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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SPOP-TAOK1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SPOP-TAOK1
FusionPDB ID: 85962
FusionGDB2.0 ID: 85962
HgeneTgene
Gene symbol

SPOP

TAOK1

Gene ID

8405

57551

Gene namespeckle type BTB/POZ proteinTAO kinase 1
SynonymsBTBD32|TEF2KFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1
Cytomap

17q21.33

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionspeckle-type POZ proteinHIB homolog 1roadkill homolog 1serine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kin
Modification date2020032920200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000347630, ENST00000393328, 
ENST00000393331, ENST00000503676, 
ENST00000504102, ENST00000513080, 
ENST00000261716, ENST00000536202, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score37 X 22 X 16=1302410 X 11 X 6=660
# samples 4611
** MAII scorelog2(46/13024*10)=-4.82339493332187
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/660*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SPOP [Title/Abstract] AND TAOK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SPOP(47679227)-TAOK1(27869579), # samples:2
Anticipated loss of major functional domain due to fusion event.SPOP-TAOK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPOP-TAOK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPOP-TAOK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SPOP-TAOK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SPOP-TAOK1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SPOP-TAOK1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SPOP-TAOK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SPOP-TAOK1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
SPOP-TAOK1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SPOP-TAOK1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SPOP-TAOK1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAOK1

GO:0006974

cellular response to DNA damage stimulus

17396146

TgeneTAOK1

GO:0016310

phosphorylation

12639963

TgeneTAOK1

GO:0046330

positive regulation of JNK cascade

16407310

TgeneTAOK1

GO:0097194

execution phase of apoptosis

16407310


check buttonFusion gene breakpoints across SPOP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TAOK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A14V-01ASPOPchr17

47679227

-TAOK1chr17

27869579

+
ChimerDB4BRCATCGA-E2-A14VSPOPchr17

47679226

-TAOK1chr17

27869578

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393328SPOPchr1747679227-ENST00000261716TAOK1chr1727869579+1069013463601346328
ENST00000393331SPOPchr1747679227-ENST00000536202TAOK1chr1727869579+323114514651451328
ENST00000347630SPOPchr1747679227-ENST00000536202TAOK1chr1727869579+310813283421328328
ENST00000504102SPOPchr1747679227-ENST00000536202TAOK1chr1727869579+312813483621348328
ENST00000503676SPOPchr1747679227-ENST00000261716TAOK1chr1727869579+1095616126261612328
ENST00000393328SPOPchr1747679226-ENST00000261716TAOK1chr1727869578+1069013463601346328
ENST00000393331SPOPchr1747679226-ENST00000536202TAOK1chr1727869578+323114514651451328
ENST00000347630SPOPchr1747679226-ENST00000536202TAOK1chr1727869578+310813283421328328
ENST00000504102SPOPchr1747679226-ENST00000536202TAOK1chr1727869578+312813483621348328
ENST00000503676SPOPchr1747679226-ENST00000261716TAOK1chr1727869578+1095616126261612328

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393328ENST00000261716SPOPchr1747679227-TAOK1chr1727869579+0.0001371680.9998628
ENST00000393331ENST00000536202SPOPchr1747679227-TAOK1chr1727869579+0.0004842130.9995158
ENST00000347630ENST00000536202SPOPchr1747679227-TAOK1chr1727869579+0.0003838810.99961615
ENST00000504102ENST00000536202SPOPchr1747679227-TAOK1chr1727869579+0.000378270.99962175
ENST00000503676ENST00000261716SPOPchr1747679227-TAOK1chr1727869579+0.000135850.9998641
ENST00000393328ENST00000261716SPOPchr1747679226-TAOK1chr1727869578+0.0001371680.9998628
ENST00000393331ENST00000536202SPOPchr1747679226-TAOK1chr1727869578+0.0004842130.9995158
ENST00000347630ENST00000536202SPOPchr1747679226-TAOK1chr1727869578+0.0003838810.99961615
ENST00000504102ENST00000536202SPOPchr1747679226-TAOK1chr1727869578+0.000378270.99962175
ENST00000503676ENST00000261716SPOPchr1747679226-TAOK1chr1727869578+0.000135850.9998641

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>85962_85962_1_SPOP-TAOK1_SPOP_chr17_47679226_ENST00000347630_TAOK1_chr17_27869578_ENST00000536202_length(amino acids)=328AA_BP=
MAMSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYL
LLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNM
VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK

--------------------------------------------------------------

>85962_85962_2_SPOP-TAOK1_SPOP_chr17_47679226_ENST00000393328_TAOK1_chr17_27869578_ENST00000261716_length(amino acids)=328AA_BP=
MAMSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYL
LLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNM
VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK

--------------------------------------------------------------

>85962_85962_3_SPOP-TAOK1_SPOP_chr17_47679226_ENST00000393331_TAOK1_chr17_27869578_ENST00000536202_length(amino acids)=328AA_BP=
MAMSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYL
LLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNM
VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK

--------------------------------------------------------------

>85962_85962_4_SPOP-TAOK1_SPOP_chr17_47679226_ENST00000503676_TAOK1_chr17_27869578_ENST00000261716_length(amino acids)=328AA_BP=
MAMSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYL
LLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNM
VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK

--------------------------------------------------------------

>85962_85962_5_SPOP-TAOK1_SPOP_chr17_47679226_ENST00000504102_TAOK1_chr17_27869578_ENST00000536202_length(amino acids)=328AA_BP=
MAMSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYL
LLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNM
VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK

--------------------------------------------------------------

>85962_85962_6_SPOP-TAOK1_SPOP_chr17_47679227_ENST00000347630_TAOK1_chr17_27869579_ENST00000536202_length(amino acids)=328AA_BP=
MAMSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYL
LLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNM
VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK

--------------------------------------------------------------

>85962_85962_7_SPOP-TAOK1_SPOP_chr17_47679227_ENST00000393328_TAOK1_chr17_27869579_ENST00000261716_length(amino acids)=328AA_BP=
MAMSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYL
LLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNM
VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK

--------------------------------------------------------------

>85962_85962_8_SPOP-TAOK1_SPOP_chr17_47679227_ENST00000393331_TAOK1_chr17_27869579_ENST00000536202_length(amino acids)=328AA_BP=
MAMSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYL
LLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNM
VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK

--------------------------------------------------------------

>85962_85962_9_SPOP-TAOK1_SPOP_chr17_47679227_ENST00000503676_TAOK1_chr17_27869579_ENST00000261716_length(amino acids)=328AA_BP=
MAMSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYL
LLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNM
VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK

--------------------------------------------------------------

>85962_85962_10_SPOP-TAOK1_SPOP_chr17_47679227_ENST00000504102_TAOK1_chr17_27869579_ENST00000536202_length(amino acids)=328AA_BP=
MAMSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYL
LLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNM
VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:47679227/chr17:27869579)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPOPchr17:47679226chr17:27869578ENST00000347630-1011173_297326.6666666666667375.0DomainBTB
HgeneSPOPchr17:47679226chr17:27869578ENST00000347630-101131_161326.6666666666667375.0DomainMATH
HgeneSPOPchr17:47679226chr17:27869578ENST00000393328-1011173_297326.6666666666667375.0DomainBTB
HgeneSPOPchr17:47679226chr17:27869578ENST00000393328-101131_161326.6666666666667375.0DomainMATH
HgeneSPOPchr17:47679226chr17:27869578ENST00000393331-1112173_297326.6666666666667375.0DomainBTB
HgeneSPOPchr17:47679226chr17:27869578ENST00000393331-111231_161326.6666666666667375.0DomainMATH
HgeneSPOPchr17:47679226chr17:27869578ENST00000503676-1011173_297326.6666666666667375.0DomainBTB
HgeneSPOPchr17:47679226chr17:27869578ENST00000503676-101131_161326.6666666666667375.0DomainMATH
HgeneSPOPchr17:47679226chr17:27869578ENST00000504102-910173_297326.6666666666667375.0DomainBTB
HgeneSPOPchr17:47679226chr17:27869578ENST00000504102-91031_161326.6666666666667375.0DomainMATH
HgeneSPOPchr17:47679227chr17:27869579ENST00000347630-1011173_297326.6666666666667375.0DomainBTB
HgeneSPOPchr17:47679227chr17:27869579ENST00000347630-101131_161326.6666666666667375.0DomainMATH
HgeneSPOPchr17:47679227chr17:27869579ENST00000393328-1011173_297326.6666666666667375.0DomainBTB
HgeneSPOPchr17:47679227chr17:27869579ENST00000393328-101131_161326.6666666666667375.0DomainMATH
HgeneSPOPchr17:47679227chr17:27869579ENST00000393331-1112173_297326.6666666666667375.0DomainBTB
HgeneSPOPchr17:47679227chr17:27869579ENST00000393331-111231_161326.6666666666667375.0DomainMATH
HgeneSPOPchr17:47679227chr17:27869579ENST00000503676-1011173_297326.6666666666667375.0DomainBTB
HgeneSPOPchr17:47679227chr17:27869579ENST00000503676-101131_161326.6666666666667375.0DomainMATH
HgeneSPOPchr17:47679227chr17:27869579ENST00000504102-910173_297326.6666666666667375.0DomainBTB
HgeneSPOPchr17:47679227chr17:27869579ENST00000504102-91031_161326.6666666666667375.0DomainMATH
HgeneSPOPchr17:47679226chr17:27869578ENST00000347630-1011123_133326.6666666666667375.0RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47679226chr17:27869578ENST00000347630-1011186_217326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679226chr17:27869578ENST00000347630-101171_191326.6666666666667375.0RegionNote=Required for nuclear localization
HgeneSPOPchr17:47679226chr17:27869578ENST00000393328-1011123_133326.6666666666667375.0RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47679226chr17:27869578ENST00000393328-1011186_217326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679226chr17:27869578ENST00000393328-101171_191326.6666666666667375.0RegionNote=Required for nuclear localization
HgeneSPOPchr17:47679226chr17:27869578ENST00000393331-1112123_133326.6666666666667375.0RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47679226chr17:27869578ENST00000393331-1112186_217326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679226chr17:27869578ENST00000393331-111271_191326.6666666666667375.0RegionNote=Required for nuclear localization
HgeneSPOPchr17:47679226chr17:27869578ENST00000503676-1011123_133326.6666666666667375.0RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47679226chr17:27869578ENST00000503676-1011186_217326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679226chr17:27869578ENST00000503676-101171_191326.6666666666667375.0RegionNote=Required for nuclear localization
HgeneSPOPchr17:47679226chr17:27869578ENST00000504102-910123_133326.6666666666667375.0RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47679226chr17:27869578ENST00000504102-910186_217326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679226chr17:27869578ENST00000504102-91071_191326.6666666666667375.0RegionNote=Required for nuclear localization
HgeneSPOPchr17:47679227chr17:27869579ENST00000347630-1011123_133326.6666666666667375.0RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47679227chr17:27869579ENST00000347630-1011186_217326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679227chr17:27869579ENST00000347630-101171_191326.6666666666667375.0RegionNote=Required for nuclear localization
HgeneSPOPchr17:47679227chr17:27869579ENST00000393328-1011123_133326.6666666666667375.0RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47679227chr17:27869579ENST00000393328-1011186_217326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679227chr17:27869579ENST00000393328-101171_191326.6666666666667375.0RegionNote=Required for nuclear localization
HgeneSPOPchr17:47679227chr17:27869579ENST00000393331-1112123_133326.6666666666667375.0RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47679227chr17:27869579ENST00000393331-1112186_217326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679227chr17:27869579ENST00000393331-111271_191326.6666666666667375.0RegionNote=Required for nuclear localization
HgeneSPOPchr17:47679227chr17:27869579ENST00000503676-1011123_133326.6666666666667375.0RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47679227chr17:27869579ENST00000503676-1011186_217326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679227chr17:27869579ENST00000503676-101171_191326.6666666666667375.0RegionNote=Required for nuclear localization
HgeneSPOPchr17:47679227chr17:27869579ENST00000504102-910123_133326.6666666666667375.0RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47679227chr17:27869579ENST00000504102-910186_217326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679227chr17:27869579ENST00000504102-91071_191326.6666666666667375.0RegionNote=Required for nuclear localization
TgeneTAOK1chr17:47679226chr17:27869578ENST000005362021618754_877700.0854.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK1chr17:47679227chr17:27869579ENST000005362021618754_877700.0854.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPOPchr17:47679226chr17:27869578ENST00000347630-1011297_355326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679226chr17:27869578ENST00000393328-1011297_355326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679226chr17:27869578ENST00000393331-1112297_355326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679226chr17:27869578ENST00000503676-1011297_355326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679226chr17:27869578ENST00000504102-910297_355326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679227chr17:27869579ENST00000347630-1011297_355326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679227chr17:27869579ENST00000393328-1011297_355326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679227chr17:27869579ENST00000393331-1112297_355326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679227chr17:27869579ENST00000503676-1011297_355326.6666666666667375.0RegionNote=Important for homodimerization
HgeneSPOPchr17:47679227chr17:27869579ENST00000504102-910297_355326.6666666666667375.0RegionNote=Important for homodimerization
TgeneTAOK1chr17:47679226chr17:27869578ENST000002617161820458_651848.01002.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK1chr17:47679226chr17:27869578ENST000002617161820754_877848.01002.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK1chr17:47679226chr17:27869578ENST000005362021618458_651700.0854.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK1chr17:47679227chr17:27869579ENST000002617161820458_651848.01002.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK1chr17:47679227chr17:27869579ENST000002617161820754_877848.01002.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK1chr17:47679227chr17:27869579ENST000005362021618458_651700.0854.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK1chr17:47679226chr17:27869578ENST000002617161820330_334848.01002.0Compositional biasNote=Poly-Glu
TgeneTAOK1chr17:47679226chr17:27869578ENST000002617161820347_379848.01002.0Compositional biasNote=Ser-rich
TgeneTAOK1chr17:47679226chr17:27869578ENST000005362021618330_334700.0854.0Compositional biasNote=Poly-Glu
TgeneTAOK1chr17:47679226chr17:27869578ENST000005362021618347_379700.0854.0Compositional biasNote=Ser-rich
TgeneTAOK1chr17:47679227chr17:27869579ENST000002617161820330_334848.01002.0Compositional biasNote=Poly-Glu
TgeneTAOK1chr17:47679227chr17:27869579ENST000002617161820347_379848.01002.0Compositional biasNote=Ser-rich
TgeneTAOK1chr17:47679227chr17:27869579ENST000005362021618330_334700.0854.0Compositional biasNote=Poly-Glu
TgeneTAOK1chr17:47679227chr17:27869579ENST000005362021618347_379700.0854.0Compositional biasNote=Ser-rich
TgeneTAOK1chr17:47679226chr17:27869578ENST00000261716182028_281848.01002.0DomainProtein kinase
TgeneTAOK1chr17:47679226chr17:27869578ENST00000536202161828_281700.0854.0DomainProtein kinase
TgeneTAOK1chr17:47679227chr17:27869579ENST00000261716182028_281848.01002.0DomainProtein kinase
TgeneTAOK1chr17:47679227chr17:27869579ENST00000536202161828_281700.0854.0DomainProtein kinase
TgeneTAOK1chr17:47679226chr17:27869578ENST00000261716182034_42848.01002.0Nucleotide bindingATP
TgeneTAOK1chr17:47679226chr17:27869578ENST00000536202161834_42700.0854.0Nucleotide bindingATP
TgeneTAOK1chr17:47679227chr17:27869579ENST00000261716182034_42848.01002.0Nucleotide bindingATP
TgeneTAOK1chr17:47679227chr17:27869579ENST00000536202161834_42700.0854.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SPOP
TAOK1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SPOP-TAOK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SPOP-TAOK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource