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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SQSTM1-NTRK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SQSTM1-NTRK2
FusionPDB ID: 86214
FusionGDB2.0 ID: 86214
HgeneTgene
Gene symbol

SQSTM1

NTRK2

Gene ID

8878

4915

Gene namesequestosome 1neurotrophic receptor tyrosine kinase 2
SynonymsA170|DMRV|FTDALS3|NADGP|OSIL|PDB3|ZIP3|p60|p62|p62BEIEE58|GP145-TrkB|OBHD|TRKB|trk-B
Cytomap

5q35.3

9q21.33

Type of geneprotein-codingprotein-coding
Descriptionsequestosome-1EBI3-associated protein of 60 kDaEBI3-associated protein p60EBIAPautophagy receptor p62oxidative stress induced likephosphotyrosine independent ligand for the Lck SH2 domain p62phosphotyrosine-independent ligand for the Lck SH2 domainBDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
Modification date2020032720200313
UniProtAcc

Q13501

Q16620

Ensembl transtripts involved in fusion geneENST idsENST00000360718, ENST00000376929, 
ENST00000389805, ENST00000402874, 
ENST00000510187, ENST00000506690, 
ENST00000277120, ENST00000304053, 
ENST00000323115, ENST00000359847, 
ENST00000376208, ENST00000395866, 
ENST00000395882, ENST00000376213, 
ENST00000376214, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score29 X 23 X 12=800410 X 9 X 7=630
# samples 3310
** MAII scorelog2(33/8004*10)=-4.60018323765993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SQSTM1 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SQSTM1(179252226)-NTRK2(87549077), # samples:3
Anticipated loss of major functional domain due to fusion event.SQSTM1-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SQSTM1-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SQSTM1-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SQSTM1-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSQSTM1

GO:0006914

autophagy

20452972

HgeneSQSTM1

GO:0007032

endosome organization

27368102

HgeneSQSTM1

GO:0031397

negative regulation of protein ubiquitination

20452972

HgeneSQSTM1

GO:0061635

regulation of protein complex stability

25127057

HgeneSQSTM1

GO:1905719

protein localization to perinuclear region of cytoplasm

27368102


check buttonFusion gene breakpoints across SQSTM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NTRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-A76L-01ASQSTM1chr5

179252226

-NTRK2chr9

87549077

+
ChimerDB4LGGTCGA-DU-A76L-01ASQSTM1chr5

179252226

+NTRK2chr9

87549077

+
ChimerDB4LGGTCGA-DU-A76LSQSTM1chr5

179252226

+NTRK2chr9

87549077

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376929SQSTM1chr5179252226+ENST00000376214NTRK2chr987549077+38998623031745480
ENST00000376929SQSTM1chr5179252226+ENST00000376213NTRK2chr987549077+38998623031745480
ENST00000389805SQSTM1chr5179252226+ENST00000376214NTRK2chr987549077+39699321781815545
ENST00000389805SQSTM1chr5179252226+ENST00000376213NTRK2chr987549077+39699321781815545
ENST00000402874SQSTM1chr5179252226+ENST00000376214NTRK2chr987549077+3809772181655545
ENST00000402874SQSTM1chr5179252226+ENST00000376213NTRK2chr987549077+3809772181655545
ENST00000510187SQSTM1chr5179252226+ENST00000376214NTRK2chr987549077+3807770161653545
ENST00000510187SQSTM1chr5179252226+ENST00000376213NTRK2chr987549077+3807770161653545
ENST00000360718SQSTM1chr5179252226+ENST00000376214NTRK2chr987549077+405910223341905523
ENST00000360718SQSTM1chr5179252226+ENST00000376213NTRK2chr987549077+405910223341905523

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376929ENST00000376214SQSTM1chr5179252226+NTRK2chr987549077+0.0033734660.9966266
ENST00000376929ENST00000376213SQSTM1chr5179252226+NTRK2chr987549077+0.0033734660.9966266
ENST00000389805ENST00000376214SQSTM1chr5179252226+NTRK2chr987549077+0.0019136030.99808645
ENST00000389805ENST00000376213SQSTM1chr5179252226+NTRK2chr987549077+0.0019136030.99808645
ENST00000402874ENST00000376214SQSTM1chr5179252226+NTRK2chr987549077+0.0017680380.99823195
ENST00000402874ENST00000376213SQSTM1chr5179252226+NTRK2chr987549077+0.0017680380.99823195
ENST00000510187ENST00000376214SQSTM1chr5179252226+NTRK2chr987549077+0.0017583430.99824166
ENST00000510187ENST00000376213SQSTM1chr5179252226+NTRK2chr987549077+0.0017583430.99824166
ENST00000360718ENST00000376214SQSTM1chr5179252226+NTRK2chr987549077+0.0031135640.99688643
ENST00000360718ENST00000376213SQSTM1chr5179252226+NTRK2chr987549077+0.0031135640.99688643

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>86214_86214_1_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000360718_NTRK2_chr9_87549077_ENST00000376213_length(amino acids)=523AA_BP=229
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILV
AVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQ
IAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY

--------------------------------------------------------------

>86214_86214_2_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000360718_NTRK2_chr9_87549077_ENST00000376214_length(amino acids)=523AA_BP=229
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILV
AVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQ
IAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY

--------------------------------------------------------------

>86214_86214_3_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000376929_NTRK2_chr9_87549077_ENST00000376213_length(amino acids)=480AA_BP=186
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLVVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDP
LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY
STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQR

--------------------------------------------------------------

>86214_86214_4_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000376929_NTRK2_chr9_87549077_ENST00000376214_length(amino acids)=480AA_BP=186
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLVVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDP
LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY
STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQR

--------------------------------------------------------------

>86214_86214_5_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000389805_NTRK2_chr9_87549077_ENST00000376213_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

--------------------------------------------------------------

>86214_86214_6_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000389805_NTRK2_chr9_87549077_ENST00000376214_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

--------------------------------------------------------------

>86214_86214_7_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000402874_NTRK2_chr9_87549077_ENST00000376213_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

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>86214_86214_8_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000402874_NTRK2_chr9_87549077_ENST00000376214_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

--------------------------------------------------------------

>86214_86214_9_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000510187_NTRK2_chr9_87549077_ENST00000376213_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

--------------------------------------------------------------

>86214_86214_10_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000510187_NTRK2_chr9_87549077_ENST00000376214_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:179252226/chr9:87549077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SQSTM1

Q13501

NTRK2

Q16620

FUNCTION: Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215). {ECO:0000250|UniProtKB:O08623, ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:33393215}.FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+473_102167.33333333333334357.0DomainPB1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+693_102167.33333333333334357.0DomainPB1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+583_102251.33333333333334441.0DomainPB1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+583_102167.33333333333334357.0DomainPB1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58228_233251.33333333333334441.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58170_220251.33333333333334441.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47122_167167.33333333333334357.0Zinc fingerZZ-type
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69122_167167.33333333333334357.0Zinc fingerZZ-type
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58122_167251.33333333333334441.0Zinc fingerZZ-type
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58122_167167.33333333333334357.0Zinc fingerZZ-type
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015148_1960554.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015197_2820554.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015295_3650554.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000030405301532_610554.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015538_8070554.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117538_807528.3333333333334823.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012148_1960478.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012197_2820478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012295_3650478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000035984701232_610478.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012538_8070478.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014148_1960538.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014197_2820538.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014295_3650538.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000037620801432_610538.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014538_8070538.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420538_807528.3333333333334823.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012148_1960322.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012197_2820322.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012295_3650322.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039586601232_610322.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012538_8070322.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013148_1960478.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013197_2820478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013295_3650478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039588201332_610478.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013538_8070478.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319544_552544.3333333333334839.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015544_5520554.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117544_552528.3333333333334823.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012544_5520478.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014544_5520538.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420544_552528.3333333333334823.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521544_552544.3333333333334839.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012544_5520322.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013544_5520478.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015116_1370554.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000030405301592_1130554.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012116_1370478.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000035984701292_1130478.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014116_1370538.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000037620801492_1130538.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012116_1370322.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039586601292_1130322.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013116_1370478.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039588201392_1130478.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST0000030405301532_4300554.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015455_8220554.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST0000035984701232_4300478.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012455_8220478.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST0000037620801432_4300538.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014455_8220538.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039586601232_4300322.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012455_8220322.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039588201332_4300478.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013455_8220478.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015431_4540554.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012431_4540478.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014431_4540538.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012431_4540322.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013431_4540478.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47272_294167.33333333333334357.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69272_294167.33333333333334357.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58272_294251.33333333333334441.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58272_294167.33333333333334357.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47389_434167.33333333333334357.0DomainUBA
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69389_434167.33333333333334357.0DomainUBA
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58389_434251.33333333333334441.0DomainUBA
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58389_434167.33333333333334357.0DomainUBA
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47228_233167.33333333333334357.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47336_341167.33333333333334357.0MotifNote=LIR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69228_233167.33333333333334357.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69336_341167.33333333333334357.0MotifNote=LIR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58336_341251.33333333333334441.0MotifNote=LIR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58228_233167.33333333333334357.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58336_341167.33333333333334357.0MotifNote=LIR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47170_220167.33333333333334357.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47321_342167.33333333333334357.0RegionMAP1LC3B-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69170_220167.33333333333334357.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69321_342167.33333333333334357.0RegionMAP1LC3B-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58321_342251.33333333333334441.0RegionMAP1LC3B-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58170_220167.33333333333334357.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58321_342167.33333333333334357.0RegionMAP1LC3B-binding
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319148_196544.3333333333334839.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319197_282544.3333333333334839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319295_365544.3333333333334839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000277120131932_61544.3333333333334839.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319538_807544.3333333333334839.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117148_196528.3333333333334823.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117197_282528.3333333333334823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117295_365528.3333333333334823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000323115111732_61528.3333333333334823.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420148_196528.3333333333334823.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420197_282528.3333333333334823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420295_365528.3333333333334823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376213142032_61528.3333333333334823.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521148_196544.3333333333334839.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521197_282544.3333333333334839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521295_365544.3333333333334839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376214152132_61544.3333333333334839.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521538_807544.3333333333334839.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319116_137544.3333333333334839.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000277120131992_113544.3333333333334839.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117116_137528.3333333333334823.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000323115111792_113528.3333333333334823.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420116_137528.3333333333334823.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376213142092_113528.3333333333334823.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521116_137544.3333333333334839.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376214152192_113544.3333333333334839.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000277120131932_430544.3333333333334839.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319455_822544.3333333333334839.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST00000323115111732_430528.3333333333334823.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117455_822528.3333333333334823.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376213142032_430528.3333333333334823.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420455_822528.3333333333334823.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376214152132_430544.3333333333334839.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521455_822544.3333333333334839.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319431_454544.3333333333334839.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117431_454528.3333333333334823.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420431_454528.3333333333334823.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521431_454544.3333333333334839.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1168_SQSTM1_179252226_NTRK2_87549077_1168_SQSTM1_179252226_NTRK2_87549077_ranked_0.pdbSQSTM1179252226179252226ENST00000376213NTRK2chr987549077+
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY
545


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SQSTM1_pLDDT.png
all structure
all structure
NTRK2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SQSTM1GABARAPL2, RAD23A, GABARAPL1, SQSTM1, LINC00341, MAP1LC3B, TRAF6, PRKCZ, IRAK1, PRKCI, NTRK1, RIPK1, NTRK2, NTRK3, LCK, MAP1LC3A, Shank1, Dlg4, Grin2a, Gria1, Chrna7, KEAP1, GABARAP, C10orf2, ABHD10, CEP78, DIP2B, BLOC1S5, EMILIN3, NSUN4, OSBPL8, INA, NIPSNAP1, GBAS, LLGL1, HADHA, GPC4, HADHB, CTNND1, ASPH, ENPP1, TRMT61B, GLG1, MRPL38, NEFM, GTF3C3, SRRM2, MYD88, MYC, MAP3K3, MAP2K5, IRF8, TRIM21, CYLD, Cep78, Poc1b, CALM1, BNIP1, NFE2L2, CUL3, PIK3CA, PPHLN1, BPTF, UBC, DAZAP2, CDC37, TRIM13, CASP8, PCK1, STAT5A, PDE4A, MAPT, ATG4B, CHMP2B, TARDBP, CUL1, CUL2, HDAC6, ATG7, FUS, CSNK2A1, ZFAND5, TUBA1A, WDFY3, ATG8, BAG3, NBR1, SNCA, TRIM63, TRIM55, TTN, RARA, PSMC2, PSMD4, MAP1LC3C, TRIM50, ARHGEF28, TGM2, PAWR, RPTOR, MTOR, AKT1S1, MLST8, RPS6KB1, RRAGC, RRAGB, CDK9, tat, SPRED2, TRIM5, AJUBA, LIMD1, MAPK14, PARP10, vif, nef, TNFRSF10A, HTT, HNRNPA2B1, SDHA, CAV1, BID, FAS, SESN2, SESN1, MALT1, IKBKG, FHOD3, NOD2, SYNPO2, PYCARD, MLH1, PARK2, BCL2, PAN2, NPM1, MBP, YWHAZ, STXBP1, FKBP4, MEIS2, TKT, HSPA4, RELN, CAMK2A, ULK2, NCOR1, NGFR, env, HIV2gp7, CALCOCO2, Prkci, CDK1, CCNB1, PRKCD, MAPK1, SMAD3, EEF1D, RPL37, GEMIN4, DVL2, CHAF1A, TP53, CASP9, HIF1A, PSMD12, PSMD3, FLNB, PSMD10, TXNL1, TNK2, LGALS3, EDEM1, CFTR, CSNK2A2, DCP2, EGLN3, EPAS1, ULK1, TOLLIP, OPTN, ATXN3, STUB1, ISG15, MOV10, NXF1, CUL7, PIK3R1, PIK3R2, AGAP1, INSR, Ubc, TBK1, CRHBP, SCCPDH, DNAI1, DNAI2, TP53INP1, LLGL2, HSPB1, Ripk3, Nr2f2, IFI16, KIAA0753, MED4, CEP135, CNTRL, SASS6, TMEM17, XPO1, CD44, KIF5B, PML, Mgp, Poc1a, Fgfr1op, ENC1, SKI, TRIB3, RBM45, MAPK13, CHDH, EPDR1, GAS6, NDUFS2, NDUFS3, GFM2, NDUFA5, CD48, LDHA, RCN2, TRAF1, GBP2, KLHL3, EPM2A, RAD54L2, HSPA5, GRIA1, UBXN1, PEX5, BCL10, ATG5, CSNK1A1, VANGL2, SERPINA1, RNF168, LRRK2, VHL, TCEB2, TCEB1, RNF166, NOTCH1, RETN, KERA, INSL5, TMX1, VWCE, CD96, HTR3A, RNF26, INO80B, DLST, TRIM25, PLIN1, TES, WDR81, PSMA6, TRIM23, PGI1, UBE2D2, UBE2D3, ID1, ID2, TAX1BP1, Map1lc3b, UBD, RMND5A, RIPK4, MAPK6, TMPO, AIM2, TRIM11, TNFAIP3, VDR, NEDD4, CNOT2, WDR77, KRAS, RXRA, TGFB1, TRIP4, C19orf80, CCNF, VIM, FLNA, RAD51, NR4A1, RAD18, REL, RELA, RNF4, RNF31, PARK7, MYO6, XIAP, DDX5, CCND1, BPLF1, ESR2, BBC3, CDC6, BRCA1, CRYAB, DNAJC10, PADI1, CALCR, USP14, DDX58, Gabarapl1, MB21D1, SMN1, CRBN, FBL, ELAVL1, KIAA1429, AMBRA1, VCP, LAMP2, ATG16L1, LRRK1, PHB, BECN1, SOX2, PARP1, USP10, MTDH, FUNDC1, GBF1, MECOM, DCAF15, asp, SHMT2, CCT7, SLIRP, SND1, FADD, BIRC2, DYRK1A, PINK1, RB1CC1, IFITM3, P2RY6, GCH1, NUB1, PPP1CA, Casp8, FBXW7, BIRC3, LMBR1L, IGF2BP1, SERPINE2, MYO5A, FN1, CTHRC1, CD59, ITIH5, TNC, SNTB1, ROBO1, TUBB2A, GDF15, CNP, RAI14, ACSL3, CEP170, TAOK2, CNST, SSR3, SLC25A11, SPATA20, FARP1, UTRN, DHX33, CHCHD3, HS2ST1, PTRH2, SOD3, BCKDK, CCDC77, IQGAP1, FKBP11, CEP350, SCO1, SNTB2, MTX2, MYO1B, PWP1, SRPR, ATAD3A, ACTR1A, SLC25A1, MOGS, GOLGA2, SMG8, DYNC1LI2, UQCRH, SRPK2, CAPZA2, POLRMT, SMARCD1, GNB1, HSD17B12, DYNC1LI1, AIFM1, DARS2, GNAI2, TUBA1C, TUBA1B, MRPS28, CEP131, WDR82, PAFAH1B1, TUBB, MRPS34, ATP5A1, NOL9, ZC3H4, ATP5B, MRPS26, MRPS18B, ERAL1, PNKP, MIB1, SRP14, SLC25A3, MRPS22, CEP250, CCDC61, CKAP4, RPS16, BICD1, RPS15, ATP5H, AP2B1, NFIX, CDK5RAP2, RRBP1, SLC25A4, RPS5, TPX2, AP2A2, IK, PPP2R1A, GOLGB1, MPRIP, AHNAK, PCNT, RPS24, CETN2, HNRNPUL1, PRRC2A, DAP3, PIBF1, TJP1, RFC4, NOL8, CEP290, MAGI1, ZNF384, IQSEC1, TAOK1, PGAM5, SMG1, GAPVD1, MRPS9, ATAD3B, CSTF3, FRYL, EPRS, ARHGEF18, SNAP23, PRPF38A, RBM12B, SLC25A10, UTP23, FGFR1OP, SMU1, RAPGEF2, OFD1, PARD3, S100A9, EIF4B, EIF5B, IGF2BP3, ATXN1, HCVgp1, IKBKB, SKP2, PHB2, PLN, MAVS, APAF1, ECSIT, G3BP1, G3BP2, BNIP3, BNIP3L, CALR, DAXX, LINC01554, HMOX1, KAT5, PDPK1, PXN, RAF1, SH3BGRL, ORF7a, E, nsp6, ORF6, ORF8, ESR1, TRIM32, RQCD1, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, PDCD4, BRD1, FIS1, MARCH5, MFN2, OCIAD1, ABL1, Rnf183, AGR2, HULC, NLRP3, NUPR1, USP8, GSK3B, UCHL5, FAM20C, GJA1, CCDC88C, PRDM9, PPIA, USP20, USP19, OTUD7B, JOSD1, IRF3, STK17A, OGT, BAG5, PSMB2, PSMD14, TRIM37, AR, MCL1, AMOT, B3GAT1, GJD3, GOLGA1, IMPDH2, KRT8, PXMP2, AMER1, ARHGAP32, BCR, C1orf198, CC2D1A, CCDC85C, CDC27, CENPB, CEP85, CNOT1, CNOT10, CSTF2T, DNAJA2, EDRF1, FAM193A, FARSA, FLJ44635, GGA3, HGS, HIST1H2BD, HIST1H3F, HSPA1B, IARS2, IFT172, IFT74, IQGAP2, JADE3, KIF7, KPNA3, LZTS2, MAGED1, NAE1, NAV1, NUDT19, OCRL, PAPD7, PDLIM7, PEBP1, PIK3C2B, PJA2, PPP1R13B, PPP2R3B, PPP2R5D, RC3H1, RIPK2, SCYL2, SEC16A, SIRT2, SMG7, SNRPE, SYNJ1, TNIP1, TNRC6A, TNRC6B, TP53BP2, TRIM26, TRIP6, TTK, UBB, VWA8, ZCCHC14, ZCCHC2, ZFP36L2, ABLIM1, KIAA1244, ASNS, CEP152, DIAPH3, DNAAF2, DRG1, DVL3, EXOC4, KIAA1671, LPP, NELFCD, NRBF2, PAK4, PDLIM3, PDLIM5, RPAP2, SDCCAG3, SIPA1L3, SLAIN2, SYNJ2, TAB2, TANC1, TTC28, TTF2, UCHL1, WRAP73, YEATS2, SYNE3, VASP, JUN, UBQLN2, CCDC50, IFIH1, VDAC1, MOAP1, CHRNB4, ZCCHC10, PRR27, IL7R, IL17F, BAGE2, HFE, CST8, POGLUT1, EDDM3B, LY6G5C, ST14, TNFSF18, GREM2, C1QTNF1, CST11, HLA-DPB1, FIBIN, ADAMTS12, GLIPR1L2, FAM46C, BTF3, ZRANB1, UXT, WBP4, IFITM1, KDR, NEDD8, KDM1A, AARS, ACLY, ACTB, ARF4, ATG9A, ATP2A2, BZW1, CACYBP, CAD, CALCOCO1, CCAR2, CCPG1, CCT2, CCT3, CCT4, CCT5, CCT6A, CEP112, CKB, CLTC, CTPS1, DDX3X, DNM1L, DYNC1H1, EEF2, EIF2S3, EIF3A, EIF4A1, ERLIN1, FASN, FASTKD2, FTL, GART, GPC1, HEXB, HIST1H2BN, HMGB1, HSP90AA1, HSP90AB1, HSPA8, HSPH1, IPO5, IPO7, KLHL8, KPNA2, KPNA4, KPNB1, LPL, LRRC59, MAT2A, MFF, MTHFD1, MTMR4, NCOA4, NPR3, NUP155, PABPC1, PAICS, PAIP1, PDCD6, PFKM, PFKP, PGD, PHGDH, PRKACA, PRKAR1A, PSMC1, PSMC3, PSMC4, PSMC5, PSMC6, PSMD2, RAB18, RAB1A, RAB21, RAB2A, RAB5C, RAB7A, RAB8A, RHEB, RPS17, RRM1, RTN4, S100A6, SAR1B, SDC2, SDC4, SDCBP, SEPT7, SMC4, SPG20, ST13P5, STIP1, SYNGR2, TAGLN2, TBC1D15, TCP1, TFRC, TM9SF2, TMEM59, TNPO1, TPP1, TRAF2, TRAF3, TRIP13, TUBB4B, VAPA, VAPB, YBX1, YWHAB, YWHAE, TRIO, HECTD1, WNK1, SPATA5L1, CTNNB1, LUZP1, MTCL1, STAM, TMEM160, POLR2B, TNKS1BP1, PPP6R3, KIF11, RTN3, ADAR, RACGAP1, BUB3, CORO1B, PABPC4, MAP7, DCXR, TSR1, DNMT1, ZC3HAV1, RPS27A, RAB6A, ADRM1, DHX9, UBA1, GSTP1, ACTG1, CISD2, DNAJA4, SETX, KIAA0101, TYSND1, STARD7, RNF114, ALKBH5, LGALS1, ARPC1A, TPM2, MRPS11, NT5C2, ACOT1, MRPS21, ARHGEF1, UBAP2L, SLC38A2, RPP38, MAP7D3, BAG1, MMS19, EARS2, SPATS2L, LGALS3BP, OXSR1, ARHGEF40, IGF2R, TUBG1, NUP188, TNPO3, PTRF, TDRD3, MORF4L2, NIF3L1, NIPBL, FTH1, CHEK2, FBXO3, RPL37A, METAP2, MRPS23, RPS19, SART1, APRT, WBSCR22, HMGB2, RPL12, PSIP1, RPS7, STRBP, ZC3H15, MAGT1, DHX37, RFC1, SRP72, PRPF31, SEMA3C, HNRNPA0, SCAMP3, SRPK1, UPF3B, ZFR, SYNCRIP, ILF2, SLK, AP3D1, ARPC4-TTLL3, RPS26, SSBP1, HNRNPAB, TMEM192, SCAP, CNR2, KLF15, SAMM50, IMMT, MTX1, MAP1LC3B2, VPS29, TOMM40, PSMB4, TRIM44,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SQSTM1all structure
NTRK2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47122_224167.33333333333334357.0GABRR3
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69122_224167.33333333333334357.0GABRR3
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58122_224167.33333333333334357.0GABRR3
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47347_352167.33333333333334357.0KEAP1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69347_352167.33333333333334357.0KEAP1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58347_352251.33333333333334441.0KEAP1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58347_352167.33333333333334357.0KEAP1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47269_440167.33333333333334357.0NTRK1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69269_440167.33333333333334357.0NTRK1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58269_440251.33333333333334441.0NTRK1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58269_440167.33333333333334357.0NTRK1
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319455_466544.3333333333334839.0MAPK8IP3/JIP3
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117455_466528.3333333333334823.0MAPK8IP3/JIP3
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420455_466528.3333333333334823.0MAPK8IP3/JIP3
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521455_466544.3333333333334839.0MAPK8IP3/JIP3


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Related Drugs to SQSTM1-NTRK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SQSTM1-NTRK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSQSTM1C4085252PAGET DISEASE OF BONE 39GENOMICS_ENGLAND;UNIPROT
HgeneSQSTM1C0002736Amyotrophic Lateral Sclerosis5CTD_human;ORPHANET
HgeneSQSTM1C4225326FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 34CTD_human;UNIPROT
HgeneSQSTM1C0029463Osteosarcoma2GENOMICS_ENGLAND
HgeneSQSTM1C0221054Welander Distal Myopathy1ORPHANET
HgeneSQSTM1C0242383Age related macular degeneration1CTD_human
HgeneSQSTM1C0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
HgeneSQSTM1C0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
HgeneSQSTM1C1853926NONAKA MYOPATHY1CTD_human;GENOMICS_ENGLAND
HgeneSQSTM1C2931290Welander distal myopathy, Swedish type1ORPHANET
HgeneSQSTM1C3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET
HgeneSQSTM1C4011788Behavioral variant of frontotemporal dementia1ORPHANET
TgeneNTRK2C0011570Mental Depression5PSYGENET
TgeneNTRK2C0011581Depressive disorder5PSYGENET
TgeneNTRK2C0041696Unipolar Depression5PSYGENET
TgeneNTRK2C0525045Mood Disorders5PSYGENET
TgeneNTRK2C1269683Major Depressive Disorder5PSYGENET
TgeneNTRK2C3151303Obesity, Hyperphagia, and Developmental Delay4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0005586Bipolar Disorder3CTD_human;PSYGENET
TgeneNTRK2C4693367EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 583GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0009171Cocaine Abuse2CTD_human
TgeneNTRK2C0036341Schizophrenia2PSYGENET
TgeneNTRK2C0038220Status Epilepticus2CTD_human
TgeneNTRK2C0236736Cocaine-Related Disorders2CTD_human
TgeneNTRK2C0270823Petit mal status2CTD_human
TgeneNTRK2C0311335Grand Mal Status Epilepticus2CTD_human
TgeneNTRK2C0393734Complex Partial Status Epilepticus2CTD_human
TgeneNTRK2C0600427Cocaine Dependence2CTD_human
TgeneNTRK2C0751217Hyperkinesia, Generalized2CTD_human
TgeneNTRK2C0751522Status Epilepticus, Subclinical2CTD_human
TgeneNTRK2C0751523Non-Convulsive Status Epilepticus2CTD_human
TgeneNTRK2C0751524Simple Partial Status Epilepticus2CTD_human
TgeneNTRK2C3887506Hyperkinesia2CTD_human
TgeneNTRK2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNTRK2C0004114Astrocytoma1CTD_human
TgeneNTRK2C0004352Autistic Disorder1CTD_human
TgeneNTRK2C0005587Depression, Bipolar1CTD_human
TgeneNTRK2C0008073Developmental Disabilities1CTD_human
TgeneNTRK2C0013415Dysthymic Disorder1PSYGENET
TgeneNTRK2C0017638Glioma1CTD_human
TgeneNTRK2C0020505Hyperphagia1CTD_human
TgeneNTRK2C0024713Manic Disorder1CTD_human
TgeneNTRK2C0027819Neuroblastoma1CTD_human
TgeneNTRK2C0028754Obesity1CTD_human
TgeneNTRK2C0036349Paranoid Schizophrenia1PSYGENET
TgeneNTRK2C0037769West Syndrome1ORPHANET
TgeneNTRK2C0085996Child Development Deviations1CTD_human
TgeneNTRK2C0085997Child Development Disorders, Specific1CTD_human
TgeneNTRK2C0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneNTRK2C0259783mixed gliomas1CTD_human
TgeneNTRK2C0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0280785Diffuse Astrocytoma1CTD_human
TgeneNTRK2C0334579Anaplastic astrocytoma1CTD_human
TgeneNTRK2C0334580Protoplasmic astrocytoma1CTD_human
TgeneNTRK2C0334581Gemistocytic astrocytoma1CTD_human
TgeneNTRK2C0334582Fibrillary Astrocytoma1CTD_human
TgeneNTRK2C0334583Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0338831Manic1CTD_human
TgeneNTRK2C0547065Mixed oligoastrocytoma1CTD_human
TgeneNTRK2C0555198Malignant Glioma1CTD_human
TgeneNTRK2C0678807prenatal alcohol exposure1PSYGENET
TgeneNTRK2C0750935Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0750936Intracranial Astrocytoma1CTD_human
TgeneNTRK2C0752347Lewy Body Disease1CTD_human
TgeneNTRK2C1519086Pilomyxoid astrocytoma1ORPHANET
TgeneNTRK2C1704230Grade I Astrocytoma1CTD_human
TgeneNTRK2C3146244Alcohol Related Birth Defect1PSYGENET