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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATXN2-TRIM37

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATXN2-TRIM37
FusionPDB ID: 8437
FusionGDB2.0 ID: 8437
HgeneTgene
Gene symbol

ATXN2

TRIM37

Gene ID

6311

4591

Gene nameataxin 2tripartite motif containing 37
SynonymsATX2|SCA2|TNRC13MUL|POB1|TEF3
Cytomap

12q24.12

17q22

Type of geneprotein-codingprotein-coding
Descriptionataxin-2spinocerebellar ataxia type 2 proteintrinucleotide repeat-containing gene 13 proteinE3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism protein
Modification date2020031320200313
UniProtAcc

Q8WWM7

.
Ensembl transtripts involved in fusion geneENST idsENST00000377617, ENST00000389153, 
ENST00000535949, ENST00000542287, 
ENST00000608853, ENST00000549455, 
ENST00000550104, 		ENST00000262294, 
ENST00000376149, ENST00000393065, 
ENST00000393066, ENST00000584889, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score22 X 21 X 8=369616 X 15 X 9=2160
# samples 2518
** MAII scorelog2(25/3696*10)=-3.88596475675397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2160*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATXN2 [Title/Abstract] AND TRIM37 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATXN2(111923075)-TRIM37(57079075), # samples:3
Anticipated loss of major functional domain due to fusion event.ATXN2-TRIM37 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATXN2-TRIM37 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATXN2-TRIM37 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATXN2-TRIM37 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATXN2-TRIM37 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM37

GO:0000122

negative regulation of transcription by RNA polymerase II

25470042

TgeneTRIM37

GO:0032088

negative regulation of NF-kappaB transcription factor activity

11279055

TgeneTRIM37

GO:0035518

histone H2A monoubiquitination

25470042

TgeneTRIM37

GO:0036353

histone H2A-K119 monoubiquitination

25470042

TgeneTRIM37

GO:0051091

positive regulation of DNA-binding transcription factor activity

23077300

TgeneTRIM37

GO:0051092

positive regulation of NF-kappaB transcription factor activity

23077300

TgeneTRIM37

GO:0051865

protein autoubiquitination

15885686

TgeneTRIM37

GO:0070842

aggresome assembly

15885686


check buttonFusion gene breakpoints across ATXN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRIM37 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-6354-01AATXN2chr12

111923075

-TRIM37chr17

57079075

-
ChimerDB4PRADTCGA-G9-6354ATXN2chr12

111923069

-TRIM37chr17

57076820

-
ChimerDB4PRADTCGA-G9-6354ATXN2chr12

111923075

-TRIM37chr17

57079075

-
ChimerDB4PRADTCGA-G9-6354ATXN2chr12

111923075

-TRIM37chr17

57079102

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000608853ATXN2chr12111923075-ENST00000393066TRIM37chr1757079075-330128342533033926
ENST00000608853ATXN2chr12111923075-ENST00000262294TRIM37chr1757079075-420928342533033926
ENST00000377617ATXN2chr12111923075-ENST00000393066TRIM37chr1757079075-3627316016233591065
ENST00000377617ATXN2chr12111923075-ENST00000262294TRIM37chr1757079075-4535316016233591065
ENST00000535949ATXN2chr12111923075-ENST00000393066TRIM37chr1757079075-272422571262456776
ENST00000535949ATXN2chr12111923075-ENST00000262294TRIM37chr1757079075-363222571262456776
ENST00000389153ATXN2chr12111923069-ENST00000393066TRIM37chr1757076820-26622312312394787
ENST00000389153ATXN2chr12111923069-ENST00000262294TRIM37chr1757076820-35702312312394787
ENST00000389153ATXN2chr12111923069-ENST00000393065TRIM37chr1757076820-27852312312394787
ENST00000608853ATXN2chr12111923069-ENST00000393066TRIM37chr1757076820-318428342532916887
ENST00000608853ATXN2chr12111923069-ENST00000262294TRIM37chr1757076820-409228342532916887
ENST00000608853ATXN2chr12111923069-ENST00000393065TRIM37chr1757076820-330728342532916887
ENST00000377617ATXN2chr12111923069-ENST00000393066TRIM37chr1757076820-3510316016232421026
ENST00000377617ATXN2chr12111923069-ENST00000262294TRIM37chr1757076820-4418316016232421026
ENST00000377617ATXN2chr12111923069-ENST00000393065TRIM37chr1757076820-3633316016232421026
ENST00000535949ATXN2chr12111923069-ENST00000393066TRIM37chr1757076820-260722571262339737
ENST00000535949ATXN2chr12111923069-ENST00000262294TRIM37chr1757076820-351522571262339737
ENST00000535949ATXN2chr12111923069-ENST00000393065TRIM37chr1757076820-273022571262339737

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000608853ENST00000393066ATXN2chr12111923075-TRIM37chr1757079075-0.0038391520.99616086
ENST00000608853ENST00000262294ATXN2chr12111923075-TRIM37chr1757079075-0.001684540.99831545
ENST00000377617ENST00000393066ATXN2chr12111923075-TRIM37chr1757079075-0.0020650470.99793494
ENST00000377617ENST00000262294ATXN2chr12111923075-TRIM37chr1757079075-0.0011262880.99887365
ENST00000535949ENST00000393066ATXN2chr12111923075-TRIM37chr1757079075-0.000637530.9993625
ENST00000535949ENST00000262294ATXN2chr12111923075-TRIM37chr1757079075-0.0002463540.99975365
ENST00000389153ENST00000393066ATXN2chr12111923069-TRIM37chr1757076820-0.0009964630.9990036
ENST00000389153ENST00000262294ATXN2chr12111923069-TRIM37chr1757076820-0.0004390940.9995609
ENST00000389153ENST00000393065ATXN2chr12111923069-TRIM37chr1757076820-0.0009599270.99904007
ENST00000608853ENST00000393066ATXN2chr12111923069-TRIM37chr1757076820-0.0049344040.9950656
ENST00000608853ENST00000262294ATXN2chr12111923069-TRIM37chr1757076820-0.0021811340.9978188
ENST00000608853ENST00000393065ATXN2chr12111923069-TRIM37chr1757076820-0.0051032020.9948968
ENST00000377617ENST00000393066ATXN2chr12111923069-TRIM37chr1757076820-0.0020731680.99792683
ENST00000377617ENST00000262294ATXN2chr12111923069-TRIM37chr1757076820-0.0009647270.99903524
ENST00000377617ENST00000393065ATXN2chr12111923069-TRIM37chr1757076820-0.002042990.997957
ENST00000535949ENST00000393066ATXN2chr12111923069-TRIM37chr1757076820-0.0007055270.9992944
ENST00000535949ENST00000262294ATXN2chr12111923069-TRIM37chr1757076820-0.000252220.9997478
ENST00000535949ENST00000393065ATXN2chr12111923069-TRIM37chr1757076820-0.0006698570.99933016

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8437_8437_1_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000377617_TRIM37_chr17_57076820_ENST00000262294_length(amino acids)=1026AA_BP=999
MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPG
SRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASPPRSGVSLARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQ
QQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVH
ILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISA
KVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIES
SAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSG
SDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRH
PRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAV
AMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSS
TSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKE
EKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMP

--------------------------------------------------------------

>8437_8437_2_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000377617_TRIM37_chr17_57076820_ENST00000393065_length(amino acids)=1026AA_BP=999
MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPG
SRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASPPRSGVSLARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQ
QQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVH
ILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISA
KVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIES
SAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSG
SDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRH
PRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAV
AMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSS
TSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKE
EKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMP

--------------------------------------------------------------

>8437_8437_3_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000377617_TRIM37_chr17_57076820_ENST00000393066_length(amino acids)=1026AA_BP=999
MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPG
SRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASPPRSGVSLARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQ
QQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVH
ILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISA
KVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIES
SAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSG
SDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRH
PRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAV
AMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSS
TSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKE
EKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMP

--------------------------------------------------------------

>8437_8437_4_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000389153_TRIM37_chr17_57076820_ENST00000262294_length(amino acids)=787AA_BP=760
MGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFK
CSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSS
YTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQ
NSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSA
HGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPR
SPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENK
GISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSN
TEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQP

--------------------------------------------------------------

>8437_8437_5_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000389153_TRIM37_chr17_57076820_ENST00000393065_length(amino acids)=787AA_BP=760
MGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFK
CSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSS
YTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQ
NSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSA
HGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPR
SPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENK
GISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSN
TEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQP

--------------------------------------------------------------

>8437_8437_6_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000389153_TRIM37_chr17_57076820_ENST00000393066_length(amino acids)=787AA_BP=760
MGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFK
CSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSS
YTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQ
NSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSA
HGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPR
SPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENK
GISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSN
TEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQP

--------------------------------------------------------------

>8437_8437_7_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000535949_TRIM37_chr17_57076820_ENST00000262294_length(amino acids)=737AA_BP=710
MRMVHILTSVVCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGEL
TANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEE
KYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSP
SSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEF
VSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRA
VTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSR
DLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAK
EFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRADTHSSFPDGE

--------------------------------------------------------------

>8437_8437_8_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000535949_TRIM37_chr17_57076820_ENST00000393065_length(amino acids)=737AA_BP=710
MRMVHILTSVVCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGEL
TANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEE
KYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSP
SSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEF
VSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRA
VTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSR
DLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAK
EFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRADTHSSFPDGE

--------------------------------------------------------------

>8437_8437_9_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000535949_TRIM37_chr17_57076820_ENST00000393066_length(amino acids)=737AA_BP=710
MRMVHILTSVVCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGEL
TANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEE
KYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSP
SSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEF
VSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRA
VTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSR
DLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAK
EFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRADTHSSFPDGE

--------------------------------------------------------------

>8437_8437_10_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000608853_TRIM37_chr17_57076820_ENST00000262294_length(amino acids)=887AA_BP=860
MARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQQQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSS
VVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGP
KREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENY
GVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQR
NREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPP
SRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSG
VPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPN
ETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKP
NSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMV

--------------------------------------------------------------

>8437_8437_11_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000608853_TRIM37_chr17_57076820_ENST00000393065_length(amino acids)=887AA_BP=860
MARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQQQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSS
VVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGP
KREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENY
GVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQR
NREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPP
SRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSG
VPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPN
ETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKP
NSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMV

--------------------------------------------------------------

>8437_8437_12_ATXN2-TRIM37_ATXN2_chr12_111923069_ENST00000608853_TRIM37_chr17_57076820_ENST00000393066_length(amino acids)=887AA_BP=860
MARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQQQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSS
VVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGP
KREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENY
GVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQR
NREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPP
SRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSG
VPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPN
ETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKP
NSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMV

--------------------------------------------------------------

>8437_8437_13_ATXN2-TRIM37_ATXN2_chr12_111923075_ENST00000377617_TRIM37_chr17_57079075_ENST00000262294_length(amino acids)=1065AA_BP=999
MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPG
SRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASPPRSGVSLARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQ
QQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVH
ILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISA
KVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIES
SAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSG
SDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRH
PRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAV
AMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSS
TSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKE
EKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMP

--------------------------------------------------------------

>8437_8437_14_ATXN2-TRIM37_ATXN2_chr12_111923075_ENST00000377617_TRIM37_chr17_57079075_ENST00000393066_length(amino acids)=1065AA_BP=999
MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPG
SRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASPPRSGVSLARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQ
QQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVH
ILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISA
KVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIES
SAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSG
SDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRH
PRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAV
AMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSS
TSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKE
EKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMP

--------------------------------------------------------------

>8437_8437_15_ATXN2-TRIM37_ATXN2_chr12_111923075_ENST00000535949_TRIM37_chr17_57079075_ENST00000262294_length(amino acids)=776AA_BP=710
MRMVHILTSVVCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGEL
TANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEE
KYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSP
SSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEF
VSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRA
VTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSR
DLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAK
EFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGMSSDSDIEC

--------------------------------------------------------------

>8437_8437_16_ATXN2-TRIM37_ATXN2_chr12_111923075_ENST00000535949_TRIM37_chr17_57079075_ENST00000393066_length(amino acids)=776AA_BP=710
MRMVHILTSVVCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGEL
TANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEE
KYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSP
SSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEF
VSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRA
VTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSR
DLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAK
EFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGMSSDSDIEC

--------------------------------------------------------------

>8437_8437_17_ATXN2-TRIM37_ATXN2_chr12_111923075_ENST00000608853_TRIM37_chr17_57079075_ENST00000262294_length(amino acids)=926AA_BP=860
MARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQQQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSS
VVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGP
KREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENY
GVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQR
NREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPP
SRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSG
VPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPN
ETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKP
NSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMV
GHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGMSSDSDIECDTENEEQEEHTSVGGFHDSFMVMTQPPDED

--------------------------------------------------------------

>8437_8437_18_ATXN2-TRIM37_ATXN2_chr12_111923075_ENST00000608853_TRIM37_chr17_57079075_ENST00000393066_length(amino acids)=926AA_BP=860
MARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQQQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSS
VVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGP
KREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENY
GVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQR
NREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPP
SRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSG
VPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPN
ETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKP
NSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMV
GHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGMSSDSDIECDTENEEQEEHTSVGGFHDSFMVMTQPPDED

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:111923075/chr17:57079075)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATXN2

Q8WWM7

.
FUNCTION: Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATXN2chr12:111923069chr17:57076820ENST00000377617-1825166_187999.33333333333341314.0Compositional biasNote=Poly-Gln
HgeneATXN2chr12:111923069chr17:57076820ENST00000377617-1825213_223999.33333333333341314.0Compositional biasNote=Poly-Ser
HgeneATXN2chr12:111923069chr17:57076820ENST00000377617-182547_158999.33333333333341314.0Compositional biasNote=Pro-rich
HgeneATXN2chr12:111923069chr17:57076820ENST00000377617-1825551_734999.33333333333341314.0Compositional biasNote=Pro-rich
HgeneATXN2chr12:111923069chr17:57076820ENST00000377617-182555_64999.33333333333341314.0Compositional biasNote=Poly-Pro
HgeneATXN2chr12:111923075chr17:57079075ENST00000377617-1825166_187999.33333333333341314.0Compositional biasNote=Poly-Gln
HgeneATXN2chr12:111923075chr17:57079075ENST00000377617-1825213_223999.33333333333341314.0Compositional biasNote=Poly-Ser
HgeneATXN2chr12:111923075chr17:57079075ENST00000377617-182547_158999.33333333333341314.0Compositional biasNote=Pro-rich
HgeneATXN2chr12:111923075chr17:57079075ENST00000377617-1825551_734999.33333333333341314.0Compositional biasNote=Pro-rich
HgeneATXN2chr12:111923075chr17:57079075ENST00000377617-182555_64999.33333333333341314.0Compositional biasNote=Poly-Pro
TgeneTRIM37chr12:111923075chr17:57079075ENST00000376149023132_2340804.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923075chr17:57079075ENST00000376149023419_4500804.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923075chr17:57079075ENST00000376149023673_7000804.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923075chr17:57079075ENST00000376149023534_5400804.0Compositional biasNote=Poly-Ser
TgeneTRIM37chr12:111923075chr17:57079075ENST00000376149023578_5810804.0Compositional biasNote=Poly-Ala
TgeneTRIM37chr12:111923075chr17:57079075ENST00000376149023276_4030804.0DomainMATH
TgeneTRIM37chr12:111923075chr17:57079075ENST0000037614902315_550804.0Zinc fingerRING-type%3B degenerate
TgeneTRIM37chr12:111923075chr17:57079075ENST0000037614902390_1320804.0Zinc fingerB box-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATXN2chr12:111923069chr17:57076820ENST00000377617-1825929_1085999.33333333333341314.0Compositional biasNote=Pro-rich
HgeneATXN2chr12:111923069chr17:57076820ENST00000550104-124166_18701015.3333333333334Compositional biasNote=Poly-Gln
HgeneATXN2chr12:111923069chr17:57076820ENST00000550104-124213_22301015.3333333333334Compositional biasNote=Poly-Ser
HgeneATXN2chr12:111923069chr17:57076820ENST00000550104-12447_15801015.3333333333334Compositional biasNote=Pro-rich
HgeneATXN2chr12:111923069chr17:57076820ENST00000550104-124551_73401015.3333333333334Compositional biasNote=Pro-rich
HgeneATXN2chr12:111923069chr17:57076820ENST00000550104-12455_6401015.3333333333334Compositional biasNote=Poly-Pro
HgeneATXN2chr12:111923069chr17:57076820ENST00000550104-124929_108501015.3333333333334Compositional biasNote=Pro-rich
HgeneATXN2chr12:111923075chr17:57079075ENST00000377617-1825929_1085999.33333333333341314.0Compositional biasNote=Pro-rich
HgeneATXN2chr12:111923075chr17:57079075ENST00000550104-124166_18701015.3333333333334Compositional biasNote=Poly-Gln
HgeneATXN2chr12:111923075chr17:57079075ENST00000550104-124213_22301015.3333333333334Compositional biasNote=Poly-Ser
HgeneATXN2chr12:111923075chr17:57079075ENST00000550104-12447_15801015.3333333333334Compositional biasNote=Pro-rich
HgeneATXN2chr12:111923075chr17:57079075ENST00000550104-124551_73401015.3333333333334Compositional biasNote=Pro-rich
HgeneATXN2chr12:111923075chr17:57079075ENST00000550104-12455_6401015.3333333333334Compositional biasNote=Poly-Pro
HgeneATXN2chr12:111923075chr17:57079075ENST00000550104-124929_108501015.3333333333334Compositional biasNote=Pro-rich
TgeneTRIM37chr12:111923069chr17:57076820ENST000002622942224132_234937.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923069chr17:57076820ENST000002622942224419_450937.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923069chr17:57076820ENST000002622942224673_700937.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923069chr17:57076820ENST000003761492123132_234776.3333333333334804.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923069chr17:57076820ENST000003761492123419_450776.3333333333334804.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923069chr17:57076820ENST000003761492123673_700776.3333333333334804.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923069chr17:57076820ENST000003930662225132_234937.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923069chr17:57076820ENST000003930662225419_450937.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923069chr17:57076820ENST000003930662225673_700937.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923075chr17:57079075ENST000002622942124132_234898.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923075chr17:57079075ENST000002622942124419_450898.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923075chr17:57079075ENST000002622942124673_700898.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923075chr17:57079075ENST000003930662125132_234898.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923075chr17:57079075ENST000003930662125419_450898.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923075chr17:57079075ENST000003930662125673_700898.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM37chr12:111923069chr17:57076820ENST000002622942224534_540937.3333333333334965.0Compositional biasNote=Poly-Ser
TgeneTRIM37chr12:111923069chr17:57076820ENST000002622942224578_581937.3333333333334965.0Compositional biasNote=Poly-Ala
TgeneTRIM37chr12:111923069chr17:57076820ENST000003761492123534_540776.3333333333334804.0Compositional biasNote=Poly-Ser
TgeneTRIM37chr12:111923069chr17:57076820ENST000003761492123578_581776.3333333333334804.0Compositional biasNote=Poly-Ala
TgeneTRIM37chr12:111923069chr17:57076820ENST000003930662225534_540937.3333333333334965.0Compositional biasNote=Poly-Ser
TgeneTRIM37chr12:111923069chr17:57076820ENST000003930662225578_581937.3333333333334965.0Compositional biasNote=Poly-Ala
TgeneTRIM37chr12:111923075chr17:57079075ENST000002622942124534_540898.3333333333334965.0Compositional biasNote=Poly-Ser
TgeneTRIM37chr12:111923075chr17:57079075ENST000002622942124578_581898.3333333333334965.0Compositional biasNote=Poly-Ala
TgeneTRIM37chr12:111923075chr17:57079075ENST000003930662125534_540898.3333333333334965.0Compositional biasNote=Poly-Ser
TgeneTRIM37chr12:111923075chr17:57079075ENST000003930662125578_581898.3333333333334965.0Compositional biasNote=Poly-Ala
TgeneTRIM37chr12:111923069chr17:57076820ENST000002622942224276_403937.3333333333334965.0DomainMATH
TgeneTRIM37chr12:111923069chr17:57076820ENST000003761492123276_403776.3333333333334804.0DomainMATH
TgeneTRIM37chr12:111923069chr17:57076820ENST000003930662225276_403937.3333333333334965.0DomainMATH
TgeneTRIM37chr12:111923075chr17:57079075ENST000002622942124276_403898.3333333333334965.0DomainMATH
TgeneTRIM37chr12:111923075chr17:57079075ENST000003930662125276_403898.3333333333334965.0DomainMATH
TgeneTRIM37chr12:111923069chr17:57076820ENST00000262294222415_55937.3333333333334965.0Zinc fingerRING-type%3B degenerate
TgeneTRIM37chr12:111923069chr17:57076820ENST00000262294222490_132937.3333333333334965.0Zinc fingerB box-type
TgeneTRIM37chr12:111923069chr17:57076820ENST00000376149212315_55776.3333333333334804.0Zinc fingerRING-type%3B degenerate
TgeneTRIM37chr12:111923069chr17:57076820ENST00000376149212390_132776.3333333333334804.0Zinc fingerB box-type
TgeneTRIM37chr12:111923069chr17:57076820ENST00000393066222515_55937.3333333333334965.0Zinc fingerRING-type%3B degenerate
TgeneTRIM37chr12:111923069chr17:57076820ENST00000393066222590_132937.3333333333334965.0Zinc fingerB box-type
TgeneTRIM37chr12:111923075chr17:57079075ENST00000262294212415_55898.3333333333334965.0Zinc fingerRING-type%3B degenerate
TgeneTRIM37chr12:111923075chr17:57079075ENST00000262294212490_132898.3333333333334965.0Zinc fingerB box-type
TgeneTRIM37chr12:111923075chr17:57079075ENST00000393066212515_55898.3333333333334965.0Zinc fingerRING-type%3B degenerate
TgeneTRIM37chr12:111923075chr17:57079075ENST00000393066212590_132898.3333333333334965.0Zinc fingerB box-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1838_ATXN2_111923075_TRIM37_57079075_ranked_0.pdbATXN2111923069111923075ENST00000393065TRIM37chr1757079075-
MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPG
SRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASPPRSGVSLARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQ
QQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVH
ILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISA
KVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIES
SAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSG
SDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRH
PRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAV
AMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSS
TSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKE
EKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMP
1065


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ATXN2_pLDDT.png
all structure
all structure
TRIM37_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATXN2
TRIM37


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATXN2-TRIM37


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATXN2-TRIM37


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource