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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLC7A5-ANP32A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC7A5-ANP32A
FusionPDB ID: 83486
FusionGDB2.0 ID: 83486
HgeneTgene
Gene symbol

SLC7A5

ANP32A

Gene ID

8140

8125

Gene namesolute carrier family 7 member 5acidic nuclear phosphoprotein 32 family member A
Synonyms4F2LC|CD98|D16S469E|E16|LAT1|MPE16C15orf1|HPPCn|I1PP2A|LANP|MAPM|PHAP1|PHAPI|PP32
Cytomap

16q24.2

15q23

Type of geneprotein-codingprotein-coding
Descriptionlarge neutral amino acids transporter small subunit 14F2 light chainCD98 light chainL-type amino acid transporter 1integral membrane protein E16sodium-independent neutral amino acid transporter LAT1solute carrier family 7 (amino acid transporter ligacidic leucine-rich nuclear phosphoprotein 32 family member Aacidic (leucine-rich) nuclear phosphoprotein 32 family, member Aacidic nuclear phosphoprotein pp32cerebellar leucine rich acidic nuclear proteinepididymis secretory sperm binding proteinhep
Modification date2020031320200313
UniProtAcc

Q9GIP4

P39687

Ensembl transtripts involved in fusion geneENST idsENST00000261622, ENST00000565644, 
ENST00000483551, ENST00000560303, 
ENST00000465139, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 9 X 10=15303 X 3 X 3=27
# samples 203
** MAII scorelog2(20/1530*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLC7A5 [Title/Abstract] AND ANP32A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLC7A5(87902491)-ANP32A(69080258), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC7A5-ANP32A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC7A5-ANP32A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC7A5

GO:1904556

L-tryptophan transmembrane transport

30867591

TgeneANP32A

GO:0006913

nucleocytoplasmic transport

11729309


check buttonFusion gene breakpoints across SLC7A5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANP32A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721-01ASLC7A5chr16

87902491

-ANP32Achr15

69080258

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261622SLC7A5chr1687902491-ENST00000465139ANP32Achr1569080258-28466046191299226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261622ENST00000465139SLC7A5chr1687902491-ANP32Achr1569080258-0.0008994220.99910057

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83486_83486_1_SLC7A5-ANP32A_SLC7A5_chr16_87902491_ENST00000261622_ANP32A_chr15_69080258_ENST00000465139_length(amino acids)=226AA_BP=
MDNSRSNEGKLEGLTDEFEELEFLSTINVGLTSIANLPKLNKLKKLELSDNRVSGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLE
NLKSLDLFNCEVTNLNDYRENVFKLLPQLTYLDGYDRDDKEAPDSDAEGYVEGLDDEEEDEDEEEYDEDAQVVEDEEDEDEEEEGEEEDV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:87902491/chr15:69080258)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC7A5

Q9GIP4

ANP32A

P39687

FUNCTION: Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:16341127, PubMed:11360199, PubMed:18439902, PubMed:10400610). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:32694517, PubMed:33045004, PubMed:33208942, PubMed:30666459). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Plays also an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110105_126179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110148_169179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-1101_49179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-11071_83179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110127_147179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-11050_70179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-11084_104179.33333333333334508.0TransmembraneHelical
TgeneANP32Achr16:87902491chr15:69080258ENST0000046513907168_24918.0250.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneANP32Achr16:87902491chr15:69080258ENST0000046513907123_16118.0250.0DomainNote=LRRCT
TgeneANP32Achr16:87902491chr15:69080258ENST0000046513907150_17418.0250.0RegionNote=Necessary for tumor-suppressive function
TgeneANP32Achr16:87902491chr15:69080258ENST000004651390718_3818.0250.0RepeatLRR 1
TgeneANP32Achr16:87902491chr15:69080258ENST000004651390743_6418.0250.0RepeatLRR 2
TgeneANP32Achr16:87902491chr15:69080258ENST000004651390765_8718.0250.0RepeatLRR 3
TgeneANP32Achr16:87902491chr15:69080258ENST000004651390789_11018.0250.0RepeatLRR 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110191_192179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110215_242179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110264_276179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110298_324179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110346_369179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110391_395179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110417_430179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110452_457179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110479_507179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110105_1260242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110148_1690242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110191_1920242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-1101_490242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110215_2420242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110264_2760242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110298_3240242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110346_3690242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110391_3950242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110417_4300242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110452_4570242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110479_5070242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-11071_830242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110170_190179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110193_214179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110243_263179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110277_297179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110325_345179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110370_390179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110396_416179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110431_451179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110458_478179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110127_1470242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110170_1900242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110193_2140242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110243_2630242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110277_2970242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110325_3450242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110370_3900242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110396_4160242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110431_4510242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110458_4780242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-11050_700242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-11084_1040242.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLC7A5
ANP32A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SLC7A5-ANP32A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC7A5-ANP32A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource