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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLC44A1-RAD23B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC44A1-RAD23B
FusionPDB ID: 83283
FusionGDB2.0 ID: 83283
HgeneTgene
Gene symbol

SLC44A1

RAD23B

Gene ID

23446

5887

Gene namesolute carrier family 44 member 1RAD23 homolog B, nucleotide excision repair protein
SynonymsCD92|CDW92|CHTL1|CTL1HHR23B|HR23B|P58
Cytomap

9q31.1-q31.2

9q31.2

Type of geneprotein-codingprotein-coding
Descriptioncholine transporter-like protein 1CDW92 antigensolute carrier family 44 (choline transporter), member 1UV excision repair protein RAD23 homolog BRAD23, yeast homolog of, BXP-C repair complementing complex 58 kDaXP-C repair complementing proteinXP-C repair-complementing complex 58 kDa protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000343170, ENST00000374720, 
ENST00000374723, ENST00000374724, 
ENST00000607692, 		ENST00000358015, 
ENST00000416373, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 9 X 7=69312 X 12 X 6=864
# samples 1214
** MAII scorelog2(12/693*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/864*10)=-2.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLC44A1 [Title/Abstract] AND RAD23B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLC44A1(108123611)-RAD23B(110068660), # samples:2
Anticipated loss of major functional domain due to fusion event.SLC44A1-RAD23B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC44A1-RAD23B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC44A1-RAD23B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC44A1-RAD23B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC44A1

GO:0015871

choline transport

16319125

HgeneSLC44A1

GO:0055085

transmembrane transport

16319125

TgeneRAD23B

GO:0000715

nucleotide-excision repair, DNA damage recognition

19941824

TgeneRAD23B

GO:0006289

nucleotide-excision repair

8168482|9734359

TgeneRAD23B

GO:0032434

regulation of proteasomal ubiquitin-dependent protein catabolic process

19435460


check buttonFusion gene breakpoints across SLC44A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAD23B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A3U0-01ASLC44A1chr9

108123611

+RAD23Bchr9

110068660

+
ChimerDB4BRCATCGA-EW-A3U0SLC44A1chr9

108123611

+RAD23Bchr9

110068659

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374723SLC44A1chr9108123611+ENST00000358015RAD23Bchr9110068660+468711472472148633
ENST00000374723SLC44A1chr9108123611+ENST00000416373RAD23Bchr9110068660+237711472472148633
ENST00000374720SLC44A1chr9108123611+ENST00000358015RAD23Bchr9110068660+468711472472148633
ENST00000374720SLC44A1chr9108123611+ENST00000416373RAD23Bchr9110068660+237711472472148633
ENST00000374724SLC44A1chr9108123611+ENST00000358015RAD23Bchr9110068660+468711472472148633
ENST00000374724SLC44A1chr9108123611+ENST00000416373RAD23Bchr9110068660+237711472472148633
ENST00000343170SLC44A1chr9108123611+ENST00000358015RAD23Bchr9110068660+467611367102137475
ENST00000343170SLC44A1chr9108123611+ENST00000416373RAD23Bchr9110068660+236611367102137475
ENST00000374723SLC44A1chr9108123611+ENST00000358015RAD23Bchr9110068659+468711472472148633
ENST00000374723SLC44A1chr9108123611+ENST00000416373RAD23Bchr9110068659+237711472472148633
ENST00000374720SLC44A1chr9108123611+ENST00000358015RAD23Bchr9110068659+468711472472148633
ENST00000374720SLC44A1chr9108123611+ENST00000416373RAD23Bchr9110068659+237711472472148633
ENST00000374724SLC44A1chr9108123611+ENST00000358015RAD23Bchr9110068659+468711472472148633
ENST00000374724SLC44A1chr9108123611+ENST00000416373RAD23Bchr9110068659+237711472472148633
ENST00000343170SLC44A1chr9108123611+ENST00000358015RAD23Bchr9110068659+467611367102137475
ENST00000343170SLC44A1chr9108123611+ENST00000416373RAD23Bchr9110068659+236611367102137475

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374723ENST00000358015SLC44A1chr9108123611+RAD23Bchr9110068660+0.001377520.99862254
ENST00000374723ENST00000416373SLC44A1chr9108123611+RAD23Bchr9110068660+0.0132775920.98672247
ENST00000374720ENST00000358015SLC44A1chr9108123611+RAD23Bchr9110068660+0.001377520.99862254
ENST00000374720ENST00000416373SLC44A1chr9108123611+RAD23Bchr9110068660+0.0132775920.98672247
ENST00000374724ENST00000358015SLC44A1chr9108123611+RAD23Bchr9110068660+0.001377520.99862254
ENST00000374724ENST00000416373SLC44A1chr9108123611+RAD23Bchr9110068660+0.0132775920.98672247
ENST00000343170ENST00000358015SLC44A1chr9108123611+RAD23Bchr9110068660+0.0001991290.99980086
ENST00000343170ENST00000416373SLC44A1chr9108123611+RAD23Bchr9110068660+0.0007744380.9992256
ENST00000374723ENST00000358015SLC44A1chr9108123611+RAD23Bchr9110068659+0.001377520.99862254
ENST00000374723ENST00000416373SLC44A1chr9108123611+RAD23Bchr9110068659+0.0132775920.98672247
ENST00000374720ENST00000358015SLC44A1chr9108123611+RAD23Bchr9110068659+0.001377520.99862254
ENST00000374720ENST00000416373SLC44A1chr9108123611+RAD23Bchr9110068659+0.0132775920.98672247
ENST00000374724ENST00000358015SLC44A1chr9108123611+RAD23Bchr9110068659+0.001377520.99862254
ENST00000374724ENST00000416373SLC44A1chr9108123611+RAD23Bchr9110068659+0.0132775920.98672247
ENST00000343170ENST00000358015SLC44A1chr9108123611+RAD23Bchr9110068659+0.0001991290.99980086
ENST00000343170ENST00000416373SLC44A1chr9108123611+RAD23Bchr9110068659+0.0007744380.9992256

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83283_83283_1_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000343170_RAD23B_chr9_110068659_ENST00000358015_length(amino acids)=475AA_BP=1
MIFFSCVTSAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILV
ILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPV
PALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYER
EQVIAALRASFNNPDRAVEYLLMGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQ
NPSLLPALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVI

--------------------------------------------------------------

>83283_83283_2_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000343170_RAD23B_chr9_110068659_ENST00000416373_length(amino acids)=475AA_BP=1
MIFFSCVTSAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILV
ILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPV
PALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYER
EQVIAALRASFNNPDRAVEYLLMGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQ
NPSLLPALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVI

--------------------------------------------------------------

>83283_83283_3_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000343170_RAD23B_chr9_110068660_ENST00000358015_length(amino acids)=475AA_BP=1
MIFFSCVTSAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILV
ILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPV
PALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYER
EQVIAALRASFNNPDRAVEYLLMGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQ
NPSLLPALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVI

--------------------------------------------------------------

>83283_83283_4_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000343170_RAD23B_chr9_110068660_ENST00000416373_length(amino acids)=475AA_BP=1
MIFFSCVTSAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILV
ILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPV
PALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYER
EQVIAALRASFNNPDRAVEYLLMGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQ
NPSLLPALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVI

--------------------------------------------------------------

>83283_83283_5_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374720_RAD23B_chr9_110068659_ENST00000358015_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

>83283_83283_6_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374720_RAD23B_chr9_110068659_ENST00000416373_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

>83283_83283_7_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374720_RAD23B_chr9_110068660_ENST00000358015_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

>83283_83283_8_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374720_RAD23B_chr9_110068660_ENST00000416373_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

>83283_83283_9_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374723_RAD23B_chr9_110068659_ENST00000358015_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

>83283_83283_10_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374723_RAD23B_chr9_110068659_ENST00000416373_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

>83283_83283_11_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374723_RAD23B_chr9_110068660_ENST00000358015_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

>83283_83283_12_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374723_RAD23B_chr9_110068660_ENST00000416373_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

>83283_83283_13_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374724_RAD23B_chr9_110068659_ENST00000358015_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

>83283_83283_14_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374724_RAD23B_chr9_110068659_ENST00000416373_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

>83283_83283_15_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374724_RAD23B_chr9_110068660_ENST00000358015_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

>83283_83283_16_SLC44A1-RAD23B_SLC44A1_chr9_108123611_ENST00000374724_RAD23B_chr9_110068660_ENST00000416373_length(amino acids)=633AA_BP=0
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRK
YVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSP
KETVTPEQLQIAEDNLRALLIYAISATVFTPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSE
PAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLL
MGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQ
ISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNF

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:108123611/chr9:110068660)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816234_238300.0658.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816260_288300.0658.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+8162_30300.0658.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+81652_212300.0658.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816234_238300.0653.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816260_288300.0653.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+8162_30300.0653.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+81652_212300.0653.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816234_238300.0655.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816260_288300.0655.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+8162_30300.0655.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+81652_212300.0655.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816234_238300.0658.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816260_288300.0658.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+8162_30300.0658.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+81652_212300.0658.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816234_238300.0653.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816260_288300.0653.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+8162_30300.0653.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+81652_212300.0653.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816234_238300.0655.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816260_288300.0655.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+8162_30300.0655.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+81652_212300.0655.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816213_233300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816239_259300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+81631_51300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816213_233300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816239_259300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+81631_51300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816213_233300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816239_259300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+81631_51300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816213_233300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816239_259300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+81631_51300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816213_233300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816239_259300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+81631_51300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816213_233300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816239_259300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+81631_51300.0655.0TransmembraneHelical
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000358015210103_10676.0410.0Compositional biasNote=Poly-Thr
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000358015210254_26076.0410.0Compositional biasNote=Poly-Ala
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000358015210261_26976.0410.0Compositional biasNote=Poly-Thr
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000358015210336_34876.0410.0Compositional biasNote=Poly-Gly
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000416373210103_1064.0338.0Compositional biasNote=Poly-Thr
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000416373210254_2604.0338.0Compositional biasNote=Poly-Ala
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000416373210261_2694.0338.0Compositional biasNote=Poly-Thr
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000416373210336_3484.0338.0Compositional biasNote=Poly-Gly
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000358015210103_10676.0410.0Compositional biasNote=Poly-Thr
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000358015210254_26076.0410.0Compositional biasNote=Poly-Ala
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000358015210261_26976.0410.0Compositional biasNote=Poly-Thr
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000358015210336_34876.0410.0Compositional biasNote=Poly-Gly
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000416373210103_1064.0338.0Compositional biasNote=Poly-Thr
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000416373210254_2604.0338.0Compositional biasNote=Poly-Ala
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000416373210261_2694.0338.0Compositional biasNote=Poly-Thr
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000416373210336_3484.0338.0Compositional biasNote=Poly-Gly
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000358015210188_22876.0410.0DomainUBA 1
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000358015210274_31776.0410.0DomainNote=STI1
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000358015210364_40476.0410.0DomainUBA 2
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000416373210188_2284.0338.0DomainUBA 1
TgeneRAD23Bchr9:108123611chr9:110068659ENST000004163732101_794.0338.0DomainUbiquitin-like
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000416373210274_3174.0338.0DomainNote=STI1
TgeneRAD23Bchr9:108123611chr9:110068659ENST00000416373210364_4044.0338.0DomainUBA 2
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000358015210188_22876.0410.0DomainUBA 1
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000358015210274_31776.0410.0DomainNote=STI1
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000358015210364_40476.0410.0DomainUBA 2
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000416373210188_2284.0338.0DomainUBA 1
TgeneRAD23Bchr9:108123611chr9:110068660ENST000004163732101_794.0338.0DomainUbiquitin-like
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000416373210274_3174.0338.0DomainNote=STI1
TgeneRAD23Bchr9:108123611chr9:110068660ENST00000416373210364_4044.0338.0DomainUBA 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816474_492300.0658.0Compositional biasNote=Cys-rich
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816474_492300.0653.0Compositional biasNote=Cys-rich
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816474_492300.0655.0Compositional biasNote=Cys-rich
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816474_492300.0658.0Compositional biasNote=Cys-rich
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816474_492300.0653.0Compositional biasNote=Cys-rich
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816474_492300.0655.0Compositional biasNote=Cys-rich
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816310_315300.0658.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816337_338300.0658.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816360_380300.0658.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816402_537300.0658.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816559_566300.0658.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816588_653300.0658.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816310_315300.0653.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816337_338300.0653.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816360_380300.0653.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816402_537300.0653.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816559_566300.0653.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816588_653300.0653.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816310_315300.0655.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816337_338300.0655.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816360_380300.0655.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816402_537300.0655.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816559_566300.0655.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816588_653300.0655.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816310_315300.0658.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816337_338300.0658.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816360_380300.0658.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816402_537300.0658.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816559_566300.0658.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816588_653300.0658.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816310_315300.0653.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816337_338300.0653.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816360_380300.0653.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816402_537300.0653.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816559_566300.0653.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816588_653300.0653.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816310_315300.0655.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816337_338300.0655.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816360_380300.0655.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816402_537300.0655.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816559_566300.0655.0Topological domainCytoplasmic
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816588_653300.0655.0Topological domainMitochondrial intermembrane
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816289_309300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816316_336300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816339_359300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816381_401300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816538_558300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374720+816567_587300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816289_309300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816316_336300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816339_359300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816381_401300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816538_558300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374723+816567_587300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816289_309300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816316_336300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816339_359300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816381_401300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816538_558300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068659ENST00000374724+816567_587300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816289_309300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816316_336300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816339_359300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816381_401300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816538_558300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374720+816567_587300.0658.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816289_309300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816316_336300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816339_359300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816381_401300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816538_558300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374723+816567_587300.0653.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816289_309300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816316_336300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816339_359300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816381_401300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816538_558300.0655.0TransmembraneHelical
HgeneSLC44A1chr9:108123611chr9:110068660ENST00000374724+816567_587300.0655.0TransmembraneHelical
TgeneRAD23Bchr9:108123611chr9:110068659ENST000003580152101_7976.0410.0DomainUbiquitin-like
TgeneRAD23Bchr9:108123611chr9:110068660ENST000003580152101_7976.0410.0DomainUbiquitin-like


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLC44A1
RAD23B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SLC44A1-RAD23B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC44A1-RAD23B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource