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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SMARCA4-SMIM7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SMARCA4-SMIM7
FusionPDB ID: 83910
FusionGDB2.0 ID: 83910
HgeneTgene
Gene symbol

SMARCA4

SMIM7

Gene ID

6597

79086

Gene nameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4small integral membrane protein 7
SynonymsBAF190|BAF190A|BRG1|CSS4|MRD16|RTPS2|SNF2|SNF2-beta|SNF2L4|SNF2LB|SWI2|hSNF2bC19orf42
Cytomap

19p13.2

19p13.11

Type of geneprotein-codingprotein-coding
Descriptiontranscription activator BRG1ATP-dependent helicase SMARCA4BRG1-associated factor 190ABRM/SWI2-related gene 1SNF2-like 4brahma protein-like 1global transcription activator homologous sequencehomeotic gene regulatormitotic growth and transcription asmall integral membrane protein 7UPF0608 protein C19orf42
Modification date2020031520200313
UniProtAcc.

Q9BQ49

Ensembl transtripts involved in fusion geneENST idsENST00000344626, ENST00000358026, 
ENST00000413806, ENST00000429416, 
ENST00000444061, ENST00000450717, 
ENST00000541122, ENST00000589677, 
ENST00000590574, ENST00000538456, 
ENST00000397349, ENST00000358726, 
ENST00000487416, ENST00000597711, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score29 X 29 X 17=142979 X 10 X 4=360
# samples 558
** MAII scorelog2(55/14297*10)=-4.70013702309346
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/360*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SMARCA4 [Title/Abstract] AND SMIM7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SMARCA4(11107220)-SMIM7(16758072), # samples:1
Anticipated loss of major functional domain due to fusion event.SMARCA4-SMIM7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA4-SMIM7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA4-SMIM7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA4-SMIM7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMARCA4

GO:0006337

nucleosome disassembly

8895581

HgeneSMARCA4

GO:0006338

chromatin remodeling

10943845|11726552

HgeneSMARCA4

GO:0045892

negative regulation of transcription, DNA-templated

12065415

HgeneSMARCA4

GO:0045944

positive regulation of transcription by RNA polymerase II

15774904|17938176

HgeneSMARCA4

GO:0051091

positive regulation of DNA-binding transcription factor activity

11950834|17938176

HgeneSMARCA4

GO:1902661

positive regulation of glucose mediated signaling pathway

22368283


check buttonFusion gene breakpoints across SMARCA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMIM7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TM-A7CF-01ASMARCA4chr19

11107220

+SMIM7chr19

16758072

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358026SMARCA4chr1911107220+ENST00000487416SMIM7chr1916758072-461320962632176637
ENST00000358026SMARCA4chr1911107220+ENST00000597711SMIM7chr1916758072-301620962632176637
ENST00000344626SMARCA4chr1911107220+ENST00000487416SMIM7chr1916758072-453420171842097637
ENST00000344626SMARCA4chr1911107220+ENST00000597711SMIM7chr1916758072-293720171842097637
ENST00000429416SMARCA4chr1911107220+ENST00000487416SMIM7chr1916758072-46102093562173705
ENST00000429416SMARCA4chr1911107220+ENST00000597711SMIM7chr1916758072-30132093562173705
ENST00000541122SMARCA4chr1911107220+ENST00000487416SMIM7chr1916758072-461420972552177640
ENST00000541122SMARCA4chr1911107220+ENST00000597711SMIM7chr1916758072-301720972552177640
ENST00000589677SMARCA4chr1911107220+ENST00000487416SMIM7chr1916758072-465921423092222637
ENST00000589677SMARCA4chr1911107220+ENST00000597711SMIM7chr1916758072-306221423092222637
ENST00000444061SMARCA4chr1911107220+ENST00000487416SMIM7chr1916758072-44251908661988640
ENST00000444061SMARCA4chr1911107220+ENST00000597711SMIM7chr1916758072-28281908661988640
ENST00000590574SMARCA4chr1911107220+ENST00000487416SMIM7chr1916758072-476622494162329637
ENST00000590574SMARCA4chr1911107220+ENST00000597711SMIM7chr1916758072-316922494162329637
ENST00000413806SMARCA4chr1911107220+ENST00000487416SMIM7chr1916758072-4329181201892630
ENST00000413806SMARCA4chr1911107220+ENST00000597711SMIM7chr1916758072-2732181201892630
ENST00000450717SMARCA4chr1911107220+ENST00000487416SMIM7chr1916758072-4329181201892630
ENST00000450717SMARCA4chr1911107220+ENST00000597711SMIM7chr1916758072-2732181201892630

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358026ENST00000487416SMARCA4chr1911107220+SMIM7chr1916758072-0.0043700290.99563
ENST00000358026ENST00000597711SMARCA4chr1911107220+SMIM7chr1916758072-0.0120566590.98794335
ENST00000344626ENST00000487416SMARCA4chr1911107220+SMIM7chr1916758072-0.0048093030.99519074
ENST00000344626ENST00000597711SMARCA4chr1911107220+SMIM7chr1916758072-0.0139622280.9860378
ENST00000429416ENST00000487416SMARCA4chr1911107220+SMIM7chr1916758072-0.0053456010.9946544
ENST00000429416ENST00000597711SMARCA4chr1911107220+SMIM7chr1916758072-0.0151107460.98488927
ENST00000541122ENST00000487416SMARCA4chr1911107220+SMIM7chr1916758072-0.0049710940.9950289
ENST00000541122ENST00000597711SMARCA4chr1911107220+SMIM7chr1916758072-0.0148134050.98518664
ENST00000589677ENST00000487416SMARCA4chr1911107220+SMIM7chr1916758072-0.0048162780.99518377
ENST00000589677ENST00000597711SMARCA4chr1911107220+SMIM7chr1916758072-0.0137799920.98622
ENST00000444061ENST00000487416SMARCA4chr1911107220+SMIM7chr1916758072-0.0047843910.99521565
ENST00000444061ENST00000597711SMARCA4chr1911107220+SMIM7chr1916758072-0.0144629490.9855371
ENST00000590574ENST00000487416SMARCA4chr1911107220+SMIM7chr1916758072-0.0045697330.99543023
ENST00000590574ENST00000597711SMARCA4chr1911107220+SMIM7chr1916758072-0.0123558990.98764414
ENST00000413806ENST00000487416SMARCA4chr1911107220+SMIM7chr1916758072-0.004350170.9956499
ENST00000413806ENST00000597711SMARCA4chr1911107220+SMIM7chr1916758072-0.0136716620.9863283
ENST00000450717ENST00000487416SMARCA4chr1911107220+SMIM7chr1916758072-0.004350170.9956499
ENST00000450717ENST00000597711SMARCA4chr1911107220+SMIM7chr1916758072-0.0136716620.9863283

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83910_83910_1_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000344626_SMIM7_chr19_16758072_ENST00000487416_length(amino acids)=637AA_BP=611
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK
RQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAE
DEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDA

--------------------------------------------------------------

>83910_83910_2_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000344626_SMIM7_chr19_16758072_ENST00000597711_length(amino acids)=637AA_BP=611
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK
RQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAE
DEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDA

--------------------------------------------------------------

>83910_83910_3_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000358026_SMIM7_chr19_16758072_ENST00000487416_length(amino acids)=637AA_BP=611
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK
RQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAE
DEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDA

--------------------------------------------------------------

>83910_83910_4_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000358026_SMIM7_chr19_16758072_ENST00000597711_length(amino acids)=637AA_BP=611
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK
RQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAE
DEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDA

--------------------------------------------------------------

>83910_83910_5_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000413806_SMIM7_chr19_16758072_ENST00000487416_length(amino acids)=630AA_BP=604
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRY
NQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL
RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPP
GMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRG
LDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREA
RITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRK
LIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDAESPFLHS

--------------------------------------------------------------

>83910_83910_6_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000413806_SMIM7_chr19_16758072_ENST00000597711_length(amino acids)=630AA_BP=604
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRY
NQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL
RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPP
GMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRG
LDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREA
RITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRK
LIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDAESPFLHS

--------------------------------------------------------------

>83910_83910_7_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000429416_SMIM7_chr19_16758072_ENST00000487416_length(amino acids)=705AA_BP=24
MAAAAASLFREEKRDAHSAPGPARRGGGGAGKSTAPAAPASRPFAQARVQWCGHGSLQPQPPGLSRRPLSAAPVKMSTPDPPLGGTPRPG
PSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAG
MGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQP
LPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWP
EGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQ
ARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQE
RKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQ

--------------------------------------------------------------

>83910_83910_8_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000429416_SMIM7_chr19_16758072_ENST00000597711_length(amino acids)=705AA_BP=24
MAAAAASLFREEKRDAHSAPGPARRGGGGAGKSTAPAAPASRPFAQARVQWCGHGSLQPQPPGLSRRPLSAAPVKMSTPDPPLGGTPRPG
PSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAG
MGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQP
LPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWP
EGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQ
ARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQE
RKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQ

--------------------------------------------------------------

>83910_83910_9_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000444061_SMIM7_chr19_16758072_ENST00000487416_length(amino acids)=640AA_BP=614
MRPLSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMH
EKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPT
PFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNM
PPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQS
RITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYK
RSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRL
MAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLS

--------------------------------------------------------------

>83910_83910_10_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000444061_SMIM7_chr19_16758072_ENST00000597711_length(amino acids)=640AA_BP=614
MRPLSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMH
EKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPT
PFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNM
PPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQS
RITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYK
RSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRL
MAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLS

--------------------------------------------------------------

>83910_83910_11_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000450717_SMIM7_chr19_16758072_ENST00000487416_length(amino acids)=630AA_BP=604
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRY
NQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL
RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPP
GMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRG
LDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREA
RITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRK
LIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDAESPFLHS

--------------------------------------------------------------

>83910_83910_12_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000450717_SMIM7_chr19_16758072_ENST00000597711_length(amino acids)=630AA_BP=604
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRY
NQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL
RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPP
GMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRG
LDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREA
RITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRK
LIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDAESPFLHS

--------------------------------------------------------------

>83910_83910_13_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000541122_SMIM7_chr19_16758072_ENST00000487416_length(amino acids)=640AA_BP=614
MRPLSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMH
EKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPT
PFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNM
PPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQS
RITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYK
RSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRL
MAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLS

--------------------------------------------------------------

>83910_83910_14_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000541122_SMIM7_chr19_16758072_ENST00000597711_length(amino acids)=640AA_BP=614
MRPLSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMH
EKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPT
PFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNM
PPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQS
RITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYK
RSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRL
MAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLS

--------------------------------------------------------------

>83910_83910_15_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000589677_SMIM7_chr19_16758072_ENST00000487416_length(amino acids)=637AA_BP=611
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK
RQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAE
DEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDA

--------------------------------------------------------------

>83910_83910_16_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000589677_SMIM7_chr19_16758072_ENST00000597711_length(amino acids)=637AA_BP=611
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK
RQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAE
DEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDA

--------------------------------------------------------------

>83910_83910_17_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000590574_SMIM7_chr19_16758072_ENST00000487416_length(amino acids)=637AA_BP=611
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK
RQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAE
DEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDA

--------------------------------------------------------------

>83910_83910_18_SMARCA4-SMIM7_SMARCA4_chr19_11107220_ENST00000590574_SMIM7_chr19_16758072_ENST00000597711_length(amino acids)=637AA_BP=611
MSAAPVKMSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKG
MSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFN
QNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPP
GPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT
PIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSK
RQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAE
DEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEAVRLLNPSDETRNSLSRDA

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11107220/chr19:16758072)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SMIM7

Q9BQ49

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+1135578_588604.01648.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+1033578_588604.01618.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+1236578_588604.01648.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+1235578_588604.01614.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+1033578_588604.01617.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+1235578_588604.01618.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+1235578_588604.01617.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+1134578_588604.01615.0Compositional biasNote=Poly-Lys
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+1135171_206604.01648.0DomainQLQ
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+1135460_532604.01648.0DomainHSA
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+1033171_206604.01618.0DomainQLQ
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+1033460_532604.01618.0DomainHSA
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+1236171_206604.01648.0DomainQLQ
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+1236460_532604.01648.0DomainHSA
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+1235171_206604.01614.0DomainQLQ
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+1235460_532604.01614.0DomainHSA
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+1033171_206604.01617.0DomainQLQ
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+1033460_532604.01617.0DomainHSA
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+1235171_206604.01618.0DomainQLQ
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+1235460_532604.01618.0DomainHSA
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+1235171_206604.01617.0DomainQLQ
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+1235460_532604.01617.0DomainHSA
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+1134171_206604.01615.0DomainQLQ
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+1134460_532604.01615.0DomainHSA
TgeneSMIM7chr19:11107220chr19:16758072ENST000004874163575_7570.6666666666666776.0Topological domainCytoplasmic

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+11351360_1364604.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+11351571_1584604.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+1135663_672604.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+10331360_1364604.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+10331571_1584604.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+1033663_672604.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+12361360_1364604.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+12361571_1584604.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+1236663_672604.01648.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+12351360_1364604.01614.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+12351571_1584604.01614.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+1235663_672604.01614.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+10331360_1364604.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+10331571_1584604.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+1033663_672604.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+12351360_1364604.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+12351571_1584604.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+1235663_672604.01618.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+12351360_1364604.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+12351571_1584604.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+1235663_672604.01617.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+11341360_1364604.01615.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+11341571_1584604.01615.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+1134663_672604.01615.0Compositional biasNote=Poly-Glu
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+11351084_1246604.01648.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+11351477_1547604.01648.0DomainBromo
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+1135766_931604.01648.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+10331084_1246604.01618.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+10331477_1547604.01618.0DomainBromo
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+1033766_931604.01618.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+12361084_1246604.01648.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+12361477_1547604.01648.0DomainBromo
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+1236766_931604.01648.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+12351084_1246604.01614.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+12351477_1547604.01614.0DomainBromo
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+1235766_931604.01614.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+10331084_1246604.01617.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+10331477_1547604.01617.0DomainBromo
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+1033766_931604.01617.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+12351084_1246604.01618.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+12351477_1547604.01618.0DomainBromo
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+1235766_931604.01618.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+12351084_1246604.01617.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+12351477_1547604.01617.0DomainBromo
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+1235766_931604.01617.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+11341084_1246604.01615.0DomainHelicase C-terminal
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+11341477_1547604.01615.0DomainBromo
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+1134766_931604.01615.0DomainHelicase ATP-binding
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+1135881_884604.01648.0MotifNote=DEGH box
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+1033881_884604.01618.0MotifNote=DEGH box
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+1236881_884604.01648.0MotifNote=DEGH box
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+1235881_884604.01614.0MotifNote=DEGH box
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+1033881_884604.01617.0MotifNote=DEGH box
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+1235881_884604.01618.0MotifNote=DEGH box
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+1235881_884604.01617.0MotifNote=DEGH box
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+1134881_884604.01615.0MotifNote=DEGH box
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+1135779_786604.01648.0Nucleotide bindingATP
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+1033779_786604.01618.0Nucleotide bindingATP
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+1236779_786604.01648.0Nucleotide bindingATP
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+1235779_786604.01614.0Nucleotide bindingATP
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+1033779_786604.01617.0Nucleotide bindingATP
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+1235779_786604.01618.0Nucleotide bindingATP
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+1235779_786604.01617.0Nucleotide bindingATP
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+1134779_786604.01615.0Nucleotide bindingATP
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000344626+1135462_728604.01648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000413806+1033462_728604.01618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000429416+1236462_728604.01648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000444061+1235462_728604.01614.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000450717+1033462_728604.01617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000541122+1235462_728604.01618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000589677+1235462_728604.01617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
HgeneSMARCA4chr19:11107220chr19:16758072ENST00000590574+1134462_728604.01615.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMIM7chr19:11107220chr19:16758072ENST000004874163518_5370.6666666666666776.0Topological domainExtracellular
TgeneSMIM7chr19:11107220chr19:16758072ENST000004874163554_7470.6666666666666776.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SMARCA4
SMIM7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SMARCA4-SMIM7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SMARCA4-SMIM7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource