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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SRI-PIP4K2C

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SRI-PIP4K2C
FusionPDB ID: 86407
FusionGDB2.0 ID: 86407
HgeneTgene
Gene symbol

SRI

PIP4K2C

Gene ID

6717

79837

Gene namesorcinphosphatidylinositol-5-phosphate 4-kinase type 2 gamma
SynonymsCP-22|CP22|SCN|V19PIP5K2C
Cytomap

7q21.12

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionsorcin22 kDa proteinH_RG167B05.1calcium binding protein amplified in mutlidrug-resistant cellsphosphatidylinositol 5-phosphate 4-kinase type-2 gammaPI(5)P 4-kinase type II gammaPIP4KII-gammaphosphatidylinositol 4-phosphate 5-kinasephosphatidylinositol 5-phosphate 4-kinase type II gammaphosphatidylinositol-4-phosphate 5-kinase, type II, gamma
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000265729, ENST00000394641, 
ENST00000419179, ENST00000431660, 
ENST00000490437, 		ENST00000354947, 
ENST00000422156, ENST00000540759, 
ENST00000550465, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 5 X 4=12010 X 15 X 6=900
# samples 715
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/900*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SRI [Title/Abstract] AND PIP4K2C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SRI(87840197)-PIP4K2C(57987808), # samples:2
SRI(87840196)-PIP4K2C(57987807), # samples:2
Anticipated loss of major functional domain due to fusion event.SRI-PIP4K2C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SRI-PIP4K2C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SRI-PIP4K2C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SRI-PIP4K2C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSRI

GO:0060315

negative regulation of ryanodine-sensitive calcium-release channel activity

17699613


check buttonFusion gene breakpoints across SRI (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PIP4K2C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6BH-01ASRIchr7

87840196

-PIP4K2Cchr12

57987807

+
ChimerDB4SARCTCGA-DX-A6BH-01ASRIchr7

87840197

-PIP4K2Cchr12

57987808

+
ChimerDB4SARCTCGA-DX-A6BHSRIchr7

87840196

-PIP4K2Cchr12

57987807

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265729SRIchr787840197-ENST00000422156PIP4K2Cchr1257987808+1570302531249398
ENST00000265729SRIchr787840197-ENST00000540759PIP4K2Cchr1257987808+2914302531393446
ENST00000265729SRIchr787840197-ENST00000550465PIP4K2Cchr1257987808+1613302531339428
ENST00000265729SRIchr787840197-ENST00000354947PIP4K2Cchr1257987808+3036302531393446
ENST00000419179SRIchr787840197-ENST00000422156PIP4K2Cchr1257987808+1527259101206398
ENST00000419179SRIchr787840197-ENST00000540759PIP4K2Cchr1257987808+2871259101350446
ENST00000419179SRIchr787840197-ENST00000550465PIP4K2Cchr1257987808+1570259101296428
ENST00000419179SRIchr787840197-ENST00000354947PIP4K2Cchr1257987808+2993259101350446
ENST00000490437SRIchr787840197-ENST00000422156PIP4K2Cchr1257987808+1450182621129355
ENST00000490437SRIchr787840197-ENST00000540759PIP4K2Cchr1257987808+2794182621273403
ENST00000490437SRIchr787840197-ENST00000550465PIP4K2Cchr1257987808+1493182621219385
ENST00000490437SRIchr787840197-ENST00000354947PIP4K2Cchr1257987808+2916182621273403
ENST00000394641SRIchr787840197-ENST00000422156PIP4K2Cchr1257987808+1551283791230383
ENST00000394641SRIchr787840197-ENST00000540759PIP4K2Cchr1257987808+2895283791374431
ENST00000394641SRIchr787840197-ENST00000550465PIP4K2Cchr1257987808+1594283791320413
ENST00000394641SRIchr787840197-ENST00000354947PIP4K2Cchr1257987808+3017283791374431
ENST00000431660SRIchr787840197-ENST00000422156PIP4K2Cchr1257987808+1534266621213383
ENST00000431660SRIchr787840197-ENST00000540759PIP4K2Cchr1257987808+2878266621357431
ENST00000431660SRIchr787840197-ENST00000550465PIP4K2Cchr1257987808+1577266621303413
ENST00000431660SRIchr787840197-ENST00000354947PIP4K2Cchr1257987808+3000266621357431
ENST00000265729SRIchr787840196-ENST00000422156PIP4K2Cchr1257987807+1570302531249398
ENST00000265729SRIchr787840196-ENST00000540759PIP4K2Cchr1257987807+2914302531393446
ENST00000265729SRIchr787840196-ENST00000550465PIP4K2Cchr1257987807+1613302531339428
ENST00000265729SRIchr787840196-ENST00000354947PIP4K2Cchr1257987807+3036302531393446
ENST00000419179SRIchr787840196-ENST00000422156PIP4K2Cchr1257987807+1527259101206398
ENST00000419179SRIchr787840196-ENST00000540759PIP4K2Cchr1257987807+2871259101350446
ENST00000419179SRIchr787840196-ENST00000550465PIP4K2Cchr1257987807+1570259101296428
ENST00000419179SRIchr787840196-ENST00000354947PIP4K2Cchr1257987807+2993259101350446
ENST00000490437SRIchr787840196-ENST00000422156PIP4K2Cchr1257987807+1450182621129355
ENST00000490437SRIchr787840196-ENST00000540759PIP4K2Cchr1257987807+2794182621273403
ENST00000490437SRIchr787840196-ENST00000550465PIP4K2Cchr1257987807+1493182621219385
ENST00000490437SRIchr787840196-ENST00000354947PIP4K2Cchr1257987807+2916182621273403
ENST00000394641SRIchr787840196-ENST00000422156PIP4K2Cchr1257987807+1551283791230383
ENST00000394641SRIchr787840196-ENST00000540759PIP4K2Cchr1257987807+2895283791374431
ENST00000394641SRIchr787840196-ENST00000550465PIP4K2Cchr1257987807+1594283791320413
ENST00000394641SRIchr787840196-ENST00000354947PIP4K2Cchr1257987807+3017283791374431
ENST00000431660SRIchr787840196-ENST00000422156PIP4K2Cchr1257987807+1534266621213383
ENST00000431660SRIchr787840196-ENST00000540759PIP4K2Cchr1257987807+2878266621357431
ENST00000431660SRIchr787840196-ENST00000550465PIP4K2Cchr1257987807+1577266621303413
ENST00000431660SRIchr787840196-ENST00000354947PIP4K2Cchr1257987807+3000266621357431

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265729ENST00000422156SRIchr787840197-PIP4K2Cchr1257987808+0.0009893920.99901056
ENST00000265729ENST00000540759SRIchr787840197-PIP4K2Cchr1257987808+0.0008334940.9991665
ENST00000265729ENST00000550465SRIchr787840197-PIP4K2Cchr1257987808+0.0006488290.9993512
ENST00000265729ENST00000354947SRIchr787840197-PIP4K2Cchr1257987808+0.0008860740.99911386
ENST00000419179ENST00000422156SRIchr787840197-PIP4K2Cchr1257987808+0.0008699010.9991301
ENST00000419179ENST00000540759SRIchr787840197-PIP4K2Cchr1257987808+0.0007773180.99922264
ENST00000419179ENST00000550465SRIchr787840197-PIP4K2Cchr1257987808+0.0005510190.99944896
ENST00000419179ENST00000354947SRIchr787840197-PIP4K2Cchr1257987808+0.0008469050.99915314
ENST00000490437ENST00000422156SRIchr787840197-PIP4K2Cchr1257987808+0.0006793760.9993206
ENST00000490437ENST00000540759SRIchr787840197-PIP4K2Cchr1257987808+0.0018266580.99817336
ENST00000490437ENST00000550465SRIchr787840197-PIP4K2Cchr1257987808+0.0008933720.9991066
ENST00000490437ENST00000354947SRIchr787840197-PIP4K2Cchr1257987808+0.0019775070.99802256
ENST00000394641ENST00000422156SRIchr787840197-PIP4K2Cchr1257987808+0.0004737770.99952626
ENST00000394641ENST00000540759SRIchr787840197-PIP4K2Cchr1257987808+0.0003931580.9996069
ENST00000394641ENST00000550465SRIchr787840197-PIP4K2Cchr1257987808+0.000532280.9994678
ENST00000394641ENST00000354947SRIchr787840197-PIP4K2Cchr1257987808+0.0004156520.9995844
ENST00000431660ENST00000422156SRIchr787840197-PIP4K2Cchr1257987808+0.0004723620.9995277
ENST00000431660ENST00000540759SRIchr787840197-PIP4K2Cchr1257987808+0.0003850470.99961495
ENST00000431660ENST00000550465SRIchr787840197-PIP4K2Cchr1257987808+0.0005267880.9994733
ENST00000431660ENST00000354947SRIchr787840197-PIP4K2Cchr1257987808+0.0004123980.9995876
ENST00000265729ENST00000422156SRIchr787840196-PIP4K2Cchr1257987807+0.0009893920.99901056
ENST00000265729ENST00000540759SRIchr787840196-PIP4K2Cchr1257987807+0.0008334940.9991665
ENST00000265729ENST00000550465SRIchr787840196-PIP4K2Cchr1257987807+0.0006488290.9993512
ENST00000265729ENST00000354947SRIchr787840196-PIP4K2Cchr1257987807+0.0008860740.99911386
ENST00000419179ENST00000422156SRIchr787840196-PIP4K2Cchr1257987807+0.0008699010.9991301
ENST00000419179ENST00000540759SRIchr787840196-PIP4K2Cchr1257987807+0.0007773180.99922264
ENST00000419179ENST00000550465SRIchr787840196-PIP4K2Cchr1257987807+0.0005510190.99944896
ENST00000419179ENST00000354947SRIchr787840196-PIP4K2Cchr1257987807+0.0008469050.99915314
ENST00000490437ENST00000422156SRIchr787840196-PIP4K2Cchr1257987807+0.0006793760.9993206
ENST00000490437ENST00000540759SRIchr787840196-PIP4K2Cchr1257987807+0.0018266580.99817336
ENST00000490437ENST00000550465SRIchr787840196-PIP4K2Cchr1257987807+0.0008933720.9991066
ENST00000490437ENST00000354947SRIchr787840196-PIP4K2Cchr1257987807+0.0019775070.99802256
ENST00000394641ENST00000422156SRIchr787840196-PIP4K2Cchr1257987807+0.0004737770.99952626
ENST00000394641ENST00000540759SRIchr787840196-PIP4K2Cchr1257987807+0.0003931580.9996069
ENST00000394641ENST00000550465SRIchr787840196-PIP4K2Cchr1257987807+0.000532280.9994678
ENST00000394641ENST00000354947SRIchr787840196-PIP4K2Cchr1257987807+0.0004156520.9995844
ENST00000431660ENST00000422156SRIchr787840196-PIP4K2Cchr1257987807+0.0004723620.9995277
ENST00000431660ENST00000540759SRIchr787840196-PIP4K2Cchr1257987807+0.0003850470.99961495
ENST00000431660ENST00000550465SRIchr787840196-PIP4K2Cchr1257987807+0.0005267880.9994733
ENST00000431660ENST00000354947SRIchr787840196-PIP4K2Cchr1257987807+0.0004123980.9995876

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>86407_86407_1_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000265729_PIP4K2C_chr12_57987807_ENST00000354947_length(amino acids)=446AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVS
SEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDF
LNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGY

--------------------------------------------------------------

>86407_86407_2_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000265729_PIP4K2C_chr12_57987807_ENST00000422156_length(amino acids)=398AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVM
RNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRG
SEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKK

--------------------------------------------------------------

>86407_86407_3_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000265729_PIP4K2C_chr12_57987807_ENST00000540759_length(amino acids)=446AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVS
SEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDF
LNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGY

--------------------------------------------------------------

>86407_86407_4_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000265729_PIP4K2C_chr12_57987807_ENST00000550465_length(amino acids)=428AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYI
VKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFL
EKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDV

--------------------------------------------------------------

>86407_86407_5_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000394641_PIP4K2C_chr12_57987807_ENST00000354947_length(amino acids)=431AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYH
QYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKK
IFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESF

--------------------------------------------------------------

>86407_86407_6_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000394641_PIP4K2C_chr12_57987807_ENST00000422156_length(amino acids)=383AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYD
LKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESE
VDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGA

--------------------------------------------------------------

>86407_86407_7_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000394641_PIP4K2C_chr12_57987807_ENST00000540759_length(amino acids)=431AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYH
QYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKK
IFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESF

--------------------------------------------------------------

>86407_86407_8_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000394641_PIP4K2C_chr12_57987807_ENST00000550465_length(amino acids)=413AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGM
YRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKI
MDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVY

--------------------------------------------------------------

>86407_86407_9_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000419179_PIP4K2C_chr12_57987807_ENST00000354947_length(amino acids)=446AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVS
SEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDF
LNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGY

--------------------------------------------------------------

>86407_86407_10_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000419179_PIP4K2C_chr12_57987807_ENST00000422156_length(amino acids)=398AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVM
RNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRG
SEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKK

--------------------------------------------------------------

>86407_86407_11_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000419179_PIP4K2C_chr12_57987807_ENST00000540759_length(amino acids)=446AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVS
SEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDF
LNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGY

--------------------------------------------------------------

>86407_86407_12_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000419179_PIP4K2C_chr12_57987807_ENST00000550465_length(amino acids)=428AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYI
VKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFL
EKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDV

--------------------------------------------------------------

>86407_86407_13_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000431660_PIP4K2C_chr12_57987807_ENST00000354947_length(amino acids)=431AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYH
QYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKK
IFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESF

--------------------------------------------------------------

>86407_86407_14_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000431660_PIP4K2C_chr12_57987807_ENST00000422156_length(amino acids)=383AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYD
LKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESE
VDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGA

--------------------------------------------------------------

>86407_86407_15_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000431660_PIP4K2C_chr12_57987807_ENST00000540759_length(amino acids)=431AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYH
QYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKK
IFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESF

--------------------------------------------------------------

>86407_86407_16_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000431660_PIP4K2C_chr12_57987807_ENST00000550465_length(amino acids)=413AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGM
YRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKI
MDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVY

--------------------------------------------------------------

>86407_86407_17_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000490437_PIP4K2C_chr12_57987807_ENST00000354947_length(amino acids)=403AA_BP=40
MQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVF
RNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDS
YMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIH
DIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQ

--------------------------------------------------------------

>86407_86407_18_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000490437_PIP4K2C_chr12_57987807_ENST00000422156_length(amino acids)=355AA_BP=40
MQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVF
RNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFL
NKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYI

--------------------------------------------------------------

>86407_86407_19_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000490437_PIP4K2C_chr12_57987807_ENST00000540759_length(amino acids)=403AA_BP=40
MQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVF
RNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDS
YMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIH
DIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQ

--------------------------------------------------------------

>86407_86407_20_SRI-PIP4K2C_SRI_chr7_87840196_ENST00000490437_PIP4K2C_chr12_57987807_ENST00000550465_length(amino acids)=385AA_BP=40
MQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASSKIKEYCPQVFRNLRDRFGIDDQDYLVSL
TRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRK
YDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDE
SEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGA

--------------------------------------------------------------

>86407_86407_21_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000265729_PIP4K2C_chr12_57987808_ENST00000354947_length(amino acids)=446AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVS
SEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDF
LNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGY

--------------------------------------------------------------

>86407_86407_22_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000265729_PIP4K2C_chr12_57987808_ENST00000422156_length(amino acids)=398AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVM
RNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRG
SEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKK

--------------------------------------------------------------

>86407_86407_23_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000265729_PIP4K2C_chr12_57987808_ENST00000540759_length(amino acids)=446AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVS
SEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDF
LNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGY

--------------------------------------------------------------

>86407_86407_24_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000265729_PIP4K2C_chr12_57987808_ENST00000550465_length(amino acids)=428AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYI
VKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFL
EKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDV

--------------------------------------------------------------

>86407_86407_25_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000394641_PIP4K2C_chr12_57987808_ENST00000354947_length(amino acids)=431AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYH
QYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKK
IFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESF

--------------------------------------------------------------

>86407_86407_26_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000394641_PIP4K2C_chr12_57987808_ENST00000422156_length(amino acids)=383AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYD
LKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESE
VDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGA

--------------------------------------------------------------

>86407_86407_27_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000394641_PIP4K2C_chr12_57987808_ENST00000540759_length(amino acids)=431AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYH
QYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKK
IFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESF

--------------------------------------------------------------

>86407_86407_28_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000394641_PIP4K2C_chr12_57987808_ENST00000550465_length(amino acids)=413AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGM
YRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKI
MDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVY

--------------------------------------------------------------

>86407_86407_29_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000419179_PIP4K2C_chr12_57987808_ENST00000354947_length(amino acids)=446AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVS
SEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDF
LNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGY

--------------------------------------------------------------

>86407_86407_30_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000419179_PIP4K2C_chr12_57987808_ENST00000422156_length(amino acids)=398AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVM
RNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRG
SEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKK

--------------------------------------------------------------

>86407_86407_31_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000419179_PIP4K2C_chr12_57987808_ENST00000540759_length(amino acids)=446AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVS
SEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDF
LNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGY

--------------------------------------------------------------

>86407_86407_32_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000419179_PIP4K2C_chr12_57987808_ENST00000550465_length(amino acids)=428AA_BP=83
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYI
VKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFL
EKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDV

--------------------------------------------------------------

>86407_86407_33_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000431660_PIP4K2C_chr12_57987808_ENST00000354947_length(amino acids)=431AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYH
QYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKK
IFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESF

--------------------------------------------------------------

>86407_86407_34_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000431660_PIP4K2C_chr12_57987808_ENST00000422156_length(amino acids)=383AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYD
LKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESE
VDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGA

--------------------------------------------------------------

>86407_86407_35_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000431660_PIP4K2C_chr12_57987808_ENST00000540759_length(amino acids)=431AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYH
QYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKK
IFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESF

--------------------------------------------------------------

>86407_86407_36_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000431660_PIP4K2C_chr12_57987808_ENST00000550465_length(amino acids)=413AA_BP=68
MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASS
KIKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGM
YRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKI
MDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVY

--------------------------------------------------------------

>86407_86407_37_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000490437_PIP4K2C_chr12_57987808_ENST00000354947_length(amino acids)=403AA_BP=40
MQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVF
RNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDS
YMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIH
DIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQ

--------------------------------------------------------------

>86407_86407_38_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000490437_PIP4K2C_chr12_57987808_ENST00000422156_length(amino acids)=355AA_BP=40
MQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVF
RNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFL
NKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYI

--------------------------------------------------------------

>86407_86407_39_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000490437_PIP4K2C_chr12_57987808_ENST00000540759_length(amino acids)=403AA_BP=40
MQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVF
RNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDS
YMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIH
DIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQ

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>86407_86407_40_SRI-PIP4K2C_SRI_chr7_87840197_ENST00000490437_PIP4K2C_chr12_57987808_ENST00000550465_length(amino acids)=385AA_BP=40
MQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQVPPPVMLLPDDFKASSKIKEYCPQVFRNLRDRFGIDDQDYLVSL
TRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRK
YDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDE
SEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:87840197/chr12:57987808)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRIchr7:87840196chr12:57987807ENST00000265729-4829_6483.0199.0DomainEF-hand 1
HgeneSRIchr7:87840196chr12:57987807ENST00000394641-4829_6468.0184.0DomainEF-hand 1
HgeneSRIchr7:87840197chr12:57987808ENST00000265729-4829_6483.0199.0DomainEF-hand 1
HgeneSRIchr7:87840197chr12:57987808ENST00000394641-4829_6468.0184.0DomainEF-hand 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRIchr7:87840196chr12:57987807ENST00000265729-48113_12483.0199.0Calcium binding2
HgeneSRIchr7:87840196chr12:57987807ENST00000265729-4883_9483.0199.0Calcium binding1
HgeneSRIchr7:87840196chr12:57987807ENST00000394641-48113_12468.0184.0Calcium binding2
HgeneSRIchr7:87840196chr12:57987807ENST00000394641-4883_9468.0184.0Calcium binding1
HgeneSRIchr7:87840197chr12:57987808ENST00000265729-48113_12483.0199.0Calcium binding2
HgeneSRIchr7:87840197chr12:57987808ENST00000265729-4883_9483.0199.0Calcium binding1
HgeneSRIchr7:87840197chr12:57987808ENST00000394641-48113_12468.0184.0Calcium binding2
HgeneSRIchr7:87840197chr12:57987808ENST00000394641-4883_9468.0184.0Calcium binding1
HgeneSRIchr7:87840196chr12:57987807ENST00000265729-48100_13583.0199.0DomainEF-hand 3
HgeneSRIchr7:87840196chr12:57987807ENST00000265729-48134_16983.0199.0DomainEF-hand 4
HgeneSRIchr7:87840196chr12:57987807ENST00000265729-4870_10383.0199.0DomainEF-hand 2
HgeneSRIchr7:87840196chr12:57987807ENST00000394641-48100_13568.0184.0DomainEF-hand 3
HgeneSRIchr7:87840196chr12:57987807ENST00000394641-48134_16968.0184.0DomainEF-hand 4
HgeneSRIchr7:87840196chr12:57987807ENST00000394641-4870_10368.0184.0DomainEF-hand 2
HgeneSRIchr7:87840197chr12:57987808ENST00000265729-48100_13583.0199.0DomainEF-hand 3
HgeneSRIchr7:87840197chr12:57987808ENST00000265729-48134_16983.0199.0DomainEF-hand 4
HgeneSRIchr7:87840197chr12:57987808ENST00000265729-4870_10383.0199.0DomainEF-hand 2
HgeneSRIchr7:87840197chr12:57987808ENST00000394641-48100_13568.0184.0DomainEF-hand 3
HgeneSRIchr7:87840197chr12:57987808ENST00000394641-48134_16968.0184.0DomainEF-hand 4
HgeneSRIchr7:87840197chr12:57987808ENST00000394641-4870_10368.0184.0DomainEF-hand 2
TgenePIP4K2Cchr7:87840196chr12:57987807ENST0000035494701043_42058.0422.0DomainPIPK
TgenePIP4K2Cchr7:87840196chr12:57987807ENST000004221560943_42058.0374.0DomainPIPK
TgenePIP4K2Cchr7:87840196chr12:57987807ENST0000054075901143_42058.0831.6666666666666DomainPIPK
TgenePIP4K2Cchr7:87840196chr12:57987807ENST0000055046501043_42058.0404.0DomainPIPK
TgenePIP4K2Cchr7:87840197chr12:57987808ENST0000035494701043_42058.0422.0DomainPIPK
TgenePIP4K2Cchr7:87840197chr12:57987808ENST000004221560943_42058.0374.0DomainPIPK
TgenePIP4K2Cchr7:87840197chr12:57987808ENST0000054075901143_42058.0831.6666666666666DomainPIPK
TgenePIP4K2Cchr7:87840197chr12:57987808ENST0000055046501043_42058.0404.0DomainPIPK


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>934_SRI_87840196_PIP4K2C_57987807_934_SRI_87840196_PIP4K2C_57987807_ranked_0.pdbSRI8784019687840196ENST00000354947PIP4K2Cchr1257987807+
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDINELSQV
PPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVS
SEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDF
LNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGY
446


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SRI_pLDDT.png
all structure
all structure
PIP4K2C_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SRI
PIP4K2C


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SRI-PIP4K2C


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SRI-PIP4K2C


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource