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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SPTBN1-SPEN

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SPTBN1-SPEN
FusionPDB ID: 86141
FusionGDB2.0 ID: 86141
HgeneTgene
Gene symbol

SPTBN1

SPEN

Gene ID

6711

64783

Gene namespectrin beta, non-erythrocytic 1RNA binding motif protein 15
SynonymsELF|HEL102|SPTB2|betaSpIIOTT|OTT1|SPEN
Cytomap

2p16.2

1p13.3

Type of geneprotein-codingprotein-coding
Descriptionspectrin beta chain, non-erythrocytic 1beta-G spectrinbeta-II spectrinbeta-fodrinbeta-spectrin 2beta-spectrin IIbeta-spectrin non-erythrocytic 1embryonic liver beta-fodrinepididymis luminal protein 102fodrin beta chainspectrin beta chain, brain RNA-binding protein 15one twenty two proteinone twenty-twoone-twenty two protein 1putative RNA-binding protein 15
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000333896, ENST00000356805, 
ENST00000471538, ENST00000375759, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 20 X 9=43206 X 7 X 3=126
# samples 268
** MAII scorelog2(26/4320*10)=-4.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SPTBN1 [Title/Abstract] AND SPEN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SPTBN1(54853321)-SPEN(16245519), # samples:1
Anticipated loss of major functional domain due to fusion event.SPTBN1-SPEN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPEN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPEN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPEN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSPEN

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

26575292

TgeneSPEN

GO:0001510

RNA methylation

27602518

TgeneSPEN

GO:0009048

dosage compensation by inactivation of X chromosome

27602518

TgeneSPEN

GO:0045652

regulation of megakaryocyte differentiation

26575292

TgeneSPEN

GO:0045892

negative regulation of transcription, DNA-templated

16129689


check buttonFusion gene breakpoints across SPTBN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPEN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE938281SPTBN1chr2

54853321

-SPENchr1

16245519

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356805SPTBN1chr254853321-ENST00000375759SPENchr116245519+1220616721588111723194
ENST00000333896SPTBN1chr254853321-ENST00000375759SPENchr116245519+1227117371653112373194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356805ENST00000375759SPTBN1chr254853321-SPENchr116245519+0.0044054050.99559456
ENST00000333896ENST00000375759SPTBN1chr254853321-SPENchr116245519+0.0044707140.99552935

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>86141_86141_1_SPTBN1-SPEN_SPTBN1_chr2_54853321_ENST00000333896_SPEN_chr1_16245519_ENST00000375759_length(amino acids)=3194AA_BP=28
MAERKPASGVSEIFQEMLYIMDWMDEMKEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRYGPVVKVVFDRLKGMALVLYN
EIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCMEKSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDY
PARGREFYSEWETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGAS
PSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHS
PSSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVS
QTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEME
DARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVENQE
VQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSE
KFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPR
LLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSV
RDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREE
NWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKE
EDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPP
SVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPY
LDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNK
SKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYAT
MGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKG
KNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKS
ASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAK
LAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVS
GILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESN
QAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRV
HSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMD
PKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSID
LENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNA
APGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNT
SEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVIS
SVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPAL
PSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMP
PHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARAT
APVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPA
PAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEP
LQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMK
PDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGN
NVLAHRSLPLSEGGPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFITYLQAKQAAGIINVPNPGSN

--------------------------------------------------------------

>86141_86141_2_SPTBN1-SPEN_SPTBN1_chr2_54853321_ENST00000356805_SPEN_chr1_16245519_ENST00000375759_length(amino acids)=3194AA_BP=28
MAERKPASGVSEIFQEMLYIMDWMDEMKEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRYGPVVKVVFDRLKGMALVLYN
EIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCMEKSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDY
PARGREFYSEWETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGAS
PSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHS
PSSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVS
QTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEME
DARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVENQE
VQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSE
KFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPR
LLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSV
RDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREE
NWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKE
EDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPP
SVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPY
LDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNK
SKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYAT
MGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKG
KNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKS
ASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAK
LAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVS
GILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESN
QAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRV
HSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMD
PKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSID
LENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNA
APGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNT
SEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVIS
SVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPAL
PSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMP
PHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARAT
APVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPA
PAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEP
LQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMK
PDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGN
NVLAHRSLPLSEGGPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFITYLQAKQAAGIINVPNPGSN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:54853321/chr1:16245519)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151170_119103665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151408_142803665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151496_152903665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151592_161203665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151928_194403665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015688_71503665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015977_100403665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015125_27703665.0Compositional biasNote=Arg-rich
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015240_32503665.0Compositional biasNote=Ser-rich
TgeneSPENchr2:54853321chr1:16245519ENST000003757590152428_252003665.0Compositional biasNote=Pro-rich
TgeneSPENchr2:54853321chr1:16245519ENST000003757590153220_348203665.0Compositional biasNote=Pro-rich
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015616_81003665.0Compositional biasNote=Arg-rich
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015624_69703665.0Compositional biasNote=Tyr-rich
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151_57303665.0DNA bindingOntology_term=ECO:0000250
TgeneSPENchr2:54853321chr1:16245519ENST000003757590152201_270703665.0DomainNote=RID
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015335_41503665.0DomainRRM 2
TgeneSPENchr2:54853321chr1:16245519ENST000003757590153498_366403665.0DomainSPOC
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015438_51303665.0DomainRRM 3
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015517_58903665.0DomainRRM 4
TgeneSPENchr2:54853321chr1:16245519ENST000003757590156_8103665.0DomainRRM 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131173_27802156.0DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1312197_230702156.0DomainPH
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-13154_15802156.0DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136173_27802365.0DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1362197_230702365.0DomainPH
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-13654_15802365.0DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1312_27502156.0RegionNote=Actin-binding
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1362_27502365.0RegionNote=Actin-binding
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311063_116602156.0RepeatSpectrin 8
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311170_125802156.0RepeatSpectrin 9
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311276_137602156.0RepeatSpectrin 10
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311381_148202156.0RepeatSpectrin 11
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311486_159002156.0RepeatSpectrin 12
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311592_169602156.0RepeatSpectrin 13
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311698_180102156.0RepeatSpectrin 14
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311805_190702156.0RepeatSpectrin 15
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311914_201402156.0RepeatSpectrin 16
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1312018_209702156.0RepeatSpectrin 17
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131303_41102156.0RepeatSpectrin 1
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131423_52502156.0RepeatSpectrin 2
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131530_63602156.0RepeatSpectrin 3
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131639_74202156.0RepeatSpectrin 4
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131745_84702156.0RepeatSpectrin 5
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131850_95202156.0RepeatSpectrin 6
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131957_106002156.0RepeatSpectrin 7
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361063_116602365.0RepeatSpectrin 8
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361170_125802365.0RepeatSpectrin 9
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361276_137602365.0RepeatSpectrin 10
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361381_148202365.0RepeatSpectrin 11
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361486_159002365.0RepeatSpectrin 12
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361592_169602365.0RepeatSpectrin 13
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361698_180102365.0RepeatSpectrin 14
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361805_190702365.0RepeatSpectrin 15
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361914_201402365.0RepeatSpectrin 16
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1362018_209702365.0RepeatSpectrin 17
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136303_41102365.0RepeatSpectrin 1
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136423_52502365.0RepeatSpectrin 2
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136530_63602365.0RepeatSpectrin 3
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136639_74202365.0RepeatSpectrin 4
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136745_84702365.0RepeatSpectrin 5
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136850_95202365.0RepeatSpectrin 6
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136957_106002365.0RepeatSpectrin 7


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SPTBN1
SPEN


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311563_209302156.0ANK2
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361563_209302365.0ANK2


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Related Drugs to SPTBN1-SPEN


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SPTBN1-SPEN


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource