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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:AVL9-ERC1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: AVL9-ERC1
	FusionPDB ID: 8541
	FusionGDB2.0 ID: 8541
		Hgene	Tgene
	Gene symbol	AVL9	ERC1
	Gene ID	23080	23085
	Gene name	AVL9 cell migration associated	ELKS/RAB6-interacting/CAST family member 1
	Synonyms	KIAA0241	Cast2\|ELKS\|ERC-1\|RAB6IP2
	Cytomap	7p14.3	12p13.33
	Type of gene	protein-coding	protein-coding
	Description	late secretory pathway protein AVL9 homologAVL9 homolog (S. cerevisiase)	ELKS/Rab6-interacting/CAST family member 1RAB6 interacting protein 2
	Modification date	20200313	20200313
	UniProtAcc	Q8NBF6	Q8IUD2
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000459629, ENST00000318709, ENST00000404479, ENST00000409301,	ENST00000355446, ENST00000360905, ENST00000397203, ENST00000543086, ENST00000546231, ENST00000589028, ENST00000536573,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 3 X 7=210	23 X 29 X 12=8004
	# samples	12	33
	** MAII score	log2(12/210*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(33/8004*10)=-4.60018323765993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: AVL9 [Title/Abstract] AND ERC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	AVL9(32535414)-ERC1(1517315), # samples:1
Anticipated loss of major functional domain due to fusion event.	AVL9-ERC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AVL9-ERC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AVL9-ERC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AVL9-ERC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AVL9	GO:0016477	cell migration	22595670
Tgene	ERC1	GO:0007252	I-kappaB phosphorylation	15218148

Fusion gene breakpoints across AVL9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ERC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-5798-01A	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000404479	AVL9	chr7	32535414	+	ENST00000543086	ERC1	chr12	1517315	+	6222	93	0	518	172
ENST00000404479	AVL9	chr7	32535414	+	ENST00000546231	ERC1	chr12	1517315	+	1018	93	0	518	172
ENST00000404479	AVL9	chr7	32535414	+	ENST00000397203	ERC1	chr12	1517315	+	6213	93	0	518	172
ENST00000404479	AVL9	chr7	32535414	+	ENST00000360905	ERC1	chr12	1517315	+	2776	93	0	518	172
ENST00000404479	AVL9	chr7	32535414	+	ENST00000589028	ERC1	chr12	1517315	+	6213	93	0	518	172
ENST00000404479	AVL9	chr7	32535414	+	ENST00000355446	ERC1	chr12	1517315	+	2832	93	1396	908	162
ENST00000318709	AVL9	chr7	32535414	+	ENST00000543086	ERC1	chr12	1517315	+	6443	314	221	739	172
ENST00000318709	AVL9	chr7	32535414	+	ENST00000546231	ERC1	chr12	1517315	+	1239	314	221	739	172
ENST00000318709	AVL9	chr7	32535414	+	ENST00000397203	ERC1	chr12	1517315	+	6434	314	221	739	172
ENST00000318709	AVL9	chr7	32535414	+	ENST00000360905	ERC1	chr12	1517315	+	2997	314	221	739	172
ENST00000318709	AVL9	chr7	32535414	+	ENST00000589028	ERC1	chr12	1517315	+	6434	314	221	739	172
ENST00000318709	AVL9	chr7	32535414	+	ENST00000355446	ERC1	chr12	1517315	+	3053	314	1617	1129	162
ENST00000409301	AVL9	chr7	32535414	+	ENST00000543086	ERC1	chr12	1517315	+	6406	277	184	702	172
ENST00000409301	AVL9	chr7	32535414	+	ENST00000546231	ERC1	chr12	1517315	+	1202	277	184	702	172
ENST00000409301	AVL9	chr7	32535414	+	ENST00000397203	ERC1	chr12	1517315	+	6397	277	184	702	172
ENST00000409301	AVL9	chr7	32535414	+	ENST00000360905	ERC1	chr12	1517315	+	2960	277	184	702	172
ENST00000409301	AVL9	chr7	32535414	+	ENST00000589028	ERC1	chr12	1517315	+	6397	277	184	702	172
ENST00000409301	AVL9	chr7	32535414	+	ENST00000355446	ERC1	chr12	1517315	+	3016	277	1580	1092	162

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000404479	ENST00000543086	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.003781859	0.99621814
ENST00000404479	ENST00000546231	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.002289605	0.99771035
ENST00000404479	ENST00000397203	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.004564012	0.995436
ENST00000404479	ENST00000360905	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.002617773	0.9973822
ENST00000404479	ENST00000589028	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.004564012	0.995436
ENST00000404479	ENST00000355446	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.009650773	0.9903493
ENST00000318709	ENST00000543086	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.003740632	0.99625933
ENST00000318709	ENST00000546231	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.003111961	0.996888
ENST00000318709	ENST00000397203	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.004521285	0.9954787
ENST00000318709	ENST00000360905	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.003629906	0.9963701
ENST00000318709	ENST00000589028	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.004521285	0.9954787
ENST00000318709	ENST00000355446	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.014591153	0.98540884
ENST00000409301	ENST00000543086	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.003776847	0.9962231
ENST00000409301	ENST00000546231	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.003963181	0.9960368
ENST00000409301	ENST00000397203	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.004558921	0.9954411
ENST00000409301	ENST00000360905	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.002848299	0.9971517
ENST00000409301	ENST00000589028	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.004558921	0.9954411
ENST00000409301	ENST00000355446	AVL9	chr7	32535414	+	ERC1	chr12	1517315	+	0.01475196	0.9852481

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8541_8541_1_AVL9-ERC1_AVL9_chr7_32535414_ENST00000318709_ERC1_chr12_1517315_ENST00000355446_length(amino acids)=162AA_BP=
MAGALSTSHVLQLEIFDLTPQYDNVNSLKQERLVENTSHHLLVNWPRNRVRKAATDRQGWMKTQTLGERVLPSHREACSQLPGTKHLMWK

--------------------------------------------------------------

>8541_8541_2_AVL9-ERC1_AVL9_chr7_32535414_ENST00000318709_ERC1_chr12_1517315_ENST00000360905_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_3_AVL9-ERC1_AVL9_chr7_32535414_ENST00000318709_ERC1_chr12_1517315_ENST00000397203_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_4_AVL9-ERC1_AVL9_chr7_32535414_ENST00000318709_ERC1_chr12_1517315_ENST00000543086_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_5_AVL9-ERC1_AVL9_chr7_32535414_ENST00000318709_ERC1_chr12_1517315_ENST00000546231_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_6_AVL9-ERC1_AVL9_chr7_32535414_ENST00000318709_ERC1_chr12_1517315_ENST00000589028_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_7_AVL9-ERC1_AVL9_chr7_32535414_ENST00000404479_ERC1_chr12_1517315_ENST00000355446_length(amino acids)=162AA_BP=
MAGALSTSHVLQLEIFDLTPQYDNVNSLKQERLVENTSHHLLVNWPRNRVRKAATDRQGWMKTQTLGERVLPSHREACSQLPGTKHLMWK

--------------------------------------------------------------

>8541_8541_8_AVL9-ERC1_AVL9_chr7_32535414_ENST00000404479_ERC1_chr12_1517315_ENST00000360905_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_9_AVL9-ERC1_AVL9_chr7_32535414_ENST00000404479_ERC1_chr12_1517315_ENST00000397203_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_10_AVL9-ERC1_AVL9_chr7_32535414_ENST00000404479_ERC1_chr12_1517315_ENST00000543086_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_11_AVL9-ERC1_AVL9_chr7_32535414_ENST00000404479_ERC1_chr12_1517315_ENST00000546231_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_12_AVL9-ERC1_AVL9_chr7_32535414_ENST00000404479_ERC1_chr12_1517315_ENST00000589028_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_13_AVL9-ERC1_AVL9_chr7_32535414_ENST00000409301_ERC1_chr12_1517315_ENST00000355446_length(amino acids)=162AA_BP=
MAGALSTSHVLQLEIFDLTPQYDNVNSLKQERLVENTSHHLLVNWPRNRVRKAATDRQGWMKTQTLGERVLPSHREACSQLPGTKHLMWK

--------------------------------------------------------------

>8541_8541_14_AVL9-ERC1_AVL9_chr7_32535414_ENST00000409301_ERC1_chr12_1517315_ENST00000360905_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_15_AVL9-ERC1_AVL9_chr7_32535414_ENST00000409301_ERC1_chr12_1517315_ENST00000397203_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_16_AVL9-ERC1_AVL9_chr7_32535414_ENST00000409301_ERC1_chr12_1517315_ENST00000543086_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_17_AVL9-ERC1_AVL9_chr7_32535414_ENST00000409301_ERC1_chr12_1517315_ENST00000546231_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

>8541_8541_18_AVL9-ERC1_AVL9_chr7_32535414_ENST00000409301_ERC1_chr12_1517315_ENST00000589028_length(amino acids)=172AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:32535414/chr12:1517315)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AVL9 Q8NBF6	ERC1 Q8IUD2
FUNCTION: Functions in cell migration. {ECO:0000269\|PubMed:22595670}.	FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269\|PubMed:15218148}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000360905

1060_1100

975.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000397203

1060_1100

975.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000543086

1060_1100

947.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000589028

1060_1100

975.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000360905

1046_1108

975.0

1117.0

Domain

FIP-RBD

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000397203

1046_1108

975.0

1117.0

Domain

FIP-RBD

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000543086

1046_1108

947.0

1089.0

Domain

FIP-RBD

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000589028

1046_1108

975.0

1117.0

Domain

FIP-RBD

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AVL9

chr7:32535414

chr12:1517315

ENST00000318709

173_340

31.0

649.0

Domain

cDENN

Hgene

AVL9

chr7:32535414

chr12:1517315

ENST00000318709

17_161

31.0

649.0

Domain

uDENN

Hgene

AVL9

chr7:32535414

chr12:1517315

ENST00000318709

342_593

31.0

649.0

Domain

dDENN

Hgene

AVL9

chr7:32535414

chr12:1517315

ENST00000318709

214_230

31.0

649.0

Transmembrane

Helical

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000360905

144_988

975.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000397203

144_988

975.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000543086

144_988

947.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ERC1

chr7:32535414

chr12:1517315

ENST00000589028

144_988

975.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

ERC1

YWHAG, TWF2, RAB6A, RAB6B, KBTBD7, IKBKB, MAP3K7, IKBKG, XIAP, ITSN2, RAD23A, SH3KBP1, CHUK, NFKBIA, CUL3, APP, ATP6V0D1, NCBP1, WDR4, ERC2, MYC, PAN2, CDK19, MAPK4, CDK20, LATS2, STK4, GFOD1, ADPRHL2, SNX2, MED4, EWSR1, SRPK2, OFD1, PCM1, CEP104, CEP162, CEP152, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, SCLT1, SASS6, DVL2, SLC16A6, KIF23, MAPRE1, RACGAP1, CHST15, PPP1R21, Actb, Cd2ap, Kif4, Myh9, Ckap5, MACROD1, PCGF1, NANOG, POU5F1, NHLRC2, CDH1, EYA4, TSHB, SPERT, TRIM25, BRCA1, LNX1, EFTUD2, MYO6, AGR2, KIAA1429, FLCN, DNAJC5, GBF1, DYNC1I2, BICD1, BICD2, APEX1, DYRK1A, nsp13, LMBR1L, PLEKHA4, CYLD, DUSP1, RASSF8, nsp16, nsp7, CIT, ANLN, KIF14, TRIM33, nsp13ab, nsp16ab, SEC62, ORF6, MKRN3, ACTR3, AGPS, AMOT, ANAPC2, CYP2C9, DCTN2, ERGIC2, GOLGA1, IMPDH2, KDM1A, KRT18, KRT19, KRT8, NDC80, NEFM, PEX14, PFN1, PXN, SEPT10, SYNE3, TMOD1, NAA40, VPS33A, NUP62, FTL, DES, YWHAQ, SERF2, YWHAB, ING1, CEP112, MFAP4, C15orf59, YWHAH, PIPSL, KRT38, KRT37, ATG16L1, TBC1D32, E, ATRX,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
AVL9
ERC1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to AVL9-ERC1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to AVL9-ERC1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	ERC1	C0238463	Papillary thyroid carcinoma	1	ORPHANET
Tgene	ERC1	C4749581	Distal monosomy 12p	1	ORPHANET