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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP9A-MACROD2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP9A-MACROD2
FusionPDB ID: 8283
FusionGDB2.0 ID: 8283
HgeneTgene
Gene symbol

ATP9A

MACROD2

Gene ID

10079

140733

Gene nameATPase phospholipid transporting 9A (putative)mono-ADP ribosylhydrolase 2
SynonymsATPIIAC20orf133|C2orf133
Cytomap

20q13.2

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IIAATPase type IV, phospholipid-transporting (P-type),(putative)ATPase, class II, type 9Aphospholipid-transporting ATPase IIAADP-ribose glycohydrolase MACROD2MACRO domain containing 2MACRO domain-containing protein 2O-acetyl-ADP-ribose deacetylase MACROD2[Protein ADP-ribosylaspartate] hydrolase MACROD2[Protein ADP-ribosylglutamate] hydrolase[Protein ADP-ribosylglutamate]
Modification date2020031320200313
UniProtAcc

O75110

A1Z1Q3

Ensembl transtripts involved in fusion geneENST idsENST00000311637, ENST00000338821, 
ENST00000402822, ENST00000477492, 
ENST00000402914, ENST00000378058, 
ENST00000407045, ENST00000464883, 
ENST00000217246, ENST00000310348, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 13 X 10=195037 X 34 X 11=13838
# samples 1641
** MAII scorelog2(16/1950*10)=-3.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/13838*10)=-5.07686772601114
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP9A [Title/Abstract] AND MACROD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP9A(50244139)-MACROD2(15843390), # samples:1
ATP9A(50255882)-MACROD2(15843390), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP9A-MACROD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP9A-MACROD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP9A-MACROD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP9A-MACROD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMACROD2

GO:0042278

purine nucleoside metabolic process

21257746

TgeneMACROD2

GO:0051725

protein de-ADP-ribosylation

23474712


check buttonFusion gene breakpoints across ATP9A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MACROD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-8280-01AATP9Achr20

50244139

-MACROD2chr20

15843390

+
ChimerDB4LUADTCGA-86-8280-01AATP9Achr20

50255882

-MACROD2chr20

15843390

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311637ATP9Achr2050244139-ENST00000217246MACROD2chr2015843390+5395144142073689
ENST00000311637ATP9Achr2050244139-ENST00000310348MACROD2chr2015843390+2143144142142713
ENST00000338821ATP9Achr2050244139-ENST00000217246MACROD2chr2015843390+606421101242742872
ENST00000338821ATP9Achr2050244139-ENST00000310348MACROD2chr2015843390+281221101242811896
ENST00000402822ATP9Achr2050244139-ENST00000217246MACROD2chr2015843390+5436148202114704
ENST00000402822ATP9Achr2050244139-ENST00000310348MACROD2chr2015843390+2184148202183727
ENST00000311637ATP9Achr2050255882-ENST00000217246MACROD2chr2015843390+5218126441896630
ENST00000311637ATP9Achr2050255882-ENST00000310348MACROD2chr2015843390+1966126441965654
ENST00000338821ATP9Achr2050255882-ENST00000217246MACROD2chr2015843390+588719331242565813
ENST00000338821ATP9Achr2050255882-ENST00000310348MACROD2chr2015843390+263519331242634837
ENST00000402822ATP9Achr2050255882-ENST00000217246MACROD2chr2015843390+5259130501937645
ENST00000402822ATP9Achr2050255882-ENST00000310348MACROD2chr2015843390+2007130502006668

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311637ENST00000217246ATP9Achr2050244139-MACROD2chr2015843390+0.0004055610.9995945
ENST00000311637ENST00000310348ATP9Achr2050244139-MACROD2chr2015843390+0.0043374450.9956625
ENST00000338821ENST00000217246ATP9Achr2050244139-MACROD2chr2015843390+0.0005088190.9994912
ENST00000338821ENST00000310348ATP9Achr2050244139-MACROD2chr2015843390+0.0056482030.99435174
ENST00000402822ENST00000217246ATP9Achr2050244139-MACROD2chr2015843390+0.0005125660.9994874
ENST00000402822ENST00000310348ATP9Achr2050244139-MACROD2chr2015843390+0.0061298710.99387014
ENST00000311637ENST00000217246ATP9Achr2050255882-MACROD2chr2015843390+0.0003345750.9996654
ENST00000311637ENST00000310348ATP9Achr2050255882-MACROD2chr2015843390+0.0046885780.99531144
ENST00000338821ENST00000217246ATP9Achr2050255882-MACROD2chr2015843390+0.000502770.9994972
ENST00000338821ENST00000310348ATP9Achr2050255882-MACROD2chr2015843390+0.0058473430.9941526
ENST00000402822ENST00000217246ATP9Achr2050255882-MACROD2chr2015843390+0.0003739540.99962604
ENST00000402822ENST00000310348ATP9Achr2050255882-MACROD2chr2015843390+0.0053779510.9946221

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8283_8283_1_ATP9A-MACROD2_ATP9A_chr20_50244139_ENST00000311637_MACROD2_chr20_15843390_ENST00000217246_length(amino acids)=689AA_BP=479
MDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTY
WVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSL
VMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRL
HLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQ
ASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEE
ECGNMAREGLRVLVVAKKSLAEEQYQDFEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQS
QDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVE

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>8283_8283_2_ATP9A-MACROD2_ATP9A_chr20_50244139_ENST00000311637_MACROD2_chr20_15843390_ENST00000310348_length(amino acids)=713AA_BP=479
MDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTY
WVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSL
VMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRL
HLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQ
ASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEE
ECGNMAREGLRVLVVAKKSLAEEQYQDFEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQS
QDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVE

--------------------------------------------------------------

>8283_8283_3_ATP9A-MACROD2_ATP9A_chr20_50244139_ENST00000338821_MACROD2_chr20_15843390_ENST00000217246_length(amino acids)=872AA_BP=662
MRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWL
GHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKE
VNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSYV
YAEEPNIDIHNFVGTFTREDSDPPISESLSIENTLWAGTVVASGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVV
VSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIF
KRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCR
VYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDW
LEEECGNMAREGLRVLVVAKKSLAEEQYQDFEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEME
EQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAV

--------------------------------------------------------------

>8283_8283_4_ATP9A-MACROD2_ATP9A_chr20_50244139_ENST00000338821_MACROD2_chr20_15843390_ENST00000310348_length(amino acids)=896AA_BP=662
MRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWL
GHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKE
VNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSYV
YAEEPNIDIHNFVGTFTREDSDPPISESLSIENTLWAGTVVASGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVV
VSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIF
KRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCR
VYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDW
LEEECGNMAREGLRVLVVAKKSLAEEQYQDFEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEME
EQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAV

--------------------------------------------------------------

>8283_8283_5_ATP9A-MACROD2_ATP9A_chr20_50244139_ENST00000402822_MACROD2_chr20_15843390_ENST00000217246_length(amino acids)=704AA_BP=494
MTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLAC
SQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVN
CLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTD
KTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQ
AEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGAD
VVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDEN
GPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYME

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>8283_8283_6_ATP9A-MACROD2_ATP9A_chr20_50244139_ENST00000402822_MACROD2_chr20_15843390_ENST00000310348_length(amino acids)=727AA_BP=494
MTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLAC
SQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVN
CLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTD
KTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQ
AEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGAD
VVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDEN
GPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYME
TEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTESQQEDQLIAGAQDEAK

--------------------------------------------------------------

>8283_8283_7_ATP9A-MACROD2_ATP9A_chr20_50255882_ENST00000311637_MACROD2_chr20_15843390_ENST00000217246_length(amino acids)=630AA_BP=420
MDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTY
WVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSL
VMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRL
HLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQ
ASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRVDRIIFCVFLEVDFKIYKKKMNEFFSVDDN
NEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDST
KNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRNGTK

--------------------------------------------------------------

>8283_8283_8_ATP9A-MACROD2_ATP9A_chr20_50255882_ENST00000311637_MACROD2_chr20_15843390_ENST00000310348_length(amino acids)=654AA_BP=420
MDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTY
WVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSL
VMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRL
HLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQ
ASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRVDRIIFCVFLEVDFKIYKKKMNEFFSVDDN
NEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDST
KNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTE

--------------------------------------------------------------

>8283_8283_9_ATP9A-MACROD2_ATP9A_chr20_50255882_ENST00000338821_MACROD2_chr20_15843390_ENST00000217246_length(amino acids)=813AA_BP=603
MRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWL
GHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKE
VNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSYV
YAEEPNIDIHNFVGTFTREDSDPPISESLSIENTLWAGTVVASGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVV
VSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIF
KRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCR
VYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRVDRIIFCVFLEVDFKIYKKKMNEFFSV
DDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQEN
DSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRN

--------------------------------------------------------------

>8283_8283_10_ATP9A-MACROD2_ATP9A_chr20_50255882_ENST00000338821_MACROD2_chr20_15843390_ENST00000310348_length(amino acids)=837AA_BP=603
MRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWL
GHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKE
VNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSYV
YAEEPNIDIHNFVGTFTREDSDPPISESLSIENTLWAGTVVASGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVV
VSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIF
KRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCR
VYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRVDRIIFCVFLEVDFKIYKKKMNEFFSV
DDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQEN
DSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVND

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>8283_8283_11_ATP9A-MACROD2_ATP9A_chr20_50255882_ENST00000402822_MACROD2_chr20_15843390_ENST00000217246_length(amino acids)=645AA_BP=435
MTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLAC
SQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVN
CLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTD
KTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQ
AEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRVDRIIFCVFLEVDFK
IYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHS
VRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPD

--------------------------------------------------------------

>8283_8283_12_ATP9A-MACROD2_ATP9A_chr20_50255882_ENST00000402822_MACROD2_chr20_15843390_ENST00000310348_length(amino acids)=668AA_BP=435
MTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLAC
SQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVN
CLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTD
KTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQ
AEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRVDRIIFCVFLEVDFK
IYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHS
VRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPD

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:50244139/chr20:15843390)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP9A

O75110

MACROD2

A1Z1Q3

FUNCTION: Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling and endosome to trans-Golgi network retrograde transport (PubMed:27733620, PubMed:30213940). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation (PubMed:30213940). Appears to be implicated in intercellular communication by negatively regulating the release of exosomes (PubMed:30947313). The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved (PubMed:30947313). {ECO:0000269|PubMed:27733620, ECO:0000269|PubMed:30213940, ECO:0000269|PubMed:30947313}.FUNCTION: Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). {ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728120_303615.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-17282_69615.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728326_332615.01048.0Topological domainExtracellular
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-172892_96615.01048.0Topological domainExtracellular
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223120_303494.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-12232_69494.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223326_332494.0927.0Topological domainExtracellular
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-122392_96494.0927.0Topological domainExtracellular
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528120_303556.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-15282_69556.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528326_332556.01048.0Topological domainExtracellular
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-152892_96556.01048.0Topological domainExtracellular
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023120_303435.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-10232_69435.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023326_332435.0927.0Topological domainExtracellular
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-102392_96435.0927.0Topological domainExtracellular
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728304_325615.01048.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728333_354615.01048.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-172870_91615.01048.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-172897_119615.01048.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223304_325494.0927.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223333_354494.0927.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-122370_91494.0927.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-122397_119494.0927.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528304_325556.01048.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528333_354556.01048.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-152870_91556.01048.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-152897_119556.01048.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023304_325435.0927.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023333_354435.0927.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-102370_91435.0927.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-102397_119435.0927.0TransmembraneHelical
TgeneMACROD2chr20:50244139chr20:15843390ENST00000217246717247_388215.0426.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:50244139chr20:15843390ENST00000310348718247_388215.0449.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:50244139chr20:15843390ENST00000378058010247_3880.0214.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:50244139chr20:15843390ENST000003780580106_90.0214.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:50244139chr20:15843390ENST00000402914314247_3880214.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:50244139chr20:15843390ENST000004029143146_90214.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:50244139chr20:15843390ENST0000040704506247_388099.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:50244139chr20:15843390ENST00000407045066_9099.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:50255882chr20:15843390ENST00000217246717247_388215.0426.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:50255882chr20:15843390ENST00000310348718247_388215.0449.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:50255882chr20:15843390ENST00000378058010247_3880.0214.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:50255882chr20:15843390ENST000003780580106_90.0214.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:50255882chr20:15843390ENST00000402914314247_3880214.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:50255882chr20:15843390ENST000004029143146_90214.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:50255882chr20:15843390ENST0000040704506247_388099.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:50255882chr20:15843390ENST00000407045066_9099.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:50244139chr20:15843390ENST0000037805801059_2400.0214.0DomainMacro
TgeneMACROD2chr20:50244139chr20:15843390ENST0000040291431459_2400214.0DomainMacro
TgeneMACROD2chr20:50244139chr20:15843390ENST000004070450659_240099.0DomainMacro
TgeneMACROD2chr20:50255882chr20:15843390ENST0000037805801059_2400.0214.0DomainMacro
TgeneMACROD2chr20:50255882chr20:15843390ENST0000040291431459_2400214.0DomainMacro
TgeneMACROD2chr20:50255882chr20:15843390ENST000004070450659_240099.0DomainMacro
TgeneMACROD2chr20:50244139chr20:15843390ENST00000378058010185_1910.0214.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000037805801077_790.0214.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000037805801090_920.0214.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000037805801097_1020.0214.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST00000402914314185_1910214.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000040291431477_790214.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000040291431490_920214.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000040291431497_1020214.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000040704506185_191099.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST000004070450677_79099.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST000004070450690_92099.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST000004070450697_102099.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST00000378058010185_1910.0214.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000037805801077_790.0214.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000037805801090_920.0214.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000037805801097_1020.0214.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST00000402914314185_1910214.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000040291431477_790214.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000040291431490_920214.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000040291431497_1020214.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000040704506185_191099.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST000004070450677_79099.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST000004070450690_92099.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST000004070450697_102099.0RegionSubstrate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-17281000_1006615.01048.0Topological domainExtracellular
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-17281031_1047615.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728355_841615.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728863_874615.01048.0Topological domainExtracellular
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728894_923615.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728943_949615.01048.0Topological domainExtracellular
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728973_978615.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-12231000_1006494.0927.0Topological domainExtracellular
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-12231031_1047494.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223355_841494.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223863_874494.0927.0Topological domainExtracellular
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223894_923494.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223943_949494.0927.0Topological domainExtracellular
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223973_978494.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-15281000_1006556.01048.0Topological domainExtracellular
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-15281031_1047556.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528355_841556.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528863_874556.01048.0Topological domainExtracellular
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528894_923556.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528943_949556.01048.0Topological domainExtracellular
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528973_978556.01048.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-10231000_1006435.0927.0Topological domainExtracellular
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-10231031_1047435.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023355_841435.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023863_874435.0927.0Topological domainExtracellular
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023894_923435.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023943_949435.0927.0Topological domainExtracellular
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023973_978435.0927.0Topological domainCytoplasmic
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-17281007_1030615.01048.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728842_862615.01048.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728875_893615.01048.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728924_942615.01048.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728950_972615.01048.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000338821-1728979_999615.01048.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-12231007_1030494.0927.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223842_862494.0927.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223875_893494.0927.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223924_942494.0927.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223950_972494.0927.0TransmembraneHelical
HgeneATP9Achr20:50244139chr20:15843390ENST00000402822-1223979_999494.0927.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-15281007_1030556.01048.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528842_862556.01048.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528875_893556.01048.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528924_942556.01048.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528950_972556.01048.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000338821-1528979_999556.01048.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-10231007_1030435.0927.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023842_862435.0927.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023875_893435.0927.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023924_942435.0927.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023950_972435.0927.0TransmembraneHelical
HgeneATP9Achr20:50255882chr20:15843390ENST00000402822-1023979_999435.0927.0TransmembraneHelical
TgeneMACROD2chr20:50244139chr20:15843390ENST000002172467176_9215.0426.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:50244139chr20:15843390ENST000003103487186_9215.0449.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:50255882chr20:15843390ENST000002172467176_9215.0426.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:50255882chr20:15843390ENST000003103487186_9215.0449.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:50244139chr20:15843390ENST0000021724671759_240215.0426.0DomainMacro
TgeneMACROD2chr20:50244139chr20:15843390ENST0000031034871859_240215.0449.0DomainMacro
TgeneMACROD2chr20:50255882chr20:15843390ENST0000021724671759_240215.0426.0DomainMacro
TgeneMACROD2chr20:50255882chr20:15843390ENST0000031034871859_240215.0449.0DomainMacro
TgeneMACROD2chr20:50244139chr20:15843390ENST00000217246717185_191215.0426.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000021724671777_79215.0426.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000021724671790_92215.0426.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000021724671797_102215.0426.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST00000310348718185_191215.0449.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000031034871877_79215.0449.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000031034871890_92215.0449.0RegionSubstrate binding
TgeneMACROD2chr20:50244139chr20:15843390ENST0000031034871897_102215.0449.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST00000217246717185_191215.0426.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000021724671777_79215.0426.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000021724671790_92215.0426.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000021724671797_102215.0426.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST00000310348718185_191215.0449.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000031034871877_79215.0449.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000031034871890_92215.0449.0RegionSubstrate binding
TgeneMACROD2chr20:50255882chr20:15843390ENST0000031034871897_102215.0449.0RegionSubstrate binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP9A
MACROD2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATP9A-MACROD2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP9A-MACROD2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource