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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLC26A6-PRKAR2A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC26A6-PRKAR2A
FusionPDB ID: 82762
FusionGDB2.0 ID: 82762
HgeneTgene
Gene symbol

SLC26A6

PRKAR2A

Gene ID

65010

5576

Gene namesolute carrier family 26 member 6protein kinase cAMP-dependent type II regulatory subunit alpha
Synonyms-PKR2|PRKAR2
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 26 member 6anion exchange transporteranion transporter 1pendrin L1solute carrier family 26 (anion exchanger), member 6sulfate anion transportercAMP-dependent protein kinase type II-alpha regulatory subunitcAMP-dependent protein kinase regulatory subunit RII alphaprotein kinase A, RII-alpha subunitprotein kinase, cAMP-dependent, regulatory subunit type II alpha
Modification date2020032920200313
UniProtAcc

Q9BXS9

P13861

Ensembl transtripts involved in fusion geneENST idsENST00000337000, ENST00000358747, 
ENST00000383733, ENST00000395550, 
ENST00000420764, ENST00000455886, 
ENST00000482282, 		ENST00000265563, 
ENST00000296446, ENST00000454963, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 2=810 X 10 X 7=700
# samples 215
** MAII scorelog2(2/8*10)=1.32192809488736log2(15/700*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLC26A6 [Title/Abstract] AND PRKAR2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC26A6

GO:0071346

cellular response to interferon-gamma

18655181

TgenePRKAR2A

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984


check buttonFusion gene breakpoints across SLC26A6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PRKAR2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..SLC26A6chr3

48664308

-PRKAR2Achr3

48828060

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000420764SLC26A6chr348664308-ENST00000265563PRKAR2Achr348828060-80302160813023980
ENST00000420764SLC26A6chr348664308-ENST00000454963PRKAR2Achr348828060-34502160813023980
ENST00000420764SLC26A6chr348664308-ENST00000296446PRKAR2Achr348828060-48952160812957958
ENST00000358747SLC26A6chr348664308-ENST00000265563PRKAR2Achr348828060-813122612303124964
ENST00000358747SLC26A6chr348664308-ENST00000454963PRKAR2Achr348828060-355122612303124964
ENST00000358747SLC26A6chr348664308-ENST00000296446PRKAR2Achr348828060-499622612303058942
ENST00000395550SLC26A6chr348664308-ENST00000265563PRKAR2Achr348828060-79912121392984981
ENST00000395550SLC26A6chr348664308-ENST00000454963PRKAR2Achr348828060-34112121392984981
ENST00000395550SLC26A6chr348664308-ENST00000296446PRKAR2Achr348828060-48562121392918959
ENST00000383733SLC26A6chr348664308-ENST00000265563PRKAR2Achr348828060-79472077522940962
ENST00000383733SLC26A6chr348664308-ENST00000454963PRKAR2Achr348828060-33672077522940962
ENST00000383733SLC26A6chr348664308-ENST00000296446PRKAR2Achr348828060-48122077522874940
ENST00000337000SLC26A6chr348664308-ENST00000265563PRKAR2Achr348828060-77191849912712873
ENST00000337000SLC26A6chr348664308-ENST00000454963PRKAR2Achr348828060-31391849912712873
ENST00000337000SLC26A6chr348664308-ENST00000296446PRKAR2Achr348828060-45841849912646851
ENST00000455886SLC26A6chr348664308-ENST00000265563PRKAR2Achr348828060-78832013392876945
ENST00000455886SLC26A6chr348664308-ENST00000454963PRKAR2Achr348828060-33032013392876945
ENST00000455886SLC26A6chr348664308-ENST00000296446PRKAR2Achr348828060-47482013392810923

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>82762_82762_1_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000337000_PRKAR2A_chr3_48828060_ENST00000265563_length(amino acids)=873AA_BP=586
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLN
DKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRV
DSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMR
SLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANA
EFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATAN
GQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVK
ADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKM
FESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELAL

--------------------------------------------------------------

>82762_82762_2_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000337000_PRKAR2A_chr3_48828060_ENST00000296446_length(amino acids)=851AA_BP=586
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLN
DKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRV
DSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMR
SLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANA
EFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATAN
GQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVK
ADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKM
FESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMD

--------------------------------------------------------------

>82762_82762_3_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000337000_PRKAR2A_chr3_48828060_ENST00000454963_length(amino acids)=873AA_BP=586
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLN
DKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRV
DSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMR
SLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANA
EFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATAN
GQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVK
ADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKM
FESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELAL

--------------------------------------------------------------

>82762_82762_4_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000358747_PRKAR2A_chr3_48828060_ENST00000265563_length(amino acids)=964AA_BP=677
MLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQ
LPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLF
QVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLN
DKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRV
DSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMR
SLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANA
EFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATA
NGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIV
KADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRK
MFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELA

--------------------------------------------------------------

>82762_82762_5_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000358747_PRKAR2A_chr3_48828060_ENST00000296446_length(amino acids)=942AA_BP=677
MLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQ
LPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLF
QVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLN
DKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRV
DSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMR
SLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANA
EFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATA
NGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIV
KADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRK
MFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVM

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>82762_82762_6_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000358747_PRKAR2A_chr3_48828060_ENST00000454963_length(amino acids)=964AA_BP=677
MLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQ
LPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLF
QVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLN
DKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRV
DSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMR
SLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANA
EFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATA
NGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIV
KADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRK
MFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELA

--------------------------------------------------------------

>82762_82762_7_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000383733_PRKAR2A_chr3_48828060_ENST00000265563_length(amino acids)=962AA_BP=675
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARD
AARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTV
VTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFA
IAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEV
RGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAGPLLSACLAPQQVSSGDKMEDATANG
QEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKA
DEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMF
ESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALV

--------------------------------------------------------------

>82762_82762_8_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000383733_PRKAR2A_chr3_48828060_ENST00000296446_length(amino acids)=940AA_BP=675
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARD
AARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTV
VTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFA
IAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEV
RGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAGPLLSACLAPQQVSSGDKMEDATANG
QEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKA
DEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMF
ESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDV

--------------------------------------------------------------

>82762_82762_9_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000383733_PRKAR2A_chr3_48828060_ENST00000454963_length(amino acids)=962AA_BP=675
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARD
AARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTV
VTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFA
IAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEV
RGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAGPLLSACLAPQQVSSGDKMEDATANG
QEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKA
DEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMF
ESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALV

--------------------------------------------------------------

>82762_82762_10_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000395550_PRKAR2A_chr3_48828060_ENST00000265563_length(amino acids)=981AA_BP=694
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARD
AARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTV
VTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFA
IAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEV
RGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVED
CKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNL
DQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLD
RVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQ

--------------------------------------------------------------

>82762_82762_11_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000395550_PRKAR2A_chr3_48828060_ENST00000296446_length(amino acids)=959AA_BP=694
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARD
AARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTV
VTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFA
IAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEV
RGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVED
CKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNL
DQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLD
RVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQTKSNKDGGNQEVEIARCHKGQYFGELALVTNK

--------------------------------------------------------------

>82762_82762_12_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000395550_PRKAR2A_chr3_48828060_ENST00000454963_length(amino acids)=981AA_BP=694
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARD
AARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTV
VTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFA
IAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEV
RGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVED
CKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNL
DQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLD
RVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQ

--------------------------------------------------------------

>82762_82762_13_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000420764_PRKAR2A_chr3_48828060_ENST00000265563_length(amino acids)=980AA_BP=693
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARD
AARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTV
VTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFA
IAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEV
RGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVED
CKMMVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLD
QEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDR
VTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQE

--------------------------------------------------------------

>82762_82762_14_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000420764_PRKAR2A_chr3_48828060_ENST00000296446_length(amino acids)=958AA_BP=693
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARD
AARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTV
VTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFA
IAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEV
RGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVED
CKMMVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLD
QEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDR
VTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQTKSNKDGGNQEVEIARCHKGQYFGELALVTNKP

--------------------------------------------------------------

>82762_82762_15_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000420764_PRKAR2A_chr3_48828060_ENST00000454963_length(amino acids)=980AA_BP=693
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARD
AARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTV
VTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFA
IAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEV
RGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVED
CKMMVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLD
QEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDR
VTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQE

--------------------------------------------------------------

>82762_82762_16_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000455886_PRKAR2A_chr3_48828060_ENST00000265563_length(amino acids)=945AA_BP=658
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVATPGPLPLLTAPGRPTGGAGPDPLRLRGHLPVR
TSCPRLYHSCSCAGLRLTAQVCVWPPSEQPLWATVPHLLLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLI
GATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIF
QCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTA
TILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLI
SQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGL
PQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVI
ERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSE
RMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKC

--------------------------------------------------------------

>82762_82762_17_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000455886_PRKAR2A_chr3_48828060_ENST00000296446_length(amino acids)=923AA_BP=658
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVATPGPLPLLTAPGRPTGGAGPDPLRLRGHLPVR
TSCPRLYHSCSCAGLRLTAQVCVWPPSEQPLWATVPHLLLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLI
GATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIF
QCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTA
TILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLI
SQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGL
PQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVI
ERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSE
RMKIVDVIGEKIYKDGERIITQTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRN

--------------------------------------------------------------

>82762_82762_18_SLC26A6-PRKAR2A_SLC26A6_chr3_48664308_ENST00000455886_PRKAR2A_chr3_48828060_ENST00000454963_length(amino acids)=945AA_BP=658
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVR
DWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVATPGPLPLLTAPGRPTGGAGPDPLRLRGHLPVR
TSCPRLYHSCSCAGLRLTAQVCVWPPSEQPLWATVPHLLLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLI
GATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIF
QCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTA
TILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLI
SQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGL
PQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVI
ERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSE
RMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKC

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:/chr3:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC26A6

Q9BXS9

PRKAR2A

P13861

FUNCTION: Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.; FUNCTION: [Isoform 4]: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (676) >>>676.pdbFusion protein BP residue: 586
CIF file (676) >>>676.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRW
GSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSG
LSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVVLE
VCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIG
ATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVV
GFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSR
SLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLK
GMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLV
VVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANA
EFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASP
KGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDG
STLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQ
EACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIER
GTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWG
LDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKI
YKDGERIITQTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYA
VGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLG
851
3D view using mol* of 676 (AA BP:586)
PDB file (692) >>>692.pdbFusion protein BP residue: 586
CIF file (692) >>>692.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRW
GSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSG
LSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVVLE
VCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIG
ATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVV
GFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSR
SLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLK
GMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLV
VVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANA
EFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASP
KGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDG
STLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQ
EACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIER
GTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWG
LDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKI
YKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCH
KGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRN
873
3D view using mol* of 692 (AA BP:586)
PDB file (710) >>>710.pdbFusion protein BP residue: 658
CIF file (710) >>>710.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRW
GSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSG
LSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVATP
GPLPLLTAPGRPTGGAGPDPLRLRGHLPVRTSCPRLYHSCSCAGLRLTAQ
VCVWPPSEQPLWATVPHLLLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLL
NDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPP
VAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVAL
GLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKL
GELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTA
TILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSE
AKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQ
EQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQV
SSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDT
VCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERI
VKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGEL
ALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESV
PLLKSLEVSERMKIVDVIGEKIYKDGERIITQTKSNKDGGNQEVEIARCH
KGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRN
923
3D view using mol* of 710 (AA BP:658)
PDB file (723) >>>723.pdbFusion protein BP residue: 675
CIF file (723) >>>723.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRW
GSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSG
LSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTF
AVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVG
LGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLS
LIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPG
ELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGS
AFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFP
VSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAV
IFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSA
TVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKL
RKQAGPLLSACLAPQQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQP
DFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKN
LDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDN
QTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIV
KNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQT
KSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDV
940
3D view using mol* of 723 (AA BP:675)
PDB file (724) >>>724.pdbFusion protein BP residue: 677
CIF file (724) >>>724.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSR
ARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALL
AGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ
ALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPL
VRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKV
GTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGL
KHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGK
IFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGN
SQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMR
SLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYS
VLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQR
CGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVN
TSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLP
QPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLF
KNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTK
DNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRI
IVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIIT
QTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVM
942
3D view using mol* of 724 (AA BP:677)
PDB file (725) >>>725.pdbFusion protein BP residue: 658
CIF file (725) >>>725.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRW
GSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSG
LSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVATP
GPLPLLTAPGRPTGGAGPDPLRLRGHLPVRTSCPRLYHSCSCAGLRLTAQ
VCVWPPSEQPLWATVPHLLLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLL
NDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPP
VAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVAL
GLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKL
GELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTA
TILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSE
AKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQ
EQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQV
SSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDT
VCLKSLKNVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERI
VKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGEL
ALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESV
PLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSIL
IRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKC
945
3D view using mol* of 725 (AA BP:658)
PDB file (732) >>>732.pdbFusion protein BP residue: 693
CIF file (732) >>>732.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRW
GSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSG
LSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTF
AVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVG
LGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLS
LIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPG
ELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGS
AFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFP
VSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAV
IFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSA
TVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKL
RKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQE
DSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTD
EQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGD
NFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVAT
SEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIV
DVIGEKIYKDGERIITQTKSNKDGGNQEVEIARCHKGQYFGELALVTNKP
RAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSS
958
3D view using mol* of 732 (AA BP:693)
PDB file (734) >>>734.pdbFusion protein BP residue: 694
CIF file (734) >>>734.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRW
GSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSG
LSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTF
AVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVG
LGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLS
LIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPG
ELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGS
AFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFP
VSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAV
IFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSA
TVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKL
RKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQ
EDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKT
DEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDG
DNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVA
TSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKI
VDVIGEKIYKDGERIITQTKSNKDGGNQEVEIARCHKGQYFGELALVTNK
PRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGS
959
3D view using mol* of 734 (AA BP:694)
PDB file (735) >>>735.pdbFusion protein BP residue: 675
CIF file (735) >>>735.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRW
GSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSG
LSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTF
AVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVG
LGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLS
LIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPG
ELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGS
AFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFP
VSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAV
IFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSA
TVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKL
RKQAGPLLSACLAPQQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQP
DFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLFKN
LDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDN
QTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIV
KNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQG
EKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALV
TNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKM
962
3D view using mol* of 735 (AA BP:675)
PDB file (736) >>>736.pdbFusion protein BP residue: 677
CIF file (736) >>>736.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSR
ARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALL
AGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ
ALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPL
VRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKV
GTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGL
KHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGK
IFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGN
SQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMR
SLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYS
VLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQR
CGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVN
TSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLP
QPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTDEQRCRLQEACKDILLF
KNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTK
DNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRI
IVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIIT
QGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELA
LVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLV
964
3D view using mol* of 736 (AA BP:677)
PDB file (743) >>>743.pdbFusion protein BP residue: 693
CIF file (743) >>>743.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRW
GSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSG
LSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTF
AVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVG
LGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLS
LIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPG
ELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGS
AFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFP
VSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAV
IFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSA
TVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKL
RKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQE
DSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKTD
EQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGD
NFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVAT
SEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIV
DVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQE
VEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPC
980
3D view using mol* of 743 (AA BP:693)
PDB file (744) >>>744.pdbFusion protein BP residue: 694
CIF file (744) >>>744.cif		SLC26A6chr348664308-PRKAR2Achr348828060-
MRAMGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRW
GSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSG
LSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTF
AVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVG
LGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLS
LIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPG
ELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGS
AFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFP
VSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA
IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAV
IFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSA
TVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKL
RKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQ
EDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNVIHPKT
DEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDG
DNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVA
TSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKI
VDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQ
EVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGP
981
3D view using mol* of 744 (AA BP:694)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SLC26A6_pLDDT.png
all structure
all structure
PRKAR2A_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SLC26A6_PRKAR2A_676_pLDDT.png (AA BP:586)
all structure
SLC26A6_PRKAR2A_676_pLDDT_and_active_sites.png (AA BP:586)
all structure
SLC26A6_PRKAR2A_676_violinplot.png (AA BP:586)
all structure
SLC26A6_PRKAR2A_692_pLDDT.png (AA BP:586)
all structure
SLC26A6_PRKAR2A_692_pLDDT_and_active_sites.png (AA BP:586)
all structure
SLC26A6_PRKAR2A_692_violinplot.png (AA BP:586)
all structure
SLC26A6_PRKAR2A_710_pLDDT.png (AA BP:658)
all structure
SLC26A6_PRKAR2A_710_pLDDT_and_active_sites.png (AA BP:658)
all structure
SLC26A6_PRKAR2A_710_violinplot.png (AA BP:658)
all structure
SLC26A6_PRKAR2A_723_pLDDT.png (AA BP:675)
all structure
SLC26A6_PRKAR2A_723_pLDDT_and_active_sites.png (AA BP:675)
all structure
SLC26A6_PRKAR2A_723_violinplot.png (AA BP:675)
all structure
SLC26A6_PRKAR2A_724_pLDDT.png (AA BP:677)
all structure
SLC26A6_PRKAR2A_724_pLDDT_and_active_sites.png (AA BP:677)
all structure
SLC26A6_PRKAR2A_724_violinplot.png (AA BP:677)
all structure
SLC26A6_PRKAR2A_725_pLDDT.png (AA BP:658)
all structure
SLC26A6_PRKAR2A_725_pLDDT_and_active_sites.png (AA BP:658)
all structure
SLC26A6_PRKAR2A_725_violinplot.png (AA BP:658)
all structure
SLC26A6_PRKAR2A_732_pLDDT.png (AA BP:693)
all structure
SLC26A6_PRKAR2A_732_pLDDT_and_active_sites.png (AA BP:693)
all structure
SLC26A6_PRKAR2A_732_violinplot.png (AA BP:693)
all structure
SLC26A6_PRKAR2A_734_pLDDT.png (AA BP:694)
all structure
SLC26A6_PRKAR2A_734_pLDDT_and_active_sites.png (AA BP:694)
all structure
SLC26A6_PRKAR2A_734_violinplot.png (AA BP:694)
all structure
SLC26A6_PRKAR2A_735_pLDDT.png (AA BP:675)
all structure
SLC26A6_PRKAR2A_735_pLDDT_and_active_sites.png (AA BP:675)
all structure
SLC26A6_PRKAR2A_735_violinplot.png (AA BP:675)
all structure
SLC26A6_PRKAR2A_736_pLDDT.png (AA BP:677)
all structure
SLC26A6_PRKAR2A_736_pLDDT_and_active_sites.png (AA BP:677)
all structure
SLC26A6_PRKAR2A_736_violinplot.png (AA BP:677)
all structure
SLC26A6_PRKAR2A_743_pLDDT.png (AA BP:693)
all structure
SLC26A6_PRKAR2A_743_pLDDT_and_active_sites.png (AA BP:693)
all structure
SLC26A6_PRKAR2A_743_violinplot.png (AA BP:693)
all structure
SLC26A6_PRKAR2A_744_pLDDT.png (AA BP:694)
all structure
SLC26A6_PRKAR2A_744_pLDDT_and_active_sites.png (AA BP:694)
all structure
SLC26A6_PRKAR2A_744_violinplot.png (AA BP:694)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
SLC26A6_PRKAR2A_676.png
all structure
SLC26A6_PRKAR2A_692.png
all structure
SLC26A6_PRKAR2A_710.png
all structure
SLC26A6_PRKAR2A_723.png
all structure
SLC26A6_PRKAR2A_724.png
all structure
SLC26A6_PRKAR2A_725.png
all structure
SLC26A6_PRKAR2A_732.png
all structure
SLC26A6_PRKAR2A_734.png
all structure
SLC26A6_PRKAR2A_735.png
all structure
SLC26A6_PRKAR2A_736.png
all structure
SLC26A6_PRKAR2A_743.png
all structure
SLC26A6_PRKAR2A_744.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
6761.0822371.152844.1230.6510.7110.8411.120.6581.7030.839Chain A: 106,110,113,114,148,149,150,151,176,177,1
80,181,190,191,192,193,194,230,232,233,237,240,243
,244,245,246,247,248,250,251,252,254,257,258,261,2
62,265,276,279,280,283,284,287,288,290,291,293,295
,296,297,298,299,300,302,303,344,345,348,349,351,3
52,376,380,385,386,389
6921.0563481.0951129.8420.4930.7350.9160.8610.8770.9821.164Chain A: 451,453,454,457,458,461,463,465,468,469,4
72,473,474,476,477,480,549,550,551,553,561,563,566
,568,582,583,584,585,586,587,588,589,590,591,592,5
93,596,597,600,613,614,615,616,617,618,619,621,622
,623,705,708,709,712,713,716,717,720,748,827
7101.0635241.1011297.9120.4490.7460.9531.0740.8791.2220.901Chain A: 789,792,793,796,797,800,802,803,814,818,8
20,821,823,829,830,831,832,833,834,835,840,841,842
,843,844,845,846,847,848,849,850,851,852,853,854,8
55,856,857,858,859,860,862,864,865,866,867,868,869
,870,871,872,873,876,877,878,879,880,881,882,883,8
86,890,904,905,907,908,911,912
7231.0652491.11689.0870.5490.7340.9170.9980.831.2011.081Chain A: 101,102,105,106,110,114,150,151,207,210,2
11,213,215,218,219,222,283,284,285,287,288,291,296
,297,298,299,300,301,359,360,361,363,364,365,367,3
68,379,404,405,406,409,410,454,455,456,457,458,459
,462
7241.0595701.1131558.9350.5010.710.9181.080.7771.390.956Chain A: 811,812,815,816,819,820,821,822,833,837,8
42,848,849,850,851,852,853,854,860,862,863,864,865
,866,867,868,869,870,871,872,873,874,875,876,877,8
78,879,880,881,883,884,885,886,887,888,889,890,891
,892,895,896,897,898,899,900,902,905,906,909,910,9
13,916,920,923,924,926,927,928,930,931,932,933,935
,936,937,940
7251.1295361.189948.7380.4020.791.0541.5510.6912.2431.002Chain A: 76,77,120,124,132,152,153,155,156,157,158
,159,160,170,171,172,173,174,175,176,177,178,179,1
80,181,182,183,185,198,199,202,204,205,206,207,208
,209,211,214,301,302,303,304,307,308,311,314,315,3
18,319,320,322,323,344,345,347,348,350,351,352,354
,355,357,358,361,362,363,364,365,366,455,456,457
7321.066091.10061410.0730.43610.73640.95050.99140.86271.14920.9027Chain A: 717,718,719,720,723,820,823,824,827,828,8
31,832,835,836,837,838,849,853,855,856,858,864,865
,866,867,868,869,870,875,876,877,878,879,880,881,8
82,883,884,885,886,887,888,889,890,891,892,893,894
,895,897,899,900,901,902,903,904,905,906,907,908,9
11,912,913,914,915,916,921,925,939,940,942,943,946
,947
7341.08922321.1351648.270.54420.76450.97051.29220.80871.59780.8115Chain A: 102,105,106,110,114,149,150,151,210,211,2
13,214,215,216,218,219,222,281,283,284,285,287,288
,291,297,298,299,300,301,361,363,364,365,367,368,3
79,403,404,405,406,407,409,410,452,454,455,456,457
,458,459,462
7351.08671111.1098259.3080.52360.80371.01871.09080.95811.13840.7311Chain A: 818,847,866,868,885,886,887,888,892,893,8
94,895,896,897,898,903,904,905,906,907,909,943,946
,947,950,957,960
7361.09622241.1369617.40.49890.78311.00921.39240.83721.66311.3883Chain A: 85,88,89,93,97,133,134,193,194,195,196,19
7,198,199,201,202,205,263,266,267,270,271,279,280,
281,282,283,284,344,346,347,348,350,351,354,387,38
8,389,392,393,435,437,438,439,440,441,442,445
7431.10081371.1217291.8930.45850.82631.0551.17130.96331.2160.7242Chain A: 865,884,886,903,904,910,911,912,913,914,9
15,916,921,922,923,924,925,927,957,958,960,961,962
,964,965,968,973,975
7441.10012131.16586.8730.52880.75250.94141.29490.71021.82331.5022Chain A: 98,101,102,105,106,110,114,150,215,218,21
9,222,283,284,285,287,288,291,296,297,298,299,300,
301,361,364,365,368,404,405,406,407,409,410,413,45
1,452,455,456,457,458,459,462

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
723ZINC000003861768DB00928Azacitidine-7.09537-7.51457
723ZINC000150588351DB11574Elbasvir-6.29391-7.43781
723ZINC000003812862DB00282Pamidronic acid-6.71788-6.82838
723ZINC000000034157DB06707Levonordefrin-6.63214-6.64964
723ZINC000003806262DB00552Pentostatin-6.48068-6.51028
723ZINC000030726187DB00305Mitomycin-6.43075-6.44705
723ZINC000000020259DB00852Pseudoephedrine-6.43504-6.44174
723ZINC000000083315DB00150Tryptophan-6.41239-6.41239
723ZINC000000057624DB00368Norepinephrine-6.3716-6.3891
723ZINC000003872520DB00609Ethionamide-6.31024-6.31114
723ZINC000003803652DB00399Zoledronic acid-5.80199-6.30839
723ZINC000000000128DB00521Carteolol-6.28462-6.28572
723ZINC000019796080DB00450Droperidol-6.09888-6.19728
723ZINC000000004785DB00564Carbamazepine-6.18436-6.18436
723ZINC000003875483DB01192Oxymorphone-6.04035-6.16375
723ZINC000000002101DB00259Sulfanilamide-6.15618-6.15618
723ZINC000000403010DB00598Labetalol-6.12155-6.14915
723ZINC000003830990DB11868Etiracetam-6.13016-6.13016
723ZINC000000074836DB00852Pseudoephedrine-6.07723-6.08393
723ZINC000000968345DB00237Butabarbital-5.99264-6.02844

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000003861768DB00928AzacitidineSmall moleculeNC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1OApproved|Investigational
ZINC000150588351DB11574ElbasvirSmall molecule[H][C@]1(CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C)C1=NC=C(N1)C1=CC2=C(C=C1)N1[C@@H](OC3=C(C=CC(=C3)C3=CN=C(N3)[C@]3([H])CCCN3C(=O)[C@@H](NC(=O)OC)C(C)C)C1=C2)C1=CC=CC=C1Approved
ZINC000003812862DB00282Pamidronic acidSmall moleculeNCCC(O)(P(O)(O)=O)P(O)(O)=OApproved
ZINC000000034157DB06707LevonordefrinSmall moleculeC[C@H](N)[C@H](O)C1=CC(O)=C(O)C=C1Approved
ZINC000003806262DB00552PentostatinSmall moleculeOC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2=C1N=CNC[C@H]2OApproved|Investigational
ZINC000030726187DB00305MitomycinSmall molecule[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=OApproved
ZINC000000020259DB00852PseudoephedrineSmall moleculeCN[C@@H](C)[C@@H](O)C1=CC=CC=C1Approved
ZINC000000083315DB00150TryptophanSmall moleculeN[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=OApproved|Nutraceutical|Withdrawn
ZINC000000057624DB00368NorepinephrineSmall moleculeNC[C@H](O)C1=CC(O)=C(O)C=C1Approved
ZINC000003872520DB00609EthionamideSmall moleculeCCC1=NC=CC(=C1)C(N)=SApproved
ZINC000003803652DB00399Zoledronic acidSmall moleculeOC(CN1C=CN=C1)(P(O)(O)=O)P(O)(O)=OApproved
ZINC000019796080DB00450DroperidolSmall moleculeFC1=CC=C(C=C1)C(=O)CCCN1CCC(=CC1)N1C(=O)NC2=CC=CC=C12Approved|Vet_approved
ZINC000000004785DB00564CarbamazepineSmall moleculeNC(=O)N1C2=CC=CC=C2C=CC2=CC=CC=C12Approved|Investigational
ZINC000003875483DB01192OxymorphoneSmall molecule[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1(O)CCC2=OApproved|Investigational|Vet_approved
ZINC000000002101DB00259SulfanilamideSmall moleculeNC1=CC=C(C=C1)S(N)(=O)=OApproved
ZINC000003830990DB11868EtiracetamSmall moleculeCCC(N1CCCC1=O)C(N)=OInvestigational

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000003861768244.2077.104434.888110.158287.61337.1170717.082510.89.386236.48901
ZINC000003861768244.2078.996434.766110.132287.56937.0650716.913510.89.305236.49601
ZINC000003861768244.2076.643431.18393.993304.89532.2940718.65511.89.707231.37201
ZINC000150588351882.036.5721345.74717.517186.345441.87802635.9722.513.258.001168.97331
ZINC000150588351882.0315.5811298.014670.728196.39430.89602598.6552.513.258.107165.89131
ZINC000150588351882.037.6941389.327750.107173.462465.75802673.8482.513.258.124173.08531
ZINC000150588351882.032.2191373.023721.483195.055456.48502655.1922.513.258.091168.49731
ZINC000150588351882.0313.7611347.364706.26205.501435.60302635.2572.513.258.253164.82431
ZINC000150588351882.036.9221403.807740.212182.531481.06402678.7442.513.258.307171.99131
ZINC000150588351882.0313.991367.982729.766188.685449.53102678.6732.513.257.973170.20832
ZINC000150588351882.0310.6561391.126719.587194.166477.37302673.6242.513.257.937169.24432
ZINC000150588351882.038.2331375.056718.117197.908459.03202655.632.513.257.962167.78732
ZINC000003812862235.079.08382.84949.638327.04906.162620.9837.759.111011
ZINC000003812862235.0711.837382.22754.693321.34806.185620.45137.759.0751011
ZINC000003812862235.074.081379.43356.179318.68404.57620.40637.759.2241011
ZINC000000034157183.2071.584399.847106.772186.848106.2270646.19954.28.948252.10900
ZINC000000034157183.2072.284398.836105.841186.106106.8890643.15454.28.781252.1900
ZINC000003806262268.2721.452502.362225.071237.12940.1620835.80349.88.337251.84800
ZINC000003806262268.2721.378469.669223.737214.90231.030809.61749.88.34256.16400
ZINC000030726187334.3312.852540.096256.014270.3913.6930959.0954.59.258.591238.61601
ZINC000030726187334.3312.798552.957260.241282.58210.1340973.0374.59.258.637236.4601
ZINC000000020259165.2351.645408.608167.77458.787182.0460662.69723.29.158384.99100
ZINC000000020259165.2351.679405.001165.63758.444180.9210657.17623.29.01384.84600
ZINC000000083315204.2283.132419.18346.221166.648206.3140687.589438.088242.50601
ZINC000000057624169.183.43375.22557.715204.72112.790592.16854.28.952246.79100
ZINC000000057624169.182.409366.47858.999201.357106.1220584.36954.28.77247.30600
ZINC000003872520166.245.779389.783134.31876.164107.12372.178612.111238.839393.10100
ZINC000003803652272.0916.149414.00425.436272.399109.4776.692698.61218.759.817123.48901
ZINC000003803652272.09110.346412.62622.493273.968109.2846.881697.13318.758.891123.12401
ZINC000003803652272.0912.82416.54522.709279.09108.4066.34697.54618.759.904121.99201
ZINC000003803652272.09111.882412.71124.614274.426108.4675.205696.7418.759.026122.96801
ZINC000003803652272.09112.418410.05122.071274.507110.8272.646702.50318.758.712123.16601
ZINC000003803652272.09112.445414.59323.463272.373114.5554.201705.32118.758.718123.72201
ZINC000000000128292.3774.66613.187358.288126.208128.69101045.95535.958.97376.8900
ZINC000019796080379.4335.336690.754177.289126.948339.68946.8281214.622168.72386.62500
ZINC000019796080379.4334.227703.161188.25122.749345.33746.8251231.012168.619387.34500
ZINC000019796080379.4336.26700.949186.412123.449344.26346.8251227.254168.598387.21500
ZINC000000004785236.2735.721457.28142.02490.922324.3350775.951228.78392.06300
ZINC000003875483301.3416.252474.627273.939118.70181.9870869.22526.258.885372.76800
ZINC000003875483301.3416.106480.915270.516128.91481.4850871.80726.258.923370.65500
ZINC000003875483301.3416.81472.187275.203114.63582.3490866.28726.258.831373.53600
ZINC000003875483301.3415.608473.205273.703117.22582.2760866.47926.258.661372.99100
ZINC000003875483301.3415.436479.799270.477127.4881.8420870.30126.258.708370.91300
ZINC000000002101172.2019.742353.0650202.93148.4961.639544.9093.55.58.855259.28100
ZINC000000403010328.415.633665.048169.772199.786295.4901141.27145.459.068270.57200
ZINC000000403010328.418.153662.671168.348200.011294.31201140.63345.459.267270.52100
ZINC000003830990170.2113.555386.854254.13132.72300627.85525.59.607259.07500
ZINC000000074836165.2352.775408.33170.31654.398183.6150661.14123.29.127385.88300
ZINC000000074836165.2351.02391.157161.33655.786174.0360642.49923.29.026384.83300
ZINC000000968345212.2481.064393.06261.431131.62900685.8462410.898385.55300
ZINC000000968345212.2481.015390.421261.219129.20100681.7872410.865385.94200
ZINC000000968345212.2480.957390.147261.047129.100682.6422410.865385.98800


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000003861768Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n10.0680571610.388956815
ZINC000150588351COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc3c(c2)O[C@@H](c2ccccc2)n2c-3cc3cc(-c4c[nH]c([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)n4)ccc32)c[nH]1)C(C)C0.0158759170.217012798
ZINC000003812862NCCC(O)(P(=O)(O)O)P(=O)(O)O0.0953442180.466020225
ZINC000000034157C[C@H](N)[C@H](O)c1ccc(O)c(O)c10.1350791920.302260037
ZINC000003806262OC[C@H]1O[C@@H](n2cnc3c2N=CNC[C@H]3O)C[C@@H]1O0.0242366470.504660299
ZINC000030726187CO[C@@]12[C@H](COC(N)=O)C3=C(C(=O)C(C)=C(N)C3=O)N1C[C@@H]1N[C@@H]120.0273154510.442185166
ZINC000000020259CN[C@@H](C)[C@@H](O)c1ccccc10.2085878950.312560893
ZINC000000083315N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O0.2723590650.412747788
ZINC000000057624NC[C@H](O)c1ccc(O)c(O)c10.187147430.309816979
ZINC000003872520CCc1cc(C(N)=S)ccn10.2860968320.394963295
ZINC000003803652O=P(O)(O)C(O)(Cn1ccnc1)P(=O)(O)O0.1000522680.353941778
ZINC000000000128CC(C)(C)NC[C@@H](O)COc1cccc2c1CCC(=O)N20.153216480.156424777
ZINC000019796080O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc10.2197276360.259906112
ZINC000000004785NC(=O)N1c2ccccc2C=Cc2ccccc210.2837256930.438255638
ZINC000003875483CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C50.0168747910.36608679
ZINC000000002101Nc1ccc(S(N)(=O)=O)cc10.4993528860.415012135
ZINC000000403010C[C@@H](CCc1ccccc1)NC[C@H](O)c1ccc(O)c(C(N)=O)c10.1638887930.349082082
ZINC000003830990CC[C@H](C(N)=O)N1CCCC1=O0.1573358610.410047131
ZINC000000074836CN[C@@H](C)[C@H](O)c1ccccc10.2085878950.312560893
ZINC000000968345CC[C@H](C)C1(CC)C(=O)NC(=O)NC1=O0.0922144390.461001225


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SLC26A6LGALS9C, NT5E, FLOT2, ENPP6, FAF2, IRGC, VAC14, PPP6R2, ATP2B2, SLC15A1, P2RX2, PMEL, LRP1, TMCO3, CD79A, PDCD1, TNFSF8, HRAS, KRAS, TF, BET1, CD81, PLP1, APOL2, TMEM128, C14orf1, AQP2, C2orf82, TMEM201, LAT, SLC26A6, RAN, M, nsp4, ORF7b, S, LDLR, TP53, ARF6, LAMP3, RAB35, RHOB, TSPAN10, SLC25A46, PKNOX2, SLC26A2, LPCAT3, SLC6A8, LMBRD2, ABHD17B, MFSD12, ARL8B, SCPEP1, PTPLB, ND1, ARHGDIB, MTX1, TNFRSF10C, LGALS3, ABCB8, PXMP2, ORMDL2, SLC7A3, SLC25A17, KRTCAP2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLC26A6all structure
PRKAR2Aall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SLC26A6-PRKAR2A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC26A6-PRKAR2A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC26A6C2239176Liver carcinoma1CTD_human