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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLCO2B1-HNF4A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLCO2B1-HNF4A
FusionPDB ID: 83599
FusionGDB2.0 ID: 83599
HgeneTgene
Gene symbol

SLCO2B1

HNF4A

Gene ID

11309

6927

Gene namesolute carrier organic anion transporter family member 2B1HNF1 homeobox A
SynonymsOATP-B|OATP2B1|OATPB|SLC21A9HNF-1A|HNF1|HNF4A|IDDM20|LFB1|MODY3|TCF-1|TCF1
Cytomap

11q13.4

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier organic anion transporter family member 2B1OATP-RP2organic anion transporter Borganic anion transporter polypeptide-related protein 2solute carrier family 21 (organic anion transporter), member 9hepatocyte nuclear factor 1-alphaHNF-1-alphaalbumin proximal factorhepatic nuclear factor 1interferon production regulator factorliver-specific transcription factor LF-B1transcription factor 1, hepatictruncated hepatocyte nuclear factor 1 alpha
Modification date2020031520200313
UniProtAcc.

P41235

Ensembl transtripts involved in fusion geneENST idsENST00000341411, ENST00000428359, 
ENST00000454962, ENST00000532236, 
ENST00000289575, ENST00000525650, 
ENST00000531756, ENST00000526660, 
ENST00000316099, ENST00000316673, 
ENST00000415691, ENST00000443598, 
ENST00000457232, ENST00000609795, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 6 X 4=966 X 6 X 5=180
# samples 57
** MAII scorelog2(5/96*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLCO2B1 [Title/Abstract] AND HNF4A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLCO2B1(74870917)-HNF4A(43034698), # samples:2
SLCO2B1(74870917)-HNF4A(43031194), # samples:2
Anticipated loss of major functional domain due to fusion event.SLCO2B1-HNF4A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLCO2B1-HNF4A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLCO2B1-HNF4A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLCO2B1-HNF4A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLCO2B1

GO:0015711

organic anion transport

12724351|22021325

HgeneSLCO2B1

GO:0055085

transmembrane transport

12724351|29871943

TgeneHNF4A

GO:0001779

natural killer cell differentiation

11301190

TgeneHNF4A

GO:0006357

regulation of transcription by RNA polymerase II

10330009

TgeneHNF4A

GO:0045893

positive regulation of transcription, DNA-templated

1989880|11980910|12453420


check buttonFusion gene breakpoints across SLCO2B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HNF4A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-AS-3777-01ASLCO2B1chr11

74870917

+HNF4Achr20

43031194

+
ChimerDB4KIRCTCGA-AS-3777-01ASLCO2B1chr11

74870917

+HNF4Achr20

43034698

+
ChimerDB4KIRCTCGA-AS-3777-01ASLCO2B1chr11

74870949

-HNF4Achr20

43034698

+
ChimerDB4LIHCTCGA-DD-A115-01ASLCO2B1chr11

74862442

-HNF4Achr20

43034698

+
ChimerDB4LIHCTCGA-DD-A115-01ASLCO2B1chr11

74870917

+HNF4Achr20

43031194

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000289575SLCO2B1chr1174862442-ENST00000316673HNF4Achr2043034698+17274113951720441
ENST00000289575SLCO2B1chr1174862442-ENST00000609795HNF4Achr2043034698+15504113951549385
ENST00000289575SLCO2B1chr1174862442-ENST00000457232HNF4Achr2043034698+16974113951690431
ENST00000289575SLCO2B1chr1174862442-ENST00000443598HNF4Achr2043034698+18104113951549384
ENST00000289575SLCO2B1chr1174862442-ENST00000316099HNF4Achr2043034698+49014113951720441
ENST00000289575SLCO2B1chr1174862442-ENST00000415691HNF4Achr2043034698+25264113951690431
ENST00000531756SLCO2B1chr1174862442-ENST00000316673HNF4Achr2043034698+16443283121637441
ENST00000531756SLCO2B1chr1174862442-ENST00000609795HNF4Achr2043034698+14673283121466384
ENST00000531756SLCO2B1chr1174862442-ENST00000457232HNF4Achr2043034698+16143283121607431
ENST00000531756SLCO2B1chr1174862442-ENST00000443598HNF4Achr2043034698+17273283121466384
ENST00000531756SLCO2B1chr1174862442-ENST00000316099HNF4Achr2043034698+48183283121637441
ENST00000531756SLCO2B1chr1174862442-ENST00000415691HNF4Achr2043034698+24433283121607431
ENST00000525650SLCO2B1chr1174862442-ENST00000316673HNF4Achr2043034698+15992832671592441
ENST00000525650SLCO2B1chr1174862442-ENST00000609795HNF4Achr2043034698+14222832671421384
ENST00000525650SLCO2B1chr1174862442-ENST00000457232HNF4Achr2043034698+15692832671562431
ENST00000525650SLCO2B1chr1174862442-ENST00000443598HNF4Achr2043034698+16822832671421384
ENST00000525650SLCO2B1chr1174862442-ENST00000316099HNF4Achr2043034698+47732832671592441
ENST00000525650SLCO2B1chr1174862442-ENST00000415691HNF4Achr2043034698+23982832671562431

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000289575ENST00000316673SLCO2B1chr1174862442-HNF4Achr2043034698+0.0301549960.96984494
ENST00000289575ENST00000609795SLCO2B1chr1174862442-HNF4Achr2043034698+0.0301950890.96980494
ENST00000289575ENST00000457232SLCO2B1chr1174862442-HNF4Achr2043034698+0.0196527430.9803473
ENST00000289575ENST00000443598SLCO2B1chr1174862442-HNF4Achr2043034698+0.026503470.97349656
ENST00000289575ENST00000316099SLCO2B1chr1174862442-HNF4Achr2043034698+0.0113707910.9886292
ENST00000289575ENST00000415691SLCO2B1chr1174862442-HNF4Achr2043034698+0.0201944910.9798055
ENST00000531756ENST00000316673SLCO2B1chr1174862442-HNF4Achr2043034698+0.0260305160.97396946
ENST00000531756ENST00000609795SLCO2B1chr1174862442-HNF4Achr2043034698+0.0301270220.969873
ENST00000531756ENST00000457232SLCO2B1chr1174862442-HNF4Achr2043034698+0.0163827650.9836172
ENST00000531756ENST00000443598SLCO2B1chr1174862442-HNF4Achr2043034698+0.0251462330.97485375
ENST00000531756ENST00000316099SLCO2B1chr1174862442-HNF4Achr2043034698+0.011066910.9889331
ENST00000531756ENST00000415691SLCO2B1chr1174862442-HNF4Achr2043034698+0.0187513960.9812486
ENST00000525650ENST00000316673SLCO2B1chr1174862442-HNF4Achr2043034698+0.0216605230.97833943
ENST00000525650ENST00000609795SLCO2B1chr1174862442-HNF4Achr2043034698+0.0276165870.97238344
ENST00000525650ENST00000457232SLCO2B1chr1174862442-HNF4Achr2043034698+0.0137832130.9862168
ENST00000525650ENST00000443598SLCO2B1chr1174862442-HNF4Achr2043034698+0.0226026870.97739726
ENST00000525650ENST00000316099SLCO2B1chr1174862442-HNF4Achr2043034698+0.0108892180.98911077
ENST00000525650ENST00000415691SLCO2B1chr1174862442-HNF4Achr2043034698+0.0171860830.98281395

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83599_83599_1_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000289575_HNF4A_chr20_43034698_ENST00000316099_length(amino acids)=441AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_2_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000289575_HNF4A_chr20_43034698_ENST00000316673_length(amino acids)=441AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_3_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000289575_HNF4A_chr20_43034698_ENST00000415691_length(amino acids)=431AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_4_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000289575_HNF4A_chr20_43034698_ENST00000443598_length(amino acids)=384AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPG

--------------------------------------------------------------

>83599_83599_5_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000289575_HNF4A_chr20_43034698_ENST00000457232_length(amino acids)=431AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_6_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000289575_HNF4A_chr20_43034698_ENST00000609795_length(amino acids)=385AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPG

--------------------------------------------------------------

>83599_83599_7_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000525650_HNF4A_chr20_43034698_ENST00000316099_length(amino acids)=441AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_8_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000525650_HNF4A_chr20_43034698_ENST00000316673_length(amino acids)=441AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_9_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000525650_HNF4A_chr20_43034698_ENST00000415691_length(amino acids)=431AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_10_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000525650_HNF4A_chr20_43034698_ENST00000443598_length(amino acids)=384AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPG

--------------------------------------------------------------

>83599_83599_11_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000525650_HNF4A_chr20_43034698_ENST00000457232_length(amino acids)=431AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_12_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000525650_HNF4A_chr20_43034698_ENST00000609795_length(amino acids)=384AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPG

--------------------------------------------------------------

>83599_83599_13_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000531756_HNF4A_chr20_43034698_ENST00000316099_length(amino acids)=441AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_14_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000531756_HNF4A_chr20_43034698_ENST00000316673_length(amino acids)=441AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_15_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000531756_HNF4A_chr20_43034698_ENST00000415691_length(amino acids)=431AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_16_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000531756_HNF4A_chr20_43034698_ENST00000443598_length(amino acids)=384AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPG

--------------------------------------------------------------

>83599_83599_17_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000531756_HNF4A_chr20_43034698_ENST00000457232_length(amino acids)=431AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHL

--------------------------------------------------------------

>83599_83599_18_SLCO2B1-HNF4A_SLCO2B1_chr11_74862442_ENST00000531756_HNF4A_chr20_43034698_ENST00000609795_length(amino acids)=384AA_BP=5
MGPRIDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRA
GMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS
DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:74870917/chr20:43034698)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HNF4A

P41235

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHNF4Achr11:74862442chr20:43034698ENST0000031609901057_13238.333333333333336475.0DNA bindingNuclear receptor
TgeneHNF4Achr11:74862442chr20:43034698ENST0000031667301057_13216.333333333333332453.0DNA bindingNuclear receptor
TgeneHNF4Achr11:74862442chr20:43034698ENST0000041569101057_13238.333333333333336465.0DNA bindingNuclear receptor
TgeneHNF4Achr11:74862442chr20:43034698ENST000004435980857_13238.333333333333336418.0DNA bindingNuclear receptor
TgeneHNF4Achr11:74862442chr20:43034698ENST0000045723201057_13216.333333333333332443.0DNA bindingNuclear receptor
TgeneHNF4Achr11:74862442chr20:43034698ENST00000316099010147_37738.333333333333336475.0DomainNR LBD
TgeneHNF4Achr11:74862442chr20:43034698ENST00000316673010147_37716.333333333333332453.0DomainNR LBD
TgeneHNF4Achr11:74862442chr20:43034698ENST00000415691010147_37738.333333333333336465.0DomainNR LBD
TgeneHNF4Achr11:74862442chr20:43034698ENST0000044359808147_37738.333333333333336418.0DomainNR LBD
TgeneHNF4Achr11:74862442chr20:43034698ENST00000457232010147_37716.333333333333332443.0DomainNR LBD
TgeneHNF4Achr11:74862442chr20:43034698ENST00000316099010368_37638.333333333333336475.0Motif9aaTAD
TgeneHNF4Achr11:74862442chr20:43034698ENST00000316673010368_37616.333333333333332453.0Motif9aaTAD
TgeneHNF4Achr11:74862442chr20:43034698ENST00000415691010368_37638.333333333333336465.0Motif9aaTAD
TgeneHNF4Achr11:74862442chr20:43034698ENST0000044359808368_37638.333333333333336418.0Motif9aaTAD
TgeneHNF4Achr11:74862442chr20:43034698ENST00000457232010368_37616.333333333333332443.0Motif9aaTAD
TgeneHNF4Achr11:74862442chr20:43034698ENST0000031609901060_8038.333333333333336475.0Zinc fingerNR C4-type
TgeneHNF4Achr11:74862442chr20:43034698ENST0000031609901096_12038.333333333333336475.0Zinc fingerNR C4-type
TgeneHNF4Achr11:74862442chr20:43034698ENST0000031667301060_8016.333333333333332453.0Zinc fingerNR C4-type
TgeneHNF4Achr11:74862442chr20:43034698ENST0000031667301096_12016.333333333333332453.0Zinc fingerNR C4-type
TgeneHNF4Achr11:74862442chr20:43034698ENST0000041569101060_8038.333333333333336465.0Zinc fingerNR C4-type
TgeneHNF4Achr11:74862442chr20:43034698ENST0000041569101096_12038.333333333333336465.0Zinc fingerNR C4-type
TgeneHNF4Achr11:74862442chr20:43034698ENST000004435980860_8038.333333333333336418.0Zinc fingerNR C4-type
TgeneHNF4Achr11:74862442chr20:43034698ENST000004435980896_12038.333333333333336418.0Zinc fingerNR C4-type
TgeneHNF4Achr11:74862442chr20:43034698ENST0000045723201060_8016.333333333333332443.0Zinc fingerNR C4-type
TgeneHNF4Achr11:74862442chr20:43034698ENST0000045723201096_12016.333333333333332443.0Zinc fingerNR C4-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114483_5435.333333333333333710.0DomainKazal-like
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112483_5430483.0DomainKazal-like
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110483_5430483.0DomainKazal-like
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114110_1155.333333333333333710.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114141_1855.333333333333333710.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-1141_495.333333333333333710.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114216_2345.333333333333333710.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114256_2735.333333333333333710.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114299_3665.333333333333333710.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114389_4085.333333333333333710.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114433_4365.333333333333333710.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114461_5645.333333333333333710.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114588_5965.333333333333333710.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114623_6555.333333333333333710.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114674_7095.333333333333333710.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-11470_885.333333333333333710.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112110_1150483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112141_1850483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-1121_490483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112216_2340483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112256_2730483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112299_3660483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112389_4080483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112433_4360483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112461_5640483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112588_5960483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112623_6550483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112674_7090483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-11270_880483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110110_1150483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110141_1850483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-1101_490483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110216_2340483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110256_2730483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110299_3660483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110389_4080483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110433_4360483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110461_5640483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110588_5960483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110623_6550483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110674_7090483.0Topological domainCytoplasmic
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-11070_880483.0Topological domainExtracellular
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114116_1405.333333333333333710.0TransmembraneHelical%3B Name%3D3
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114186_2155.333333333333333710.0TransmembraneHelical%3B Name%3D4
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114235_2555.333333333333333710.0TransmembraneHelical%3B Name%3D5
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114274_2985.333333333333333710.0TransmembraneHelical%3B Name%3D6
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114367_3885.333333333333333710.0TransmembraneHelical%3B Name%3D7
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114409_4325.333333333333333710.0TransmembraneHelical%3B Name%3D8
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114437_4605.333333333333333710.0TransmembraneHelical%3B Name%3D9
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-11450_695.333333333333333710.0TransmembraneHelical%3B Name%3D1
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114565_5875.333333333333333710.0TransmembraneHelical%3B Name%3D10
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114597_6225.333333333333333710.0TransmembraneHelical%3B Name%3D11
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-114656_6735.333333333333333710.0TransmembraneHelical%3B Name%3D12
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000289575-11489_1095.333333333333333710.0TransmembraneHelical%3B Name%3D2
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112116_1400483.0TransmembraneHelical%3B Name%3D3
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112186_2150483.0TransmembraneHelical%3B Name%3D4
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112235_2550483.0TransmembraneHelical%3B Name%3D5
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112274_2980483.0TransmembraneHelical%3B Name%3D6
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112367_3880483.0TransmembraneHelical%3B Name%3D7
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112409_4320483.0TransmembraneHelical%3B Name%3D8
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112437_4600483.0TransmembraneHelical%3B Name%3D9
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-11250_690483.0TransmembraneHelical%3B Name%3D1
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112565_5870483.0TransmembraneHelical%3B Name%3D10
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112597_6220483.0TransmembraneHelical%3B Name%3D11
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-112656_6730483.0TransmembraneHelical%3B Name%3D12
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000341411-11289_1090483.0TransmembraneHelical%3B Name%3D2
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110116_1400483.0TransmembraneHelical%3B Name%3D3
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110186_2150483.0TransmembraneHelical%3B Name%3D4
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110235_2550483.0TransmembraneHelical%3B Name%3D5
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110274_2980483.0TransmembraneHelical%3B Name%3D6
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110367_3880483.0TransmembraneHelical%3B Name%3D7
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110409_4320483.0TransmembraneHelical%3B Name%3D8
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110437_4600483.0TransmembraneHelical%3B Name%3D9
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-11050_690483.0TransmembraneHelical%3B Name%3D1
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110565_5870483.0TransmembraneHelical%3B Name%3D10
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110597_6220483.0TransmembraneHelical%3B Name%3D11
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-110656_6730483.0TransmembraneHelical%3B Name%3D12
HgeneSLCO2B1chr11:74862442chr20:43034698ENST00000454962-11089_1090483.0TransmembraneHelical%3B Name%3D2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLCO2B1
HNF4A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SLCO2B1-HNF4A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLCO2B1-HNF4A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource