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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLC22A5-RAD50

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC22A5-RAD50
FusionPDB ID: 82487
FusionGDB2.0 ID: 82487
HgeneTgene
Gene symbol

SLC22A5

RAD50

Gene ID

6584

10111

Gene namesolute carrier family 22 member 5RAD50 double strand break repair protein
SynonymsCDSP|OCTN2NBSLD|RAD502|hRad50
Cytomap

5q31.1

5q31.1

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 22 member 5high-affinity sodium dependent carnitine cotransporterorganic cation/carnitine transporter 2DNA repair protein RAD50RAD50 homolog, double strand break repair protein
Modification date2020031520200320
UniProtAcc.

RINT1

Ensembl transtripts involved in fusion geneENST idsENST00000245407, ENST00000435065, 
ENST00000479605, 		ENST00000265335, 
ENST00000378823, ENST00000487596, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 5 X 4=1002 X 3 X 3=18
# samples 75
** MAII scorelog2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/18*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLC22A5 [Title/Abstract] AND RAD50 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLC22A5(131722843)-RAD50(131976364), # samples:2
Anticipated loss of major functional domain due to fusion event.SLC22A5-RAD50 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC22A5-RAD50 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC22A5-RAD50 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC22A5-RAD50 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC22A5

GO:0015697

quaternary ammonium group transport

9618255

HgeneSLC22A5

GO:0015879

carnitine transport

9685390

HgeneSLC22A5

GO:0070715

sodium-dependent organic cation transport

9685390|15238359

TgeneRAD50

GO:0000019

regulation of mitotic recombination

8756642

TgeneRAD50

GO:0006281

DNA repair

9705271

TgeneRAD50

GO:0006310

DNA recombination

9705271

TgeneRAD50

GO:0006974

cellular response to DNA damage stimulus

17500065

TgeneRAD50

GO:0007004

telomere maintenance via telomerase

9705271

TgeneRAD50

GO:0031954

positive regulation of protein autophosphorylation

15790808

TgeneRAD50

GO:0033674

positive regulation of kinase activity

15790808

TgeneRAD50

GO:1904354

negative regulation of telomere capping

17694070


check buttonFusion gene breakpoints across SLC22A5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAD50 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-FU-A5XV-01ASLC22A5chr5

131706057

+RAD50chr5

131894976

+
ChimerDB4KIRPTCGA-BQ-5876-01ASLC22A5chr5

131722843

+RAD50chr5

131976364

+
ChimerDB4KIRPTCGA-BQ-5876SLC22A5chr5

131722843

+RAD50chr5

131976363

+
ChimerDB4KIRPTCGA-BQ-5876SLC22A5chr5

131722843

+RAD50chr5

131976364

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000245407SLC22A5chr5131722843+ENST00000378823RAD50chr5131976364+375011721071492461
ENST00000245407SLC22A5chr5131722843+ENST00000265335RAD50chr5131976364+318911721071492461
ENST00000435065SLC22A5chr5131722843+ENST00000378823RAD50chr5131976364+3601102301343447
ENST00000435065SLC22A5chr5131722843+ENST00000265335RAD50chr5131976364+3040102301343447
ENST00000245407SLC22A5chr5131722843+ENST00000378823RAD50chr5131976363+375011721071492461
ENST00000245407SLC22A5chr5131722843+ENST00000265335RAD50chr5131976363+318911721071492461
ENST00000435065SLC22A5chr5131722843+ENST00000378823RAD50chr5131976363+3601102301343447
ENST00000435065SLC22A5chr5131722843+ENST00000265335RAD50chr5131976363+3040102301343447

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000245407ENST00000378823SLC22A5chr5131722843+RAD50chr5131976364+0.0010474270.9989525
ENST00000245407ENST00000265335SLC22A5chr5131722843+RAD50chr5131976364+0.0012097770.9987902
ENST00000435065ENST00000378823SLC22A5chr5131722843+RAD50chr5131976364+0.0010021920.99899787
ENST00000435065ENST00000265335SLC22A5chr5131722843+RAD50chr5131976364+0.0011121610.99888784
ENST00000245407ENST00000378823SLC22A5chr5131722843+RAD50chr5131976363+0.0010474270.9989525
ENST00000245407ENST00000265335SLC22A5chr5131722843+RAD50chr5131976363+0.0012097770.9987902
ENST00000435065ENST00000378823SLC22A5chr5131722843+RAD50chr5131976363+0.0010021920.99899787
ENST00000435065ENST00000265335SLC22A5chr5131722843+RAD50chr5131976363+0.0011121610.99888784

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>82487_82487_1_SLC22A5-RAD50_SLC22A5_chr5_131722843_ENST00000245407_RAD50_chr5_131976363_ENST00000265335_length(amino acids)=461AA_BP=1
MGRLLPGLPGRRRVPRAHAQSPPRSPTPGRALWASEGGMRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRV
PDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKA
PLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST
LGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSEVLASL
IIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVK

--------------------------------------------------------------

>82487_82487_2_SLC22A5-RAD50_SLC22A5_chr5_131722843_ENST00000245407_RAD50_chr5_131976363_ENST00000378823_length(amino acids)=461AA_BP=1
MGRLLPGLPGRRRVPRAHAQSPPRSPTPGRALWASEGGMRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRV
PDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKA
PLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST
LGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSEVLASL
IIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVK

--------------------------------------------------------------

>82487_82487_3_SLC22A5-RAD50_SLC22A5_chr5_131722843_ENST00000245407_RAD50_chr5_131976364_ENST00000265335_length(amino acids)=461AA_BP=1
MGRLLPGLPGRRRVPRAHAQSPPRSPTPGRALWASEGGMRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRV
PDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKA
PLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST
LGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSEVLASL
IIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVK

--------------------------------------------------------------

>82487_82487_4_SLC22A5-RAD50_SLC22A5_chr5_131722843_ENST00000245407_RAD50_chr5_131976364_ENST00000378823_length(amino acids)=461AA_BP=1
MGRLLPGLPGRRRVPRAHAQSPPRSPTPGRALWASEGGMRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRV
PDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKA
PLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST
LGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSEVLASL
IIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVK

--------------------------------------------------------------

>82487_82487_5_SLC22A5-RAD50_SLC22A5_chr5_131722843_ENST00000435065_RAD50_chr5_131976363_ENST00000265335_length(amino acids)=447AA_BP=0
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIA
NFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLG
SFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVL
PLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSEVLASLIIRLALAETFCLNC

--------------------------------------------------------------

>82487_82487_6_SLC22A5-RAD50_SLC22A5_chr5_131722843_ENST00000435065_RAD50_chr5_131976363_ENST00000378823_length(amino acids)=447AA_BP=0
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIA
NFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLG
SFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVL
PLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSEVLASLIIRLALAETFCLNC

--------------------------------------------------------------

>82487_82487_7_SLC22A5-RAD50_SLC22A5_chr5_131722843_ENST00000435065_RAD50_chr5_131976364_ENST00000265335_length(amino acids)=447AA_BP=0
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIA
NFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLG
SFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVL
PLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSEVLASLIIRLALAETFCLNC

--------------------------------------------------------------

>82487_82487_8_SLC22A5-RAD50_SLC22A5_chr5_131722843_ENST00000435065_RAD50_chr5_131976364_ENST00000378823_length(amino acids)=447AA_BP=0
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIA
NFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLG
SFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVL
PLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSEVLASLIIRLALAETFCLNC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:131722843/chr5:131976364)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RAD50

RINT1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.792

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510218_225317.0558.0Nucleotide bindingATP
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611218_225341.0582.0Nucleotide bindingATP
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510218_225317.0558.0Nucleotide bindingATP
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611218_225341.0582.0Nucleotide bindingATP
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510164_172317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510194_197317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+5101_20317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510219_232317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510254_257317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+51042_142317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611164_172341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611194_197341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+6111_20341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611219_232341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611254_257341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611279_341341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+61142_142341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510164_172317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510194_197317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+5101_20317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510219_232317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510254_257317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+51042_142317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611164_172341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611194_197341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+6111_20341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611219_232341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611254_257341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611279_341341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+61142_142341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510143_163317.0558.0TransmembraneHelical%3B Name%3D2
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510173_193317.0558.0TransmembraneHelical%3B Name%3D3
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510198_218317.0558.0TransmembraneHelical%3B Name%3D4
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+51021_41317.0558.0TransmembraneHelical%3B Name%3D1
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510233_253317.0558.0TransmembraneHelical%3B Name%3D5
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510258_278317.0558.0TransmembraneHelical%3B Name%3D6
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611143_163341.0582.0TransmembraneHelical%3B Name%3D2
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611173_193341.0582.0TransmembraneHelical%3B Name%3D3
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611198_218341.0582.0TransmembraneHelical%3B Name%3D4
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+61121_41341.0582.0TransmembraneHelical%3B Name%3D1
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611233_253341.0582.0TransmembraneHelical%3B Name%3D5
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611258_278341.0582.0TransmembraneHelical%3B Name%3D6
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510143_163317.0558.0TransmembraneHelical%3B Name%3D2
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510173_193317.0558.0TransmembraneHelical%3B Name%3D3
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510198_218317.0558.0TransmembraneHelical%3B Name%3D4
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+51021_41317.0558.0TransmembraneHelical%3B Name%3D1
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510233_253317.0558.0TransmembraneHelical%3B Name%3D5
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510258_278317.0558.0TransmembraneHelical%3B Name%3D6
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611143_163341.0582.0TransmembraneHelical%3B Name%3D2
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611173_193341.0582.0TransmembraneHelical%3B Name%3D3
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611198_218341.0582.0TransmembraneHelical%3B Name%3D4
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+61121_41341.0582.0TransmembraneHelical%3B Name%3D1
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611233_253341.0582.0TransmembraneHelical%3B Name%3D5
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611258_278341.0582.0TransmembraneHelical%3B Name%3D6
TgeneRAD50chr5:131722843chr5:131976363ENST0000037882322251201_12381067.01174.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneRAD50chr5:131722843chr5:131976364ENST0000037882322251201_12381067.01174.0Compositional biasNote=Ala/Asp-rich (DA-box)

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510279_341317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510363_373317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510395_406317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510428_430317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510452_462317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510484_488317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611363_373341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611395_406341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611428_430341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611452_462341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611484_488341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510279_341317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510363_373317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510395_406317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510428_430317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510452_462317.0558.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510484_488317.0558.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611363_373341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611395_406341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611428_430341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611452_462341.0582.0Topological domainCytoplasmic
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611484_488341.0582.0Topological domainExtracellular
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510342_362317.0558.0TransmembraneHelical%3B Name%3D7
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510374_394317.0558.0TransmembraneHelical%3B Name%3D8
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510407_427317.0558.0TransmembraneHelical%3B Name%3D9
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510431_451317.0558.0TransmembraneHelical%3B Name%3D10
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510463_483317.0558.0TransmembraneHelical%3B Name%3D11
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000245407+510489_509317.0558.0TransmembraneHelical%3B Name%3D12
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611342_362341.0582.0TransmembraneHelical%3B Name%3D7
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611374_394341.0582.0TransmembraneHelical%3B Name%3D8
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611407_427341.0582.0TransmembraneHelical%3B Name%3D9
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611431_451341.0582.0TransmembraneHelical%3B Name%3D10
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611463_483341.0582.0TransmembraneHelical%3B Name%3D11
HgeneSLC22A5chr5:131722843chr5:131976363ENST00000435065+611489_509341.0582.0TransmembraneHelical%3B Name%3D12
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510342_362317.0558.0TransmembraneHelical%3B Name%3D7
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510374_394317.0558.0TransmembraneHelical%3B Name%3D8
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510407_427317.0558.0TransmembraneHelical%3B Name%3D9
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510431_451317.0558.0TransmembraneHelical%3B Name%3D10
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510463_483317.0558.0TransmembraneHelical%3B Name%3D11
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000245407+510489_509317.0558.0TransmembraneHelical%3B Name%3D12
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611342_362341.0582.0TransmembraneHelical%3B Name%3D7
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611374_394341.0582.0TransmembraneHelical%3B Name%3D8
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611407_427341.0582.0TransmembraneHelical%3B Name%3D9
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611431_451341.0582.0TransmembraneHelical%3B Name%3D10
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611463_483341.0582.0TransmembraneHelical%3B Name%3D11
HgeneSLC22A5chr5:131722843chr5:131976364ENST00000435065+611489_509341.0582.0TransmembraneHelical%3B Name%3D12
TgeneRAD50chr5:131722843chr5:131976363ENST000002653352225228_3591206.01313.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976363ENST000002653352225401_5981206.01313.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976363ENST000002653352225635_6731206.01313.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976363ENST000002653352225706_7341206.01313.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976363ENST000002653352225789_10791206.01313.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976363ENST000003788232225228_3591067.01174.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976363ENST000003788232225401_5981067.01174.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976363ENST000003788232225635_6731067.01174.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976363ENST000003788232225706_7341067.01174.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976363ENST000003788232225789_10791067.01174.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976364ENST000002653352225228_3591206.01313.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976364ENST000002653352225401_5981206.01313.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976364ENST000002653352225635_6731206.01313.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976364ENST000002653352225706_7341206.01313.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976364ENST000002653352225789_10791206.01313.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976364ENST000003788232225228_3591067.01174.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976364ENST000003788232225401_5981067.01174.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976364ENST000003788232225635_6731067.01174.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976364ENST000003788232225706_7341067.01174.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976364ENST000003788232225789_10791067.01174.0Coiled coilOntology_term=ECO:0000255
TgeneRAD50chr5:131722843chr5:131976363ENST0000026533522251201_12381206.01313.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneRAD50chr5:131722843chr5:131976364ENST0000026533522251201_12381206.01313.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneRAD50chr5:131722843chr5:131976363ENST000002653352225635_7341206.01313.0DomainZinc-hook
TgeneRAD50chr5:131722843chr5:131976363ENST000003788232225635_7341067.01174.0DomainZinc-hook
TgeneRAD50chr5:131722843chr5:131976364ENST000002653352225635_7341206.01313.0DomainZinc-hook
TgeneRAD50chr5:131722843chr5:131976364ENST000003788232225635_7341067.01174.0DomainZinc-hook
TgeneRAD50chr5:131722843chr5:131976363ENST00000265335222536_431206.01313.0Nucleotide bindingATP
TgeneRAD50chr5:131722843chr5:131976363ENST00000378823222536_431067.01174.0Nucleotide bindingATP
TgeneRAD50chr5:131722843chr5:131976364ENST00000265335222536_431206.01313.0Nucleotide bindingATP
TgeneRAD50chr5:131722843chr5:131976364ENST00000378823222536_431067.01174.0Nucleotide bindingATP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>965_SLC22A5_131722843_RAD50_131976364_965_SLC22A5_131722843_RAD50_131976364_ranked_0.pdbSLC22A5131722843131722843ENST00000265335RAD50chr5131976364+
MGRLLPGLPGRRRVPRAHAQSPPRSPTPGRALWASEGGMRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRV
PDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKA
PLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST
LGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSEVLASL
IIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVK
461


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SLC22A5_pLDDT.png
all structure
all structure
RAD50_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLC22A5
RAD50


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SLC22A5-RAD50


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC22A5-RAD50


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource