UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SMARCB1-TTC3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SMARCB1-TTC3
	FusionPDB ID: 83934
	FusionGDB2.0 ID: 83934
		Hgene	Tgene
	Gene symbol	SMARCB1	TTC3
	Gene ID	6598	7267
	Gene name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	tetratricopeptide repeat domain 3
	Synonyms	BAF47\|CSS3\|INI1\|MRD15\|PPP1R144\|RDT\|RTPS1\|SNF5\|SNF5L1\|SWNTS1\|Sfh1p\|Snr1\|hSNFS	DCRR1\|RNF105\|TPRDIII
	Cytomap	22q11.23\|22q11	21q22.13
	Type of gene	protein-coding	protein-coding
	Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1BRG1-associated factor 47SNF5 homologSWI/SNF-related matrix-associated proteinhSNF5integrase interactor 1 proteinmalignant rhabdoid tumor suppressorprotein	E3 ubiquitin-protein ligase TTC3RING finger protein 105RING-type E3 ubiquitin transferase TTC3TPR repeat protein 3TPR repeat protein Dtetratricopeptide repeat protein 3
	Modification date	20200313	20200320
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000263121, ENST00000344921, ENST00000407082, ENST00000407422, ENST00000477836,	ENST00000479930, ENST00000399010, ENST00000540756, ENST00000354749, ENST00000355666, ENST00000399017,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 15 X 8=1680	19 X 18 X 9=3078
	# samples	19	24
	** MAII score	log2(19/1680*10)=-3.14438990933518 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/3078*10)=-3.68088692071969 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SMARCB1 [Title/Abstract] AND TTC3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SMARCB1(24175831)-TTC3(38538777), # samples:1
Anticipated loss of major functional domain due to fusion event.	SMARCB1-TTC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SMARCB1-TTC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SMARCB1-TTC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SMARCB1-TTC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SMARCB1	GO:0006337	nucleosome disassembly	8895581
Hgene	SMARCB1	GO:0006338	chromatin remodeling	11726552
Hgene	SMARCB1	GO:0039692	single stranded viral RNA replication via double stranded DNA intermediate	14963118
Hgene	SMARCB1	GO:0045944	positive regulation of transcription by RNA polymerase II	11950834
Hgene	SMARCB1	GO:0051091	positive regulation of DNA-binding transcription factor activity	11950834
Hgene	SMARCB1	GO:1902661	positive regulation of glucose mediated signaling pathway	22368283
Tgene	TTC3	GO:0006511	ubiquitin-dependent protein catabolic process	20059950
Tgene	TTC3	GO:0070936	protein K48-linked ubiquitination	20059950

Fusion gene breakpoints across SMARCB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TTC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BI050912	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000344921	SMARCB1	chr22	24175831	+	ENST00000355666	TTC3	chr21	38538777	-	4625	1279	1236	3095	619
ENST00000344921	SMARCB1	chr22	24175831	+	ENST00000399017	TTC3	chr21	38538777	-	4634	1279	1236	3095	619
ENST00000344921	SMARCB1	chr22	24175831	+	ENST00000354749	TTC3	chr21	38538777	-	4634	1279	1236	3095	619
ENST00000263121	SMARCB1	chr22	24175831	+	ENST00000355666	TTC3	chr21	38538777	-	4587	1241	1198	3057	619
ENST00000263121	SMARCB1	chr22	24175831	+	ENST00000399017	TTC3	chr21	38538777	-	4596	1241	1198	3057	619
ENST00000263121	SMARCB1	chr22	24175831	+	ENST00000354749	TTC3	chr21	38538777	-	4596	1241	1198	3057	619
ENST00000407422	SMARCB1	chr22	24175831	+	ENST00000355666	TTC3	chr21	38538777	-	4540	1194	1151	3010	619
ENST00000407422	SMARCB1	chr22	24175831	+	ENST00000399017	TTC3	chr21	38538777	-	4549	1194	1151	3010	619
ENST00000407422	SMARCB1	chr22	24175831	+	ENST00000354749	TTC3	chr21	38538777	-	4549	1194	1151	3010	619
ENST00000407082	SMARCB1	chr22	24175831	+	ENST00000355666	TTC3	chr21	38538777	-	4412	1066	1023	2882	619
ENST00000407082	SMARCB1	chr22	24175831	+	ENST00000399017	TTC3	chr21	38538777	-	4421	1066	1023	2882	619
ENST00000407082	SMARCB1	chr22	24175831	+	ENST00000354749	TTC3	chr21	38538777	-	4421	1066	1023	2882	619

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000344921	ENST00000355666	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.000547533	0.9994524
ENST00000344921	ENST00000399017	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.000550266	0.9994497
ENST00000344921	ENST00000354749	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.000550266	0.9994497
ENST00000263121	ENST00000355666	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.000518949	0.999481
ENST00000263121	ENST00000399017	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.00052181	0.99947816
ENST00000263121	ENST00000354749	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.00052181	0.99947816
ENST00000407422	ENST00000355666	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.000539696	0.9994603
ENST00000407422	ENST00000399017	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.000542777	0.9994572
ENST00000407422	ENST00000354749	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.000542777	0.9994572
ENST00000407082	ENST00000355666	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.000454174	0.99954575
ENST00000407082	ENST00000399017	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.000457774	0.99954224
ENST00000407082	ENST00000354749	SMARCB1	chr22	24175831	+	TTC3	chr21	38538777	-	0.000457774	0.99954224

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83934_83934_1_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000263121_TTC3_chr21_38538777_ENST00000354749_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

>83934_83934_2_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000263121_TTC3_chr21_38538777_ENST00000355666_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

>83934_83934_3_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000263121_TTC3_chr21_38538777_ENST00000399017_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

>83934_83934_4_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000344921_TTC3_chr21_38538777_ENST00000354749_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

>83934_83934_5_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000344921_TTC3_chr21_38538777_ENST00000355666_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

>83934_83934_6_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000344921_TTC3_chr21_38538777_ENST00000399017_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

>83934_83934_7_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000407082_TTC3_chr21_38538777_ENST00000354749_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

>83934_83934_8_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000407082_TTC3_chr21_38538777_ENST00000355666_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

>83934_83934_9_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000407082_TTC3_chr21_38538777_ENST00000399017_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

>83934_83934_10_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000407422_TTC3_chr21_38538777_ENST00000354749_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

>83934_83934_11_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000407422_TTC3_chr21_38538777_ENST00000355666_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

>83934_83934_12_SMARCB1-TTC3_SMARCB1_chr22_24175831_ENST00000407422_TTC3_chr21_38538777_ENST00000399017_length(amino acids)=619AA_BP=15
MRWRRRSATRTGTRAGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIE
KEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEM
YTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRD
PAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGN
HAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFP
CYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDV

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:24175831/chr21:38538777)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000354749

1018_1029

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000354749

1020_1029

2026.0

Compositional bias

Note=Poly-Lys

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000354749

1172_1185

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000354749

1563_1579

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000354749

1899_1902

2026.0

Compositional bias

Note=Poly-Lys

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000354749

453_456

2026.0

Compositional bias

Note=Poly-Ser

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000355666

1018_1029

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000355666

1020_1029

2026.0

Compositional bias

Note=Poly-Lys

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000355666

1172_1185

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000355666

1563_1579

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000355666

1899_1902

2026.0

Compositional bias

Note=Poly-Lys

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000355666

453_456

2026.0

Compositional bias

Note=Poly-Ser

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000399017

1018_1029

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000399017

1020_1029

2026.0

Compositional bias

Note=Poly-Lys

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000399017

1172_1185

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000399017

1563_1579

2026.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000399017

1899_1902

2026.0

Compositional bias

Note=Poly-Lys

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000399017

453_456

2026.0

Compositional bias

Note=Poly-Ser

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000354749

231_264

2026.0

Repeat

Note=TPR 1

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000354749

266_298

2026.0

Repeat

Note=TPR 2

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000354749

536_572

2026.0

Repeat

Note=TPR 3

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000354749

576_609

2026.0

Repeat

Note=TPR 4

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000355666

231_264

2026.0

Repeat

Note=TPR 1

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000355666

266_298

2026.0

Repeat

Note=TPR 2

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000355666

536_572

2026.0

Repeat

Note=TPR 3

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000355666

576_609

2026.0

Repeat

Note=TPR 4

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000399017

231_264

2026.0

Repeat

Note=TPR 1

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000399017

266_298

2026.0

Repeat

Note=TPR 2

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000399017

536_572

2026.0

Repeat

Note=TPR 3

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000399017

576_609

2026.0

Repeat

Note=TPR 4

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000354749

1957_1997

2026.0

Zinc finger

RING-type

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000355666

1957_1997

2026.0

Zinc finger

RING-type

Tgene

TTC3

chr22:24175831

chr21:38538777

ENST00000399017

1957_1997

2026.0

Zinc finger

RING-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SMARCB1

chr22:24175831

chr21:38538777

ENST00000263121

183_243

386.0

Region

Note=HIV-1 integrase-binding

Hgene

SMARCB1

chr22:24175831

chr21:38538777

ENST00000263121

186_245

386.0

Region

MYC-binding

Hgene

SMARCB1

chr22:24175831

chr21:38538777

ENST00000263121

186_319

386.0

Region

Note=2 X approximate tandem repeats

Hgene

SMARCB1

chr22:24175831

chr21:38538777

ENST00000263121

1_113

386.0

Region

DNA-binding

Hgene

SMARCB1

chr22:24175831

chr21:38538777

ENST00000407422

183_243

377.0

Region

Note=HIV-1 integrase-binding

Hgene

SMARCB1

chr22:24175831

chr21:38538777

ENST00000407422

186_245

377.0

Region

MYC-binding

Hgene

SMARCB1

chr22:24175831

chr21:38538777

ENST00000407422

186_319

377.0

Region

Note=2 X approximate tandem repeats

Hgene

SMARCB1

chr22:24175831

chr21:38538777

ENST00000407422

1_113

377.0

Region

DNA-binding

Hgene

SMARCB1

chr22:24175831

chr21:38538777

ENST00000263121

259_319

386.0

Repeat

Note=2

Hgene

SMARCB1

chr22:24175831

chr21:38538777

ENST00000407422

259_319

377.0

Repeat

Note=2

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SMARCB1
TTC3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	SMARCB1	chr22:24175831	chr21:38538777	ENST00000263121	+	1	9	304_318	0	386.0	PPP1R15A
Hgene	SMARCB1	chr22:24175831	chr21:38538777	ENST00000407422	+	1	9	304_318	0	377.0	PPP1R15A

Top

Related Drugs to SMARCB1-TTC3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SMARCB1-TTC3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source