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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SQSTM1-NTRK1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SQSTM1-NTRK1
	FusionPDB ID: 86213
	FusionGDB2.0 ID: 86213
		Hgene	Tgene
	Gene symbol	SQSTM1	NTRK1
	Gene ID	8878	4914
	Gene name	sequestosome 1	neurotrophic receptor tyrosine kinase 1
	Synonyms	A170\|DMRV\|FTDALS3\|NADGP\|OSIL\|PDB3\|ZIP3\|p60\|p62\|p62B	MTC\|TRK\|TRK1\|TRKA\|Trk-A\|p140-TrkA
	Cytomap	5q35.3	1q23.1
	Type of gene	protein-coding	protein-coding
	Description	sequestosome-1EBI3-associated protein of 60 kDaEBI3-associated protein p60EBIAPautophagy receptor p62oxidative stress induced likephosphotyrosine independent ligand for the Lck SH2 domain p62phosphotyrosine-independent ligand for the Lck SH2 domain	high affinity nerve growth factor receptorOncogene TRKTRK1-transforming tyrosine kinase proteingp140trkneurotrophic tyrosine kinase, receptor, type 1tropomyosin-related kinase Atyrosine kinase receptor A
	Modification date	20200327	20200313
	UniProtAcc	Q13501	P04629
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000360718, ENST00000376929, ENST00000389805, ENST00000402874, ENST00000510187, ENST00000506690,	ENST00000531606, ENST00000358660, ENST00000368196, ENST00000392302, ENST00000524377,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	29 X 23 X 12=8004	25 X 24 X 13=7800
	# samples	33	33
	** MAII score	log2(33/8004*10)=-4.60018323765993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(33/7800*10)=-4.56293619439116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SQSTM1 [Title/Abstract] AND NTRK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SQSTM1(179252226)-NTRK1(156844363), # samples:3
Anticipated loss of major functional domain due to fusion event.	SQSTM1-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SQSTM1-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SQSTM1-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SQSTM1-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SQSTM1	GO:0006914	autophagy	20452972
Hgene	SQSTM1	GO:0007032	endosome organization	27368102
Hgene	SQSTM1	GO:0031397	negative regulation of protein ubiquitination	20452972
Hgene	SQSTM1	GO:0061635	regulation of protein complex stability	25127057
Hgene	SQSTM1	GO:1905719	protein localization to perinuclear region of cytoplasm	27368102
Tgene	NTRK1	GO:0006468	protein phosphorylation	15488758
Tgene	NTRK1	GO:0008285	negative regulation of cell proliferation	15488758
Tgene	NTRK1	GO:0010976	positive regulation of neuron projection development	15488758
Tgene	NTRK1	GO:0018108	peptidyl-tyrosine phosphorylation	2927393
Tgene	NTRK1	GO:0043547	positive regulation of GTPase activity	15488758
Tgene	NTRK1	GO:0046579	positive regulation of Ras protein signal transduction	15488758
Tgene	NTRK1	GO:0046777	protein autophosphorylation	15488758
Tgene	NTRK1	GO:0048011	neurotrophin TRK receptor signaling pathway	15488758
Tgene	NTRK1	GO:0051092	positive regulation of NF-kappaB transcription factor activity	15488758
Tgene	NTRK1	GO:0070374	positive regulation of ERK1 and ERK2 cascade	15488758
Tgene	NTRK1	GO:1904646	cellular response to amyloid-beta	11927634

Fusion gene breakpoints across SQSTM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NTRK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-ET-A40S-01A	SQSTM1	chr5	179252226	-	NTRK1	chr1	156844363	+
ChimerDB4	THCA	TCGA-ET-A40S-01A	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+
ChimerDB4	THCA	TCGA-ET-A40S	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+
ChimerKB4	.	.	SQSTM1	chr5	179260031	+	NTRK1	chr1	179260031	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000376929	SQSTM1	chr5	179252226	+	ENST00000392302	NTRK1	chr1	156844363	+	2210	862	303	2057	584
ENST00000376929	SQSTM1	chr5	179252226	+	ENST00000368196	NTRK1	chr1	156844363	+	2266	862	303	2057	584
ENST00000376929	SQSTM1	chr5	179252226	+	ENST00000524377	NTRK1	chr1	156844363	+	2058	862	303	2057	584
ENST00000376929	SQSTM1	chr5	179252226	+	ENST00000358660	NTRK1	chr1	156844363	+	2136	862	303	2066	587
ENST00000389805	SQSTM1	chr5	179252226	+	ENST00000392302	NTRK1	chr1	156844363	+	2280	932	178	2127	649
ENST00000389805	SQSTM1	chr5	179252226	+	ENST00000368196	NTRK1	chr1	156844363	+	2336	932	178	2127	649
ENST00000389805	SQSTM1	chr5	179252226	+	ENST00000524377	NTRK1	chr1	156844363	+	2128	932	178	2127	650
ENST00000389805	SQSTM1	chr5	179252226	+	ENST00000358660	NTRK1	chr1	156844363	+	2206	932	178	2136	652
ENST00000402874	SQSTM1	chr5	179252226	+	ENST00000392302	NTRK1	chr1	156844363	+	2120	772	18	1967	649
ENST00000402874	SQSTM1	chr5	179252226	+	ENST00000368196	NTRK1	chr1	156844363	+	2176	772	18	1967	649
ENST00000402874	SQSTM1	chr5	179252226	+	ENST00000524377	NTRK1	chr1	156844363	+	1968	772	18	1967	649
ENST00000402874	SQSTM1	chr5	179252226	+	ENST00000358660	NTRK1	chr1	156844363	+	2046	772	18	1976	652
ENST00000510187	SQSTM1	chr5	179252226	+	ENST00000392302	NTRK1	chr1	156844363	+	2118	770	16	1965	649
ENST00000510187	SQSTM1	chr5	179252226	+	ENST00000368196	NTRK1	chr1	156844363	+	2174	770	16	1965	649
ENST00000510187	SQSTM1	chr5	179252226	+	ENST00000524377	NTRK1	chr1	156844363	+	1966	770	16	1965	650
ENST00000510187	SQSTM1	chr5	179252226	+	ENST00000358660	NTRK1	chr1	156844363	+	2044	770	16	1974	652
ENST00000360718	SQSTM1	chr5	179252226	+	ENST00000392302	NTRK1	chr1	156844363	+	2370	1022	334	2217	627
ENST00000360718	SQSTM1	chr5	179252226	+	ENST00000368196	NTRK1	chr1	156844363	+	2426	1022	334	2217	627
ENST00000360718	SQSTM1	chr5	179252226	+	ENST00000524377	NTRK1	chr1	156844363	+	2218	1022	334	2217	628
ENST00000360718	SQSTM1	chr5	179252226	+	ENST00000358660	NTRK1	chr1	156844363	+	2296	1022	334	2226	630
ENST00000376929	SQSTM1	chr5	179252226	+	ENST00000392302	NTRK1	chr1	156844362	+	2210	862	303	2057	584
ENST00000376929	SQSTM1	chr5	179252226	+	ENST00000368196	NTRK1	chr1	156844362	+	2266	862	303	2057	584
ENST00000376929	SQSTM1	chr5	179252226	+	ENST00000524377	NTRK1	chr1	156844362	+	2058	862	303	2057	584
ENST00000376929	SQSTM1	chr5	179252226	+	ENST00000358660	NTRK1	chr1	156844362	+	2136	862	303	2066	587
ENST00000389805	SQSTM1	chr5	179252226	+	ENST00000392302	NTRK1	chr1	156844362	+	2280	932	178	2127	649
ENST00000389805	SQSTM1	chr5	179252226	+	ENST00000368196	NTRK1	chr1	156844362	+	2336	932	178	2127	649
ENST00000389805	SQSTM1	chr5	179252226	+	ENST00000524377	NTRK1	chr1	156844362	+	2128	932	178	2127	650
ENST00000389805	SQSTM1	chr5	179252226	+	ENST00000358660	NTRK1	chr1	156844362	+	2206	932	178	2136	652
ENST00000402874	SQSTM1	chr5	179252226	+	ENST00000392302	NTRK1	chr1	156844362	+	2120	772	18	1967	649
ENST00000402874	SQSTM1	chr5	179252226	+	ENST00000368196	NTRK1	chr1	156844362	+	2176	772	18	1967	649
ENST00000402874	SQSTM1	chr5	179252226	+	ENST00000524377	NTRK1	chr1	156844362	+	1968	772	18	1967	649
ENST00000402874	SQSTM1	chr5	179252226	+	ENST00000358660	NTRK1	chr1	156844362	+	2046	772	18	1976	652
ENST00000510187	SQSTM1	chr5	179252226	+	ENST00000392302	NTRK1	chr1	156844362	+	2118	770	16	1965	649
ENST00000510187	SQSTM1	chr5	179252226	+	ENST00000368196	NTRK1	chr1	156844362	+	2174	770	16	1965	649
ENST00000510187	SQSTM1	chr5	179252226	+	ENST00000524377	NTRK1	chr1	156844362	+	1966	770	16	1965	650
ENST00000510187	SQSTM1	chr5	179252226	+	ENST00000358660	NTRK1	chr1	156844362	+	2044	770	16	1974	652
ENST00000360718	SQSTM1	chr5	179252226	+	ENST00000392302	NTRK1	chr1	156844362	+	2370	1022	334	2217	627
ENST00000360718	SQSTM1	chr5	179252226	+	ENST00000368196	NTRK1	chr1	156844362	+	2426	1022	334	2217	627
ENST00000360718	SQSTM1	chr5	179252226	+	ENST00000524377	NTRK1	chr1	156844362	+	2218	1022	334	2217	628
ENST00000360718	SQSTM1	chr5	179252226	+	ENST00000358660	NTRK1	chr1	156844362	+	2296	1022	334	2226	630

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000376929	ENST00000392302	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.064512745	0.9354873
ENST00000376929	ENST00000368196	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.060600635	0.93939936
ENST00000376929	ENST00000524377	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.068584524	0.93141544
ENST00000376929	ENST00000358660	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.07324924	0.9267508
ENST00000389805	ENST00000392302	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.014738659	0.9852614
ENST00000389805	ENST00000368196	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.013649617	0.98635036
ENST00000389805	ENST00000524377	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.016944364	0.9830556
ENST00000389805	ENST00000358660	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.017846063	0.9821539
ENST00000402874	ENST00000392302	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.015581833	0.98441815
ENST00000402874	ENST00000368196	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.014335574	0.98566437
ENST00000402874	ENST00000524377	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.017941963	0.98205805
ENST00000402874	ENST00000358660	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.018892307	0.98110765
ENST00000510187	ENST00000392302	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.01551159	0.98448837
ENST00000510187	ENST00000368196	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.014290657	0.9857093
ENST00000510187	ENST00000524377	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.017857099	0.98214287
ENST00000510187	ENST00000358660	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.018812936	0.9811871
ENST00000360718	ENST00000392302	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.050021477	0.94997853
ENST00000360718	ENST00000368196	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.048503857	0.9514962
ENST00000360718	ENST00000524377	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.052762415	0.94723755
ENST00000360718	ENST00000358660	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844363	+	0.05830915	0.9416909
ENST00000376929	ENST00000392302	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.064512745	0.9354873
ENST00000376929	ENST00000368196	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.060600635	0.93939936
ENST00000376929	ENST00000524377	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.068584524	0.93141544
ENST00000376929	ENST00000358660	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.07324924	0.9267508
ENST00000389805	ENST00000392302	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.014738659	0.9852614
ENST00000389805	ENST00000368196	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.013649617	0.98635036
ENST00000389805	ENST00000524377	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.016944364	0.9830556
ENST00000389805	ENST00000358660	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.017846063	0.9821539
ENST00000402874	ENST00000392302	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.015581833	0.98441815
ENST00000402874	ENST00000368196	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.014335574	0.98566437
ENST00000402874	ENST00000524377	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.017941963	0.98205805
ENST00000402874	ENST00000358660	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.018892307	0.98110765
ENST00000510187	ENST00000392302	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.01551159	0.98448837
ENST00000510187	ENST00000368196	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.014290657	0.9857093
ENST00000510187	ENST00000524377	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.017857099	0.98214287
ENST00000510187	ENST00000358660	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.018812936	0.9811871
ENST00000360718	ENST00000392302	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.050021477	0.94997853
ENST00000360718	ENST00000368196	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.048503857	0.9514962
ENST00000360718	ENST00000524377	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.052762415	0.94723755
ENST00000360718	ENST00000358660	SQSTM1	chr5	179252226	+	NTRK1	chr1	156844362	+	0.05830915	0.9416909

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>86213_86213_1_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000360718_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=630AA_BP=227
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVL
NKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFL
AECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED
VAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTT
ESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG

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>86213_86213_2_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000360718_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=627AA_BP=227
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVL
NKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAEC
HNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAP
GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESD

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>86213_86213_3_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000360718_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=627AA_BP=227
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVL
NKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAEC
HNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAP
GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESD

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>86213_86213_4_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000360718_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=628AA_BP=227
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVL
NKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAEC
HNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAP
GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESD

--------------------------------------------------------------

>86213_86213_5_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000360718_NTRK1_chr1_156844363_ENST00000358660_length(amino acids)=630AA_BP=227
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVL
NKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFL
AECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED
VAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTT
ESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG

--------------------------------------------------------------

>86213_86213_6_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000360718_NTRK1_chr1_156844363_ENST00000368196_length(amino acids)=627AA_BP=227
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVL
NKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAEC
HNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAP
GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESD

--------------------------------------------------------------

>86213_86213_7_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000360718_NTRK1_chr1_156844363_ENST00000392302_length(amino acids)=627AA_BP=227
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVL
NKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAEC
HNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAP
GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESD

--------------------------------------------------------------

>86213_86213_8_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000360718_NTRK1_chr1_156844363_ENST00000524377_length(amino acids)=628AA_BP=227
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVL
NKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAEC
HNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAP
GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESD

--------------------------------------------------------------

>86213_86213_9_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000376929_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=587AA_BP=184
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGK
GSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQH
QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG
QGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERP

--------------------------------------------------------------

>86213_86213_10_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000376929_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=584AA_BP=184
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGK
GSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHI
VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGL
VVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC

--------------------------------------------------------------

>86213_86213_11_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000376929_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=584AA_BP=184
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGK
GSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHI
VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGL
VVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC

--------------------------------------------------------------

>86213_86213_12_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000376929_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=584AA_BP=184
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGK
GSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHI
VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGL
VVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC

--------------------------------------------------------------

>86213_86213_13_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000376929_NTRK1_chr1_156844363_ENST00000358660_length(amino acids)=587AA_BP=184
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGK
GSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQH
QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG
QGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERP

--------------------------------------------------------------

>86213_86213_14_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000376929_NTRK1_chr1_156844363_ENST00000368196_length(amino acids)=584AA_BP=184
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGK
GSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHI
VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGL
VVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC

--------------------------------------------------------------

>86213_86213_15_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000376929_NTRK1_chr1_156844363_ENST00000392302_length(amino acids)=584AA_BP=184
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGK
GSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHI
VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGL
VVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC

--------------------------------------------------------------

>86213_86213_16_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000376929_NTRK1_chr1_156844363_ENST00000524377_length(amino acids)=584AA_BP=184
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGK
GSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHI
VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGL
VVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC

--------------------------------------------------------------

>86213_86213_17_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000389805_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=652AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHH
IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRH
GDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVG
GRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI

--------------------------------------------------------------

>86213_86213_18_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000389805_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_19_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000389805_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_20_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000389805_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=650AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_21_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000389805_NTRK1_chr1_156844363_ENST00000358660_length(amino acids)=652AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHH
IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRH
GDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVG
GRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI

--------------------------------------------------------------

>86213_86213_22_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000389805_NTRK1_chr1_156844363_ENST00000368196_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_23_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000389805_NTRK1_chr1_156844363_ENST00000392302_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_24_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000389805_NTRK1_chr1_156844363_ENST00000524377_length(amino acids)=650AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_25_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000402874_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=652AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHH
IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRH
GDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVG
GRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI

--------------------------------------------------------------

>86213_86213_26_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000402874_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_27_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000402874_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_28_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000402874_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_29_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000402874_NTRK1_chr1_156844363_ENST00000358660_length(amino acids)=652AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHH
IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRH
GDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVG
GRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI

--------------------------------------------------------------

>86213_86213_30_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000402874_NTRK1_chr1_156844363_ENST00000368196_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_31_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000402874_NTRK1_chr1_156844363_ENST00000392302_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_32_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000402874_NTRK1_chr1_156844363_ENST00000524377_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_33_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000510187_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=652AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHH
IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRH
GDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVG
GRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI

--------------------------------------------------------------

>86213_86213_34_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000510187_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_35_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000510187_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_36_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000510187_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=650AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_37_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000510187_NTRK1_chr1_156844363_ENST00000358660_length(amino acids)=652AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHH
IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRH
GDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVG
GRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI

--------------------------------------------------------------

>86213_86213_38_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000510187_NTRK1_chr1_156844363_ENST00000368196_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_39_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000510187_NTRK1_chr1_156844363_ENST00000392302_length(amino acids)=649AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

--------------------------------------------------------------

>86213_86213_40_SQSTM1-NTRK1_SQSTM1_chr5_179252226_ENST00000510187_NTRK1_chr1_156844363_ENST00000524377_length(amino acids)=650AA_BP=249
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLDTNSTSGDPVEKKDETPFG
VSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKR
RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT
MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:179252226/chr1:156844363)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SQSTM1 Q13501	NTRK1 P04629
FUNCTION: Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215). {ECO:0000250\|UniProtKB:O08623, ECO:0000250\|UniProtKB:Q64337, ECO:0000269\|PubMed:10356400, ECO:0000269\|PubMed:10747026, ECO:0000269\|PubMed:11244088, ECO:0000269\|PubMed:12471037, ECO:0000269\|PubMed:15340068, ECO:0000269\|PubMed:15802564, ECO:0000269\|PubMed:15911346, ECO:0000269\|PubMed:15953362, ECO:0000269\|PubMed:16079148, ECO:0000269\|PubMed:16286508, ECO:0000269\|PubMed:19931284, ECO:0000269\|PubMed:20168092, ECO:0000269\|PubMed:20452972, ECO:0000269\|PubMed:22622177, ECO:0000269\|PubMed:24128730, ECO:0000269\|PubMed:27368102, ECO:0000269\|PubMed:28380357, ECO:0000269\|PubMed:28404643, ECO:0000269\|PubMed:29496741, ECO:0000269\|PubMed:33393215}.	FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250\|UniProtKB:P35739, ECO:0000250\|UniProtKB:Q3UFB7, ECO:0000269\|PubMed:11244088, ECO:0000269\|PubMed:1281417, ECO:0000269\|PubMed:15488758, ECO:0000269\|PubMed:17196528, ECO:0000269\|PubMed:1849459, ECO:0000269\|PubMed:1850821, ECO:0000269\|PubMed:22649032, ECO:0000269\|PubMed:27445338, ECO:0000269\|PubMed:27676246, ECO:0000269\|PubMed:8155326, ECO:0000269\|PubMed:8325889}.; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. {ECO:0000269\|PubMed:15488758}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000360718

3_102

167.33333333333334

357.0

Domain

PB1

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000376929

3_102

167.33333333333334

357.0

Domain

PB1

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000389805

3_102

251.33333333333334

441.0

Domain

PB1

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000402874

3_102

167.33333333333334

357.0

Domain

PB1

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000360718

3_102

167.33333333333334

357.0

Domain

PB1

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000376929

3_102

167.33333333333334

357.0

Domain

PB1

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000389805

3_102

251.33333333333334

441.0

Domain

PB1

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000402874

3_102

167.33333333333334

357.0

Domain

PB1

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000389805

228_233

251.33333333333334

441.0

Motif

Note=TRAF6-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000389805

228_233

251.33333333333334

441.0

Motif

Note=TRAF6-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000389805

170_220

251.33333333333334

441.0

Region

Note=LIM protein-binding (LB)

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000389805

170_220

251.33333333333334

441.0

Region

Note=LIM protein-binding (LB)

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000360718

122_167

167.33333333333334

357.0

Zinc finger

ZZ-type

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000376929

122_167

167.33333333333334

357.0

Zinc finger

ZZ-type

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000389805

122_167

251.33333333333334

441.0

Zinc finger

ZZ-type

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000402874

122_167

167.33333333333334

357.0

Zinc finger

ZZ-type

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000360718

122_167

167.33333333333334

357.0

Zinc finger

ZZ-type

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000376929

122_167

167.33333333333334

357.0

Zinc finger

ZZ-type

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000389805

122_167

251.33333333333334

441.0

Zinc finger

ZZ-type

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000402874

122_167

167.33333333333334

357.0

Zinc finger

ZZ-type

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

510_781

392.3333333333333

791.0

Domain

Protein kinase

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

510_781

362.3333333333333

761.0

Domain

Protein kinase

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

510_781

398.3333333333333

797.0

Domain

Protein kinase

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

510_781

392.3333333333333

791.0

Domain

Protein kinase

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

510_781

362.3333333333333

761.0

Domain

Protein kinase

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

510_781

398.3333333333333

797.0

Domain

Protein kinase

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

537_541

392.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

607_611

392.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

537_541

362.3333333333333

761.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

607_611

362.3333333333333

761.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

537_541

398.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

607_611

398.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

537_541

392.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

607_611

392.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

537_541

362.3333333333333

761.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

607_611

362.3333333333333

761.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

537_541

398.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

607_611

398.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

516_524

392.3333333333333

791.0

Nucleotide binding

ATP

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

516_524

362.3333333333333

761.0

Nucleotide binding

ATP

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

516_524

398.3333333333333

797.0

Nucleotide binding

ATP

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

516_524

392.3333333333333

791.0

Nucleotide binding

ATP

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

516_524

362.3333333333333

761.0

Nucleotide binding

ATP

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

516_524

398.3333333333333

797.0

Nucleotide binding

ATP

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

440_796

392.3333333333333

791.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

440_796

362.3333333333333

761.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

440_796

398.3333333333333

797.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

440_796

392.3333333333333

791.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

440_796

362.3333333333333

761.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

440_796

398.3333333333333

797.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

424_439

392.3333333333333

791.0

Transmembrane

Helical

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

424_439

362.3333333333333

761.0

Transmembrane

Helical

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

424_439

398.3333333333333

797.0

Transmembrane

Helical

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

424_439

392.3333333333333

791.0

Transmembrane

Helical

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

424_439

362.3333333333333

761.0

Transmembrane

Helical

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

424_439

398.3333333333333

797.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000360718

272_294

167.33333333333334

357.0

Compositional bias

Note=Ser-rich

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000376929

272_294

167.33333333333334

357.0

Compositional bias

Note=Ser-rich

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000389805

272_294

251.33333333333334

441.0

Compositional bias

Note=Ser-rich

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000402874

272_294

167.33333333333334

357.0

Compositional bias

Note=Ser-rich

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000360718

272_294

167.33333333333334

357.0

Compositional bias

Note=Ser-rich

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000376929

272_294

167.33333333333334

357.0

Compositional bias

Note=Ser-rich

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000389805

272_294

251.33333333333334

441.0

Compositional bias

Note=Ser-rich

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000402874

272_294

167.33333333333334

357.0

Compositional bias

Note=Ser-rich

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000360718

389_434

167.33333333333334

357.0

Domain

UBA

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000376929

389_434

167.33333333333334

357.0

Domain

UBA

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000389805

389_434

251.33333333333334

441.0

Domain

UBA

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000402874

389_434

167.33333333333334

357.0

Domain

UBA

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000360718

389_434

167.33333333333334

357.0

Domain

UBA

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000376929

389_434

167.33333333333334

357.0

Domain

UBA

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000389805

389_434

251.33333333333334

441.0

Domain

UBA

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000402874

389_434

167.33333333333334

357.0

Domain

UBA

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000360718

228_233

167.33333333333334

357.0

Motif

Note=TRAF6-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000360718

336_341

167.33333333333334

357.0

Motif

Note=LIR

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000376929

228_233

167.33333333333334

357.0

Motif

Note=TRAF6-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000376929

336_341

167.33333333333334

357.0

Motif

Note=LIR

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000389805

336_341

251.33333333333334

441.0

Motif

Note=LIR

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000402874

228_233

167.33333333333334

357.0

Motif

Note=TRAF6-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000402874

336_341

167.33333333333334

357.0

Motif

Note=LIR

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000360718

228_233

167.33333333333334

357.0

Motif

Note=TRAF6-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000360718

336_341

167.33333333333334

357.0

Motif

Note=LIR

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000376929

228_233

167.33333333333334

357.0

Motif

Note=TRAF6-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000376929

336_341

167.33333333333334

357.0

Motif

Note=LIR

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000389805

336_341

251.33333333333334

441.0

Motif

Note=LIR

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000402874

228_233

167.33333333333334

357.0

Motif

Note=TRAF6-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000402874

336_341

167.33333333333334

357.0

Motif

Note=LIR

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000360718

170_220

167.33333333333334

357.0

Region

Note=LIM protein-binding (LB)

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000360718

321_342

167.33333333333334

357.0

Region

MAP1LC3B-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000376929

170_220

167.33333333333334

357.0

Region

Note=LIM protein-binding (LB)

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000376929

321_342

167.33333333333334

357.0

Region

MAP1LC3B-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000389805

321_342

251.33333333333334

441.0

Region

MAP1LC3B-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000402874

170_220

167.33333333333334

357.0

Region

Note=LIM protein-binding (LB)

Hgene

SQSTM1

chr5:179252226

chr1:156844362

ENST00000402874

321_342

167.33333333333334

357.0

Region

MAP1LC3B-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000360718

170_220

167.33333333333334

357.0

Region

Note=LIM protein-binding (LB)

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000360718

321_342

167.33333333333334

357.0

Region

MAP1LC3B-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000376929

170_220

167.33333333333334

357.0

Region

Note=LIM protein-binding (LB)

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000376929

321_342

167.33333333333334

357.0

Region

MAP1LC3B-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000389805

321_342

251.33333333333334

441.0

Region

MAP1LC3B-binding

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000402874

170_220

167.33333333333334

357.0

Region

Note=LIM protein-binding (LB)

Hgene

SQSTM1

chr5:179252226

chr1:156844363

ENST00000402874

321_342

167.33333333333334

357.0

Region

MAP1LC3B-binding

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

148_193

392.3333333333333

791.0

Domain

Note=LRRCT

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

194_283

392.3333333333333

791.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

299_365

392.3333333333333

791.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

148_193

362.3333333333333

761.0

Domain

Note=LRRCT

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

194_283

362.3333333333333

761.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

299_365

362.3333333333333

761.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

148_193

398.3333333333333

797.0

Domain

Note=LRRCT

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

194_283

398.3333333333333

797.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

299_365

398.3333333333333

797.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

148_193

392.3333333333333

791.0

Domain

Note=LRRCT

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

194_283

392.3333333333333

791.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

299_365

392.3333333333333

791.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

148_193

362.3333333333333

761.0

Domain

Note=LRRCT

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

194_283

362.3333333333333

761.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

299_365

362.3333333333333

761.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

148_193

398.3333333333333

797.0

Domain

Note=LRRCT

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

194_283

398.3333333333333

797.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

299_365

398.3333333333333

797.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

116_137

392.3333333333333

791.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

90_113

392.3333333333333

791.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

116_137

362.3333333333333

761.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

90_113

362.3333333333333

761.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

116_137

398.3333333333333

797.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

90_113

398.3333333333333

797.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

116_137

392.3333333333333

791.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

90_113

392.3333333333333

791.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

116_137

362.3333333333333

761.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

90_113

362.3333333333333

761.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

116_137

398.3333333333333

797.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

90_113

398.3333333333333

797.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000368196

33_423

392.3333333333333

791.0

Topological domain

Extracellular

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000392302

33_423

362.3333333333333

761.0

Topological domain

Extracellular

Tgene

NTRK1

chr5:179252226

chr1:156844362

ENST00000524377

33_423

398.3333333333333

797.0

Topological domain

Extracellular

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000368196

33_423

392.3333333333333

791.0

Topological domain

Extracellular

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000392302

33_423

362.3333333333333

761.0

Topological domain

Extracellular

Tgene

NTRK1

chr5:179252226

chr1:156844363

ENST00000524377

33_423

398.3333333333333

797.0

Topological domain

Extracellular

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
NTRK1	ABL1, NGF, MATK, PLCG1, GRB2, CAV1, NTF3, SQSTM1, SH2B1, SHC1, SH2B2, ARHGAP32, FRS2, NTRK1, RAP1A, SHC3, GIPC1, RGS19, PTPN1, TRAF6, NEDD4, CBL, HSP90AA1, HSPA4, CDC37, NEDD4L, MYC, SGSM3, SORBS1, TNK2, SNX17, SNX27, GAREML, SOS2, PIK3CA, GAREM, PIK3C2B, ARHGEF40, PIK3R1, PIK3R2, SOS1, PIK3CB, PML, UBC, AMFR, CBLB, GAB1, EPN1, PIK3C2A, ANKRD13A, DOCK4, TRIO, LGR5, WRNIP1, RABEP1, PDGFRA, KANK2, RABGEF1, VAV2, TBC1D15, PTPN11, GAK, IRS2, PCDHGC3, EPS15, LRRN3, HUWE1, ACVR1B, MIB1, OFD1, PIBF1, ZNF497, TXN, CAT, FABP3, JUP, DSG1, TGM1, CFL1, LCN1, HIST2H4A, DSP, PFN1, LGALS3BP, HIST1H2BL, LTF, S100A9, IGLL5, TGM3, DSC1, LYZ, DCD, LEKR1, ENO2, PPIA, BTN1A1, XRCC5, XRCC6, HLA-A, GSTP1, ABCB7, PA2G4, PRDX1, HDGF, HSPA4L, TBC1D10B, HP1BP3, KIF26B, SYT4, RHOBTB3, NOTCH3, GAB2, ATAD3A, RBM15B, KCNH2, USP15, PDCD11, RBFOX2, RBM14, RNF31, ADNP, ZC3HAV1, MAP7D1, USP4, JAK1, PTPRS, PDGFRB, HIST1H1C, USP11, PPFIBP1, INTS6, VGF, ARHGEF11, SMPD4, SYNPO2, HNRNPM, SLC27A4, DDX41, EGFR, H1FX, ASAP1, HIST1H1B, RRBP1, EPHA2, KIDINS220, CPT1A, UNC5B, IGF1R, DDR2, AUP1, XPR1, RP9, MARK2, REPS1, EMD, SMARCA4, DDX21, DAB2IP, C7, MSTO1, CDC27, ZNF629, ASAP2, NCAPH2, SRBD1, ATAD3B, TCF12, PLEKHA6, INPPL1, PRPF4B, DPM1, SMARCA1, FIP1L1, DLGAP5, PLEKHH3, TRA2A, ACIN1, DDX10, TAX1BP1, SMARCA5, RABEP2, DDX5, MYO1C, SRSF10, DNAJA2, RET, TRA2B, MYEF2, PNPLA6, SLC12A2, TAF6L, RSL1D1, ARAP3, DDX18, ABL2, KHDRBS1, CERK, SRSF7, SPTLC2, PBXIP1, DNAJA1, IQGAP3, DDX31, ZC3H11A, PLRG1, CNP, FMR1, HIP1R, KIAA1429, CDC5L, ARAP1, ZNF316, SMARCC2, EML5, VANGL2, SLC25A1, UNC5C, SLC16A1, RFC1, ZKSCAN1, CHD1, PTK7, SMARCD2, AP3B1, YTHDC2, AKAP8L, RPL15, CTNND1, PHLDB1, ZNF574, DDX27, TOM1, RASA1, MORC2, MTCH2, IMMT, SMARCC1, ROR2, CAPN2, DNAJC11, SYT11, AP2A1, LBR, MEPCE, NCAPD3, CEP97, QKI, LRRC41, LPCAT2, EPS15L1, LAS1L, TMEM131, CWF19L2, NCAPG2, MAP4K5, CCP110, ARHGEF2, ITGAV, ZC3H18, CWC22, VIM, FAM171A1, TMEM132A, SRSF9, SOGA1, NKRF, RBL1, FMNL3, TOP1, PIGT, RBM15, GBAS, EDC3, WDR5, NOP2, GNL2, SLC25A11, RRP1B, FAM115A, INTS5, SLC25A5, AAK1, HERC5, CCNT1, FERMT2, CDC42BPA, MRPL28, UBAP2, WWP2, SEC24B, HNRNPU, GPD2, FXR2, DHX15, SLC25A22, SSR1, PLXNB2, PROX1, TEX10, USP19, FTSJ3, TMEM59, GTF3C2, PGAM5, CPSF1, KLHL22, TMX3, SIN3A, NOP58, PTCD3, RPRD2, DHX9, PICALM, FARP1, SLC25A6, ERLIN2, SMARCD1, RHOT1, ALDH1B1, SGPL1, USP9X, HNRNPF, KIAA1211, MAPK7, DDX17, GSE1, DVL3, MRPL44, DNAJB6, GTPBP4, HNRNPA0, PLXNA4, SFXN3, NAT10, DDX28, SNW1, MYO6, MRPL24, PRRT4, FAM98A, PURA, DHX29, C1QBP, TRIP4, TBK1, RBM28, ZNF609, POLRMT, PCDHB3, XRN1, HSD17B11, DKC1, DHX30, CDK13, SENP3, LPHN2, GPATCH4, NDUFA9, RASA4, MCCC1, DDX24, RPL14, RPS8, ATG2B, MYO1B, PTPN12, CEBPZ, ILVBL, RALY, KIF14, ZC3H7A, MOV10, MAP4K4, DHX57, RBMX, FXR1, MRPS35, SART1, MARK3, DECR1, CCDC88A, ANKLE2, PRPF31, LARP7, RPL10, PACS1, RPL13, FAM120A, SLC25A13, ADAR, CDK1, HNRNPR, CSNK1E, DLG1, LEMD3, NOL9, IFT122, NCLN, STK11IP, GATAD2B, CHERP, LARP4, MAP3K1, HNRNPUL2, PPIL2, ESYT2, MYH10, RPL8, UQCRC2, NDUFA10, HAX1, HELLS, MED14, RBM42, CHCHD3, RPL7, ABCD3, TUBGCP6, MRPS9, SNRNP200, IGF2BP3, LRCH3, MRPL3, RSBN1L, SAFB, TUBG1, ALDH16A1, ARHGEF12, EPB41L5, AP2A2, SRSF6, HLTF, PTPLAD1, TMPO, AGO2, POP1, RPS9, HDAC6, ILF3, VWA8, ABCB1, SCRIB, GTF3C5, YBX1, RBM4, PTPN9, PRPF8, BRD3, TRIM24, CLASP2, MADD, TCF4, MAP4K3, TSC2, DDX23, RPL7A, RRP12, PRKD2, TRMT1L, EDC4, CSTF3, RPS2, NDUFS2, RPL13A, PTPRR, ATP7A, EXD2, IK, HIP1, MATR3, IGSF3, PTPRF, SPATA5L1, EFTUD2, RPS3A, TUBGCP5, TTN, GIT1, PATL1, NUP160, PDE4B, SUN2, PTPN23, RPS6, DCP1A, CDC73, MEX3A, EIF2AK2, RPL3, PPP1R10, SRP72, ELAVL3, NOM1, RPL18, CEP170, THRAP3, MED17, MRPS7, DDX20, PDPR, SH3PXD2A, DBN1, DAP3, OAS3, STT3B, COPE, MED12, AP3D1, CAPRIN1, PHB2, U2SURP, BSG, TECR, FARSA, HSD17B12, RPL4, HNRNPUL1, PPFIA1, MRPS22, TBL3, GNL3, MTA2, CPSF2, ATP2B1, AP3B2, PPIP5K2, DDX56, ASCC3, FMNL2, SMCHD1, MYBBP1A, SRPK2, RHOT2, SRP68, PUM1, SLC25A3, SRPK1, RPL19, BEND3, SEC61A1, LSG1, NOC3L, TNKS1BP1, GTF3C3, TUBGCP3, PRPF40A, TRMT10C, URGCP, XRN2, MSH3, XRCC1, GEMIN4, DIS3L2, BCLAF1, SBF2, DHTKD1, ATXN2, ARID4B, TOR1AIP1, RPL29, NAA16, PRPF6, KIFAP3, TMEM33, WASF2, NACAD, LIG3, POLE, CKAP4, TCEB3, MTA1, GNA13, DHX38, PHF6, ELAVL4, DDX3X, CTR9, PRPF19, CAMSAP2, PRMT3, SH3PXD2B, SCAF8, MAGED1, ILF2, TONSL, PPP1R12A, SRSF5, KIAA0020, PTBP1, CAD, ACSL3, CHD1L, STAU1, MRPL38, DVL2, GNAI3, RPL10A, RPL6, MRPS5, CDK11B, MRPS34, PES1, ATP5C1, STXBP3, HNRNPLL, CHTF18, VPS39, SART3, COPA, PRPF3, UBE2O, ABCF2, HNRNPH3, EARS2, DHX40, ARHGEF7, EMC1, CASK, PTK2, SORT1, OGT, ATP12A, LMNB1, SLC4A7, PFKP, VDAC2, RBM25, ATL3, DHX36, TFIP11, EXOSC10, GTF3C1, SRSF1, PPP6C, TRAPPC9, RAD21, DNAJC13, ACOT1, ZC3H4, SRRM1, NDUFS3, DYRK1A, INTS1, SF3B2, EHHADH, MYO9B, ASCC2, WDR11, RPN1, EHD4, WDR91, SMARCAL1, NBAS, PI4KA, PAF1, EIF2B4, NUP107, EMC2, SYNE1, KLHL13, TBL1XR1, DNAJC10, SEC16A, METTL13, C7orf50, CDC42BPB, CLCN5, PGM3, DOCK7, ALYREF, POLR3A, TOP3A, WDR48, WDR81, DOCK1, CSNK2A2, CYC1, TLE3, THOC2, EIF2S3, MYO5A, SNX9, TARDBP, NAP1L4, CRKL, YTHDF2, PYGB, PABPC1, LTV1, PSMD4, KTN1, UBTF, WDR6, FUBP3, UBXN7, PHB, PDXP, CNOT3, TBL2, LLGL1, PLOD1, AHSA1, AAAS, ERGIC1, LARP4B, CYFIP1, DNM1, TARS2, ACSL1, ATXN1L, WDR59, SUCLA2, MLH1, CSNK2B, SYNCRIP, WDR36, FAM91A1, MTDH, UBE3C, CAPN1, BRIX1, DNAJB11, EDEM3, PLOD3, CLASP1, DPYSL3, MED16, NONO, EPM2AIP1, NT5DC2, ADRBK2, RPTOR, TELO2, MRPL37, PRKACB, ELMO1, TRAPPC8, ANAPC1, NIPSNAP1, EWSR1, PIK3R4, POLD1, IQGAP1, PRRC2A, COG1, ANKRD44, TFRC, DIEXF, FHOD1, SERPINH1, SPATA5, MED1, ABCF3, ZSWIM8, LMNA, HAT1, PABPC4, SMC4, HADH, RNGTT, TUBGCP2, ZNF598, SKIV2L2, GNB2L1, LARP1, DIP2B, BCR, IDH3B, LSM14A, FBL, NDUFS1, APPL2, USP39, SMC2, HCFC1, LANCL1, POLR2B, UPF2, CCBL2, MRPL15, MAGED2, AGK, GNPAT, AIMP1, GTF3C4, KDM1A, SCAMP3, RDH11, SRGAP2, CRNKL1, RFC5, PFKL, SPTBN1, PHOX2A, VDAC3, HNRNPA1, WDR26, DNM2, HAUS5, LCMT2, MCM7, CLINT1, UGDH, ACO1, TRIM46, PHKB, USP10, PCF11, YTHDF3, AARS2, FIGNL1, SFPQ, ATP5A1, NUP133, CPSF3, ANKRD28, PNN, C9orf64, ABCF1, ATL1, NAP1L1, HSPA9, MCCC2, FKBP5, CNOT1, TAF6, NEMF, UHRF1, SDHA, PELP1, HADHB, OAT, NEK9, AP3M1, PRKCA, LPCAT1, MRPL39, AFG3L2, WASF1, HNRNPL, RALGAPB, HK1, GBA, PLD3, CPSF7, HADHA, PDE12, DCX, LIMA1, HNRNPA2B1, POLR2A, MYH9, ZNF207, DDX55, ELP3, EIF2B5, MICAL1, TTI1, NES, HSDL1, GPSM1, PPM1F, C4orf27, SRRM2, OSBPL9, STAT3, IRF2BPL, KLC2, P3H1, STAT5B, UQCRC1, PCK2, CCAR2, TBC1D5, SACM1L, QARS, XPO4, CHD4, KIF2A, TACC3, NCL, BTAF1, RARS2, NCKAP1, EIF3D, RPS3, YME1L1, EIF4A3, HAUS6, HNRNPDL, MON2, G3BP2, WDHD1, CSNK1A1, SDAD1, RPS25, LSM14B, AP1M1, CCDC47, HNRNPK, DNMT1, NUP85, CUL5, TANC1, STAT1, COG5, STOML2, CDC45, OSBPL11, CIC, ABCD2, ARFGEF1, TROVE2, GBF1, SRPRB, UBE3A, GTPBP1, SCCPDH, RPS4X, PRPF4, ACTL6A, CCAR1, KIAA1033, TRAPPC12, HNRNPA3, FASTKD5, LYN, VPS18, PGRMC2, NUP214, AIFM1, TSG101, PPP6R3, OCRL, GANAB, IARS, SARS2, ATP2A2, EXOC1, NCAPH, TTC27, GNE, SRC, MIOS, ZCCHC8, GOLGA2, CARM1, ABCC1, PRMT5, LEO1, LMNB2, USP8, DARS, GYS1, APEH, ZYG11B, AKAP1, ELAVL1, MCM5, LRWD1, PSMC1, MOGS, TRIM28, EXOC6, LUC7L3, ANKFY1, NSUN2, HDAC2, G3BP1, QRICH1, INTS3, UBR1, XAB2, DYNC1LI1, TUFM, GAA, EXOC8, DHX8, LIMCH1, CLTC, SRPR, RNH1, ABI2, AQR, PREP, PPM1E, COG2, SEPT9, IDH2, MFN2, EXOC4, VPS33B, INTS4, GNB1, MSH6, HNRNPC, ERLIN1, EPRS, LRRC49, RPAP1, MCM3, PSMC4, PSMD3, GNL1, TRIP13, CUX1, PFAS, MAP1S, LRCH1, MRPL19, ABCD1, EIF3F, PDS5B, SMC3, KIF4A, FANCD2, IRF2BP1, SMC1A, RNF20, CLPX, NOC2L, DLAT, CTBP1, APPL1, NAA35, VPS45, PUM2, RELA, NUP210, RANBP9, DNAJC9, WRN, PRKAA1, AIMP2, VPS8, MAD1L1, MRE11A, ATP13A1, ATG7, CEP131, TRIM33, SLC25A10, HERC4, LRRFIP1, POLR1C, IPO9, GEMIN5, METAP2, SMG8, WASL, PPP1CB, SCFD1, RANBP3, RB1, CLTA, RNF40, SNRNP70, NCSTN, MGEA5, NARS, EIF4E, INPP4A, TFB2M, SEL1L, ARGLU1, PPP4R1, ANKRD17, TTK, RAD50, KIF2C, GOLGA3, TRAPPC11, GIGYF2, MSI2, CYFIP2, CDK5, HBS1L, IFT81, UFL1, PFKM, SMARCAD1, WDR35, PRIM2, NAMPT, PSMD2, MSH2, SOGA3, HEATR6, SFXN1, ARCN1, OGDH, FDPS, PSMC5, INSR, IRF2BP2, DDOST, ATXN2L, CSNK2A1, EIF2S2, MAP4, LTN1, COPB1, BRAT1, SMC6, SNRPN, RIC8A, SKIV2L, EIF4A1, KIF15, CLPTM1L, KPNA1, VPS16, VPS26B, RNPEP, RBM39, PMS1, FAM129B, RFC3, NUP155, RBM26, KIF21A, GAPVD1, C2CD5, WAPAL, RPS13, ARHGEF1, ACTR1A, KLC4, ISLR2, DCK, LRRC8A, STT3A, BOP1, RPN2, AFTPH, ORC3, FOXK1, CD2BP2, PDHA1, PPP6R1, PANK4, KIAA0196, WDR77, CHUK, DDX1, COLGALT1, VAPA, PPME1, CAMSAP1, RABL6, RTCB, SRRT, PIK3C3, NUMA1, STXBP1, OTUB1, UBAP2L, EXOC5, LRRC59, EXOC3, RQCD1, FLII, COPG2, USP5, XPOT, TIMM44, ATP1A1, SBF1, ARPC1B, PLK1, OSBPL8, BAG6, PPP6R2, FAM98B, VPS52, FADS2, EIF4G2, EIF4G3, HSPA8, POLR1B, PSMC6, SFSWAP, VPS33A, MCM10, AVL9, RINT1, PPIB, FBXL18, MFAP1, KIF13B, ATP2C1, ERCC2, CTTNBP2NL, WDR82, VARS, KPNA6, MIA3, HEATR1, SEC23B, AASDHPPT, POLR3B, ALDH18A1, PIKFYVE, MPP6, MRI1, CAPN7, RAB3GAP2, NCAPD2, UGGT1, IKBKAP, KDM3B, CLNS1A, FEN1, ECH1, AP2B1, HNRNPH1, RARS, AGPS, FANCI, PYCR2, EHD1, BUB3, KIF5B, SYMPK, PC, ACAA2, NDC80, PRRC2C, MTHFD1L, FASN, RANBP6, VPS11, NUP93, STRN, SCYL1, DDX19A, GTF2I, SEC23A, CTNNB1, STAM, VPRBP, VCL, PDHB, SEC24D, ERCC4, GRN, ACADM, HSPA6, ERCC6L, RPL5, ARHGAP17, DDX6, MAPK8IP3, TJP1, RIOK1, ERP29, PARG, NUP205, PALLD, COG4, TPP2, EPB41, VAC14, FUS, ZW10, KIF11, GET4, MCM6, EIF2S1, CSDE1, DHX16, GFM1, RABGAP1, TTC28, XPO1, EXOC2, DCTN1, ACBD3, RFC4, PARP1, COPG1, GPRIN1, EIF3C, CUL1, C14orf166, RTL1, STRIP1, MRPS2, PPP2R5D, EIF4G1, EXOSC4, MCM4, SEC63, WDR1, CUL4B, CRMP1, NSF, RNMT, BLVRA, UBE4A, PCBP1, MLLT4, RNF214, ARVCF, CKAP5, NUP188, SMCR8, CTNNA1, SYT1, PCM1, KNTC1, GFPT1, THYN1, SARM1, LPIN1, TIA1, NUP54, PKN1, SUMO4, DICER1, KIF3A, IPO8, CLIC4, PSMD14, GLG1, ABCE1, SMEK1, NCAPG, PPP5C, RTF1, IARS2, PDS5A, PHGDH, RPS6KA3, LONP1, ROCK1, CDK6, LARS, KPNA3, HNRNPAB, MCM2, PPP2R2A, HSP90AB2P, VCPIP1, PCBP2, RPA1, SEC24A, HECTD3, RCC2, DIS3, SMS, KHSRP, CLGN, GNAS, FOCAD, SEC23IP, ACOT7, HK2, CCDC6, MFN1, WDR7, CNN3, KIAA1524, RAB3GAP1, OXCT1, SBNO1, PRPSAP2, ACTR3, CTPS2, TMEM43, FAM21A, LRRC47, VAPB, SCYL2, STRN4, NAE1, SREK1, TFG, SF3A1, CDK2, GPKOW, GPHN, PDCD4, U2AF2, UNC45A, VPS35, NAA15, ASNS, TOP2B, ACO2, AGAP3, ROCK2, NUDT21, NPEPPS, ADD1, AP1G1, CPSF6, DNAJC2, RPS5, CTPS1, IDH1, SEC24C, KIF3B, ACTR2, CPD, EEF1D, SAMHD1, ETFB, DNM1L, LRPPRC, MCMBP, RBM12, OPA1, FARSB, UPF1, PCMT1, USO1, COG3, CLPTM1, TLK2, PRUNE, ASPSCR1, MARS, PYCR1, TCERG1, MED23, PITPNB, ARPC2, UBE4B, DBR1, ETFA, BICD1, KLC1, WDR70, PXDN, DPYSL4, USP7, CLUH, TBRG4, OGFR, SV2A, PDCD6IP, PDLIM5, PSMC2, TRAP1, DRG1, SMEK2, TCP1, TNPO2, CALD1, ARIH2, POR, FKBP3, DCTN2, NPM1, USP48, IPO13, NUP88, NNT, TAOK1, PPWD1, PSPC1, PABPN1, POLA1, MTR, BCCIP, RUVBL2, C16orf62, SORD, PPP2CA, STRN3, RUVBL1, PPP1CA, CACTIN, RPAP3, VPS51, TUBB3, PRKDC, HSPA5, CCDC132, MRPS27, RBBP4, CAPZA1, SLC4A1AP, THUMPD3, FAF1, CDK4, GSTO1, NCBP1, CAPZB, SNRPA, TXLNG, NELFE, MUT, DYNC1LI2, CTTN, DYNC1I2, TIMELESS, CBS, TTLL12, ESYT1, LAMB1, KARS, PPIL4, LRRC40, TXLNA, RAD23B, TBCE, ACAD9, THADA, GCN1L1, SLK, PNKP, ACLY, ATP6V0A1, VTA1, TXNDC5, OXSR1, ACACA, TNPO3, CCDC93, TIPRL, RAN, HOOK3, PSME4, YWHAQ, PPM1G, PSMC3, SCARB2, EXOC7, DFNA5, TRMT6, CPNE3, SLC3A2, G6PD, EIF2B1, SF3B1, EXOC6B, HGS, DYNC1H1, DNAJC7, CANX, TSR1, TTC37, DARS2, ZPR1, SERBP1, HSP90AB1, TBCB, UCHL5, IMPDH2, PUF60, RANGAP1, PDXDC1, YWHAH, LARS2, ZC3H15, GMPS, YWHAG, SUPV3L1, SPAG9, IMPDH1, HSD17B10, GTF2F1, EXOSC9, CUL3, ARHGAP35, TUBB4B, EIF5B, KIF5C, PDIA6, LDHA, ATL2, SNX1, SF3B3, SRM, MAP2, DIAPH1, DBH, NHLRC2, ELP2, GRPEL1, TWF1, WBP11, ERP44, SERPINB6, VCP, HSPH1, CMTR1, KIF1A, USP47, EML4, PRMT1, ATP6V1B2, GPS1, CAND1, CLPB, PCNA, RPLP0, CORO7, TUBB, ANXA2, API5, SUPT16H, RUFY1, KIAA1279, PDIA3, ACTA1, SF3A3, DCTN4, CUL2, WARS, PGM2, NELFB, XPO5, UGP2, HSP90B1, GSR, SHMT2, IPO11, EIF3E, RDX, DNAJB1, KIAA1598, AARS, EFTUD1, HEATR5B, ENAH, TNPO1, LIG1, NRD1, DLD, STRA6, PAFAH1B1, NT5C2, SSRP1, NTRK3, HDGFRP2, EIF3G, CSE1L, ACAT1, TBCD, NAA10, MTHFD1, RALA, EIF3A, PRPS1, ISOC1, IPO7, HNRNPD, GAPDH, U2AF1, SUPT5H, PSMD8, RPS6KA1, NUF2, GDAP1, VPS26A, TUBB2B, CDH2, TMOD1, CBR1, HDLBP, CS, HSPD1, LMAN1, EIF3B, DDB1, PSMD1, DPYSL2, STRAP, RTN4, FLNA, AHCY, HSD17B4, GOLIM4, SPTAN1, IPO4, PKM, EIF3I, SF1, BZW2, XPO7, ACADVL, STAG2, DPP9, RECQL, GDI1, GARS, MMS19, EIF2A, IPO5, TCOF1, RAB5C, SAP30BP, VDAC1, TUBA1A, SEPT2, DBNL, PLAA, TOMM70A, NOMO1, ISYNA1, CTNNA2, EEF1B2, PAK4, NELFCD, GSPT1, KPNB1, MAP1A, COPS4, YWHAZ, KPNA2, EIF4B, PLS3, COPS3, HSPBP1, AP1B1, NASP, DDX39A, LUC7L2, APMAP, SEC31A, SRSF2, TXNRD1, ATP1A3, RRM2, COG7, FSD1, PRDX4, DCPS, NCAM1, NUDCD1, NAA25, RPL9, NPLOC4, YWHAB, ATP1B1, LSS, DNAAF5, METTL16, COPS6, XPNPEP1, ELAC2, PUS7, CCT3, SFN, AGL, PAPOLA, SRSF11, ALDH2, PSME2, CKMT1B, LDHB, PSMA7, RAB11A, PPP2R1A, GNAO1, LUC7L, COPS5, IMPA1, RRM1, PPID, DPP3, KIAA0368, SLC1A5, YARS, NUP50, TPM4, ITGB1, SARS, SEZ6L2, GTF2F2, GART, ALDOC, PSMD11, EIF6, DFFA, RAP1GDS1, NELFA, CARS, CCT4, P4HB, FSCN1, PSMD13, PSMA5, CCT5, PAPSS1, OSBP, SAE1, ATP6V1A, LMAN2, YWHAE, SRP54, IDE, SNX2, RPSA, BZW1, SND1, UBQLN1, MAPK1, CALR, MARCKSL1, SUGT1, TBC1D4, GLRX3, LETM1, HMGB1, EIF3H, SLC9A3R1, DDX42, LAP3, PRKCSH, EEF2, PSMD6, BCAP31, ANXA11, ACTN1, CCT6A, PSMA4, ANXA5, CCT7, EIF3L, FUBP1, SSB, PGM1, MAPRE1, UBA2, AMPD2, PPAT, CLIC1, CCT2, ECHS1, LTA4H, USP14, CCT8, ANK2, PDIA4, TPR, NRCAM, MAT2A, HTATSF1, THOP1, RANBP1, RSRC2, NMT1, AK2, EEF1G, TPM3, PSMA3, EIF4H, GLUD1, CAP1, TKT, ATP5B, TXNL1, STIP1, HMGB2, GGH, HSPB1, CALU, RPL17, PSMA1, RSRC1, ST13, PRDX6, EIF3J, PNPT1, APEX1, TARS, MARCKS, PSMA6, EEF1A1, COPB2, NUDT5, HSPA1A, ERO1L, ME2, RPH3A, ESD, EIF5, ADSL, RUFY3, DPYSL5, ANXA6, NUDC, NANS, GOT2, GLDC, PSAT1, SET, PAK2, UBA6, UCHL1, L1CAM, PGLS, MAP1B, CCDC124, EIF3M, VAT1, PAFAH1B3, ALDOA, IRGQ, UBQLN2, NACA, OLA1, ACTN4, ARHGDIA, PSMD7, CACYBP, PSMA2, CPNE1, MDH2, PGAM1, DDX46, ACAT2, ALCAM, HARS, CKB, FKBP4, ASNA1, GPI, INA, HYOU1, CHGA, MDH1, EZR, ANP32A, UBA1, ARG1, ANP32B, PAICS, ATIC, TPI1, PPA1, TALDO1, PGK1, DDX39B, TLN1, AKR1B1, ENO1, NGFR, TPTE, GGA1, GGA2, GGA3, USP36, NDFIP1, SOCS2, CDK12, EPHB4, NDUFA4L2, AKT1, SLC5A5, DOT1L, AKT2, SHC4, TRAF4, PTPN6, ERBB2, EGR1, HIPK2, POU4F2,
SQSTM1	GABARAPL2, RAD23A, GABARAPL1, SQSTM1, LINC00341, MAP1LC3B, TRAF6, PRKCZ, IRAK1, PRKCI, NTRK1, RIPK1, NTRK2, NTRK3, LCK, MAP1LC3A, Shank1, Dlg4, Grin2a, Gria1, Chrna7, KEAP1, GABARAP, C10orf2, ABHD10, CEP78, DIP2B, BLOC1S5, EMILIN3, NSUN4, OSBPL8, INA, NIPSNAP1, GBAS, LLGL1, HADHA, GPC4, HADHB, CTNND1, ASPH, ENPP1, TRMT61B, GLG1, MRPL38, NEFM, GTF3C3, SRRM2, MYD88, MYC, MAP3K3, MAP2K5, IRF8, TRIM21, CYLD, Cep78, Poc1b, CALM1, BNIP1, NFE2L2, CUL3, PIK3CA, PPHLN1, BPTF, UBC, DAZAP2, CDC37, TRIM13, CASP8, PCK1, STAT5A, PDE4A, MAPT, ATG4B, CHMP2B, TARDBP, CUL1, CUL2, HDAC6, ATG7, FUS, CSNK2A1, ZFAND5, TUBA1A, WDFY3, ATG8, BAG3, NBR1, SNCA, TRIM63, TRIM55, TTN, RARA, PSMC2, PSMD4, MAP1LC3C, TRIM50, ARHGEF28, TGM2, PAWR, RPTOR, MTOR, AKT1S1, MLST8, RPS6KB1, RRAGC, RRAGB, CDK9, tat, SPRED2, TRIM5, AJUBA, LIMD1, MAPK14, PARP10, vif, nef, TNFRSF10A, HTT, HNRNPA2B1, SDHA, CAV1, BID, FAS, SESN2, SESN1, MALT1, IKBKG, FHOD3, NOD2, SYNPO2, PYCARD, MLH1, PARK2, BCL2, PAN2, NPM1, MBP, YWHAZ, STXBP1, FKBP4, MEIS2, TKT, HSPA4, RELN, CAMK2A, ULK2, NCOR1, NGFR, env, HIV2gp7, CALCOCO2, Prkci, CDK1, CCNB1, PRKCD, MAPK1, SMAD3, EEF1D, RPL37, GEMIN4, DVL2, CHAF1A, TP53, CASP9, HIF1A, PSMD12, PSMD3, FLNB, PSMD10, TXNL1, TNK2, LGALS3, EDEM1, CFTR, CSNK2A2, DCP2, EGLN3, EPAS1, ULK1, TOLLIP, OPTN, ATXN3, STUB1, ISG15, MOV10, NXF1, CUL7, PIK3R1, PIK3R2, AGAP1, INSR, Ubc, TBK1, CRHBP, SCCPDH, DNAI1, DNAI2, TP53INP1, LLGL2, HSPB1, Ripk3, Nr2f2, IFI16, KIAA0753, MED4, CEP135, CNTRL, SASS6, TMEM17, XPO1, CD44, KIF5B, PML, Mgp, Poc1a, Fgfr1op, ENC1, SKI, TRIB3, RBM45, MAPK13, CHDH, EPDR1, GAS6, NDUFS2, NDUFS3, GFM2, NDUFA5, CD48, LDHA, RCN2, TRAF1, GBP2, KLHL3, EPM2A, RAD54L2, HSPA5, GRIA1, UBXN1, PEX5, BCL10, ATG5, CSNK1A1, VANGL2, SERPINA1, RNF168, LRRK2, VHL, TCEB2, TCEB1, RNF166, NOTCH1, RETN, KERA, INSL5, TMX1, VWCE, CD96, HTR3A, RNF26, INO80B, DLST, TRIM25, PLIN1, TES, WDR81, PSMA6, TRIM23, PGI1, UBE2D2, UBE2D3, ID1, ID2, TAX1BP1, Map1lc3b, UBD, RMND5A, RIPK4, MAPK6, TMPO, AIM2, TRIM11, TNFAIP3, VDR, NEDD4, CNOT2, WDR77, KRAS, RXRA, TGFB1, TRIP4, C19orf80, CCNF, VIM, FLNA, RAD51, NR4A1, RAD18, REL, RELA, RNF4, RNF31, PARK7, MYO6, XIAP, DDX5, CCND1, BPLF1, ESR2, BBC3, CDC6, BRCA1, CRYAB, DNAJC10, PADI1, CALCR, USP14, DDX58, Gabarapl1, MB21D1, SMN1, CRBN, FBL, ELAVL1, KIAA1429, AMBRA1, VCP, LAMP2, ATG16L1, LRRK1, PHB, BECN1, SOX2, PARP1, USP10, MTDH, FUNDC1, GBF1, MECOM, DCAF15, asp, SHMT2, CCT7, SLIRP, SND1, FADD, BIRC2, DYRK1A, PINK1, RB1CC1, IFITM3, P2RY6, GCH1, NUB1, PPP1CA, Casp8, FBXW7, BIRC3, LMBR1L, IGF2BP1, SERPINE2, MYO5A, FN1, CTHRC1, CD59, ITIH5, TNC, SNTB1, ROBO1, TUBB2A, GDF15, CNP, RAI14, ACSL3, CEP170, TAOK2, CNST, SSR3, SLC25A11, SPATA20, FARP1, UTRN, DHX33, CHCHD3, HS2ST1, PTRH2, SOD3, BCKDK, CCDC77, IQGAP1, FKBP11, CEP350, SCO1, SNTB2, MTX2, MYO1B, PWP1, SRPR, ATAD3A, ACTR1A, SLC25A1, MOGS, GOLGA2, SMG8, DYNC1LI2, UQCRH, SRPK2, CAPZA2, POLRMT, SMARCD1, GNB1, HSD17B12, DYNC1LI1, AIFM1, DARS2, GNAI2, TUBA1C, TUBA1B, MRPS28, CEP131, WDR82, PAFAH1B1, TUBB, MRPS34, ATP5A1, NOL9, ZC3H4, ATP5B, MRPS26, MRPS18B, ERAL1, PNKP, MIB1, SRP14, SLC25A3, MRPS22, CEP250, CCDC61, CKAP4, RPS16, BICD1, RPS15, ATP5H, AP2B1, NFIX, CDK5RAP2, RRBP1, SLC25A4, RPS5, TPX2, AP2A2, IK, PPP2R1A, GOLGB1, MPRIP, AHNAK, PCNT, RPS24, CETN2, HNRNPUL1, PRRC2A, DAP3, PIBF1, TJP1, RFC4, NOL8, CEP290, MAGI1, ZNF384, IQSEC1, TAOK1, PGAM5, SMG1, GAPVD1, MRPS9, ATAD3B, CSTF3, FRYL, EPRS, ARHGEF18, SNAP23, PRPF38A, RBM12B, SLC25A10, UTP23, FGFR1OP, SMU1, RAPGEF2, OFD1, PARD3, S100A9, EIF4B, EIF5B, IGF2BP3, ATXN1, HCVgp1, IKBKB, SKP2, PHB2, PLN, MAVS, APAF1, ECSIT, G3BP1, G3BP2, BNIP3, BNIP3L, CALR, DAXX, LINC01554, HMOX1, KAT5, PDPK1, PXN, RAF1, SH3BGRL, ORF7a, E, nsp6, ORF6, ORF8, ESR1, TRIM32, RQCD1, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, PDCD4, BRD1, FIS1, MARCH5, MFN2, OCIAD1, ABL1, Rnf183, AGR2, HULC, NLRP3, NUPR1, USP8, GSK3B, UCHL5, FAM20C, GJA1, CCDC88C, PRDM9, PPIA, USP20, USP19, OTUD7B, JOSD1, IRF3, STK17A, OGT, BAG5, PSMB2, PSMD14, TRIM37, AR, MCL1, AMOT, B3GAT1, GJD3, GOLGA1, IMPDH2, KRT8, PXMP2, AMER1, ARHGAP32, BCR, C1orf198, CC2D1A, CCDC85C, CDC27, CENPB, CEP85, CNOT1, CNOT10, CSTF2T, DNAJA2, EDRF1, FAM193A, FARSA, FLJ44635, GGA3, HGS, HIST1H2BD, HIST1H3F, HSPA1B, IARS2, IFT172, IFT74, IQGAP2, JADE3, KIF7, KPNA3, LZTS2, MAGED1, NAE1, NAV1, NUDT19, OCRL, PAPD7, PDLIM7, PEBP1, PIK3C2B, PJA2, PPP1R13B, PPP2R3B, PPP2R5D, RC3H1, RIPK2, SCYL2, SEC16A, SIRT2, SMG7, SNRPE, SYNJ1, TNIP1, TNRC6A, TNRC6B, TP53BP2, TRIM26, TRIP6, TTK, UBB, VWA8, ZCCHC14, ZCCHC2, ZFP36L2, ABLIM1, KIAA1244, ASNS, CEP152, DIAPH3, DNAAF2, DRG1, DVL3, EXOC4, KIAA1671, LPP, NELFCD, NRBF2, PAK4, PDLIM3, PDLIM5, RPAP2, SDCCAG3, SIPA1L3, SLAIN2, SYNJ2, TAB2, TANC1, TTC28, TTF2, UCHL1, WRAP73, YEATS2, SYNE3, VASP, JUN, UBQLN2, CCDC50, IFIH1, VDAC1, MOAP1, CHRNB4, ZCCHC10, PRR27, IL7R, IL17F, BAGE2, HFE, CST8, POGLUT1, EDDM3B, LY6G5C, ST14, TNFSF18, GREM2, C1QTNF1, CST11, HLA-DPB1, FIBIN, ADAMTS12, GLIPR1L2, FAM46C, BTF3, ZRANB1, UXT, WBP4, IFITM1, KDR, NEDD8, KDM1A, AARS, ACLY, ACTB, ARF4, ATG9A, ATP2A2, BZW1, CACYBP, CAD, CALCOCO1, CCAR2, CCPG1, CCT2, CCT3, CCT4, CCT5, CCT6A, CEP112, CKB, CLTC, CTPS1, DDX3X, DNM1L, DYNC1H1, EEF2, EIF2S3, EIF3A, EIF4A1, ERLIN1, FASN, FASTKD2, FTL, GART, GPC1, HEXB, HIST1H2BN, HMGB1, HSP90AA1, HSP90AB1, HSPA8, HSPH1, IPO5, IPO7, KLHL8, KPNA2, KPNA4, KPNB1, LPL, LRRC59, MAT2A, MFF, MTHFD1, MTMR4, NCOA4, NPR3, NUP155, PABPC1, PAICS, PAIP1, PDCD6, PFKM, PFKP, PGD, PHGDH, PRKACA, PRKAR1A, PSMC1, PSMC3, PSMC4, PSMC5, PSMC6, PSMD2, RAB18, RAB1A, RAB21, RAB2A, RAB5C, RAB7A, RAB8A, RHEB, RPS17, RRM1, RTN4, S100A6, SAR1B, SDC2, SDC4, SDCBP, SEPT7, SMC4, SPG20, ST13P5, STIP1, SYNGR2, TAGLN2, TBC1D15, TCP1, TFRC, TM9SF2, TMEM59, TNPO1, TPP1, TRAF2, TRAF3, TRIP13, TUBB4B, VAPA, VAPB, YBX1, YWHAB, YWHAE, TRIO, HECTD1, WNK1, SPATA5L1, CTNNB1, LUZP1, MTCL1, STAM, TMEM160, POLR2B, TNKS1BP1, PPP6R3, KIF11, RTN3, ADAR, RACGAP1, BUB3, CORO1B, PABPC4, MAP7, DCXR, TSR1, DNMT1, ZC3HAV1, RPS27A, RAB6A, ADRM1, DHX9, UBA1, GSTP1, ACTG1, CISD2, DNAJA4, SETX, KIAA0101, TYSND1, STARD7, RNF114, ALKBH5, LGALS1, ARPC1A, TPM2, MRPS11, NT5C2, ACOT1, MRPS21, ARHGEF1, UBAP2L, SLC38A2, RPP38, MAP7D3, BAG1, MMS19, EARS2, SPATS2L, LGALS3BP, OXSR1, ARHGEF40, IGF2R, TUBG1, NUP188, TNPO3, PTRF, TDRD3, MORF4L2, NIF3L1, NIPBL, FTH1, CHEK2, FBXO3, RPL37A, METAP2, MRPS23, RPS19, SART1, APRT, WBSCR22, HMGB2, RPL12, PSIP1, RPS7, STRBP, ZC3H15, MAGT1, DHX37, RFC1, SRP72, PRPF31, SEMA3C, HNRNPA0, SCAMP3, SRPK1, UPF3B, ZFR, SYNCRIP, ILF2, SLK, AP3D1, ARPC4-TTLL3, RPS26, SSBP1, HNRNPAB, TMEM192, SCAP, CNR2, KLF15, SAMM50, IMMT, MTX1, MAP1LC3B2, VPS29, TOMM40, PSMB4, TRIM44,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SQSTM1
NTRK1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	SQSTM1	chr5:179252226	chr1:156844362	ENST00000360718	+	4	7	122_224	167.33333333333334	357.0	GABRR3
Hgene	SQSTM1	chr5:179252226	chr1:156844362	ENST00000376929	+	6	9	122_224	167.33333333333334	357.0	GABRR3
Hgene	SQSTM1	chr5:179252226	chr1:156844362	ENST00000402874	+	5	8	122_224	167.33333333333334	357.0	GABRR3
Hgene	SQSTM1	chr5:179252226	chr1:156844363	ENST00000360718	+	4	7	122_224	167.33333333333334	357.0	GABRR3
Hgene	SQSTM1	chr5:179252226	chr1:156844363	ENST00000376929	+	6	9	122_224	167.33333333333334	357.0	GABRR3
Hgene	SQSTM1	chr5:179252226	chr1:156844363	ENST00000402874	+	5	8	122_224	167.33333333333334	357.0	GABRR3
Hgene	SQSTM1	chr5:179252226	chr1:156844362	ENST00000360718	+	4	7	347_352	167.33333333333334	357.0	KEAP1
Hgene	SQSTM1	chr5:179252226	chr1:156844362	ENST00000376929	+	6	9	347_352	167.33333333333334	357.0	KEAP1
Hgene	SQSTM1	chr5:179252226	chr1:156844362	ENST00000389805	+	5	8	347_352	251.33333333333334	441.0	KEAP1
Hgene	SQSTM1	chr5:179252226	chr1:156844362	ENST00000402874	+	5	8	347_352	167.33333333333334	357.0	KEAP1
Hgene	SQSTM1	chr5:179252226	chr1:156844363	ENST00000360718	+	4	7	347_352	167.33333333333334	357.0	KEAP1
Hgene	SQSTM1	chr5:179252226	chr1:156844363	ENST00000376929	+	6	9	347_352	167.33333333333334	357.0	KEAP1
Hgene	SQSTM1	chr5:179252226	chr1:156844363	ENST00000389805	+	5	8	347_352	251.33333333333334	441.0	KEAP1
Hgene	SQSTM1	chr5:179252226	chr1:156844363	ENST00000402874	+	5	8	347_352	167.33333333333334	357.0	KEAP1
Hgene	SQSTM1	chr5:179252226	chr1:156844362	ENST00000360718	+	4	7	269_440	167.33333333333334	357.0	NTRK1
Hgene	SQSTM1	chr5:179252226	chr1:156844362	ENST00000376929	+	6	9	269_440	167.33333333333334	357.0	NTRK1
Hgene	SQSTM1	chr5:179252226	chr1:156844362	ENST00000389805	+	5	8	269_440	251.33333333333334	441.0	NTRK1
Hgene	SQSTM1	chr5:179252226	chr1:156844362	ENST00000402874	+	5	8	269_440	167.33333333333334	357.0	NTRK1
Hgene	SQSTM1	chr5:179252226	chr1:156844363	ENST00000360718	+	4	7	269_440	167.33333333333334	357.0	NTRK1
Hgene	SQSTM1	chr5:179252226	chr1:156844363	ENST00000376929	+	6	9	269_440	167.33333333333334	357.0	NTRK1
Hgene	SQSTM1	chr5:179252226	chr1:156844363	ENST00000389805	+	5	8	269_440	251.33333333333334	441.0	NTRK1
Hgene	SQSTM1	chr5:179252226	chr1:156844363	ENST00000402874	+	5	8	269_440	167.33333333333334	357.0	NTRK1

Top

Related Drugs to SQSTM1-NTRK1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SQSTM1-NTRK1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	SQSTM1	C4085252	PAGET DISEASE OF BONE 3	9	GENOMICS_ENGLAND;UNIPROT
Hgene	SQSTM1	C0002736	Amyotrophic Lateral Sclerosis	5	CTD_human;ORPHANET
Hgene	SQSTM1	C4225326	FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 3	4	CTD_human;UNIPROT
Hgene	SQSTM1	C0029463	Osteosarcoma	2	GENOMICS_ENGLAND
Hgene	SQSTM1	C0221054	Welander Distal Myopathy	1	ORPHANET
Hgene	SQSTM1	C0242383	Age related macular degeneration	1	CTD_human
Hgene	SQSTM1	C0393554	Amyotrophic Lateral Sclerosis With Dementia	1	CTD_human
Hgene	SQSTM1	C0543859	Amyotrophic Lateral Sclerosis, Guam Form	1	CTD_human
Hgene	SQSTM1	C1853926	NONAKA MYOPATHY	1	CTD_human;GENOMICS_ENGLAND
Hgene	SQSTM1	C2931290	Welander distal myopathy, Swedish type	1	ORPHANET
Hgene	SQSTM1	C3888102	Frontotemporal Dementia With Motor Neuron Disease	1	ORPHANET
Hgene	SQSTM1	C4011788	Behavioral variant of frontotemporal dementia	1	ORPHANET
Tgene	NTRK1	C0020074	HSAN Type IV	17	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	NTRK1	C0238463	Papillary thyroid carcinoma	3	ORPHANET
Tgene	NTRK1	C0002768	Congenital Pain Insensitivity	1	ORPHANET
Tgene	NTRK1	C0005586	Bipolar Disorder	1	CTD_human
Tgene	NTRK1	C0005587	Depression, Bipolar	1	CTD_human
Tgene	NTRK1	C0017638	Glioma	1	CTD_human
Tgene	NTRK1	C0020075	Hereditary Sensory Autonomic Neuropathy, Type 5	1	CTD_human;ORPHANET
Tgene	NTRK1	C0024713	Manic Disorder	1	CTD_human
Tgene	NTRK1	C0027796	Neuralgia	1	CTD_human
Tgene	NTRK1	C0027819	Neuroblastoma	1	CTD_human
Tgene	NTRK1	C0033958	Psychosis, Brief Reactive	1	CTD_human
Tgene	NTRK1	C0033975	Psychotic Disorders	1	CTD_human
Tgene	NTRK1	C0036337	Schizoaffective Disorder	1	CTD_human
Tgene	NTRK1	C0036341	Schizophrenia	1	CTD_human
Tgene	NTRK1	C0036358	Schizophreniform Disorders	1	CTD_human
Tgene	NTRK1	C0038870	Neuralgia, Supraorbital	1	CTD_human
Tgene	NTRK1	C0042656	Neuralgia, Vidian	1	CTD_human
Tgene	NTRK1	C0234247	Neuralgia, Atypical	1	CTD_human
Tgene	NTRK1	C0234249	Neuralgia, Stump	1	CTD_human
Tgene	NTRK1	C0259783	mixed gliomas	1	CTD_human
Tgene	NTRK1	C0273115	Lung Injury	1	CTD_human
Tgene	NTRK1	C0338831	Manic	1	CTD_human
Tgene	NTRK1	C0423711	Neuralgia, Perineal	1	CTD_human
Tgene	NTRK1	C0423712	Neuralgia, Iliohypogastric Nerve	1	CTD_human
Tgene	NTRK1	C0555198	Malignant Glioma	1	CTD_human
Tgene	NTRK1	C0598589	Inherited neuropathies	1	GENOMICS_ENGLAND
Tgene	NTRK1	C0751371	Neuralgia, Ilioinguinal	1	CTD_human
Tgene	NTRK1	C0751372	Nerve Pain	1	CTD_human
Tgene	NTRK1	C0751373	Paroxysmal Nerve Pain	1	CTD_human
Tgene	NTRK1	C0752347	Lewy Body Disease	1	CTD_human
Tgene	NTRK1	C1833921	Familial medullary thyroid carcinoma	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	NTRK1	C2350344	Chronic Lung Injury	1	CTD_human