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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SRCIN1-LASP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SRCIN1-LASP1
	FusionPDB ID: 86251
	FusionGDB2.0 ID: 86251
		Hgene	Tgene
	Gene symbol	SRCIN1	LASP1
	Gene ID	80725	3927
	Gene name	SRC kinase signaling inhibitor 1	LIM and SH3 protein 1
	Synonyms	P140\|SNIP	Lasp-1\|MLN50
	Cytomap	17q12	17q12
	Type of gene	protein-coding	protein-coding
	Description	SRC kinase signaling inhibitor 1P130Cas-associated proteinSNAP-25-interacting proteinSNAP25-interacting proteinp140Cap	LIM and SH3 domain protein 1metastatic lymph node gene 50 protein
	Modification date	20200320	20200313
	UniProtAcc	.	Q14847
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264659, ENST00000578925, ENST00000398579,	ENST00000318008, ENST00000433206, ENST00000435347,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 14 X 6=840	16 X 20 X 9=2880
	# samples	11	20
	** MAII score	log2(11/840*10)=-2.93288580414146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(20/2880*10)=-3.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SRCIN1 [Title/Abstract] AND LASP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SRCIN1(36761886)-LASP1(37070578), # samples:2 SRCIN1(36761937)-LASP1(37070578), # samples:2
Anticipated loss of major functional domain due to fusion event.	SRCIN1-LASP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SRCIN1-LASP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SRCIN1-LASP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SRCIN1-LASP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SRCIN1	GO:0061098	positive regulation of protein tyrosine kinase activity	17525734
Hgene	SRCIN1	GO:0061099	negative regulation of protein tyrosine kinase activity	17525734

Fusion gene breakpoints across SRCIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LASP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	READ	TCGA-EI-6509-01A	SRCIN1	chr17	36761886	-	LASP1	chr17	37070578	+
ChimerDB4	READ	TCGA-EI-6509-01A	SRCIN1	chr17	36761937	-	LASP1	chr17	37070578	+
ChimerDB4	READ	TCGA-EI-6509	SRCIN1	chr17	36760732	-	LASP1	chr17	37070578	+
ChimerDB4	READ	TCGA-EI-6509	SRCIN1	chr17	36761886	-	LASP1	chr17	37070578	+
ChimerDB4	READ	TCGA-EI-6509	SRCIN1	chr17	36761937	-	LASP1	chr17	37070578	+
ChimerDB4	READ	TCGA-EI-6509	SRCIN1	chr17	36761939	-	LASP1	chr17	37070576	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264659	SRCIN1	chr17	36761939	-	ENST00000318008	LASP1	chr17	37070576	+	3668	247	76	675	199
ENST00000264659	SRCIN1	chr17	36761939	-	ENST00000433206	LASP1	chr17	37070576	+	1224	247	76	675	199
ENST00000264659	SRCIN1	chr17	36761939	-	ENST00000435347	LASP1	chr17	37070576	+	3335	247	76	675	199
ENST00000578925	SRCIN1	chr17	36761939	-	ENST00000318008	LASP1	chr17	37070576	+	3580	159	814	1410	198
ENST00000578925	SRCIN1	chr17	36761939	-	ENST00000433206	LASP1	chr17	37070576	+	1136	159	48	587	179
ENST00000578925	SRCIN1	chr17	36761939	-	ENST00000435347	LASP1	chr17	37070576	+	3247	159	814	1410	198
ENST00000264659	SRCIN1	chr17	36761937	-	ENST00000318008	LASP1	chr17	37070578	+	3668	247	76	675	199
ENST00000264659	SRCIN1	chr17	36761937	-	ENST00000433206	LASP1	chr17	37070578	+	1224	247	76	675	199
ENST00000264659	SRCIN1	chr17	36761937	-	ENST00000435347	LASP1	chr17	37070578	+	3335	247	76	675	199
ENST00000578925	SRCIN1	chr17	36761937	-	ENST00000318008	LASP1	chr17	37070578	+	3580	159	814	1410	198
ENST00000578925	SRCIN1	chr17	36761937	-	ENST00000433206	LASP1	chr17	37070578	+	1136	159	48	587	179
ENST00000578925	SRCIN1	chr17	36761937	-	ENST00000435347	LASP1	chr17	37070578	+	3247	159	814	1410	198

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264659	ENST00000318008	SRCIN1	chr17	36761939	-	LASP1	chr17	37070576	+	0.79328716	0.20671286
ENST00000264659	ENST00000433206	SRCIN1	chr17	36761939	-	LASP1	chr17	37070576	+	0.4543947	0.54560536
ENST00000264659	ENST00000435347	SRCIN1	chr17	36761939	-	LASP1	chr17	37070576	+	0.73957324	0.26042673
ENST00000578925	ENST00000318008	SRCIN1	chr17	36761939	-	LASP1	chr17	37070576	+	0.7939137	0.20608631
ENST00000578925	ENST00000433206	SRCIN1	chr17	36761939	-	LASP1	chr17	37070576	+	0.39135125	0.6086488
ENST00000578925	ENST00000435347	SRCIN1	chr17	36761939	-	LASP1	chr17	37070576	+	0.7412363	0.25876367
ENST00000264659	ENST00000318008	SRCIN1	chr17	36761937	-	LASP1	chr17	37070578	+	0.79328716	0.20671286
ENST00000264659	ENST00000433206	SRCIN1	chr17	36761937	-	LASP1	chr17	37070578	+	0.4543947	0.54560536
ENST00000264659	ENST00000435347	SRCIN1	chr17	36761937	-	LASP1	chr17	37070578	+	0.73957324	0.26042673
ENST00000578925	ENST00000318008	SRCIN1	chr17	36761937	-	LASP1	chr17	37070578	+	0.7939137	0.20608631
ENST00000578925	ENST00000433206	SRCIN1	chr17	36761937	-	LASP1	chr17	37070578	+	0.39135125	0.6086488
ENST00000578925	ENST00000435347	SRCIN1	chr17	36761937	-	LASP1	chr17	37070578	+	0.7412363	0.25876367

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>86251_86251_1_SRCIN1-LASP1_SRCIN1_chr17_36761937_ENST00000264659_LASP1_chr17_37070578_ENST00000318008_length(amino acids)=199AA_BP=4
MVHPGGARAPGPPAWHRAPGLGPSEEPARRREGERQAGRPGAPAPRAPARWGTLRPKIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSY
RRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYG

--------------------------------------------------------------

>86251_86251_2_SRCIN1-LASP1_SRCIN1_chr17_36761937_ENST00000264659_LASP1_chr17_37070578_ENST00000433206_length(amino acids)=199AA_BP=4
MVHPGGARAPGPPAWHRAPGLGPSEEPARRREGERQAGRPGAPAPRAPARWGTLRPKIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSY
RRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYG

--------------------------------------------------------------

>86251_86251_3_SRCIN1-LASP1_SRCIN1_chr17_36761937_ENST00000264659_LASP1_chr17_37070578_ENST00000435347_length(amino acids)=199AA_BP=4
MVHPGGARAPGPPAWHRAPGLGPSEEPARRREGERQAGRPGAPAPRAPARWGTLRPKIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSY
RRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYG

--------------------------------------------------------------

>86251_86251_4_SRCIN1-LASP1_SRCIN1_chr17_36761937_ENST00000578925_LASP1_chr17_37070578_ENST00000318008_length(amino acids)=198AA_BP=
MERAWASLGEAGLEWETCWPVGLTCPSVLSPHILLPSSSHTHTFQGWGEPDCQDPRSGAPYIPQSGIHFLVPGMAMGTLPLCRDQWDGLY
LSFSKRGLCPPGVSLPTSLLRGNNRRMGFLLWGEFIPSPRVPSHTVILPSCPRRPAAGKELPRKHSLGQVLAFLNFRDSYRKEGNKEFSS

--------------------------------------------------------------

>86251_86251_5_SRCIN1-LASP1_SRCIN1_chr17_36761937_ENST00000578925_LASP1_chr17_37070578_ENST00000433206_length(amino acids)=179AA_BP=37
MGPSEEPARRREGERQAGRPGAPAPRAPARWGTLRPKIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQ

--------------------------------------------------------------

>86251_86251_6_SRCIN1-LASP1_SRCIN1_chr17_36761937_ENST00000578925_LASP1_chr17_37070578_ENST00000435347_length(amino acids)=198AA_BP=
MERAWASLGEAGLEWETCWPVGLTCPSVLSPHILLPSSSHTHTFQGWGEPDCQDPRSGAPYIPQSGIHFLVPGMAMGTLPLCRDQWDGLY
LSFSKRGLCPPGVSLPTSLLRGNNRRMGFLLWGEFIPSPRVPSHTVILPSCPRRPAAGKELPRKHSLGQVLAFLNFRDSYRKEGNKEFSS

--------------------------------------------------------------

>86251_86251_7_SRCIN1-LASP1_SRCIN1_chr17_36761939_ENST00000264659_LASP1_chr17_37070576_ENST00000318008_length(amino acids)=199AA_BP=4
MVHPGGARAPGPPAWHRAPGLGPSEEPARRREGERQAGRPGAPAPRAPARWGTLRPKIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSY
RRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYG

--------------------------------------------------------------

>86251_86251_8_SRCIN1-LASP1_SRCIN1_chr17_36761939_ENST00000264659_LASP1_chr17_37070576_ENST00000433206_length(amino acids)=199AA_BP=4
MVHPGGARAPGPPAWHRAPGLGPSEEPARRREGERQAGRPGAPAPRAPARWGTLRPKIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSY
RRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYG

--------------------------------------------------------------

>86251_86251_9_SRCIN1-LASP1_SRCIN1_chr17_36761939_ENST00000264659_LASP1_chr17_37070576_ENST00000435347_length(amino acids)=199AA_BP=4
MVHPGGARAPGPPAWHRAPGLGPSEEPARRREGERQAGRPGAPAPRAPARWGTLRPKIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSY
RRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYG

--------------------------------------------------------------

>86251_86251_10_SRCIN1-LASP1_SRCIN1_chr17_36761939_ENST00000578925_LASP1_chr17_37070576_ENST00000318008_length(amino acids)=198AA_BP=
MERAWASLGEAGLEWETCWPVGLTCPSVLSPHILLPSSSHTHTFQGWGEPDCQDPRSGAPYIPQSGIHFLVPGMAMGTLPLCRDQWDGLY
LSFSKRGLCPPGVSLPTSLLRGNNRRMGFLLWGEFIPSPRVPSHTVILPSCPRRPAAGKELPRKHSLGQVLAFLNFRDSYRKEGNKEFSS

--------------------------------------------------------------

>86251_86251_11_SRCIN1-LASP1_SRCIN1_chr17_36761939_ENST00000578925_LASP1_chr17_37070576_ENST00000433206_length(amino acids)=179AA_BP=37
MGPSEEPARRREGERQAGRPGAPAPRAPARWGTLRPKIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQ

--------------------------------------------------------------

>86251_86251_12_SRCIN1-LASP1_SRCIN1_chr17_36761939_ENST00000578925_LASP1_chr17_37070576_ENST00000435347_length(amino acids)=198AA_BP=
MERAWASLGEAGLEWETCWPVGLTCPSVLSPHILLPSSSHTHTFQGWGEPDCQDPRSGAPYIPQSGIHFLVPGMAMGTLPLCRDQWDGLY
LSFSKRGLCPPGVSLPTSLLRGNNRRMGFLLWGEFIPSPRVPSHTVILPSCPRRPAAGKELPRKHSLGQVLAFLNFRDSYRKEGNKEFSS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:36761886/chr17:37070578)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LASP1 Q14847
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LASP1

chr17:36761937

chr17:37070578

ENST00000318008

201_204

119.0

262.0

Compositional bias

Note=Poly-Gly

Tgene

LASP1

chr17:36761937

chr17:37070578

ENST00000435347

201_204

119.0

708.3333333333334

Compositional bias

Note=Poly-Gly

Tgene

LASP1

chr17:36761939

chr17:37070576

ENST00000318008

201_204

119.0

262.0

Compositional bias

Note=Poly-Gly

Tgene

LASP1

chr17:36761939

chr17:37070576

ENST00000435347

201_204

119.0

708.3333333333334

Compositional bias

Note=Poly-Gly

Tgene

LASP1

chr17:36761937

chr17:37070578

ENST00000318008

202_261

119.0

262.0

Domain

SH3

Tgene

LASP1

chr17:36761937

chr17:37070578

ENST00000435347

202_261

119.0

708.3333333333334

Domain

SH3

Tgene

LASP1

chr17:36761939

chr17:37070576

ENST00000318008

202_261

119.0

262.0

Domain

SH3

Tgene

LASP1

chr17:36761939

chr17:37070576

ENST00000435347

202_261

119.0

708.3333333333334

Domain

SH3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SRCIN1

chr17:36761937

chr17:37070578

ENST00000264659

654_674

7.333333333333333

1184.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SRCIN1

chr17:36761937

chr17:37070578

ENST00000264659

726_746

7.333333333333333

1184.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SRCIN1

chr17:36761939

chr17:37070576

ENST00000264659

654_674

7.333333333333333

1184.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SRCIN1

chr17:36761939

chr17:37070576

ENST00000264659

726_746

7.333333333333333

1184.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SRCIN1

chr17:36761937

chr17:37070578

ENST00000264659

471_504

7.333333333333333

1184.0

Compositional bias

Note=Pro-rich

Hgene

SRCIN1

chr17:36761937

chr17:37070578

ENST00000264659

956_1014

7.333333333333333

1184.0

Compositional bias

Note=Pro-rich

Hgene

SRCIN1

chr17:36761939

chr17:37070576

ENST00000264659

471_504

7.333333333333333

1184.0

Compositional bias

Note=Pro-rich

Hgene

SRCIN1

chr17:36761939

chr17:37070576

ENST00000264659

956_1014

7.333333333333333

1184.0

Compositional bias

Note=Pro-rich

Tgene

LASP1

chr17:36761937

chr17:37070578

ENST00000318008

5_56

119.0

262.0

Domain

LIM zinc-binding

Tgene

LASP1

chr17:36761937

chr17:37070578

ENST00000435347

5_56

119.0

708.3333333333334

Domain

LIM zinc-binding

Tgene

LASP1

chr17:36761939

chr17:37070576

ENST00000318008

5_56

119.0

262.0

Domain

LIM zinc-binding

Tgene

LASP1

chr17:36761939

chr17:37070576

ENST00000435347

5_56

119.0

708.3333333333334

Domain

LIM zinc-binding

Tgene

LASP1

chr17:36761937

chr17:37070578

ENST00000318008

61_95

119.0

262.0

Repeat

Note=Nebulin 1

Tgene

LASP1

chr17:36761937

chr17:37070578

ENST00000318008

97_131

119.0

262.0

Repeat

Note=Nebulin 2

Tgene

LASP1

chr17:36761937

chr17:37070578

ENST00000435347

61_95

119.0

708.3333333333334

Repeat

Note=Nebulin 1

Tgene

LASP1

chr17:36761937

chr17:37070578

ENST00000435347

97_131

119.0

708.3333333333334

Repeat

Note=Nebulin 2

Tgene

LASP1

chr17:36761939

chr17:37070576

ENST00000318008

61_95

119.0

262.0

Repeat

Note=Nebulin 1

Tgene

LASP1

chr17:36761939

chr17:37070576

ENST00000318008

97_131

119.0

262.0

Repeat

Note=Nebulin 2

Tgene

LASP1

chr17:36761939

chr17:37070576

ENST00000435347

61_95

119.0

708.3333333333334

Repeat

Note=Nebulin 1

Tgene

LASP1

chr17:36761939

chr17:37070576

ENST00000435347

97_131

119.0

708.3333333333334

Repeat

Note=Nebulin 2

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>265_SRCIN1_36761937_LASP1_37070578_ranked_0.pdb	SRCIN1	36761937	36761937	ENST00000435347	LASP1	chr17	37070578	+	MVHPGGARAPGPPAWHRAPGLGPSEEPARRREGERQAGRPGAPAPRAPARWGTLRPKIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSY RRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYG	199

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

SRCIN1_pLDDT.png

LASP1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

LASP1

TRIP13, PLSCR1, FHL3, MDFI, ZYX, Fancc, TERF1, TINF2, ACD, POT1, ATXN1, FN1, DAZAP2, Prkg1, Prkaca, CD81, GOLGA2, PSMA3, REL, TRIM27, TCF4, FXR2, SPRY2, ARHGEF15, ZC2HC1A, THAP1, SEPT3, LZTS2, RHOXF2, KRTAP4-2, ZBTB9, ZDHHC17, CCDC8, ILK, HAX1, DNAAF2, THAP8, FYTTD1, NFYA, OR10H3, RDH12, SLC25A32, SLC25A44, C11orf65, TAS2R41, AHNAK, ARFGAP1, DDB1, EIF4B, HSPB1, HSPE1, LGALS1, MAP4, NXF1, CRK, STAT3, SH2D2A, CEP170, FBF1, SCLT1, DCTN1, Prkcz, U2AF2, CDH1, ZNF764, SNRNP27, PGK1, EZR, SPTAN1, NCL, UHRF1, NAT10, PDIA5, API5, KRT18, KRT2, G3BP2, AP3M1, NCOR2, CDK12, MYO1C, ACTR3, CLTC, DNMT1, EHMT2, SNAI1, HIST1H3A, TRIM25, TES, PPP6C, EFTUD2, TNIP2, RBPMS, DPF2, COPS5, SFN, MYC, CDK9, CANX, ATG16L1, DCAF15, BICD1, BICD2, BMH1, BMH2, TRIM28, FAM168A, POLD1, DMRT3, POU1F1, ANKS1A, PITX1, CAMK2A, RBFOX1, CHERP, DTX2, NUTF2, VAC14, MED25, HOXA1, CRYBA1, TENC1, TFG, OTX1, GCM2, TEKT3, CPSF3L, ARHGEF16, BHLHE40, ZC3H10, VEZF1, RNF38, SPAG8, GUCD1, BAHD1, GAS8, LMO4, YTHDF1, FAM168B, TEKT5, BAG4, FOXH1, PRR35, PPP1R32, OXER1, TEKT4, CRYBA2, TLX3, RBPMS2, CERCAM, LENG8, MGAT5B, VPS37C, HNRNPF, EVX2, CATSPER1, YES1, UFSP1, CSTF2T, MKRN3, C14orf119, CTNNA3, HGS, WWOX, KRTAP19-6, KRTAP6-2, KRTAP19-4, KRTAP10-8, UBQLN2, C19orf54, NOXA1, ARID5A, CYSRT1, KRTAP26-1, QRICH1, PRR20B, PRR20A, DOK6, VGLL3, KRTAP3-3, KRTAP3-2, KRTAP12-4, PRR20D, PRR20C, PRR20E, KRTAP19-3, FBXO17, PLEKHA4, HCVgp1, PRNP, NUPR1, BRD4, USP15, RIN3, ACTB, PFN1, PRPH, RDX, TJP2, VASP, VIM, NAA40, FAM24B, RPL35A, HSPA1A, BTF3, EP300, STAT1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SRCIN1
LASP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	SRCIN1	chr17:36761937	chr17:37070578	ENST00000264659	-	1	19	647_697	7.333333333333333	1184.0	SNAP25
Hgene	SRCIN1	chr17:36761939	chr17:37070576	ENST00000264659	-	1	19	647_697	7.333333333333333	1184.0	SNAP25

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Related Drugs to SRCIN1-LASP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SRCIN1-LASP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	LASP1	C0004352	Autistic Disorder	1	CTD_human
Tgene	LASP1	C0014170	Endometrial Neoplasms	1	CTD_human
Tgene	LASP1	C0036341	Schizophrenia	1	PSYGENET
Tgene	LASP1	C0476089	Endometrial Carcinoma	1	CTD_human