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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLC4A4-PICALM

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC4A4-PICALM
FusionPDB ID: 83386
FusionGDB2.0 ID: 83386
HgeneTgene
Gene symbol

SLC4A4

PICALM

Gene ID

8671

8301

Gene namesolute carrier family 4 member 4phosphatidylinositol binding clathrin assembly protein
SynonymsHNBC1|KNBC|NBC1|NBC2|NBCe1-A|SLC4A5|hhNMC|kNBC1|pNBCCALM|CLTH|LAP
Cytomap

4q13.3

11q14.2

Type of geneprotein-codingprotein-coding
Descriptionelectrogenic sodium bicarbonate cotransporter 1Na(+)/HCO3(-) cotransportersodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)solute carrier family 4 (sodium bicarbonate cotransporterphosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein
Modification date2020031320200322
UniProtAcc.

Q13492

Ensembl transtripts involved in fusion geneENST idsENST00000514331, ENST00000264485, 
ENST00000351898, ENST00000425175, 
ENST00000340595, ENST00000512686, 
ENST00000356360, ENST00000393346, 
ENST00000526033, ENST00000528398, 
ENST00000532317, ENST00000528411, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 12 X 5=72035 X 26 X 12=10920
# samples 1344
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(44/10920*10)=-4.63332552228256
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLC4A4 [Title/Abstract] AND PICALM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLC4A4(72121116)-PICALM(85670103), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC4A4-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC4A4-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC4A4-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC4A4-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC4A4-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SLC4A4-PICALM seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC4A4-PICALM seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SLC4A4-PICALM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC4A4

GO:0006814

sodium ion transport

16769890

HgeneSLC4A4

GO:0015701

bicarbonate transport

10069984

HgeneSLC4A4

GO:0035725

sodium ion transmembrane transport

10069984

HgeneSLC4A4

GO:0042391

regulation of membrane potential

10069984|15273250

HgeneSLC4A4

GO:0051453

regulation of intracellular pH

10069984

TgenePICALM

GO:0006897

endocytosis

22118466

TgenePICALM

GO:0006898

receptor-mediated endocytosis

10436022

TgenePICALM

GO:0032880

regulation of protein localization

10436022

TgenePICALM

GO:0045893

positive regulation of transcription, DNA-templated

11425879

TgenePICALM

GO:0048261

negative regulation of receptor-mediated endocytosis

10436022

TgenePICALM

GO:1905224

clathrin-coated pit assembly

16262731


check buttonFusion gene breakpoints across SLC4A4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PICALM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-28-5209-01ASLC4A4chr4

72121116

+PICALMchr11

85670103

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264485SLC4A4chr472121116+ENST00000526033PICALMchr1185670103-174337084389101
ENST00000264485SLC4A4chr472121116+ENST00000393346PICALMchr1185670103-61737084389101
ENST00000425175SLC4A4chr472121116+ENST00000526033PICALMchr1185670103-174337084389101
ENST00000425175SLC4A4chr472121116+ENST00000393346PICALMchr1185670103-61737084389101
ENST00000351898SLC4A4chr472121116+ENST00000526033PICALMchr1185670103-170232943348101
ENST00000351898SLC4A4chr472121116+ENST00000393346PICALMchr1185670103-57632943348101

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264485ENST00000526033SLC4A4chr472121116+PICALMchr1185670103-0.0092820430.99071795
ENST00000264485ENST00000393346SLC4A4chr472121116+PICALMchr1185670103-0.0185820930.98141795
ENST00000425175ENST00000526033SLC4A4chr472121116+PICALMchr1185670103-0.0092820430.99071795
ENST00000425175ENST00000393346SLC4A4chr472121116+PICALMchr1185670103-0.0185820930.98141795
ENST00000351898ENST00000526033SLC4A4chr472121116+PICALMchr1185670103-0.0193403810.98065954
ENST00000351898ENST00000393346SLC4A4chr472121116+PICALMchr1185670103-0.0222196910.9777803

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83386_83386_1_SLC4A4-PICALM_SLC4A4_chr4_72121116_ENST00000264485_PICALM_chr11_85670103_ENST00000393346_length(amino acids)=101AA_BP=
MEERRKPDPRRMEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKERISENYSDKSDIENADESSSS

--------------------------------------------------------------

>83386_83386_2_SLC4A4-PICALM_SLC4A4_chr4_72121116_ENST00000264485_PICALM_chr11_85670103_ENST00000526033_length(amino acids)=101AA_BP=
MEERRKPDPRRMEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKERISENYSDKSDIENADESSSS

--------------------------------------------------------------

>83386_83386_3_SLC4A4-PICALM_SLC4A4_chr4_72121116_ENST00000351898_PICALM_chr11_85670103_ENST00000393346_length(amino acids)=101AA_BP=
MEERRKPDPRRMEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKERISENYSDKSDIENADESSSS

--------------------------------------------------------------

>83386_83386_4_SLC4A4-PICALM_SLC4A4_chr4_72121116_ENST00000351898_PICALM_chr11_85670103_ENST00000526033_length(amino acids)=101AA_BP=
MEERRKPDPRRMEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKERISENYSDKSDIENADESSSS

--------------------------------------------------------------

>83386_83386_5_SLC4A4-PICALM_SLC4A4_chr4_72121116_ENST00000425175_PICALM_chr11_85670103_ENST00000393346_length(amino acids)=101AA_BP=
MEERRKPDPRRMEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKERISENYSDKSDIENADESSSS

--------------------------------------------------------------

>83386_83386_6_SLC4A4-PICALM_SLC4A4_chr4_72121116_ENST00000425175_PICALM_chr11_85670103_ENST00000526033_length(amino acids)=101AA_BP=
MEERRKPDPRRMEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKERISENYSDKSDIENADESSSS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:72121116/chr11:85670103)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PICALM

Q13492

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+3261009_102484.333333333333331684.6666666666667Compositional biasNote=Lys-rich
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+1231009_102402318.3333333333335Compositional biasNote=Lys-rich
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+3241009_102484.333333333333331194.6666666666667Compositional biasNote=Lys-rich
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+3251009_102484.333333333333331095.0Compositional biasNote=Lys-rich
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+1111009_10240647.0Compositional biasNote=Lys-rich
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326961_98684.333333333333331684.6666666666667IntramembraneDiscontinuously helical
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123961_98602318.3333333333335IntramembraneDiscontinuously helical
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324961_98684.333333333333331194.6666666666667IntramembraneDiscontinuously helical
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325961_98684.333333333333331095.0IntramembraneDiscontinuously helical
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111961_9860647.0IntramembraneDiscontinuously helical
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+3261002_100484.333333333333331684.6666666666667RegionNote=CA2-binding
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+3261057_105984.333333333333331684.6666666666667RegionNote=Required for basolateral targeting
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+1231002_100402318.3333333333335RegionNote=CA2-binding
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+1231057_105902318.3333333333335RegionNote=Required for basolateral targeting
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+3241002_100484.333333333333331194.6666666666667RegionNote=CA2-binding
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+3241057_105984.333333333333331194.6666666666667RegionNote=Required for basolateral targeting
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+3251002_100484.333333333333331095.0RegionNote=CA2-binding
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+3251057_105984.333333333333331095.0RegionNote=Required for basolateral targeting
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+1111002_10040647.0RegionNote=CA2-binding
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+1111057_10590647.0RegionNote=Required for basolateral targeting
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+3261_46684.333333333333331684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326492_50184.333333333333331684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326521_52184.333333333333331684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326543_55084.333333333333331684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326572_58584.333333333333331684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326610_69284.333333333333331684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326711_72584.333333333333331684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326746_77984.333333333333331684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326808_81984.333333333333331684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326837_83784.333333333333331684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326856_87784.333333333333331684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326895_90184.333333333333331684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326919_96084.333333333333331684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326987_107984.333333333333331684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+1231_46602318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123492_50102318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123521_52102318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123543_55002318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123572_58502318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123610_69202318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123711_72502318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123746_77902318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123808_81902318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123837_83702318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123856_87702318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123895_90102318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123919_96002318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123987_107902318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+3241_46684.333333333333331194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324492_50184.333333333333331194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324521_52184.333333333333331194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324543_55084.333333333333331194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324572_58584.333333333333331194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324610_69284.333333333333331194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324711_72584.333333333333331194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324746_77984.333333333333331194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324808_81984.333333333333331194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324837_83784.333333333333331194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324856_87784.333333333333331194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324895_90184.333333333333331194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324919_96084.333333333333331194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324987_107984.333333333333331194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+3251_46684.333333333333331095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325492_50184.333333333333331095.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325521_52184.333333333333331095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325543_55084.333333333333331095.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325572_58584.333333333333331095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325610_69284.333333333333331095.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325711_72584.333333333333331095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325746_77984.333333333333331095.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325808_81984.333333333333331095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325837_83784.333333333333331095.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325856_87784.333333333333331095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325895_90184.333333333333331095.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325919_96084.333333333333331095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325987_107984.333333333333331095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+1111_4660647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111492_5010647.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111521_5210647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111543_5500647.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111572_5850647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111610_6920647.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111711_7250647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111746_7790647.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111808_8190647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111837_8370647.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111856_8770647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111895_9010647.0Topological domainExtracellular
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111919_9600647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111987_10790647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326467_49184.333333333333331684.6666666666667TransmembraneHelical%3B Name%3D1
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326502_52084.333333333333331684.6666666666667TransmembraneHelical%3B Name%3D2
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326522_54284.333333333333331684.6666666666667TransmembraneDiscontinuously helical%3B Name%3D3
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326551_57184.333333333333331684.6666666666667TransmembraneHelical%3B Name%3D4
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326586_60984.333333333333331684.6666666666667TransmembraneHelical%3B Name%3D5
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326693_71084.333333333333331684.6666666666667TransmembraneHelical%3B Name%3D6
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326726_74584.333333333333331684.6666666666667TransmembraneHelical%3B Name%3D7
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326780_80784.333333333333331684.6666666666667TransmembraneHelical%3B Name%3D8
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326820_83684.333333333333331684.6666666666667TransmembraneHelical%3B Name%3D9
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326838_85584.333333333333331684.6666666666667TransmembraneDiscontinuously helical%3B Name%3D10
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326878_89484.333333333333331684.6666666666667TransmembraneHelical%3B Name%3D11
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326902_91884.333333333333331684.6666666666667TransmembraneHelical%3B Name%3D12
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123467_49102318.3333333333335TransmembraneHelical%3B Name%3D1
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123502_52002318.3333333333335TransmembraneHelical%3B Name%3D2
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123522_54202318.3333333333335TransmembraneDiscontinuously helical%3B Name%3D3
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123551_57102318.3333333333335TransmembraneHelical%3B Name%3D4
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123586_60902318.3333333333335TransmembraneHelical%3B Name%3D5
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123693_71002318.3333333333335TransmembraneHelical%3B Name%3D6
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123726_74502318.3333333333335TransmembraneHelical%3B Name%3D7
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123780_80702318.3333333333335TransmembraneHelical%3B Name%3D8
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123820_83602318.3333333333335TransmembraneHelical%3B Name%3D9
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123838_85502318.3333333333335TransmembraneDiscontinuously helical%3B Name%3D10
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123878_89402318.3333333333335TransmembraneHelical%3B Name%3D11
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123902_91802318.3333333333335TransmembraneHelical%3B Name%3D12
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324467_49184.333333333333331194.6666666666667TransmembraneHelical%3B Name%3D1
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324502_52084.333333333333331194.6666666666667TransmembraneHelical%3B Name%3D2
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324522_54284.333333333333331194.6666666666667TransmembraneDiscontinuously helical%3B Name%3D3
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324551_57184.333333333333331194.6666666666667TransmembraneHelical%3B Name%3D4
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324586_60984.333333333333331194.6666666666667TransmembraneHelical%3B Name%3D5
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324693_71084.333333333333331194.6666666666667TransmembraneHelical%3B Name%3D6
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324726_74584.333333333333331194.6666666666667TransmembraneHelical%3B Name%3D7
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324780_80784.333333333333331194.6666666666667TransmembraneHelical%3B Name%3D8
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324820_83684.333333333333331194.6666666666667TransmembraneHelical%3B Name%3D9
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324838_85584.333333333333331194.6666666666667TransmembraneDiscontinuously helical%3B Name%3D10
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324878_89484.333333333333331194.6666666666667TransmembraneHelical%3B Name%3D11
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324902_91884.333333333333331194.6666666666667TransmembraneHelical%3B Name%3D12
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325467_49184.333333333333331095.0TransmembraneHelical%3B Name%3D1
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325502_52084.333333333333331095.0TransmembraneHelical%3B Name%3D2
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325522_54284.333333333333331095.0TransmembraneDiscontinuously helical%3B Name%3D3
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325551_57184.333333333333331095.0TransmembraneHelical%3B Name%3D4
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325586_60984.333333333333331095.0TransmembraneHelical%3B Name%3D5
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325693_71084.333333333333331095.0TransmembraneHelical%3B Name%3D6
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325726_74584.333333333333331095.0TransmembraneHelical%3B Name%3D7
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325780_80784.333333333333331095.0TransmembraneHelical%3B Name%3D8
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325820_83684.333333333333331095.0TransmembraneHelical%3B Name%3D9
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325838_85584.333333333333331095.0TransmembraneDiscontinuously helical%3B Name%3D10
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325878_89484.333333333333331095.0TransmembraneHelical%3B Name%3D11
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325902_91884.333333333333331095.0TransmembraneHelical%3B Name%3D12
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111467_4910647.0TransmembraneHelical%3B Name%3D1
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111502_5200647.0TransmembraneHelical%3B Name%3D2
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111522_5420647.0TransmembraneDiscontinuously helical%3B Name%3D3
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111551_5710647.0TransmembraneHelical%3B Name%3D4
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111586_6090647.0TransmembraneHelical%3B Name%3D5
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111693_7100647.0TransmembraneHelical%3B Name%3D6
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111726_7450647.0TransmembraneHelical%3B Name%3D7
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111780_8070647.0TransmembraneHelical%3B Name%3D8
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111820_8360647.0TransmembraneHelical%3B Name%3D9
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111838_8550647.0TransmembraneDiscontinuously helical%3B Name%3D10
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111878_8940647.0TransmembraneHelical%3B Name%3D11
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111902_9180647.0TransmembraneHelical%3B Name%3D12
TgenePICALMchr4:72121116chr11:85670103ENST00000356360171914_145628.0633.0DomainENTH
TgenePICALMchr4:72121116chr11:85670103ENST00000393346182014_145648.0653.0DomainENTH
TgenePICALMchr4:72121116chr11:85670103ENST00000526033182014_145641.0646.0DomainENTH
TgenePICALMchr4:72121116chr11:85670103ENST00000528398171914_145547.0552.0DomainENTH
TgenePICALMchr4:72121116chr11:85670103ENST00000532317182014_145606.0611.0DomainENTH


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
PICALMPLCG1, CLTC, ITSN1, AP2A1, HIP1R, LAMTOR3, EEF1A1, SEC24D, DNM2, EGFR, FLOT1, SEC24C, ATP6V1E1, ILF3, HNRNPDL, SH3GLB2, ABCC2, ATP6V1F, CD55, SIRT1, FN1, VCAM1, ITGA4, PELI2, KLHL20, SLC25A41, ITLN1, ATF6B, SLC25A32, SOX2, FAM64A, CYP1A1, HNRNPA1, UNK, NTRK1, C14orf166, CARS, CPPED1, HNRNPD, ILVBL, ITGB1, LPP, PAPOLA, DDX1, EWSR1, FERMT2, FUS, ILK, NPLOC4, PFKM, PTPRF, VCL, PXN, STXBP1, TRIM25, UNC13D, XPO1, AP2B1, AP2M1, CLTA, CLTB, DAB2, EPS15, GAK, MYO6, PIK3C2A, SEC13, CLTCL1, CAPZA2, DBN1, MYH9, LIMA1, GTSE1, ANLN, MYO19, MYO18A, CLINT1, SEC16A, TNRC6A, BMP2K, MICAL3, DENND1A, WNK1, PRRC2B, STON2, FCHO2, Actb, Myh9, Myo1c, Tpm1, Lima1, Calml3, Sec24c, MCM2, SNW1, CDC5L, SMURF1, CDH1, STAMBPL1, RALBP1, SNRNP27, DLST, FCHO1, RBPMS, CRX, AGR2, CDK9, TGOLN2, ATG16L1, MAP1LC3A, DYRK1A, APEX1, SCARB2, VMP1, MTMR4, TENM1, ATXN1, ZC3H10, ATXN1L, PLEKHA4, ORF6, ORF3a, SMAP2, CIT, ECT2, KIF14, KIF20A, MKI67, HNRNPH1, CDC42, Rnf183, E, WDR76, GGA2, FAM20C, OGT, ISG15, ARF6, B3GAT1, C11orf52, DIRAS3, GJA1, KRAS, LAMP2, LAMP3, LAMTOR1, MARCKS, OCLN, RAB35, RHOB, STX6, STX7, SYNE3, ZFPL1, NAA40, PIP, SNAP91, MTSS1L, BAG2, DDX3Y, ZBTB2, DNAJB6, PINK1, WIF1, ZNF444, CCR1, CENPQ, DOK4, ST3GAL5, BBS1, RBM47, C10orf88, NTNG1, C11orf49, DNAJC6, MBNL1, RDH11, MED17, POGZ, SERBP1, RBM38, FSCN1, IFITM1, IFITM3, ACE2, M, nsp14, DDX3X,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLC4A4
PICALMall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000264485+326748_77984.333333333333331684.6666666666667CA4
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000340595+123748_77902318.3333333333335CA4
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000351898+324748_77984.333333333333331194.6666666666667CA4
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000425175+325748_77984.333333333333331095.0CA4
HgeneSLC4A4chr4:72121116chr11:85670103ENST00000512686+111748_7790647.0CA4
TgenePICALMchr4:72121116chr11:85670103ENST000003563601719221_294628.0633.0PIMREG
TgenePICALMchr4:72121116chr11:85670103ENST000003933461820221_294648.0653.0PIMREG
TgenePICALMchr4:72121116chr11:85670103ENST000005260331820221_294641.0646.0PIMREG
TgenePICALMchr4:72121116chr11:85670103ENST000005283981719221_294547.0552.0PIMREG
TgenePICALMchr4:72121116chr11:85670103ENST000005323171820221_294606.0611.0PIMREG


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Related Drugs to SLC4A4-PICALM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC4A4-PICALM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePICALMC0002395Alzheimer's Disease2CTD_human
TgenePICALMC0011265Presenile dementia2CTD_human
TgenePICALMC0276496Familial Alzheimer Disease (FAD)2CTD_human
TgenePICALMC0494463Alzheimer Disease, Late Onset2CTD_human
TgenePICALMC0546126Acute Confusional Senile Dementia2CTD_human
TgenePICALMC0750900Alzheimer's Disease, Focal Onset2CTD_human
TgenePICALMC0750901Alzheimer Disease, Early Onset2CTD_human
TgenePICALMC0234985Mental deterioration1CTD_human
TgenePICALMC0338656Impaired cognition1CTD_human
TgenePICALMC1270972Mild cognitive disorder1CTD_human