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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SRSF7-HNRNPLL

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SRSF7-HNRNPLL
	FusionPDB ID: 86647
	FusionGDB2.0 ID: 86647
		Hgene	Tgene
	Gene symbol	SRSF7	HNRNPLL
	Gene ID	6432	92906
	Gene name	serine and arginine rich splicing factor 7	heterogeneous nuclear ribonucleoprotein L like
	Synonyms	9G8\|AAG3\|SFRS7	HNRPLL\|SRRF
	Cytomap	2p22.1	2p22.1
	Type of gene	protein-coding	protein-coding
	Description	serine/arginine-rich splicing factor 7SR splicing factor 7aging-associated protein 3splicing factor 9G8splicing factor, arginine/serine-rich 7, 35kDa	heterogeneous nuclear ribonucleoprotein L-likestromal RNA regulating factor
	Modification date	20200313	20200327
	UniProtAcc	.	Q8WVV9
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000313117, ENST00000409276, ENST00000446327,	ENST00000498516, ENST00000358367, ENST00000378915, ENST00000409328, ENST00000449105, ENST00000608859, ENST00000409636, ENST00000410076,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 2=32	6 X 7 X 4=168
	# samples	4	6
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/168*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SRSF7 [Title/Abstract] AND HNRNPLL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SRSF7(38973286)-HNRNPLL(38829742), # samples:2
Anticipated loss of major functional domain due to fusion event.	SRSF7-HNRNPLL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SRSF7-HNRNPLL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SRSF7-HNRNPLL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SRSF7-HNRNPLL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SRSF7-HNRNPLL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SRSF7	GO:0008380	RNA splicing	8013463
Hgene	SRSF7	GO:0048025	negative regulation of mRNA splicing, via spliceosome	15009664
Tgene	HNRNPLL	GO:0033120	positive regulation of RNA splicing	18669861

Fusion gene breakpoints across SRSF7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HNRNPLL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-DS-A1O9-01A	SRSF7	chr2	38973286	-	HNRNPLL	chr2	38829742	-
ChimerDB4	CESC	TCGA-DS-A1O9	SRSF7	chr2	38973286	-	HNRNPLL	chr2	38829742	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000313117	SRSF7	chr2	38973286	-	ENST00000409636	HNRNPLL	chr2	38829742	-	4707	900	52	2502	816
ENST00000313117	SRSF7	chr2	38973286	-	ENST00000410076	HNRNPLL	chr2	38829742	-	2514	900	52	1716	554
ENST00000409276	SRSF7	chr2	38973286	-	ENST00000409636	HNRNPLL	chr2	38829742	-	4562	755	15	2357	780
ENST00000409276	SRSF7	chr2	38973286	-	ENST00000410076	HNRNPLL	chr2	38829742	-	2369	755	15	1571	518

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000313117	ENST00000409636	SRSF7	chr2	38973286	-	HNRNPLL	chr2	38829742	-	0.000298563	0.99970144
ENST00000313117	ENST00000410076	SRSF7	chr2	38973286	-	HNRNPLL	chr2	38829742	-	0.002792976	0.997207
ENST00000409276	ENST00000409636	SRSF7	chr2	38973286	-	HNRNPLL	chr2	38829742	-	0.000276799	0.99972314
ENST00000409276	ENST00000410076	SRSF7	chr2	38973286	-	HNRNPLL	chr2	38829742	-	0.003411704	0.99658835

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>86647_86647_1_SRSF7-HNRNPLL_SRSF7_chr2_38973286_ENST00000313117_HNRNPLL_chr2_38829742_ENST00000409636_length(amino acids)=816AA_BP=1
MCRAEQRDDACAKRSGRIYKREPGLFLVVPPGLLAGEGVCQLLRHSSPGRCLLKSRARGSVIMSRYGRYGGETKVYVGNLGTGAGKGELE
RAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYD
CHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRRSRSASLRRSRSGSIKGSRYFQSPSRSRSRSRSISRPRS
SRSKSRSPSPKRRETYEEDREYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCES
VVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNP
LYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGR
RDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLF
CLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASK
NIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPNGSNPYTLKLCF

--------------------------------------------------------------

>86647_86647_2_SRSF7-HNRNPLL_SRSF7_chr2_38973286_ENST00000313117_HNRNPLL_chr2_38829742_ENST00000410076_length(amino acids)=554AA_BP=1
MCRAEQRDDACAKRSGRIYKREPGLFLVVPPGLLAGEGVCQLLRHSSPGRCLLKSRARGSVIMSRYGRYGGETKVYVGNLGTGAGKGELE
RAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYD
CHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRRSRSASLRRSRSGSIKGSRYFQSPSRSRSRSRSISRPRS
SRSKSRSPSPKRRETYEEDREYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCES
VVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNP
LYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGR

--------------------------------------------------------------

>86647_86647_3_SRSF7-HNRNPLL_SRSF7_chr2_38973286_ENST00000409276_HNRNPLL_chr2_38829742_ENST00000409636_length(amino acids)=780AA_BP=149
MAGEGVCQLLRHSSPGRCLLKSRARGSVIMSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAE
DAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYDCHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSR
GRRSRSASPRRSRSISLRRSRSASLRRSRSGSIKGSRSPSRSRSRSRSISRPRSSRSKSRSPSPKRRETYEEDREYESQAKRLKTEEGEI
DYSAEEGENRREATPRGGGDGGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENID
SAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEF
ESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPS
RYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHL
NNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTF

--------------------------------------------------------------

>86647_86647_4_SRSF7-HNRNPLL_SRSF7_chr2_38973286_ENST00000409276_HNRNPLL_chr2_38829742_ENST00000410076_length(amino acids)=518AA_BP=149
MAGEGVCQLLRHSSPGRCLLKSRARGSVIMSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAE
DAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYDCHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSR
GRRSRSASPRRSRSISLRRSRSASLRRSRSGSIKGSRSPSRSRSRSRSISRPRSSRSKSRSPSPKRRETYEEDREYESQAKRLKTEEGEI
DYSAEEGENRREATPRGGGDGGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENID
SAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEF

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:38973286/chr2:38829742)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HNRNPLL Q8WVV9
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269\|PubMed:18669861}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000313117

11_84

220.66666666666666

239.0

Domain

RRM

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000313117

153_160

220.66666666666666

239.0

Repeat

Note=1

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000313117

161_168

220.66666666666666

239.0

Repeat

Note=2

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000313117

169_176

220.66666666666666

239.0

Repeat

Note=3

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000313117

177_184

220.66666666666666

239.0

Repeat

Note=4

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000313117

211_218

220.66666666666666

239.0

Repeat

Note=5%3B approximate

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000313117

104_120

220.66666666666666

239.0

Zinc finger

CCHC-type

Tgene

HNRNPLL

chr2:38973286

chr2:38829742

ENST00000409636

2_7

3.6666666666666665

538.0

Compositional bias

Note=Poly-Ser

Tgene

HNRNPLL

chr2:38973286

chr2:38829742

ENST00000409636

49_57

3.6666666666666665

538.0

Compositional bias

Note=Poly-Gly

Tgene

HNRNPLL

chr2:38973286

chr2:38829742

ENST00000410076

2_7

3.6666666666666665

276.0

Compositional bias

Note=Poly-Ser

Tgene

HNRNPLL

chr2:38973286

chr2:38829742

ENST00000410076

49_57

3.6666666666666665

276.0

Compositional bias

Note=Poly-Gly

Tgene

HNRNPLL

chr2:38973286

chr2:38829742

ENST00000409636

166_244

3.6666666666666665

538.0

Domain

RRM 2

Tgene

HNRNPLL

chr2:38973286

chr2:38829742

ENST00000409636

335_409

3.6666666666666665

538.0

Domain

RRM 3

Tgene

HNRNPLL

chr2:38973286

chr2:38829742

ENST00000409636

76_150

3.6666666666666665

538.0

Domain

RRM 1

Tgene

HNRNPLL

chr2:38973286

chr2:38829742

ENST00000410076

166_244

3.6666666666666665

276.0

Domain

RRM 2

Tgene

HNRNPLL

chr2:38973286

chr2:38829742

ENST00000410076

335_409

3.6666666666666665

276.0

Domain

RRM 3

Tgene

HNRNPLL

chr2:38973286

chr2:38829742

ENST00000410076

76_150

3.6666666666666665

276.0

Domain

RRM 1

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000313117

121_238

220.66666666666666

239.0

Compositional bias

Note=Arg/Ser-rich (RS domain)

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000446327

121_238

227.0

Compositional bias

Note=Arg/Ser-rich (RS domain)

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000446327

11_84

227.0

Domain

RRM

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000313117

153_226

220.66666666666666

239.0

Region

Note=6 X 8 AA repeats of R-R-S-R-S-X-S-X

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000446327

153_226

227.0

Region

Note=6 X 8 AA repeats of R-R-S-R-S-X-S-X

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000313117

219_226

220.66666666666666

239.0

Repeat

Note=6%3B approximate

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000446327

153_160

227.0

Repeat

Note=1

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000446327

161_168

227.0

Repeat

Note=2

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000446327

169_176

227.0

Repeat

Note=3

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000446327

177_184

227.0

Repeat

Note=4

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000446327

211_218

227.0

Repeat

Note=5%3B approximate

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000446327

219_226

227.0

Repeat

Note=6%3B approximate

Hgene

SRSF7

chr2:38973286

chr2:38829742

ENST00000446327

104_120

227.0

Zinc finger

CCHC-type

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1594_SRSF7_38973286_HNRNPLL_38829742_ranked_0.pdb	SRSF7	38973286	38973286	ENST00000410076	HNRNPLL	chr2	38829742	-	MCRAEQRDDACAKRSGRIYKREPGLFLVVPPGLLAGEGVCQLLRHSSPGRCLLKSRARGSVIMSRYGRYGGETKVYVGNLGTGAGKGELE RAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYD CHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRRSRSASLRRSRSGSIKGSRYFQSPSRSRSRSRSISRPRS SRSKSRSPSPKRRETYEEDREYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCES VVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNP LYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGR RDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLF CLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASK NIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPNGSNPYTLKLCF	816

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

SRSF7_pLDDT.png

HNRNPLL_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SRSF7
HNRNPLL

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to SRSF7-HNRNPLL

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SRSF7-HNRNPLL

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source