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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:AXL-ZNF565

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: AXL-ZNF565
	FusionPDB ID: 8583
	FusionGDB2.0 ID: 8583
		Hgene	Tgene
	Gene symbol	AXL	ZNF565
	Gene ID	558	147929
	Gene name	AXL receptor tyrosine kinase	zinc finger protein 565
	Synonyms	ARK\|JTK11\|Tyro7\|UFO	-
	Cytomap	19q13.2	19q13.12
	Type of gene	protein-coding	protein-coding
	Description	tyrosine-protein kinase receptor UFOAXL oncogeneAXL transforming sequence/gene	zinc finger protein 565
	Modification date	20200327	20200313
	UniProtAcc	P30530	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000301178, ENST00000359092, ENST00000593513, ENST00000594880,	ENST00000304116, ENST00000355114, ENST00000392173,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 7 X 5=280	8 X 4 X 5=160
	# samples	8	8
	** MAII score	log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/160*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: AXL [Title/Abstract] AND ZNF565 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	AXL(41762516)-ZNF565(36686058), # samples:3
Anticipated loss of major functional domain due to fusion event.	AXL-ZNF565 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AXL-ZNF565 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AXL-ZNF565 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AXL-ZNF565 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AXL	GO:0001961	positive regulation of cytokine-mediated signaling pathway	18840707
Hgene	AXL	GO:0006909	phagocytosis	21501828
Hgene	AXL	GO:0032689	negative regulation of interferon-gamma production	18840707
Hgene	AXL	GO:0032825	positive regulation of natural killer cell differentiation	18840707
Hgene	AXL	GO:0035457	cellular response to interferon-alpha	19657094
Hgene	AXL	GO:0071222	cellular response to lipopolysaccharide	19657094
Hgene	AXL	GO:2000669	negative regulation of dendritic cell apoptotic process	19657094

Fusion gene breakpoints across AXL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNF565 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-25-1877-01A	AXL	chr19	41762516	-	ZNF565	chr19	36686058	-
ChimerDB4	OV	TCGA-25-1877-01A	AXL	chr19	41762516	+	ZNF565	chr19	36686058	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000301178	AXL	chr19	41762516	+	ENST00000304116	ZNF565	chr19	36686058	-	4057	2386	181	3876	1231
ENST00000301178	AXL	chr19	41762516	+	ENST00000392173	ZNF565	chr19	36686058	-	4049	2386	181	3876	1231
ENST00000301178	AXL	chr19	41762516	+	ENST00000355114	ZNF565	chr19	36686058	-	4049	2386	181	3876	1231
ENST00000359092	AXL	chr19	41762516	+	ENST00000304116	ZNF565	chr19	36686058	-	3998	2327	149	3817	1222
ENST00000359092	AXL	chr19	41762516	+	ENST00000392173	ZNF565	chr19	36686058	-	3990	2327	149	3817	1222
ENST00000359092	AXL	chr19	41762516	+	ENST00000355114	ZNF565	chr19	36686058	-	3990	2327	149	3817	1222
ENST00000593513	AXL	chr19	41762516	+	ENST00000304116	ZNF565	chr19	36686058	-	3439	1768	160	3258	1032
ENST00000593513	AXL	chr19	41762516	+	ENST00000392173	ZNF565	chr19	36686058	-	3431	1768	160	3258	1032
ENST00000593513	AXL	chr19	41762516	+	ENST00000355114	ZNF565	chr19	36686058	-	3431	1768	160	3258	1032

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000301178	ENST00000304116	AXL	chr19	41762516	+	ZNF565	chr19	36686058	-	0.001883398	0.9981166
ENST00000301178	ENST00000392173	AXL	chr19	41762516	+	ZNF565	chr19	36686058	-	0.001879186	0.99812084
ENST00000301178	ENST00000355114	AXL	chr19	41762516	+	ZNF565	chr19	36686058	-	0.001879186	0.99812084
ENST00000359092	ENST00000304116	AXL	chr19	41762516	+	ZNF565	chr19	36686058	-	0.002267848	0.99773216
ENST00000359092	ENST00000392173	AXL	chr19	41762516	+	ZNF565	chr19	36686058	-	0.002278268	0.99772173
ENST00000359092	ENST00000355114	AXL	chr19	41762516	+	ZNF565	chr19	36686058	-	0.002278268	0.99772173
ENST00000593513	ENST00000304116	AXL	chr19	41762516	+	ZNF565	chr19	36686058	-	0.001908066	0.9980919
ENST00000593513	ENST00000392173	AXL	chr19	41762516	+	ZNF565	chr19	36686058	-	0.001918133	0.9980819
ENST00000593513	ENST00000355114	AXL	chr19	41762516	+	ZNF565	chr19	36686058	-	0.001918133	0.9980819

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8583_8583_1_AXL-ZNF565_AXL_chr19_41762516_ENST00000301178_ZNF565_chr19_36686058_ENST00000304116_length(amino acids)=1231AA_BP=777
MAPMAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVP
LGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDA
VPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSND
GMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPR
APLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFS
WPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVA
LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGD
LHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA
IESLADRVYTSKSDVGLVTFRDVAIEFSLEEWKCLEPAQRDLYREVTLENFGHLASLGLSISKPDVVSLLEQGKEPWMIANDVTGPWCPD
LESRCEKFLQKDIFEIGAFNWEIMESLKCSDLEGSDFRADWECEGQFERQVNEECYFKQVNVTYGHMPVFQHHTSHTVRQSRETGEKLME
CHECGKAFSRGSHLIQHQKIHTGEKPFGCKECGKAFSRASHLVQHQRIHTGEKPYDCKDCGKAFGRTSELILHQRLHTGVKPYECKECGK
TFRQHSQLILHQRTHTGEKPYVCKDCGKAFIRGSQLTVHRRIHTGARPYECKECGKAFRQHSQLTVHQRIHTGEKPYECKECGKGFIHSS
EVTRHQRIHSGEKPYECKECGKAFRQHAQLTRHQRVHTGDRPYECKDCGKAFSRSSYLIQHQRIHTGDKPYECKECGKAFIRVSQLTHHQ

--------------------------------------------------------------

>8583_8583_2_AXL-ZNF565_AXL_chr19_41762516_ENST00000301178_ZNF565_chr19_36686058_ENST00000355114_length(amino acids)=1231AA_BP=777
MAPMAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVP
LGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDA
VPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSND
GMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPR
APLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFS
WPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVA
LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGD
LHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA
IESLADRVYTSKSDVGLVTFRDVAIEFSLEEWKCLEPAQRDLYREVTLENFGHLASLGLSISKPDVVSLLEQGKEPWMIANDVTGPWCPD
LESRCEKFLQKDIFEIGAFNWEIMESLKCSDLEGSDFRADWECEGQFERQVNEECYFKQVNVTYGHMPVFQHHTSHTVRQSRETGEKLME
CHECGKAFSRGSHLIQHQKIHTGEKPFGCKECGKAFSRASHLVQHQRIHTGEKPYDCKDCGKAFGRTSELILHQRLHTGVKPYECKECGK
TFRQHSQLILHQRTHTGEKPYVCKDCGKAFIRGSQLTVHRRIHTGARPYECKECGKAFRQHSQLTVHQRIHTGEKPYECKECGKGFIHSS
EVTRHQRIHSGEKPYECKECGKAFRQHAQLTRHQRVHTGDRPYECKDCGKAFSRSSYLIQHQRIHTGDKPYECKECGKAFIRVSQLTHHQ

--------------------------------------------------------------

>8583_8583_3_AXL-ZNF565_AXL_chr19_41762516_ENST00000301178_ZNF565_chr19_36686058_ENST00000392173_length(amino acids)=1231AA_BP=777
MAPMAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVP
LGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDA
VPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSND
GMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPR
APLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFS
WPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVA
LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGD
LHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA
IESLADRVYTSKSDVGLVTFRDVAIEFSLEEWKCLEPAQRDLYREVTLENFGHLASLGLSISKPDVVSLLEQGKEPWMIANDVTGPWCPD
LESRCEKFLQKDIFEIGAFNWEIMESLKCSDLEGSDFRADWECEGQFERQVNEECYFKQVNVTYGHMPVFQHHTSHTVRQSRETGEKLME
CHECGKAFSRGSHLIQHQKIHTGEKPFGCKECGKAFSRASHLVQHQRIHTGEKPYDCKDCGKAFGRTSELILHQRLHTGVKPYECKECGK
TFRQHSQLILHQRTHTGEKPYVCKDCGKAFIRGSQLTVHRRIHTGARPYECKECGKAFRQHSQLTVHQRIHTGEKPYECKECGKGFIHSS
EVTRHQRIHSGEKPYECKECGKAFRQHAQLTRHQRVHTGDRPYECKDCGKAFSRSSYLIQHQRIHTGDKPYECKECGKAFIRVSQLTHHQ

--------------------------------------------------------------

>8583_8583_4_AXL-ZNF565_AXL_chr19_41762516_ENST00000359092_ZNF565_chr19_36686058_ENST00000304116_length(amino acids)=1222AA_BP=768
MAPMAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVP
LGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDA
VPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSND
GMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPR
APLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPAFSWPWWYVLLG
AVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGE
FGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSR
LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVY
TSKSDVGLVTFRDVAIEFSLEEWKCLEPAQRDLYREVTLENFGHLASLGLSISKPDVVSLLEQGKEPWMIANDVTGPWCPDLESRCEKFL
QKDIFEIGAFNWEIMESLKCSDLEGSDFRADWECEGQFERQVNEECYFKQVNVTYGHMPVFQHHTSHTVRQSRETGEKLMECHECGKAFS
RGSHLIQHQKIHTGEKPFGCKECGKAFSRASHLVQHQRIHTGEKPYDCKDCGKAFGRTSELILHQRLHTGVKPYECKECGKTFRQHSQLI
LHQRTHTGEKPYVCKDCGKAFIRGSQLTVHRRIHTGARPYECKECGKAFRQHSQLTVHQRIHTGEKPYECKECGKGFIHSSEVTRHQRIH
SGEKPYECKECGKAFRQHAQLTRHQRVHTGDRPYECKDCGKAFSRSSYLIQHQRIHTGDKPYECKECGKAFIRVSQLTHHQRIHTCEKPY

--------------------------------------------------------------

>8583_8583_5_AXL-ZNF565_AXL_chr19_41762516_ENST00000359092_ZNF565_chr19_36686058_ENST00000355114_length(amino acids)=1222AA_BP=768
MAPMAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVP
LGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDA
VPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSND
GMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPR
APLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPAFSWPWWYVLLG
AVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGE
FGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSR
LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVY
TSKSDVGLVTFRDVAIEFSLEEWKCLEPAQRDLYREVTLENFGHLASLGLSISKPDVVSLLEQGKEPWMIANDVTGPWCPDLESRCEKFL
QKDIFEIGAFNWEIMESLKCSDLEGSDFRADWECEGQFERQVNEECYFKQVNVTYGHMPVFQHHTSHTVRQSRETGEKLMECHECGKAFS
RGSHLIQHQKIHTGEKPFGCKECGKAFSRASHLVQHQRIHTGEKPYDCKDCGKAFGRTSELILHQRLHTGVKPYECKECGKTFRQHSQLI
LHQRTHTGEKPYVCKDCGKAFIRGSQLTVHRRIHTGARPYECKECGKAFRQHSQLTVHQRIHTGEKPYECKECGKGFIHSSEVTRHQRIH
SGEKPYECKECGKAFRQHAQLTRHQRVHTGDRPYECKDCGKAFSRSSYLIQHQRIHTGDKPYECKECGKAFIRVSQLTHHQRIHTCEKPY

--------------------------------------------------------------

>8583_8583_6_AXL-ZNF565_AXL_chr19_41762516_ENST00000359092_ZNF565_chr19_36686058_ENST00000392173_length(amino acids)=1222AA_BP=768
MAPMAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVP
LGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDA
VPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSND
GMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPR
APLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPAFSWPWWYVLLG
AVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGE
FGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSR
LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVY
TSKSDVGLVTFRDVAIEFSLEEWKCLEPAQRDLYREVTLENFGHLASLGLSISKPDVVSLLEQGKEPWMIANDVTGPWCPDLESRCEKFL
QKDIFEIGAFNWEIMESLKCSDLEGSDFRADWECEGQFERQVNEECYFKQVNVTYGHMPVFQHHTSHTVRQSRETGEKLMECHECGKAFS
RGSHLIQHQKIHTGEKPFGCKECGKAFSRASHLVQHQRIHTGEKPYDCKDCGKAFGRTSELILHQRLHTGVKPYECKECGKTFRQHSQLI
LHQRTHTGEKPYVCKDCGKAFIRGSQLTVHRRIHTGARPYECKECGKAFRQHSQLTVHQRIHTGEKPYECKECGKGFIHSSEVTRHQRIH
SGEKPYECKECGKAFRQHAQLTRHQRVHTGDRPYECKDCGKAFSRSSYLIQHQRIHTGDKPYECKECGKAFIRVSQLTHHQRIHTCEKPY

--------------------------------------------------------------

>8583_8583_7_AXL-ZNF565_AXL_chr19_41762516_ENST00000593513_ZNF565_chr19_36686058_ENST00000304116_length(amino acids)=1032AA_BP=578
MNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSNDGMGIQAGEPDPPEEPLTSQ
ASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDT
PEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLI
LALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN
QDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPT
QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVGLVT
FRDVAIEFSLEEWKCLEPAQRDLYREVTLENFGHLASLGLSISKPDVVSLLEQGKEPWMIANDVTGPWCPDLESRCEKFLQKDIFEIGAF
NWEIMESLKCSDLEGSDFRADWECEGQFERQVNEECYFKQVNVTYGHMPVFQHHTSHTVRQSRETGEKLMECHECGKAFSRGSHLIQHQK
IHTGEKPFGCKECGKAFSRASHLVQHQRIHTGEKPYDCKDCGKAFGRTSELILHQRLHTGVKPYECKECGKTFRQHSQLILHQRTHTGEK
PYVCKDCGKAFIRGSQLTVHRRIHTGARPYECKECGKAFRQHSQLTVHQRIHTGEKPYECKECGKGFIHSSEVTRHQRIHSGEKPYECKE
CGKAFRQHAQLTRHQRVHTGDRPYECKDCGKAFSRSSYLIQHQRIHTGDKPYECKECGKAFIRVSQLTHHQRIHTCEKPYECRECGMAFI

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>8583_8583_8_AXL-ZNF565_AXL_chr19_41762516_ENST00000593513_ZNF565_chr19_36686058_ENST00000355114_length(amino acids)=1032AA_BP=578
MNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSNDGMGIQAGEPDPPEEPLTSQ
ASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDT
PEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLI
LALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN
QDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPT
QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVGLVT
FRDVAIEFSLEEWKCLEPAQRDLYREVTLENFGHLASLGLSISKPDVVSLLEQGKEPWMIANDVTGPWCPDLESRCEKFLQKDIFEIGAF
NWEIMESLKCSDLEGSDFRADWECEGQFERQVNEECYFKQVNVTYGHMPVFQHHTSHTVRQSRETGEKLMECHECGKAFSRGSHLIQHQK
IHTGEKPFGCKECGKAFSRASHLVQHQRIHTGEKPYDCKDCGKAFGRTSELILHQRLHTGVKPYECKECGKTFRQHSQLILHQRTHTGEK
PYVCKDCGKAFIRGSQLTVHRRIHTGARPYECKECGKAFRQHSQLTVHQRIHTGEKPYECKECGKGFIHSSEVTRHQRIHSGEKPYECKE
CGKAFRQHAQLTRHQRVHTGDRPYECKDCGKAFSRSSYLIQHQRIHTGDKPYECKECGKAFIRVSQLTHHQRIHTCEKPYECRECGMAFI

--------------------------------------------------------------

>8583_8583_9_AXL-ZNF565_AXL_chr19_41762516_ENST00000593513_ZNF565_chr19_36686058_ENST00000392173_length(amino acids)=1032AA_BP=578
MNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSNDGMGIQAGEPDPPEEPLTSQ
ASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDT
PEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLI
LALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN
QDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPT
QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVGLVT
FRDVAIEFSLEEWKCLEPAQRDLYREVTLENFGHLASLGLSISKPDVVSLLEQGKEPWMIANDVTGPWCPDLESRCEKFLQKDIFEIGAF
NWEIMESLKCSDLEGSDFRADWECEGQFERQVNEECYFKQVNVTYGHMPVFQHHTSHTVRQSRETGEKLMECHECGKAFSRGSHLIQHQK
IHTGEKPFGCKECGKAFSRASHLVQHQRIHTGEKPYDCKDCGKAFGRTSELILHQRLHTGVKPYECKECGKTFRQHSQLILHQRTHTGEK
PYVCKDCGKAFIRGSQLTVHRRIHTGARPYECKECGKAFRQHSQLTVHQRIHTGEKPYECKECGKGFIHSSEVTRHQRIHSGEKPYECKE
CGKAFRQHAQLTRHQRVHTGDRPYECKDCGKAFSRSSYLIQHQRIHTGDKPYECKECGKAFIRVSQLTHHQRIHTCEKPYECRECGMAFI

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:41762516/chr19:36686058)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AXL P30530	.
FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269\|PubMed:10403904, ECO:0000269\|PubMed:11484958, ECO:0000269\|PubMed:12364394, ECO:0000269\|PubMed:12490074, ECO:0000269\|PubMed:15507525, ECO:0000269\|PubMed:15733062, ECO:0000269\|PubMed:1656220, ECO:0000269\|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269\|PubMed:17005688, ECO:0000269\|PubMed:21501828, ECO:0000269\|PubMed:22156524, ECO:0000269\|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269\|PubMed:22673088}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000301178

139_222

732.0

895.0

Domain

Note=Ig-like C2-type 2

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000301178

227_331

732.0

895.0

Domain

Fibronectin type-III 1

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000301178

27_128

732.0

895.0

Domain

Note=Ig-like C2-type 1

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000301178

336_428

732.0

895.0

Domain

Fibronectin type-III 2

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000359092

139_222

723.0

886.0

Domain

Note=Ig-like C2-type 2

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000359092

227_331

723.0

886.0

Domain

Fibronectin type-III 1

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000359092

27_128

723.0

886.0

Domain

Note=Ig-like C2-type 1

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000359092

336_428

723.0

886.0

Domain

Fibronectin type-III 2

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000301178

542_550

732.0

895.0

Nucleotide binding

ATP

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000359092

542_550

723.0

886.0

Nucleotide binding

ATP

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000301178

26_451

732.0

895.0

Topological domain

Extracellular

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000359092

26_451

723.0

886.0

Topological domain

Extracellular

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000301178

452_472

732.0

895.0

Transmembrane

Helical

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000359092

452_472

723.0

886.0

Transmembrane

Helical

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

46_117

3.0

500.0

Domain

KRAB

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

46_117

3.0

500.0

Domain

KRAB

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

207_229

3.0

500.0

Zinc finger

C2H2-type 1

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

235_257

3.0

500.0

Zinc finger

C2H2-type 2

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

263_285

3.0

500.0

Zinc finger

C2H2-type 3

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

291_313

3.0

500.0

Zinc finger

C2H2-type 4

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

319_341

3.0

500.0

Zinc finger

C2H2-type 5

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

347_369

3.0

500.0

Zinc finger

C2H2-type 6

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

375_397

3.0

500.0

Zinc finger

C2H2-type 7

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

403_425

3.0

500.0

Zinc finger

C2H2-type 8

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

431_453

3.0

500.0

Zinc finger

C2H2-type 9

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

459_481

3.0

500.0

Zinc finger

C2H2-type 10

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

487_509

3.0

500.0

Zinc finger

C2H2-type 11

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000304116

515_537

3.0

500.0

Zinc finger

C2H2-type 12

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

207_229

3.0

500.0

Zinc finger

C2H2-type 1

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

235_257

3.0

500.0

Zinc finger

C2H2-type 2

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

263_285

3.0

500.0

Zinc finger

C2H2-type 3

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

291_313

3.0

500.0

Zinc finger

C2H2-type 4

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

319_341

3.0

500.0

Zinc finger

C2H2-type 5

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

347_369

3.0

500.0

Zinc finger

C2H2-type 6

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

375_397

3.0

500.0

Zinc finger

C2H2-type 7

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

403_425

3.0

500.0

Zinc finger

C2H2-type 8

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

431_453

3.0

500.0

Zinc finger

C2H2-type 9

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

459_481

3.0

500.0

Zinc finger

C2H2-type 10

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

487_509

3.0

500.0

Zinc finger

C2H2-type 11

Tgene

ZNF565

chr19:41762516

chr19:36686058

ENST00000392173

515_537

3.0

500.0

Zinc finger

C2H2-type 12

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000301178

536_807

732.0

895.0

Domain

Protein kinase

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000359092

536_807

723.0

886.0

Domain

Protein kinase

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000301178

473_894

732.0

895.0

Topological domain

Cytoplasmic

Hgene

AXL

chr19:41762516

chr19:36686058

ENST00000359092

473_894

723.0

886.0

Topological domain

Cytoplasmic

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
AXL
ZNF565

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to AXL-ZNF565

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to AXL-ZNF565

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source