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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SMARCA4-C19orf38

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SMARCA4-C19orf38
FusionPDB ID: 83885
FusionGDB2.0 ID: 83885
HgeneTgene
Gene symbol

SMARCA4

C19orf38

Gene ID

6597

255809

Gene nameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4chromosome 19 open reading frame 38
SynonymsBAF190|BAF190A|BRG1|CSS4|MRD16|RTPS2|SNF2|SNF2-beta|SNF2L4|SNF2LB|SWI2|hSNF2bHIDE1
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription activator BRG1ATP-dependent helicase SMARCA4BRG1-associated factor 190ABRM/SWI2-related gene 1SNF2-like 4brahma protein-like 1global transcription activator homologous sequencehomeotic gene regulatormitotic growth and transcription aprotein HIDE1Highly expressed in immature dendritic cell transcript 1
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000344626, ENST00000358026, 
ENST00000413806, ENST00000429416, 
ENST00000444061, ENST00000450717, 
ENST00000541122, ENST00000589677, 
ENST00000590574, ENST00000538456, 
ENST00000397820, ENST00000592854, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score29 X 29 X 17=1429710 X 12 X 8=960
# samples 5517
** MAII scorelog2(55/14297*10)=-4.70013702309346
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/960*10)=-2.49749965947082
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SMARCA4 [Title/Abstract] AND C19orf38 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SMARCA4(11101999)-C19orf38(10979894), # samples:3
C19orf38(10976921)-SMARCA4(11103145), # samples:1
Anticipated loss of major functional domain due to fusion event.SMARCA4-C19orf38 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA4-C19orf38 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA4-C19orf38 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA4-C19orf38 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA4-C19orf38 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SMARCA4-C19orf38 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SMARCA4-C19orf38 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SMARCA4-C19orf38 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMARCA4

GO:0006337

nucleosome disassembly

8895581

HgeneSMARCA4

GO:0006338

chromatin remodeling

10943845|11726552

HgeneSMARCA4

GO:0045892

negative regulation of transcription, DNA-templated

12065415

HgeneSMARCA4

GO:0045944

positive regulation of transcription by RNA polymerase II

15774904|17938176

HgeneSMARCA4

GO:0051091

positive regulation of DNA-binding transcription factor activity

11950834|17938176

HgeneSMARCA4

GO:1902661

positive regulation of glucose mediated signaling pathway

22368283


check buttonFusion gene breakpoints across SMARCA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C19orf38 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2771-01ASMARCA4chr19

11101999

-C19orf38chr19

10979894

+
ChimerDB4LUSCTCGA-66-2771-01ASMARCA4chr19

11101999

+C19orf38chr19

10979894

+
ChimerDB4LUSCTCGA-66-2771SMARCA4chr19

11101999

+C19orf38chr19

10979894

+
ChimerDB4OVTCGA-09-1659SMARCA4chr19

11170863

+C19orf38chr19

10973845

+
ChimerDB4STADTCGA-BR-4357-01ASMARCA4chr19

11098600

-C19orf38chr19

10979894

+
ChimerDB4UCECTCGA-D1-A16S-01ASMARCA4chr19

11123788

+C19orf38chr19

10968992

+
ChimerDB4UCECTCGA-D1-A16SSMARCA4chr19

11123788

+C19orf38chr19

10968991

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358026SMARCA4chr1911101999+ENST00000397820C19orf38chr1910979894+227617032631852529
ENST00000344626SMARCA4chr1911101999+ENST00000397820C19orf38chr1910979894+219716241841773529
ENST00000429416SMARCA4chr1911101999+ENST00000397820C19orf38chr1910979894+22731700561849597
ENST00000541122SMARCA4chr1911101999+ENST00000397820C19orf38chr1910979894+227717042551853532
ENST00000589677SMARCA4chr1911101999+ENST00000397820C19orf38chr1910979894+232217493091898529
ENST00000444061SMARCA4chr1911101999+ENST00000397820C19orf38chr1910979894+20881515661664532
ENST00000590574SMARCA4chr1911101999+ENST00000397820C19orf38chr1910979894+242918564162005529
ENST00000413806SMARCA4chr1911101999+ENST00000397820C19orf38chr1910979894+1992141901568522
ENST00000450717SMARCA4chr1911101999+ENST00000397820C19orf38chr1910979894+1992141901568522
ENST00000358026SMARCA4chr1911098600-ENST00000592854C19orf38chr1910979894+165514022631654464
ENST00000344626SMARCA4chr1911098600-ENST00000592854C19orf38chr1910979894+157613231841575464
ENST00000429416SMARCA4chr1911098600-ENST00000592854C19orf38chr1910979894+16521399561651532
ENST00000541122SMARCA4chr1911098600-ENST00000592854C19orf38chr1910979894+165614032551655467
ENST00000589677SMARCA4chr1911098600-ENST00000592854C19orf38chr1910979894+170114483091700464
ENST00000444061SMARCA4chr1911098600-ENST00000592854C19orf38chr1910979894+14671214661466467
ENST00000590574SMARCA4chr1911098600-ENST00000592854C19orf38chr1910979894+180815554161807464
ENST00000413806SMARCA4chr1911098600-ENST00000592854C19orf38chr1910979894+1371111801370457
ENST00000450717SMARCA4chr1911098600-ENST00000592854C19orf38chr1910979894+1371111801370457

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358026ENST00000397820SMARCA4chr1911101999+C19orf38chr1910979894+0.057262170.94273776
ENST00000344626ENST00000397820SMARCA4chr1911101999+C19orf38chr1910979894+0.0547250770.94527495
ENST00000429416ENST00000397820SMARCA4chr1911101999+C19orf38chr1910979894+0.0507407340.9492593
ENST00000541122ENST00000397820SMARCA4chr1911101999+C19orf38chr1910979894+0.06741990.93258005
ENST00000589677ENST00000397820SMARCA4chr1911101999+C19orf38chr1910979894+0.056319410.9436806
ENST00000444061ENST00000397820SMARCA4chr1911101999+C19orf38chr1910979894+0.0527923260.94720775
ENST00000590574ENST00000397820SMARCA4chr1911101999+C19orf38chr1910979894+0.0582492460.94175076
ENST00000413806ENST00000397820SMARCA4chr1911101999+C19orf38chr1910979894+0.0614072940.93859273
ENST00000450717ENST00000397820SMARCA4chr1911101999+C19orf38chr1910979894+0.0614072940.93859273
ENST00000358026ENST00000592854SMARCA4chr1911098600-C19orf38chr1910979894+0.139820590.8601794
ENST00000344626ENST00000592854SMARCA4chr1911098600-C19orf38chr1910979894+0.073196770.92680323
ENST00000429416ENST00000592854SMARCA4chr1911098600-C19orf38chr1910979894+0.079346350.9206537
ENST00000541122ENST00000592854SMARCA4chr1911098600-C19orf38chr1910979894+0.152767930.84723204
ENST00000589677ENST00000592854SMARCA4chr1911098600-C19orf38chr1910979894+0.0654507060.93454933
ENST00000444061ENST00000592854SMARCA4chr1911098600-C19orf38chr1910979894+0.0519814230.9480186
ENST00000590574ENST00000592854SMARCA4chr1911098600-C19orf38chr1910979894+0.126178590.87382144
ENST00000413806ENST00000592854SMARCA4chr1911098600-C19orf38chr1910979894+0.083897820.9161021
ENST00000450717ENST00000592854SMARCA4chr1911098600-C19orf38chr1910979894+0.083897820.9161021

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83885_83885_1_SMARCA4-C19orf38_SMARCA4_chr19_11098600_ENST00000344626_C19orf38_chr19_10979894_ENST00000592854_length(amino acids)=464AA_BP=260
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRKRCQKKTRPPWMITQAPLPPPATPGPGRGPLPRPPRLRPPNSALSGPASEAEDWGTPLSPGIRGPEVPPA

--------------------------------------------------------------

>83885_83885_2_SMARCA4-C19orf38_SMARCA4_chr19_11098600_ENST00000358026_C19orf38_chr19_10979894_ENST00000592854_length(amino acids)=464AA_BP=260
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRKRCQKKTRPPWMITQAPLPPPATPGPGRGPLPRPPRLRPPNSALSGPASEAEDWGTPLSPGIRGPEVPPA

--------------------------------------------------------------

>83885_83885_3_SMARCA4-C19orf38_SMARCA4_chr19_11098600_ENST00000413806_C19orf38_chr19_10979894_ENST00000592854_length(amino acids)=457AA_BP=253
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRY
NQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL
RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPP
GMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRG
LDPVEILQEREYRKRCQKKTRPPWMITQAPLPPPATPGPGRGPLPRPPRLRPPNSALSGPASEAEDWGTPLSPGIRGPEVPPATSGGALS

--------------------------------------------------------------

>83885_83885_4_SMARCA4-C19orf38_SMARCA4_chr19_11098600_ENST00000429416_C19orf38_chr19_10979894_ENST00000592854_length(amino acids)=532AA_BP=44
MAAAAASLFREEKRDAHSAPGPARRGGGGAGKSTAPAAPASRPFAQARVQWCGHGSLQPQPPGLSRRPLSAAPVKMSTPDPPLGGTPRPG
PSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAG
MGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQP
LPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWP
EGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRKR

--------------------------------------------------------------

>83885_83885_5_SMARCA4-C19orf38_SMARCA4_chr19_11098600_ENST00000444061_C19orf38_chr19_10979894_ENST00000592854_length(amino acids)=467AA_BP=263
MRPLSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMH
EKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPT
PFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNM
PPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQS
RITPIQKPRGLDPVEILQEREYRKRCQKKTRPPWMITQAPLPPPATPGPGRGPLPRPPRLRPPNSALSGPASEAEDWGTPLSPGIRGPEV

--------------------------------------------------------------

>83885_83885_6_SMARCA4-C19orf38_SMARCA4_chr19_11098600_ENST00000450717_C19orf38_chr19_10979894_ENST00000592854_length(amino acids)=457AA_BP=253
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRY
NQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL
RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPP
GMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRG
LDPVEILQEREYRKRCQKKTRPPWMITQAPLPPPATPGPGRGPLPRPPRLRPPNSALSGPASEAEDWGTPLSPGIRGPEVPPATSGGALS

--------------------------------------------------------------

>83885_83885_7_SMARCA4-C19orf38_SMARCA4_chr19_11098600_ENST00000541122_C19orf38_chr19_10979894_ENST00000592854_length(amino acids)=467AA_BP=263
MRPLSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMH
EKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPT
PFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNM
PPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQS
RITPIQKPRGLDPVEILQEREYRKRCQKKTRPPWMITQAPLPPPATPGPGRGPLPRPPRLRPPNSALSGPASEAEDWGTPLSPGIRGPEV

--------------------------------------------------------------

>83885_83885_8_SMARCA4-C19orf38_SMARCA4_chr19_11098600_ENST00000589677_C19orf38_chr19_10979894_ENST00000592854_length(amino acids)=464AA_BP=260
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRKRCQKKTRPPWMITQAPLPPPATPGPGRGPLPRPPRLRPPNSALSGPASEAEDWGTPLSPGIRGPEVPPA

--------------------------------------------------------------

>83885_83885_9_SMARCA4-C19orf38_SMARCA4_chr19_11098600_ENST00000590574_C19orf38_chr19_10979894_ENST00000592854_length(amino acids)=464AA_BP=260
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRKRCQKKTRPPWMITQAPLPPPATPGPGRGPLPRPPRLRPPNSALSGPASEAEDWGTPLSPGIRGPEVPPA

--------------------------------------------------------------

>83885_83885_10_SMARCA4-C19orf38_SMARCA4_chr19_11101999_ENST00000344626_C19orf38_chr19_10979894_ENST00000397820_length(amino acids)=529AA_BP=480
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK

--------------------------------------------------------------

>83885_83885_11_SMARCA4-C19orf38_SMARCA4_chr19_11101999_ENST00000358026_C19orf38_chr19_10979894_ENST00000397820_length(amino acids)=529AA_BP=480
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK

--------------------------------------------------------------

>83885_83885_12_SMARCA4-C19orf38_SMARCA4_chr19_11101999_ENST00000413806_C19orf38_chr19_10979894_ENST00000397820_length(amino acids)=522AA_BP=473
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRY
NQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL
RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPP
GMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRG
LDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREA

--------------------------------------------------------------

>83885_83885_13_SMARCA4-C19orf38_SMARCA4_chr19_11101999_ENST00000429416_C19orf38_chr19_10979894_ENST00000397820_length(amino acids)=597AA_BP=44
MAAAAASLFREEKRDAHSAPGPARRGGGGAGKSTAPAAPASRPFAQARVQWCGHGSLQPQPPGLSRRPLSAAPVKMSTPDPPLGGTPRPG
PSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAG
MGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQP
LPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWP
EGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQ
ARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQE

--------------------------------------------------------------

>83885_83885_14_SMARCA4-C19orf38_SMARCA4_chr19_11101999_ENST00000444061_C19orf38_chr19_10979894_ENST00000397820_length(amino acids)=532AA_BP=483
MRPLSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMH
EKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPT
PFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNM
PPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQS
RITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYK

--------------------------------------------------------------

>83885_83885_15_SMARCA4-C19orf38_SMARCA4_chr19_11101999_ENST00000450717_C19orf38_chr19_10979894_ENST00000397820_length(amino acids)=522AA_BP=473
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRY
NQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL
RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPP
GMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRG
LDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREA

--------------------------------------------------------------

>83885_83885_16_SMARCA4-C19orf38_SMARCA4_chr19_11101999_ENST00000541122_C19orf38_chr19_10979894_ENST00000397820_length(amino acids)=532AA_BP=483
MRPLSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMH
EKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPT
PFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNM
PPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQS
RITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYK

--------------------------------------------------------------

>83885_83885_17_SMARCA4-C19orf38_SMARCA4_chr19_11101999_ENST00000589677_C19orf38_chr19_10979894_ENST00000397820_length(amino acids)=529AA_BP=480
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK

--------------------------------------------------------------

>83885_83885_18_SMARCA4-C19orf38_SMARCA4_chr19_11101999_ENST00000590574_C19orf38_chr19_10979894_ENST00000397820_length(amino acids)=529AA_BP=480
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11101999/chr19:10979894)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-635171_206372.66666666666671648.0DomainQLQ
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-533171_206372.66666666666671618.0DomainQLQ
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-736171_206372.66666666666671648.0DomainQLQ
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-735171_206372.66666666666671614.0DomainQLQ
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-533171_206372.66666666666671617.0DomainQLQ
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-735171_206372.66666666666671618.0DomainQLQ
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-735171_206372.66666666666671617.0DomainQLQ
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-634171_206372.66666666666671615.0DomainQLQ
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+835171_206473.01648.0DomainQLQ
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+733171_206473.01618.0DomainQLQ
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+936171_206473.01648.0DomainQLQ
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+935171_206473.01614.0DomainQLQ
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+733171_206473.01617.0DomainQLQ
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+935171_206473.01618.0DomainQLQ
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+935171_206473.01617.0DomainQLQ
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+834171_206473.01615.0DomainQLQ

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-6351360_1364372.66666666666671648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-6351571_1584372.66666666666671648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-635578_588372.66666666666671648.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-635663_672372.66666666666671648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-5331360_1364372.66666666666671618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-5331571_1584372.66666666666671618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-533578_588372.66666666666671618.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-533663_672372.66666666666671618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-7361360_1364372.66666666666671648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-7361571_1584372.66666666666671648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-736578_588372.66666666666671648.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-736663_672372.66666666666671648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-7351360_1364372.66666666666671614.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-7351571_1584372.66666666666671614.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-735578_588372.66666666666671614.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-735663_672372.66666666666671614.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-5331360_1364372.66666666666671617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-5331571_1584372.66666666666671617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-533578_588372.66666666666671617.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-533663_672372.66666666666671617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-7351360_1364372.66666666666671618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-7351571_1584372.66666666666671618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-735578_588372.66666666666671618.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-735663_672372.66666666666671618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-7351360_1364372.66666666666671617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-7351571_1584372.66666666666671617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-735578_588372.66666666666671617.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-735663_672372.66666666666671617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-6341360_1364372.66666666666671615.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-6341571_1584372.66666666666671615.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-634578_588372.66666666666671615.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-634663_672372.66666666666671615.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+8351360_1364473.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+8351571_1584473.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+835578_588473.01648.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+835663_672473.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+7331360_1364473.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+7331571_1584473.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+733578_588473.01618.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+733663_672473.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+9361360_1364473.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+9361571_1584473.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+936578_588473.01648.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+936663_672473.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+9351360_1364473.01614.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+9351571_1584473.01614.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+935578_588473.01614.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+935663_672473.01614.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+7331360_1364473.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+7331571_1584473.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+733578_588473.01617.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+733663_672473.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+9351360_1364473.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+9351571_1584473.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+935578_588473.01618.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+935663_672473.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+9351360_1364473.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+9351571_1584473.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+935578_588473.01617.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+935663_672473.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+8341360_1364473.01615.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+8341571_1584473.01615.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+834578_588473.01615.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+834663_672473.01615.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-6351084_1246372.66666666666671648.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-6351477_1547372.66666666666671648.0DomainBromo
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-635460_532372.66666666666671648.0DomainHSA
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-635766_931372.66666666666671648.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-5331084_1246372.66666666666671618.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-5331477_1547372.66666666666671618.0DomainBromo
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-533460_532372.66666666666671618.0DomainHSA
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-533766_931372.66666666666671618.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-7361084_1246372.66666666666671648.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-7361477_1547372.66666666666671648.0DomainBromo
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-736460_532372.66666666666671648.0DomainHSA
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-736766_931372.66666666666671648.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-7351084_1246372.66666666666671614.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-7351477_1547372.66666666666671614.0DomainBromo
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-735460_532372.66666666666671614.0DomainHSA
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-735766_931372.66666666666671614.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-5331084_1246372.66666666666671617.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-5331477_1547372.66666666666671617.0DomainBromo
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-533460_532372.66666666666671617.0DomainHSA
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-533766_931372.66666666666671617.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-7351084_1246372.66666666666671618.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-7351477_1547372.66666666666671618.0DomainBromo
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-735460_532372.66666666666671618.0DomainHSA
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-735766_931372.66666666666671618.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-7351084_1246372.66666666666671617.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-7351477_1547372.66666666666671617.0DomainBromo
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-735460_532372.66666666666671617.0DomainHSA
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-735766_931372.66666666666671617.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-6341084_1246372.66666666666671615.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-6341477_1547372.66666666666671615.0DomainBromo
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-634460_532372.66666666666671615.0DomainHSA
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-634766_931372.66666666666671615.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+8351084_1246473.01648.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+8351477_1547473.01648.0DomainBromo
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+835460_532473.01648.0DomainHSA
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+835766_931473.01648.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+7331084_1246473.01618.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+7331477_1547473.01618.0DomainBromo
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+733460_532473.01618.0DomainHSA
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+733766_931473.01618.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+9361084_1246473.01648.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+9361477_1547473.01648.0DomainBromo
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+936460_532473.01648.0DomainHSA
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+936766_931473.01648.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+9351084_1246473.01614.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+9351477_1547473.01614.0DomainBromo
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+935460_532473.01614.0DomainHSA
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+935766_931473.01614.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+7331084_1246473.01617.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+7331477_1547473.01617.0DomainBromo
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+733460_532473.01617.0DomainHSA
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+733766_931473.01617.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+9351084_1246473.01618.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+9351477_1547473.01618.0DomainBromo
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+935460_532473.01618.0DomainHSA
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+935766_931473.01618.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+9351084_1246473.01617.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+9351477_1547473.01617.0DomainBromo
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+935460_532473.01617.0DomainHSA
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+935766_931473.01617.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+8341084_1246473.01615.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+8341477_1547473.01615.0DomainBromo
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+834460_532473.01615.0DomainHSA
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+834766_931473.01615.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-635881_884372.66666666666671648.0MotifNote=DEGH box
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-533881_884372.66666666666671618.0MotifNote=DEGH box
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-736881_884372.66666666666671648.0MotifNote=DEGH box
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-735881_884372.66666666666671614.0MotifNote=DEGH box
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-533881_884372.66666666666671617.0MotifNote=DEGH box
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-735881_884372.66666666666671618.0MotifNote=DEGH box
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-735881_884372.66666666666671617.0MotifNote=DEGH box
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-634881_884372.66666666666671615.0MotifNote=DEGH box
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+835881_884473.01648.0MotifNote=DEGH box
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+733881_884473.01618.0MotifNote=DEGH box
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+936881_884473.01648.0MotifNote=DEGH box
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+935881_884473.01614.0MotifNote=DEGH box
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+733881_884473.01617.0MotifNote=DEGH box
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+935881_884473.01618.0MotifNote=DEGH box
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+935881_884473.01617.0MotifNote=DEGH box
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+834881_884473.01615.0MotifNote=DEGH box
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-635779_786372.66666666666671648.0Nucleotide bindingATP
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-533779_786372.66666666666671618.0Nucleotide bindingATP
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-736779_786372.66666666666671648.0Nucleotide bindingATP
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-735779_786372.66666666666671614.0Nucleotide bindingATP
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-533779_786372.66666666666671617.0Nucleotide bindingATP
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-735779_786372.66666666666671618.0Nucleotide bindingATP
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-735779_786372.66666666666671617.0Nucleotide bindingATP
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-634779_786372.66666666666671615.0Nucleotide bindingATP
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+835779_786473.01648.0Nucleotide bindingATP
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+733779_786473.01618.0Nucleotide bindingATP
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+936779_786473.01648.0Nucleotide bindingATP
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+935779_786473.01614.0Nucleotide bindingATP
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+733779_786473.01617.0Nucleotide bindingATP
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+935779_786473.01618.0Nucleotide bindingATP
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+935779_786473.01617.0Nucleotide bindingATP
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+834779_786473.01615.0Nucleotide bindingATP
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000344626-635462_728372.66666666666671648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000413806-533462_728372.66666666666671618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000429416-736462_728372.66666666666671648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000444061-735462_728372.66666666666671614.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000450717-533462_728372.66666666666671617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000541122-735462_728372.66666666666671618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000589677-735462_728372.66666666666671617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11098600chr19:10979894ENST00000590574-634462_728372.66666666666671615.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000344626+835462_728473.01648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000413806+733462_728473.01618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000429416+936462_728473.01648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000444061+935462_728473.01614.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000450717+733462_728473.01617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000541122+935462_728473.01618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000589677+935462_728473.01617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11101999chr19:10979894ENST00000590574+834462_728473.01615.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneC19orf38chr19:11098600chr19:10979894ENST0000039782057139_230181.0231.0Topological domainCytoplasmic
TgeneC19orf38chr19:11098600chr19:10979894ENST000003978205720_117181.0231.0Topological domainExtracellular
TgeneC19orf38chr19:11098600chr19:10979894ENST0000059285468139_230181.0231.0Topological domainCytoplasmic
TgeneC19orf38chr19:11098600chr19:10979894ENST000005928546820_117181.0231.0Topological domainExtracellular
TgeneC19orf38chr19:11101999chr19:10979894ENST0000039782057139_230181.0231.0Topological domainCytoplasmic
TgeneC19orf38chr19:11101999chr19:10979894ENST000003978205720_117181.0231.0Topological domainExtracellular
TgeneC19orf38chr19:11101999chr19:10979894ENST0000059285468139_230181.0231.0Topological domainCytoplasmic
TgeneC19orf38chr19:11101999chr19:10979894ENST000005928546820_117181.0231.0Topological domainExtracellular
TgeneC19orf38chr19:11098600chr19:10979894ENST0000039782057118_138181.0231.0TransmembraneHelical
TgeneC19orf38chr19:11098600chr19:10979894ENST0000059285468118_138181.0231.0TransmembraneHelical
TgeneC19orf38chr19:11101999chr19:10979894ENST0000039782057118_138181.0231.0TransmembraneHelical
TgeneC19orf38chr19:11101999chr19:10979894ENST0000059285468118_138181.0231.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1266_SMARCA4_11101999_C19orf38_10979894_1266_SMARCA4_11101999_C19orf38_10979894_ranked_0.pdbSMARCA41109860011101999ENST00000592854C19orf38chr1910979894+
MAAAAASLFREEKRDAHSAPGPARRGGGGAGKSTAPAAPASRPFAQARVQWCGHGSLQPQPPGLSRRPLSAAPVKMSTPDPPLGGTPRPG
PSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAG
MGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQP
LPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWP
EGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQ
ARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQE
597


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SMARCA4_pLDDT.png
all structure
all structure

all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SMARCA4
C19orf38


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SMARCA4-C19orf38


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SMARCA4-C19orf38


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource