENST00000236137ENST00000381309SLC19A2chr1169446393-KDM4Cchr97046862+0.0006008130.9993992
ENST00000236137ENST00000442236SLC19A2chr1169446393-KDM4Cchr97046862+0.0013280570.998672

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>82375_82375_1_SLC19A2-KDM4C_SLC19A2_chr1_169446393_ENST00000236137_KDM4C_chr9_7046862_ENST00000381306_length(amino acids)=601AA_BP=307
MALQGEGVTRGYKCLTLTPVGGGGEGRGRAGSPPLAPRMDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPF
LTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYY
SYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKV
QNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRL
KLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYS
CRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTL

--------------------------------------------------------------

>82375_82375_2_SLC19A2-KDM4C_SLC19A2_chr1_169446393_ENST00000236137_KDM4C_chr9_7046862_ENST00000381309_length(amino acids)=610AA_BP=307
MALQGEGVTRGYKCLTLTPVGGGGEGRGRAGSPPLAPRMDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPF
LTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYY
SYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKV
QNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRL
KLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYS
CRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTL

--------------------------------------------------------------

>82375_82375_3_SLC19A2-KDM4C_SLC19A2_chr1_169446393_ENST00000236137_KDM4C_chr9_7046862_ENST00000442236_length(amino acids)=610AA_BP=307
MALQGEGVTRGYKCLTLTPVGGGGEGRGRAGSPPLAPRMDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPF
LTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYY
SYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKV
QNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRL
KLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYS
CRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTL

--------------------------------------------------------------

>82375_82375_4_SLC19A2-KDM4C_SLC19A2_chr1_169446393_ENST00000236137_KDM4C_chr9_7046862_ENST00000535193_length(amino acids)=367AA_BP=307
MALQGEGVTRGYKCLTLTPVGGGGEGRGRAGSPPLAPRMDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPF
LTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYY
SYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKV
QNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRL

--------------------------------------------------------------

>82375_82375_5_SLC19A2-KDM4C_SLC19A2_chr1_169446393_ENST00000236137_KDM4C_chr9_7046862_ENST00000543771_length(amino acids)=367AA_BP=307
MALQGEGVTRGYKCLTLTPVGGGGEGRGRAGSPPLAPRMDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPF
LTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYY
SYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKV
QNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:169446393/chr9:7046862)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KDM4C

Q9H3R0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26119_128269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26150_165269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26186_191269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-261_28269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-2647_72269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-2692_99269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26100_118269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26129_149269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26166_185269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26192_208269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-2629_46269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-2673_91269.0498.0TransmembraneHelical
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421877_934753.01048.0DomainNote=Tudor 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421935_991753.01048.0DomainNote=Tudor 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422877_934753.01057.0DomainNote=Tudor 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422935_991753.01057.0DomainNote=Tudor 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418877_934775.0836.0DomainNote=Tudor 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418935_991775.0836.0DomainNote=Tudor 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418877_934753.0814.0DomainNote=Tudor 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418935_991753.0814.0DomainNote=Tudor 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421752_785753.01048.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421808_865753.01048.0Zinc fingerPHD-type 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422752_785753.01057.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422808_865753.01057.0Zinc fingerPHD-type 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418808_865775.0836.0Zinc fingerPHD-type 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418752_785753.0814.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418808_865753.0814.0Zinc fingerPHD-type 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26209_285269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26311_337269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26355_363269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26381_386269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26410_419269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26444_455269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26480_497269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15119_1280297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15150_1650297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15186_1910297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-151_280297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15209_2850297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15311_3370297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15355_3630297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15381_3860297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15410_4190297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15444_4550297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-1547_720297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15480_4970297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-1592_990297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26286_310269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26338_354269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26364_380269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26387_409269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26420_443269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26456_479269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15100_1180297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15129_1490297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15166_1850297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15192_2080297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15286_3100297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-1529_460297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15338_3540297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15364_3800297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15387_4090297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15420_4430297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15456_4790297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-1573_910297.0TransmembraneHelical
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421144_310753.01048.0DomainJmjC
TgeneKDM4Cchr1:169446393chr9:7046862ENST00000381306142116_58753.01048.0DomainJmjN
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422144_310753.01057.0DomainJmjC
TgeneKDM4Cchr1:169446393chr9:7046862ENST00000381309142216_58753.01057.0DomainJmjN
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418144_310775.0836.0DomainJmjC
TgeneKDM4Cchr1:169446393chr9:7046862ENST00000535193141816_58775.0836.0DomainJmjN
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418144_310753.0814.0DomainJmjC
TgeneKDM4Cchr1:169446393chr9:7046862ENST00000543771141816_58753.0814.0DomainJmjN
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421689_747753.01048.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422689_747753.01057.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418689_747775.0836.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418752_785775.0836.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418689_747753.0814.0Zinc fingerNote=PHD-type 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLC19A2
KDM4C


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SLC19A2-KDM4C


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC19A2-KDM4C


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource