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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP9B-PARD6G

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP9B-PARD6G
FusionPDB ID: 8304
FusionGDB2.0 ID: 8304
HgeneTgene
Gene symbol

ATP9B

PARD6G

Gene ID

374868

84552

Gene nameATPase phospholipid transporting 9B (putative)par-6 family cell polarity regulator gamma
SynonymsATPASEP|ATPIIB|HUSSY-20|NEO1L|hMMR1PAR-6G|PAR6gamma
Cytomap

18q23

18q23

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IIBATPase type IV, phospholipid transporting (P-type)ATPase, class II, type 9Bmacrophage MHC receptor 1partitioning defective 6 homolog gammaPAR-6 gamma proteinPAR6Dpar-6 partitioning defective 6 homolog gamma
Modification date2020031320200327
UniProtAcc

O43861

.
Ensembl transtripts involved in fusion geneENST idsENST00000307671, ENST00000426216, 
ENST00000458297, ENST00000543761, 
ENST00000586722, ENST00000591464, 
ENST00000353265, ENST00000470488, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 16 X 5=120010 X 3 X 8=240
# samples 1510
** MAII scorelog2(15/1200*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP9B [Title/Abstract] AND PARD6G [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP9B(76974038)-PARD6G(77960815), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP9B-PARD6G seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP9B-PARD6G seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP9B-PARD6G seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP9B-PARD6G seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATP9B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PARD6G (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1319-01AATP9Bchr18

76974038

+PARD6Gchr18

77960815

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000426216ATP9Bchr1876974038+ENST00000353265PARD6Gchr1877960815-47221124172182721
ENST00000426216ATP9Bchr1876974038+ENST00000470488PARD6Gchr1877960815-16481124171375452
ENST00000307671ATP9Bchr1876974038+ENST00000353265PARD6Gchr1877960815-47191121142179721
ENST00000307671ATP9Bchr1876974038+ENST00000470488PARD6Gchr1877960815-16451121141372452

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000426216ENST00000353265ATP9Bchr1876974038+PARD6Gchr1877960815-0.0013742780.99862576
ENST00000426216ENST00000470488ATP9Bchr1876974038+PARD6Gchr1877960815-0.0006341940.99936587
ENST00000307671ENST00000353265ATP9Bchr1876974038+PARD6Gchr1877960815-0.0013899630.99861
ENST00000307671ENST00000470488ATP9Bchr1876974038+PARD6Gchr1877960815-0.0006563460.9993437

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8304_8304_1_ATP9B-PARD6G_ATP9B_chr18_76974038_ENST00000307671_PARD6G_chr18_77960815_ENST00000353265_length(amino acids)=721AA_BP=369
MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEEGFENEESDYHTLPRARIMQRKRGLEWFVCD
GWKFLCTSCCGWLINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLY
TYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLD
GETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSV
MNTSNPKNKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGS
LGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFI
SRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVL
QNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVT

--------------------------------------------------------------

>8304_8304_2_ATP9B-PARD6G_ATP9B_chr18_76974038_ENST00000307671_PARD6G_chr18_77960815_ENST00000470488_length(amino acids)=452AA_BP=369
MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEEGFENEESDYHTLPRARIMQRKRGLEWFVCD
GWKFLCTSCCGWLINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLY
TYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLD
GETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSV
MNTSNPKNKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKRDDGALRP

--------------------------------------------------------------

>8304_8304_3_ATP9B-PARD6G_ATP9B_chr18_76974038_ENST00000426216_PARD6G_chr18_77960815_ENST00000353265_length(amino acids)=721AA_BP=369
MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEEGFENEESDYHTLPRARIMQRKRGLEWFVCD
GWKFLCTSCCGWLINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLY
TYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLD
GETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSV
MNTSNPKNKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGS
LGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFI
SRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVL
QNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVT

--------------------------------------------------------------

>8304_8304_4_ATP9B-PARD6G_ATP9B_chr18_76974038_ENST00000426216_PARD6G_chr18_77960815_ENST00000470488_length(amino acids)=452AA_BP=369
MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEEGFENEESDYHTLPRARIMQRKRGLEWFVCD
GWKFLCTSCCGWLINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLY
TYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLD
GETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSV
MNTSNPKNKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKRDDGALRP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:76974038/chr18:77960815)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP9B

O43861

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129169_173369.01137.0Topological domainExtracellular
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+11291_146369.01137.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130169_173369.01148.0Topological domainExtracellular
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+11301_146369.01148.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129147_168369.01137.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129174_196369.01137.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130147_168369.01148.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130174_196369.01148.0TransmembraneHelical
TgenePARD6Gchr18:76974038chr18:77960815ENST0000035326503134_15124.0377.0DomainNote=Pseudo-CRIB
TgenePARD6Gchr18:76974038chr18:77960815ENST0000035326503158_25124.0377.0DomainPDZ
TgenePARD6Gchr18:76974038chr18:77960815ENST0000047048803134_15124.0108.0DomainNote=Pseudo-CRIB
TgenePARD6Gchr18:76974038chr18:77960815ENST0000047048803158_25124.0108.0DomainPDZ

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+11291032_1038369.01137.0Topological domainExtracellular
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+11291062_1067369.01137.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+11291089_1105369.01137.0Topological domainExtracellular
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+11291131_1147369.01137.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129197_380369.01137.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129402_409369.01137.0Topological domainExtracellular
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129432_930369.01137.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129952_963369.01137.0Topological domainExtracellular
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129983_1012369.01137.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+11301032_1038369.01148.0Topological domainExtracellular
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+11301062_1067369.01148.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+11301089_1105369.01148.0Topological domainExtracellular
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+11301131_1147369.01148.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130197_380369.01148.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130402_409369.01148.0Topological domainExtracellular
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130432_930369.01148.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130952_963369.01148.0Topological domainExtracellular
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130983_1012369.01148.0Topological domainCytoplasmic
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+11291013_1031369.01137.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+11291039_1061369.01137.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+11291068_1088369.01137.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+11291106_1130369.01137.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129381_401369.01137.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129410_431369.01137.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129931_951369.01137.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000307671+1129964_982369.01137.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+11301013_1031369.01148.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+11301039_1061369.01148.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+11301068_1088369.01148.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+11301106_1130369.01148.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130381_401369.01148.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130410_431369.01148.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130931_951369.01148.0TransmembraneHelical
HgeneATP9Bchr18:76974038chr18:77960815ENST00000426216+1130964_982369.01148.0TransmembraneHelical
TgenePARD6Gchr18:76974038chr18:77960815ENST000003532650318_9824.0377.0DomainPB1
TgenePARD6Gchr18:76974038chr18:77960815ENST000004704880318_9824.0108.0DomainPB1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP9B
PARD6G


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATP9B-PARD6G


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP9B-PARD6G


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource