UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:B3GALNT2-BMPR1B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: B3GALNT2-BMPR1B
	FusionPDB ID: 8658
	FusionGDB2.0 ID: 8658
		Hgene	Tgene
	Gene symbol	B3GALNT2	BMPR1B
	Gene ID	148789	658
	Gene name	beta-1,3-N-acetylgalactosaminyltransferase 2	bone morphogenetic protein receptor type 1B
	Synonyms	B3GalNAc-T2\|MDDGA11	ALK-6\|ALK6\|AMDD\|BDA1D\|BDA2\|CDw293
	Cytomap	1q42.3	4q22.3
	Type of gene	protein-coding	protein-coding
	Description	UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2UDP-GalNAc:betaGlcNAc beta-1,3-galactosaminyltransferase, polypeptide 2beta-1,3-GalNAc-T2	bone morphogenetic protein receptor type-1BBMP type-1B receptorBMPR-1Bactivin receptor-like kinase 6bone morphogenetic protein receptor, type IBserine/threonine receptor kinase
	Modification date	20200313	20200313
	UniProtAcc	Q8NCR0	O00238
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000313984, ENST00000366600, ENST00000494378,	ENST00000502683, ENST00000264568, ENST00000394931, ENST00000440890, ENST00000515059,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 8 X 7=392	12 X 12 X 4=576
	# samples	8	12
	** MAII score	log2(8/392*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/576*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: B3GALNT2 [Title/Abstract] AND BMPR1B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	B3GALNT2(235657990)-BMPR1B(96046133), # samples:1
Anticipated loss of major functional domain due to fusion event.	B3GALNT2-BMPR1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. B3GALNT2-BMPR1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. B3GALNT2-BMPR1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. B3GALNT2-BMPR1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	B3GALNT2	GO:0006493	protein O-linked glycosylation	23929950
Tgene	BMPR1B	GO:0006468	protein phosphorylation	12065756
Tgene	BMPR1B	GO:0030509	BMP signaling pathway	18436533

Fusion gene breakpoints across B3GALNT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BMPR1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A1IU	B3GALNT2	chr1	235657990	-	BMPR1B	chr4	96046133	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366600	B3GALNT2	chr1	235657990	-	ENST00000515059	BMPR1B	chr4	96046133	+	5327	489	49	1551	500
ENST00000366600	B3GALNT2	chr1	235657990	-	ENST00000440890	BMPR1B	chr4	96046133	+	1696	489	49	1551	500
ENST00000366600	B3GALNT2	chr1	235657990	-	ENST00000264568	BMPR1B	chr4	96046133	+	1696	489	49	1551	500
ENST00000366600	B3GALNT2	chr1	235657990	-	ENST00000394931	BMPR1B	chr4	96046133	+	1895	489	49	1551	500
ENST00000313984	B3GALNT2	chr1	235657990	-	ENST00000515059	BMPR1B	chr4	96046133	+	5391	553	170	1615	481
ENST00000313984	B3GALNT2	chr1	235657990	-	ENST00000440890	BMPR1B	chr4	96046133	+	1760	553	170	1615	481
ENST00000313984	B3GALNT2	chr1	235657990	-	ENST00000264568	BMPR1B	chr4	96046133	+	1760	553	170	1615	481
ENST00000313984	B3GALNT2	chr1	235657990	-	ENST00000394931	BMPR1B	chr4	96046133	+	1959	553	170	1615	481

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366600	ENST00000515059	B3GALNT2	chr1	235657990	-	BMPR1B	chr4	96046133	+	0.000218835	0.9997812
ENST00000366600	ENST00000440890	B3GALNT2	chr1	235657990	-	BMPR1B	chr4	96046133	+	0.00363899	0.99636096
ENST00000366600	ENST00000264568	B3GALNT2	chr1	235657990	-	BMPR1B	chr4	96046133	+	0.00363899	0.99636096
ENST00000366600	ENST00000394931	B3GALNT2	chr1	235657990	-	BMPR1B	chr4	96046133	+	0.002737373	0.9972626
ENST00000313984	ENST00000515059	B3GALNT2	chr1	235657990	-	BMPR1B	chr4	96046133	+	0.000480829	0.9995192
ENST00000313984	ENST00000440890	B3GALNT2	chr1	235657990	-	BMPR1B	chr4	96046133	+	0.011176093	0.98882395
ENST00000313984	ENST00000264568	B3GALNT2	chr1	235657990	-	BMPR1B	chr4	96046133	+	0.011176093	0.98882395
ENST00000313984	ENST00000394931	B3GALNT2	chr1	235657990	-	BMPR1B	chr4	96046133	+	0.007132756	0.99286723

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8658_8658_1_B3GALNT2-BMPR1B_B3GALNT2_chr1_235657990_ENST00000313984_BMPR1B_chr4_96046133_ENST00000264568_length(amino acids)=481AA_BP=37
MRNWLVLLCPCVLGAALHLWLRLRSPPPACASGAGPAGGVSLLLPRLECNGAVSAHPNLHLPGSRDSPASASQVAGITDQLALFPQWKST
HYDVVVGVLSARNNHELRNVIRSTWMRHLLQHPTLSQRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIA
KQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYL
KSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE
VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMT

--------------------------------------------------------------

>8658_8658_2_B3GALNT2-BMPR1B_B3GALNT2_chr1_235657990_ENST00000313984_BMPR1B_chr4_96046133_ENST00000394931_length(amino acids)=481AA_BP=37
MRNWLVLLCPCVLGAALHLWLRLRSPPPACASGAGPAGGVSLLLPRLECNGAVSAHPNLHLPGSRDSPASASQVAGITDQLALFPQWKST
HYDVVVGVLSARNNHELRNVIRSTWMRHLLQHPTLSQRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIA
KQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYL
KSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE
VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMT

--------------------------------------------------------------

>8658_8658_3_B3GALNT2-BMPR1B_B3GALNT2_chr1_235657990_ENST00000313984_BMPR1B_chr4_96046133_ENST00000440890_length(amino acids)=481AA_BP=37
MRNWLVLLCPCVLGAALHLWLRLRSPPPACASGAGPAGGVSLLLPRLECNGAVSAHPNLHLPGSRDSPASASQVAGITDQLALFPQWKST
HYDVVVGVLSARNNHELRNVIRSTWMRHLLQHPTLSQRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIA
KQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYL
KSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE
VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMT

--------------------------------------------------------------

>8658_8658_4_B3GALNT2-BMPR1B_B3GALNT2_chr1_235657990_ENST00000313984_BMPR1B_chr4_96046133_ENST00000515059_length(amino acids)=481AA_BP=37
MRNWLVLLCPCVLGAALHLWLRLRSPPPACASGAGPAGGVSLLLPRLECNGAVSAHPNLHLPGSRDSPASASQVAGITDQLALFPQWKST
HYDVVVGVLSARNNHELRNVIRSTWMRHLLQHPTLSQRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIA
KQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYL
KSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE
VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMT

--------------------------------------------------------------

>8658_8658_5_B3GALNT2-BMPR1B_B3GALNT2_chr1_235657990_ENST00000366600_BMPR1B_chr4_96046133_ENST00000264568_length(amino acids)=500AA_BP=146
MRDRRSGAGSCEEPSRRRRARGRACSEWSLVSRRPSVSALAGPLPLRRDAGEPGSRRGRPMRNWLVLLCPCVLGAALHLWLRLRSPPPAC
ASGAGPADQLALFPQWKSTHYDVVVGVLSARNNHELRNVIRSTWMRHLLQHPTLSQRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQ
SQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSW
TQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTN
EVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPS

--------------------------------------------------------------

>8658_8658_6_B3GALNT2-BMPR1B_B3GALNT2_chr1_235657990_ENST00000366600_BMPR1B_chr4_96046133_ENST00000394931_length(amino acids)=500AA_BP=146
MRDRRSGAGSCEEPSRRRRARGRACSEWSLVSRRPSVSALAGPLPLRRDAGEPGSRRGRPMRNWLVLLCPCVLGAALHLWLRLRSPPPAC
ASGAGPADQLALFPQWKSTHYDVVVGVLSARNNHELRNVIRSTWMRHLLQHPTLSQRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQ
SQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSW
TQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTN
EVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPS

--------------------------------------------------------------

>8658_8658_7_B3GALNT2-BMPR1B_B3GALNT2_chr1_235657990_ENST00000366600_BMPR1B_chr4_96046133_ENST00000440890_length(amino acids)=500AA_BP=146
MRDRRSGAGSCEEPSRRRRARGRACSEWSLVSRRPSVSALAGPLPLRRDAGEPGSRRGRPMRNWLVLLCPCVLGAALHLWLRLRSPPPAC
ASGAGPADQLALFPQWKSTHYDVVVGVLSARNNHELRNVIRSTWMRHLLQHPTLSQRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQ
SQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSW
TQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTN
EVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPS

--------------------------------------------------------------

>8658_8658_8_B3GALNT2-BMPR1B_B3GALNT2_chr1_235657990_ENST00000366600_BMPR1B_chr4_96046133_ENST00000515059_length(amino acids)=500AA_BP=146
MRDRRSGAGSCEEPSRRRRARGRACSEWSLVSRRPSVSALAGPLPLRRDAGEPGSRRGRPMRNWLVLLCPCVLGAALHLWLRLRSPPPAC
ASGAGPADQLALFPQWKSTHYDVVVGVLSARNNHELRNVIRSTWMRHLLQHPTLSQRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQ
SQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSW
TQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTN
EVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:235657990/chr4:96046133)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
B3GALNT2 Q8NCR0	BMPR1B O00238
FUNCTION: Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. {ECO:0000269\|PubMed:14724282, ECO:0000269\|PubMed:23453667, ECO:0000269\|PubMed:23929950}.	FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. {ECO:0000250\|UniProtKB:P36898}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

B3GALNT2

chr1:235657990

chr4:96046133

ENST00000313984

1_6

127.66666666666667

327.0

Topological domain

Cytoplasmic

Hgene

B3GALNT2

chr1:235657990

chr4:96046133

ENST00000366600

1_6

86.66666666666667

501.0

Topological domain

Cytoplasmic

Hgene

B3GALNT2

chr1:235657990

chr4:96046133

ENST00000313984

7_23

127.66666666666667

327.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

B3GALNT2

chr1:235657990

chr4:96046133

ENST00000366600

7_23

86.66666666666667

501.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000264568

174_203

148.66666666666666

503.0

Domain

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000264568

204_494

148.66666666666666

503.0

Domain

Protein kinase

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000394931

174_203

148.66666666666666

503.0

Domain

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000394931

204_494

148.66666666666666

503.0

Domain

Protein kinase

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000440890

204_494

178.66666666666666

533.0

Domain

Protein kinase

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000515059

174_203

148.66666666666666

503.0

Domain

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000515059

204_494

148.66666666666666

503.0

Domain

Protein kinase

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000264568

210_218

148.66666666666666

503.0

Nucleotide binding

ATP

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000394931

210_218

148.66666666666666

503.0

Nucleotide binding

ATP

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000440890

210_218

178.66666666666666

533.0

Nucleotide binding

ATP

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000515059

210_218

148.66666666666666

503.0

Nucleotide binding

ATP

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000264568

149_502

148.66666666666666

503.0

Topological domain

Cytoplasmic

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000394931

149_502

148.66666666666666

503.0

Topological domain

Cytoplasmic

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000515059

149_502

148.66666666666666

503.0

Topological domain

Cytoplasmic

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

B3GALNT2

chr1:235657990

chr4:96046133

ENST00000313984

24_500

127.66666666666667

327.0

Topological domain

Lumenal

Hgene

B3GALNT2

chr1:235657990

chr4:96046133

ENST00000366600

24_500

86.66666666666667

501.0

Topological domain

Lumenal

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000440890

174_203

178.66666666666666

533.0

Domain

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000264568

14_126

148.66666666666666

503.0

Topological domain

Extracellular

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000394931

14_126

148.66666666666666

503.0

Topological domain

Extracellular

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000440890

149_502

178.66666666666666

533.0

Topological domain

Cytoplasmic

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000440890

14_126

178.66666666666666

533.0

Topological domain

Extracellular

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000515059

14_126

148.66666666666666

503.0

Topological domain

Extracellular

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000264568

127_148

148.66666666666666

503.0

Transmembrane

Helical

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000394931

127_148

148.66666666666666

503.0

Transmembrane

Helical

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000440890

127_148

178.66666666666666

533.0

Transmembrane

Helical

Tgene

BMPR1B

chr1:235657990

chr4:96046133

ENST00000515059

127_148

148.66666666666666

503.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
B3GALNT2
BMPR1B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to B3GALNT2-BMPR1B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to B3GALNT2-BMPR1B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source