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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLC25A3-EZH2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC25A3-EZH2
FusionPDB ID: 82679
FusionGDB2.0 ID: 82679
HgeneTgene
Gene symbol

SLC25A3

EZH2

Gene ID

5250

2146

Gene namesolute carrier family 25 member 3enhancer of zeste 2 polycomb repressive complex 2 subunit
SynonymsOK/SW-cl.48|PHC|PTPENX-1|ENX1|EZH2b|KMT6|KMT6A|WVS|WVS2
Cytomap

12q23.1

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionphosphate carrier protein, mitochondrialphosphate transport proteinsolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3histone-lysine N-methyltransferase EZH2enhancer of zeste homolog 2lysine N-methyltransferase 6
Modification date2020031320200329
UniProtAcc.

Q15910

Ensembl transtripts involved in fusion geneENST idsENST00000188376, ENST00000228318, 
ENST00000401722, ENST00000547534, 
ENST00000548847, ENST00000549338, 
ENST00000551265, ENST00000551917, 
ENST00000552981, 		ENST00000536783, 
ENST00000320356, ENST00000350995, 
ENST00000460911, ENST00000476773, 
ENST00000478654, ENST00000483967, 
ENST00000541220, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 12 X 4=62410 X 7 X 5=350
# samples 139
** MAII scorelog2(13/624*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/350*10)=-1.95935801550265
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLC25A3 [Title/Abstract] AND EZH2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLC25A3(98987913)-EZH2(148511229), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC25A3-EZH2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SLC25A3-EZH2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SLC25A3-EZH2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC25A3-EZH2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEZH2

GO:0000122

negative regulation of transcription by RNA polymerase II

20154697

TgeneEZH2

GO:0010718

positive regulation of epithelial to mesenchymal transition

20154697

TgeneEZH2

GO:0043406

positive regulation of MAP kinase activity

20154697

TgeneEZH2

GO:0043547

positive regulation of GTPase activity

20154697

TgeneEZH2

GO:0045814

negative regulation of gene expression, epigenetic

20154697

TgeneEZH2

GO:0070734

histone H3-K27 methylation

24474760

TgeneEZH2

GO:0071902

positive regulation of protein serine/threonine kinase activity

20154697


check buttonFusion gene breakpoints across SLC25A3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EZH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8081SLC25A3chr12

98987913

+EZH2chr7

148511229

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000401722SLC25A3chr1298987913+ENST00000478654EZH2chr7148511229-1153307150890246
ENST00000401722SLC25A3chr1298987913+ENST00000460911EZH2chr7148511229-1152307150890246
ENST00000401722SLC25A3chr1298987913+ENST00000350995EZH2chr7148511229-1152307150890246
ENST00000401722SLC25A3chr1298987913+ENST00000320356EZH2chr7148511229-1152307150890246
ENST00000401722SLC25A3chr1298987913+ENST00000541220EZH2chr7148511229-1152307150890246
ENST00000401722SLC25A3chr1298987913+ENST00000476773EZH2chr7148511229-1055307150890246
ENST00000401722SLC25A3chr1298987913+ENST00000483967EZH2chr7148511229-1012307150890246
ENST00000228318SLC25A3chr1298987913+ENST00000478654EZH2chr7148511229-112327793860255
ENST00000228318SLC25A3chr1298987913+ENST00000460911EZH2chr7148511229-112227793860255
ENST00000228318SLC25A3chr1298987913+ENST00000350995EZH2chr7148511229-112227793860255
ENST00000228318SLC25A3chr1298987913+ENST00000320356EZH2chr7148511229-112227793860255
ENST00000228318SLC25A3chr1298987913+ENST00000541220EZH2chr7148511229-112227793860255
ENST00000228318SLC25A3chr1298987913+ENST00000476773EZH2chr7148511229-102527793860255
ENST00000228318SLC25A3chr1298987913+ENST00000483967EZH2chr7148511229-98227793860255
ENST00000188376SLC25A3chr1298987913+ENST00000478654EZH2chr7148511229-13575111381094318
ENST00000188376SLC25A3chr1298987913+ENST00000460911EZH2chr7148511229-13565111381094318
ENST00000188376SLC25A3chr1298987913+ENST00000350995EZH2chr7148511229-13565111381094318
ENST00000188376SLC25A3chr1298987913+ENST00000320356EZH2chr7148511229-13565111381094318
ENST00000188376SLC25A3chr1298987913+ENST00000541220EZH2chr7148511229-13565111381094318
ENST00000188376SLC25A3chr1298987913+ENST00000476773EZH2chr7148511229-12595111381094318
ENST00000188376SLC25A3chr1298987913+ENST00000483967EZH2chr7148511229-12165111381094318
ENST00000551917SLC25A3chr1298987913+ENST00000478654EZH2chr7148511229-109424891831246
ENST00000551917SLC25A3chr1298987913+ENST00000460911EZH2chr7148511229-109324891831246
ENST00000551917SLC25A3chr1298987913+ENST00000350995EZH2chr7148511229-109324891831246
ENST00000551917SLC25A3chr1298987913+ENST00000320356EZH2chr7148511229-109324891831246
ENST00000551917SLC25A3chr1298987913+ENST00000541220EZH2chr7148511229-109324891831246
ENST00000551917SLC25A3chr1298987913+ENST00000476773EZH2chr7148511229-99624891831246
ENST00000551917SLC25A3chr1298987913+ENST00000483967EZH2chr7148511229-95324891831246
ENST00000552981SLC25A3chr1298987913+ENST00000478654EZH2chr7148511229-108824258825255
ENST00000552981SLC25A3chr1298987913+ENST00000460911EZH2chr7148511229-108724258825255
ENST00000552981SLC25A3chr1298987913+ENST00000350995EZH2chr7148511229-108724258825255
ENST00000552981SLC25A3chr1298987913+ENST00000320356EZH2chr7148511229-108724258825255
ENST00000552981SLC25A3chr1298987913+ENST00000541220EZH2chr7148511229-108724258825255
ENST00000552981SLC25A3chr1298987913+ENST00000476773EZH2chr7148511229-99024258825255
ENST00000552981SLC25A3chr1298987913+ENST00000483967EZH2chr7148511229-94724258825255
ENST00000547534SLC25A3chr1298987913+ENST00000478654EZH2chr7148511229-106221632799255
ENST00000547534SLC25A3chr1298987913+ENST00000460911EZH2chr7148511229-106121632799255
ENST00000547534SLC25A3chr1298987913+ENST00000350995EZH2chr7148511229-106121632799255
ENST00000547534SLC25A3chr1298987913+ENST00000320356EZH2chr7148511229-106121632799255
ENST00000547534SLC25A3chr1298987913+ENST00000541220EZH2chr7148511229-106121632799255
ENST00000547534SLC25A3chr1298987913+ENST00000476773EZH2chr7148511229-96421632799255
ENST00000547534SLC25A3chr1298987913+ENST00000483967EZH2chr7148511229-92121632799255
ENST00000549338SLC25A3chr1298987913+ENST00000478654EZH2chr7148511229-105621053793246
ENST00000549338SLC25A3chr1298987913+ENST00000460911EZH2chr7148511229-105521053793246
ENST00000549338SLC25A3chr1298987913+ENST00000350995EZH2chr7148511229-105521053793246
ENST00000549338SLC25A3chr1298987913+ENST00000320356EZH2chr7148511229-105521053793246
ENST00000549338SLC25A3chr1298987913+ENST00000541220EZH2chr7148511229-105521053793246
ENST00000549338SLC25A3chr1298987913+ENST00000476773EZH2chr7148511229-95821053793246
ENST00000549338SLC25A3chr1298987913+ENST00000483967EZH2chr7148511229-91521053793246
ENST00000548847SLC25A3chr1298987913+ENST00000478654EZH2chr7148511229-125741138994318
ENST00000548847SLC25A3chr1298987913+ENST00000460911EZH2chr7148511229-125641138994318
ENST00000548847SLC25A3chr1298987913+ENST00000350995EZH2chr7148511229-125641138994318
ENST00000548847SLC25A3chr1298987913+ENST00000320356EZH2chr7148511229-125641138994318
ENST00000548847SLC25A3chr1298987913+ENST00000541220EZH2chr7148511229-125641138994318
ENST00000548847SLC25A3chr1298987913+ENST00000476773EZH2chr7148511229-115941138994318
ENST00000548847SLC25A3chr1298987913+ENST00000483967EZH2chr7148511229-111641138994318

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000401722ENST00000478654SLC25A3chr1298987913+EZH2chr7148511229-0.002455310.9975447
ENST00000401722ENST00000460911SLC25A3chr1298987913+EZH2chr7148511229-0.0024759260.9975241
ENST00000401722ENST00000350995SLC25A3chr1298987913+EZH2chr7148511229-0.0024759260.9975241
ENST00000401722ENST00000320356SLC25A3chr1298987913+EZH2chr7148511229-0.0024759260.9975241
ENST00000401722ENST00000541220SLC25A3chr1298987913+EZH2chr7148511229-0.0024759260.9975241
ENST00000401722ENST00000476773SLC25A3chr1298987913+EZH2chr7148511229-0.0029046990.99709535
ENST00000401722ENST00000483967SLC25A3chr1298987913+EZH2chr7148511229-0.0032565220.9967435
ENST00000228318ENST00000478654SLC25A3chr1298987913+EZH2chr7148511229-0.0025117070.99748826
ENST00000228318ENST00000460911SLC25A3chr1298987913+EZH2chr7148511229-0.002530190.9974698
ENST00000228318ENST00000350995SLC25A3chr1298987913+EZH2chr7148511229-0.002530190.9974698
ENST00000228318ENST00000320356SLC25A3chr1298987913+EZH2chr7148511229-0.002530190.9974698
ENST00000228318ENST00000541220SLC25A3chr1298987913+EZH2chr7148511229-0.002530190.9974698
ENST00000228318ENST00000476773SLC25A3chr1298987913+EZH2chr7148511229-0.0029508490.99704915
ENST00000228318ENST00000483967SLC25A3chr1298987913+EZH2chr7148511229-0.003343460.99665654
ENST00000188376ENST00000478654SLC25A3chr1298987913+EZH2chr7148511229-0.0029518280.9970482
ENST00000188376ENST00000460911SLC25A3chr1298987913+EZH2chr7148511229-0.0029837790.9970162
ENST00000188376ENST00000350995SLC25A3chr1298987913+EZH2chr7148511229-0.0029837790.9970162
ENST00000188376ENST00000320356SLC25A3chr1298987913+EZH2chr7148511229-0.0029837790.9970162
ENST00000188376ENST00000541220SLC25A3chr1298987913+EZH2chr7148511229-0.0029837790.9970162
ENST00000188376ENST00000476773SLC25A3chr1298987913+EZH2chr7148511229-0.0033294210.99667054
ENST00000188376ENST00000483967SLC25A3chr1298987913+EZH2chr7148511229-0.0037883590.99621165
ENST00000551917ENST00000478654SLC25A3chr1298987913+EZH2chr7148511229-0.002481430.99751854
ENST00000551917ENST00000460911SLC25A3chr1298987913+EZH2chr7148511229-0.0024889940.997511
ENST00000551917ENST00000350995SLC25A3chr1298987913+EZH2chr7148511229-0.0024889940.997511
ENST00000551917ENST00000320356SLC25A3chr1298987913+EZH2chr7148511229-0.0024889940.997511
ENST00000551917ENST00000541220SLC25A3chr1298987913+EZH2chr7148511229-0.0024889940.997511
ENST00000551917ENST00000476773SLC25A3chr1298987913+EZH2chr7148511229-0.002913090.99708694
ENST00000551917ENST00000483967SLC25A3chr1298987913+EZH2chr7148511229-0.0031331320.9968669
ENST00000552981ENST00000478654SLC25A3chr1298987913+EZH2chr7148511229-0.0025400410.99745995
ENST00000552981ENST00000460911SLC25A3chr1298987913+EZH2chr7148511229-0.0025434380.9974566
ENST00000552981ENST00000350995SLC25A3chr1298987913+EZH2chr7148511229-0.0025434380.9974566
ENST00000552981ENST00000320356SLC25A3chr1298987913+EZH2chr7148511229-0.0025434380.9974566
ENST00000552981ENST00000541220SLC25A3chr1298987913+EZH2chr7148511229-0.0025434380.9974566
ENST00000552981ENST00000476773SLC25A3chr1298987913+EZH2chr7148511229-0.002981750.9970182
ENST00000552981ENST00000483967SLC25A3chr1298987913+EZH2chr7148511229-0.0031759160.99682415
ENST00000547534ENST00000478654SLC25A3chr1298987913+EZH2chr7148511229-0.0027107540.9972893
ENST00000547534ENST00000460911SLC25A3chr1298987913+EZH2chr7148511229-0.0027186080.9972813
ENST00000547534ENST00000350995SLC25A3chr1298987913+EZH2chr7148511229-0.0027186080.9972813
ENST00000547534ENST00000320356SLC25A3chr1298987913+EZH2chr7148511229-0.0027186080.9972813
ENST00000547534ENST00000541220SLC25A3chr1298987913+EZH2chr7148511229-0.0027186080.9972813
ENST00000547534ENST00000476773SLC25A3chr1298987913+EZH2chr7148511229-0.0032101060.9967899
ENST00000547534ENST00000483967SLC25A3chr1298987913+EZH2chr7148511229-0.0034878020.99651223
ENST00000549338ENST00000478654SLC25A3chr1298987913+EZH2chr7148511229-0.0028094420.99719054
ENST00000549338ENST00000460911SLC25A3chr1298987913+EZH2chr7148511229-0.0028157820.9971842
ENST00000549338ENST00000350995SLC25A3chr1298987913+EZH2chr7148511229-0.0028157820.9971842
ENST00000549338ENST00000320356SLC25A3chr1298987913+EZH2chr7148511229-0.0028157820.9971842
ENST00000549338ENST00000541220SLC25A3chr1298987913+EZH2chr7148511229-0.0028157820.9971842
ENST00000549338ENST00000476773SLC25A3chr1298987913+EZH2chr7148511229-0.0033571330.9966428
ENST00000549338ENST00000483967SLC25A3chr1298987913+EZH2chr7148511229-0.0037016640.9962984
ENST00000548847ENST00000478654SLC25A3chr1298987913+EZH2chr7148511229-0.0028661690.99713385
ENST00000548847ENST00000460911SLC25A3chr1298987913+EZH2chr7148511229-0.0029029190.99709713
ENST00000548847ENST00000350995SLC25A3chr1298987913+EZH2chr7148511229-0.0029029190.99709713
ENST00000548847ENST00000320356SLC25A3chr1298987913+EZH2chr7148511229-0.0029029190.99709713
ENST00000548847ENST00000541220SLC25A3chr1298987913+EZH2chr7148511229-0.0029029190.99709713
ENST00000548847ENST00000476773SLC25A3chr1298987913+EZH2chr7148511229-0.0033794730.99662054
ENST00000548847ENST00000483967SLC25A3chr1298987913+EZH2chr7148511229-0.0039510040.996049

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>82679_82679_1_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000188376_EZH2_chr7_148511229_ENST00000320356_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_2_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000188376_EZH2_chr7_148511229_ENST00000350995_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_3_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000188376_EZH2_chr7_148511229_ENST00000460911_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_4_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000188376_EZH2_chr7_148511229_ENST00000476773_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_5_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000188376_EZH2_chr7_148511229_ENST00000478654_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_6_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000188376_EZH2_chr7_148511229_ENST00000483967_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_7_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000188376_EZH2_chr7_148511229_ENST00000541220_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_8_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000228318_EZH2_chr7_148511229_ENST00000320356_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_9_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000228318_EZH2_chr7_148511229_ENST00000350995_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_10_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000228318_EZH2_chr7_148511229_ENST00000460911_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_11_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000228318_EZH2_chr7_148511229_ENST00000476773_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_12_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000228318_EZH2_chr7_148511229_ENST00000478654_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_13_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000228318_EZH2_chr7_148511229_ENST00000483967_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_14_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000228318_EZH2_chr7_148511229_ENST00000541220_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_15_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000401722_EZH2_chr7_148511229_ENST00000320356_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_16_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000401722_EZH2_chr7_148511229_ENST00000350995_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_17_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000401722_EZH2_chr7_148511229_ENST00000460911_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_18_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000401722_EZH2_chr7_148511229_ENST00000476773_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_19_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000401722_EZH2_chr7_148511229_ENST00000478654_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_20_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000401722_EZH2_chr7_148511229_ENST00000483967_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_21_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000401722_EZH2_chr7_148511229_ENST00000541220_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_22_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000547534_EZH2_chr7_148511229_ENST00000320356_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_23_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000547534_EZH2_chr7_148511229_ENST00000350995_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_24_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000547534_EZH2_chr7_148511229_ENST00000460911_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_25_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000547534_EZH2_chr7_148511229_ENST00000476773_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_26_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000547534_EZH2_chr7_148511229_ENST00000478654_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_27_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000547534_EZH2_chr7_148511229_ENST00000483967_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_28_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000547534_EZH2_chr7_148511229_ENST00000541220_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

--------------------------------------------------------------

>82679_82679_29_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000548847_EZH2_chr7_148511229_ENST00000320356_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_30_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000548847_EZH2_chr7_148511229_ENST00000350995_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_31_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000548847_EZH2_chr7_148511229_ENST00000460911_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_32_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000548847_EZH2_chr7_148511229_ENST00000476773_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_33_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000548847_EZH2_chr7_148511229_ENST00000478654_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_34_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000548847_EZH2_chr7_148511229_ENST00000483967_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_35_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000548847_EZH2_chr7_148511229_ENST00000541220_length(amino acids)=318AA_BP=123
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQR
GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAK

--------------------------------------------------------------

>82679_82679_36_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000549338_EZH2_chr7_148511229_ENST00000320356_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_37_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000549338_EZH2_chr7_148511229_ENST00000350995_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_38_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000549338_EZH2_chr7_148511229_ENST00000460911_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_39_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000549338_EZH2_chr7_148511229_ENST00000476773_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_40_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000549338_EZH2_chr7_148511229_ENST00000478654_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_41_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000549338_EZH2_chr7_148511229_ENST00000483967_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_42_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000549338_EZH2_chr7_148511229_ENST00000541220_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_43_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000551917_EZH2_chr7_148511229_ENST00000320356_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_44_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000551917_EZH2_chr7_148511229_ENST00000350995_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_45_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000551917_EZH2_chr7_148511229_ENST00000460911_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_46_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000551917_EZH2_chr7_148511229_ENST00000476773_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_47_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000551917_EZH2_chr7_148511229_ENST00000478654_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

--------------------------------------------------------------

>82679_82679_48_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000551917_EZH2_chr7_148511229_ENST00000483967_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

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>82679_82679_49_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000551917_EZH2_chr7_148511229_ENST00000541220_length(amino acids)=246AA_BP=51
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGA
ADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK

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>82679_82679_50_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000552981_EZH2_chr7_148511229_ENST00000320356_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

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>82679_82679_51_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000552981_EZH2_chr7_148511229_ENST00000350995_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

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>82679_82679_52_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000552981_EZH2_chr7_148511229_ENST00000460911_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

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>82679_82679_53_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000552981_EZH2_chr7_148511229_ENST00000476773_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

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>82679_82679_54_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000552981_EZH2_chr7_148511229_ENST00000478654_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

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>82679_82679_55_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000552981_EZH2_chr7_148511229_ENST00000483967_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

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>82679_82679_56_SLC25A3-EZH2_SLC25A3_chr12_98987913_ENST00000552981_EZH2_chr7_148511229_ENST00000541220_length(amino acids)=255AA_BP=60
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEGQNRFPGCRCKAQCNTKQCPCYLAVRECD
PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNN

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:98987913/chr7:148511229)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EZH2

Q15910

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30923826}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEZH2chr12:98987913chr7:148511229ENST000003509951219523_605513.3333333333334708.0Compositional biasNote=Cys-rich
TgeneEZH2chr12:98987913chr7:148511229ENST000004767731219523_605501.3333333333333696.0Compositional biasNote=Cys-rich
TgeneEZH2chr12:98987913chr7:148511229ENST000004786541320523_605501.3333333333333696.0Compositional biasNote=Cys-rich
TgeneEZH2chr12:98987913chr7:148511229ENST000005412201219523_605501.3333333333333696.0Compositional biasNote=Cys-rich
TgeneEZH2chr12:98987913chr7:148511229ENST000003203561320612_727557.3333333333334752.0DomainSET
TgeneEZH2chr12:98987913chr7:148511229ENST000003509951219612_727513.3333333333334708.0DomainSET
TgeneEZH2chr12:98987913chr7:148511229ENST000004609111320612_727552.3333333333334747.0DomainSET
TgeneEZH2chr12:98987913chr7:148511229ENST000004767731219503_605501.3333333333333696.0DomainCXC
TgeneEZH2chr12:98987913chr7:148511229ENST000004767731219612_727501.3333333333333696.0DomainSET
TgeneEZH2chr12:98987913chr7:148511229ENST000004786541320503_605501.3333333333333696.0DomainCXC
TgeneEZH2chr12:98987913chr7:148511229ENST000004786541320612_727501.3333333333333696.0DomainSET
TgeneEZH2chr12:98987913chr7:148511229ENST000004839671320612_727543.3333333333334738.0DomainSET
TgeneEZH2chr12:98987913chr7:148511229ENST000005412201219503_605501.3333333333333696.0DomainCXC
TgeneEZH2chr12:98987913chr7:148511229ENST000005412201219612_727501.3333333333333696.0DomainSET

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17160_24452.333333333333336362.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17261_33952.333333333333336362.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+1763_14752.333333333333336362.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28160_24452.333333333333336363.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28261_33952.333333333333336363.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+2863_14752.333333333333336363.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28160_24452.333333333333336362.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28261_33952.333333333333336362.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+2863_14752.333333333333336362.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28160_24452.333333333333336362.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28261_33952.333333333333336362.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+2863_14752.333333333333336362.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28160_24452.333333333333336363.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28261_33952.333333333333336363.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+2863_14752.333333333333336363.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28160_24452.333333333333336362.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28261_33952.333333333333336362.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+2863_14752.333333333333336362.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17142_16152.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17184_21852.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17239_26152.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17285_31452.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17334_36252.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+1750_6352.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+1787_12152.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28142_16152.333333333333336363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28184_21852.333333333333336363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28239_26152.333333333333336363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28285_31452.333333333333336363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28334_36252.333333333333336363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+2850_6352.333333333333336363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+2887_12152.333333333333336363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28142_16152.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28184_21852.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28239_26152.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28285_31452.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28334_36252.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+2850_6352.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+2887_12152.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28142_16152.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28184_21852.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28239_26152.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28285_31452.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28334_36252.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+2850_6352.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+2887_12152.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28142_16152.333333333333336363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28184_21852.333333333333336363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28239_26152.333333333333336363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28285_31452.333333333333336363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28334_36252.333333333333336363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+2850_6352.333333333333336363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+2887_12152.333333333333336363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28142_16152.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28184_21852.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28239_26152.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28285_31452.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28334_36252.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+2850_6352.333333333333336362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+2887_12152.333333333333336362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17122_14152.333333333333336362.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17162_18352.333333333333336362.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17219_23852.333333333333336362.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17262_28452.333333333333336362.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+17315_33352.333333333333336362.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000188376+1764_8652.333333333333336362.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28122_14152.333333333333336363.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28162_18352.333333333333336363.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28219_23852.333333333333336363.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28262_28452.333333333333336363.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+28315_33352.333333333333336363.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000228318+2864_8652.333333333333336363.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28122_14152.333333333333336362.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28162_18352.333333333333336362.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28219_23852.333333333333336362.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28262_28452.333333333333336362.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+28315_33352.333333333333336362.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000401722+2864_8652.333333333333336362.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28122_14152.333333333333336362.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28162_18352.333333333333336362.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28219_23852.333333333333336362.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28262_28452.333333333333336362.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+28315_33352.333333333333336362.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000549338+2864_8652.333333333333336362.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28122_14152.333333333333336363.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28162_18352.333333333333336363.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28219_23852.333333333333336363.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28262_28452.333333333333336363.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+28315_33352.333333333333336363.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000551917+2864_8652.333333333333336363.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28122_14152.333333333333336362.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28162_18352.333333333333336362.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28219_23852.333333333333336362.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28262_28452.333333333333336362.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+28315_33352.333333333333336362.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A3chr12:98987913chr7:148511229ENST00000552981+2864_8652.333333333333336362.0TransmembraneHelical%3B Name%3D1
TgeneEZH2chr12:98987913chr7:148511229ENST000003203561320523_605557.3333333333334752.0Compositional biasNote=Cys-rich
TgeneEZH2chr12:98987913chr7:148511229ENST000004609111320523_605552.3333333333334747.0Compositional biasNote=Cys-rich
TgeneEZH2chr12:98987913chr7:148511229ENST000004839671320523_605543.3333333333334738.0Compositional biasNote=Cys-rich
TgeneEZH2chr12:98987913chr7:148511229ENST000003203561320503_605557.3333333333334752.0DomainCXC
TgeneEZH2chr12:98987913chr7:148511229ENST000003509951219503_605513.3333333333334708.0DomainCXC
TgeneEZH2chr12:98987913chr7:148511229ENST000004609111320503_605552.3333333333334747.0DomainCXC
TgeneEZH2chr12:98987913chr7:148511229ENST000004839671320503_605543.3333333333334738.0DomainCXC


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLC25A3
EZH2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneEZH2chr12:98987913chr7:148511229ENST000003203561320329_522557.3333333333334752.0CDYL
TgeneEZH2chr12:98987913chr7:148511229ENST000003509951219329_522513.3333333333334708.0CDYL
TgeneEZH2chr12:98987913chr7:148511229ENST000004609111320329_522552.3333333333334747.0CDYL
TgeneEZH2chr12:98987913chr7:148511229ENST000004767731219329_522501.3333333333333696.0CDYL
TgeneEZH2chr12:98987913chr7:148511229ENST000004786541320329_522501.3333333333333696.0CDYL
TgeneEZH2chr12:98987913chr7:148511229ENST000004839671320329_522543.3333333333334738.0CDYL
TgeneEZH2chr12:98987913chr7:148511229ENST000005412201219329_522501.3333333333333696.0CDYL
TgeneEZH2chr12:98987913chr7:148511229ENST0000032035613201_340557.3333333333334752.0DNMT1%2C DNMT3A and DNMT3B
TgeneEZH2chr12:98987913chr7:148511229ENST0000035099512191_340513.3333333333334708.0DNMT1%2C DNMT3A and DNMT3B
TgeneEZH2chr12:98987913chr7:148511229ENST0000046091113201_340552.3333333333334747.0DNMT1%2C DNMT3A and DNMT3B
TgeneEZH2chr12:98987913chr7:148511229ENST0000047677312191_340501.3333333333333696.0DNMT1%2C DNMT3A and DNMT3B
TgeneEZH2chr12:98987913chr7:148511229ENST0000047865413201_340501.3333333333333696.0DNMT1%2C DNMT3A and DNMT3B
TgeneEZH2chr12:98987913chr7:148511229ENST0000048396713201_340543.3333333333334738.0DNMT1%2C DNMT3A and DNMT3B
TgeneEZH2chr12:98987913chr7:148511229ENST0000054122012191_340501.3333333333333696.0DNMT1%2C DNMT3A and DNMT3B
TgeneEZH2chr12:98987913chr7:148511229ENST00000320356132039_68557.3333333333334752.0EED
TgeneEZH2chr12:98987913chr7:148511229ENST00000350995121939_68513.3333333333334708.0EED
TgeneEZH2chr12:98987913chr7:148511229ENST00000460911132039_68552.3333333333334747.0EED
TgeneEZH2chr12:98987913chr7:148511229ENST00000476773121939_68501.3333333333333696.0EED
TgeneEZH2chr12:98987913chr7:148511229ENST00000478654132039_68501.3333333333333696.0EED
TgeneEZH2chr12:98987913chr7:148511229ENST00000483967132039_68543.3333333333334738.0EED
TgeneEZH2chr12:98987913chr7:148511229ENST00000541220121939_68501.3333333333333696.0EED


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Related Drugs to SLC25A3-EZH2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC25A3-EZH2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource