UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level3
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Potential Active Site Information

leaf

Potentially Interacting Small Molecules through Virtual Screening

leaf

Biochemical Features of Small Molecules with ADME

leaf

Drug Toxicity Information

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:SS18-SSX1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SS18-SSX1
FusionPDB ID: 86682
FusionGDB2.0 ID: 86682
HgeneTgene
Gene symbol

SS18

SSX1

Gene ID

6760

6756

Gene nameSS18 subunit of BAF chromatin remodeling complexSSX family member 1
SynonymsSSXT|SYTCT5.1|SSRC
Cytomap

18q11.2

Xp11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein SSXTSS18, nBAF chromatin remodeling complex subunitsynovial sarcoma translocated to X chromosome proteinsynovial sarcoma translocation, chromosome 18synovial sarcoma, translocated to X chromosomeprotein SSX1cancer/testis antigen 5.1cancer/testis antigen family 5, member 1sarcoma, synovial, X-chromosome-related 1synovial sarcoma, X breakpoint 1
Modification date2020032920200313
UniProtAcc

O75177

Q16384

Ensembl transtripts involved in fusion geneENST idsENST00000269137, ENST00000415083, 
ENST00000539849, ENST00000542420, 
ENST00000542743, ENST00000545952, 
ENST00000585241, 		ENST00000376919, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 33 X 8=63364 X 10 X 3=120
# samples 389
** MAII scorelog2(38/6336*10)=-4.05950101174866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/120*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SS18 [Title/Abstract] AND SSX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SS18(23612363)-SSX1(48123217), # samples:7
SSX1(48121826)-SS18(23610363), # samples:1
Anticipated loss of major functional domain due to fusion event.SS18-SSX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SS18-SSX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SS18-SSX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SS18-SSX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SSX1-SS18 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SSX1-SS18 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SS18-SSX1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SS18-SSX1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSS18

GO:0045944

positive regulation of transcription by RNA polymerase II

15919756


check buttonFusion gene breakpoints across SS18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SSX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A7EOSS18chr18

23612362

-SSX1chrX

48123216

+
ChimerDB4SARCTCGA-DX-A7ERSS18chr18

23612362

-SSX1chrX

48123216

+
ChimerDB4SARCTCGA-DX-AB3B-01ASS18chr18

23612363

-SSX1chrX

48123217

+
ChimerDB4SARCTCGA-FX-A8OOSS18chr18

23612362

-SSX1chrX

48123216

+
ChimerDB4SARCTCGA-MJ-A850-01ASS18chr18

23612363

-SSX1chrX

48123217

+
ChimerDB4SARCTCGA-MJ-A850SS18chr18

23612362

-SSX1chrX

48123216

+
ChimerDB4SARCTCGA-X6-A8C7-01ASS18chr18

23612363

-SSX1chrX

48123217

+
ChimerDB4SARCTCGA-X6-A8C7SS18chr18

23612362

-SSX1chrX

48123216

+
ChimerKB3..SS18chr18

23612362

-SSX1chrX

48121200

+
ChimerKB3..SS18chr18

23612362

-SSX1chrX

48123216

+
ChimerKB3..SS18chr18

23612362

-SSX1chrX

48123278

+
ChimerKB3..SS18chr18

23615029

-SSX1chrX

48123278

+
ChimerKB3..SS18chr18

23615074

-SSX1chrX

48123215

+
ChimerKB3..SS18chr18

23670542

-SSX1chrX

48123215

+
ChimerKB4..SS18chr18

23612362

-SSX1chrX

48123216

+
ChiTaRS5.0N/AAB300354SS18chr18

23612363

-SSX1chrX

48123215

+
ChiTaRS5.0N/AAB300355SS18chr18

23612363

-SSX1chrX

48123215

+
ChiTaRS5.0N/AAF402618SS18chr18

23603577

-SSX1chrX

48123278

+
ChiTaRS5.0N/AAF404831SS18chr18

23610422

-SSX1chrX

48121902

+
ChiTaRS5.0N/AAY138487SS18chr18

23320134

-SSX1chrX

48121364

+
ChiTaRS5.0N/AS79325SS18chr18

23612363

-SSX1chrX

48123215

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000542420SS18chr1823612362-ENST00000376919SSX1chrX48121200+21651283591300413
ENST00000539849SS18chr1823612362-ENST00000376919SSX1chrX48121200+205611741901191333
ENST00000415083SS18chr1823612362-ENST00000376919SSX1chrX48123216+21181286561522488
ENST00000269137SS18chr1823612362-ENST00000376919SSX1chrX48123216+230114691611705514
ENST00000545952SS18chr1823612362-ENST00000376919SSX1chrX48123216+211612843031520405
ENST00000415083SS18chr1823612362-ENST00000376919SSX1chrX48123278+20561286561339427
ENST00000269137SS18chr1823612362-ENST00000376919SSX1chrX48123278+223914691611522453
ENST00000545952SS18chr1823612362-ENST00000376919SSX1chrX48123278+205412843031337344
ENST00000415083SS18chr1823612363-ENST00000376919SSX1chrX48123217+21181286561522488
ENST00000269137SS18chr1823612363-ENST00000376919SSX1chrX48123217+230114691611705514
ENST00000545952SS18chr1823612363-ENST00000376919SSX1chrX48123217+211612843031520405
ENST00000415083SS18chr1823612362-ENST00000376919SSX1chrX48123216+21181286561522488
ENST00000269137SS18chr1823612362-ENST00000376919SSX1chrX48123216+230114691611705514
ENST00000545952SS18chr1823612362-ENST00000376919SSX1chrX48123216+211612843031520405
ENST00000415083SS18chr1823612363-ENST00000376919SSX1chrX48123215+21181286561522488
ENST00000269137SS18chr1823612363-ENST00000376919SSX1chrX48123215+230114691611705514
ENST00000545952SS18chr1823612363-ENST00000376919SSX1chrX48123215+211612843031520405

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415083ENST00000376919SS18chr1823612363-SSX1chrX48123217+0.0023013250.9976987
ENST00000269137ENST00000376919SS18chr1823612363-SSX1chrX48123217+0.0027727260.99722725
ENST00000545952ENST00000376919SS18chr1823612363-SSX1chrX48123217+0.0011157620.99888426
ENST00000415083ENST00000376919SS18chr1823612362-SSX1chrX48123216+0.0023013250.9976987
ENST00000269137ENST00000376919SS18chr1823612362-SSX1chrX48123216+0.0027727260.99722725
ENST00000545952ENST00000376919SS18chr1823612362-SSX1chrX48123216+0.0011157620.99888426
ENST00000415083ENST00000376919SS18chr1823612363-SSX1chrX48123215+0.0023013250.9976987
ENST00000269137ENST00000376919SS18chr1823612363-SSX1chrX48123215+0.0027727260.99722725
ENST00000545952ENST00000376919SS18chr1823612363-SSX1chrX48123215+0.0011157620.99888426

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>86682_86682_1_SS18-SSX1_SS18_chr18_23612362_ENST00000269137_SSX1_chrX_48123216_ENST00000376919_length(amino acids)=514AA_BP=435
MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLADSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQ
CIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQM
NGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQ
QYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQD
AYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEDENDSK

--------------------------------------------------------------

>86682_86682_2_SS18-SSX1_SS18_chr18_23612362_ENST00000269137_SSX1_chrX_48123278_ENST00000376919_length(amino acids)=453AA_BP=436
MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLADSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQ
CIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQM
NGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQ
QYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQD
AYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQPTKRWETTAPPRKS

--------------------------------------------------------------

>86682_86682_3_SS18-SSX1_SS18_chr18_23612362_ENST00000415083_SSX1_chrX_48123216_ENST00000376919_length(amino acids)=488AA_BP=409
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGM
NQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT
MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDY
YGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG
QQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEDENDSKGVSEASGPQNDGKQLHPPGKANISEK

--------------------------------------------------------------

>86682_86682_4_SS18-SSX1_SS18_chr18_23612362_ENST00000415083_SSX1_chrX_48123278_ENST00000376919_length(amino acids)=427AA_BP=410
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGM
NQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT
MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDY
YGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG

--------------------------------------------------------------

>86682_86682_5_SS18-SSX1_SS18_chr18_23612362_ENST00000539849_SSX1_chrX_48121200_ENST00000376919_length(amino acids)=333AA_BP=
MPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQS
MPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQ
QYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQY

--------------------------------------------------------------

>86682_86682_6_SS18-SSX1_SS18_chr18_23612362_ENST00000542420_SSX1_chrX_48121200_ENST00000376919_length(amino acids)=413AA_BP=
MTSLPSPGCRDNSGRPLLPGGMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQ
SGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMS
QGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYG
DQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQ

--------------------------------------------------------------

>86682_86682_7_SS18-SSX1_SS18_chr18_23612362_ENST00000545952_SSX1_chrX_48123216_ENST00000376919_length(amino acids)=405AA_BP=326
MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ
LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM
GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP
GQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEDENDSKGVSEASGPQNDGKQLHPPG

--------------------------------------------------------------

>86682_86682_8_SS18-SSX1_SS18_chr18_23612362_ENST00000545952_SSX1_chrX_48123278_ENST00000376919_length(amino acids)=344AA_BP=327
MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ
LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM
GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP

--------------------------------------------------------------

>86682_86682_9_SS18-SSX1_SS18_chr18_23612363_ENST00000269137_SSX1_chrX_48123215_ENST00000376919_length(amino acids)=514AA_BP=435
MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLADSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQ
CIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQM
NGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQ
QYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQD
AYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEDENDSK

--------------------------------------------------------------

>86682_86682_10_SS18-SSX1_SS18_chr18_23612363_ENST00000269137_SSX1_chrX_48123217_ENST00000376919_length(amino acids)=514AA_BP=435
MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLADSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQ
CIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQM
NGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQ
QYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQD
AYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEDENDSK

--------------------------------------------------------------

>86682_86682_11_SS18-SSX1_SS18_chr18_23612363_ENST00000415083_SSX1_chrX_48123215_ENST00000376919_length(amino acids)=488AA_BP=409
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGM
NQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT
MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDY
YGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG
QQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEDENDSKGVSEASGPQNDGKQLHPPGKANISEK

--------------------------------------------------------------

>86682_86682_12_SS18-SSX1_SS18_chr18_23612363_ENST00000415083_SSX1_chrX_48123217_ENST00000376919_length(amino acids)=488AA_BP=409
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGM
NQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT
MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDY
YGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG
QQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEDENDSKGVSEASGPQNDGKQLHPPGKANISEK

--------------------------------------------------------------

>86682_86682_13_SS18-SSX1_SS18_chr18_23612363_ENST00000545952_SSX1_chrX_48123215_ENST00000376919_length(amino acids)=405AA_BP=326
MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ
LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM
GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP
GQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEDENDSKGVSEASGPQNDGKQLHPPG

--------------------------------------------------------------

>86682_86682_14_SS18-SSX1_SS18_chr18_23612363_ENST00000545952_SSX1_chrX_48123217_ENST00000376919_length(amino acids)=405AA_BP=326
MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ
LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM
GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP
GQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEDENDSKGVSEASGPQNDGKQLHPPG

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:23612363/chrX:48123217)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SS18

O75177

SSX1

Q16384

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Could act as a modulator of transcription.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSS18chr18:23612362chrX:48123216ENST00000269137-91095_99379.0388.0Compositional biasNote=Poly-Pro
HgeneSS18chr18:23612362chrX:48123216ENST00000415083-101195_99410.0419.0Compositional biasNote=Poly-Pro
HgeneSS18chr18:23612363chrX:48123215ENST00000269137-91095_99379.0388.0Compositional biasNote=Poly-Pro
HgeneSS18chr18:23612363chrX:48123215ENST00000415083-101195_99410.0419.0Compositional biasNote=Poly-Pro
HgeneSS18chr18:23612363chrX:48123217ENST00000269137-91095_99379.0388.0Compositional biasNote=Poly-Pro
HgeneSS18chr18:23612363chrX:48123217ENST00000415083-101195_99410.0419.0Compositional biasNote=Poly-Pro
HgeneSS18chr18:23612362chrX:48123216ENST00000269137-910374_377379.0388.0MotifSH2-binding
HgeneSS18chr18:23612362chrX:48123216ENST00000269137-91050_53379.0388.0MotifSH2-binding
HgeneSS18chr18:23612362chrX:48123216ENST00000415083-1011374_377410.0419.0MotifSH2-binding
HgeneSS18chr18:23612362chrX:48123216ENST00000415083-1011392_401410.0419.0MotifSH3-binding
HgeneSS18chr18:23612362chrX:48123216ENST00000415083-101150_53410.0419.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123215ENST00000269137-910374_377379.0388.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123215ENST00000269137-91050_53379.0388.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123215ENST00000415083-1011374_377410.0419.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123215ENST00000415083-1011392_401410.0419.0MotifSH3-binding
HgeneSS18chr18:23612363chrX:48123215ENST00000415083-101150_53410.0419.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123217ENST00000269137-910374_377379.0388.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123217ENST00000269137-91050_53379.0388.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123217ENST00000415083-1011374_377410.0419.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123217ENST00000415083-1011392_401410.0419.0MotifSH3-binding
HgeneSS18chr18:23612363chrX:48123217ENST00000415083-101150_53410.0419.0MotifSH2-binding
HgeneSS18chr18:23612362chrX:48123216ENST00000269137-9102_186379.0388.0RegionNote=Transcriptional activation
HgeneSS18chr18:23612362chrX:48123216ENST00000269137-910344_369379.0388.0RegionNote=2 X 13 AA imperfect tandem repeats
HgeneSS18chr18:23612362chrX:48123216ENST00000415083-10112_186410.0419.0RegionNote=Transcriptional activation
HgeneSS18chr18:23612362chrX:48123216ENST00000415083-1011344_369410.0419.0RegionNote=2 X 13 AA imperfect tandem repeats
HgeneSS18chr18:23612363chrX:48123215ENST00000269137-9102_186379.0388.0RegionNote=Transcriptional activation
HgeneSS18chr18:23612363chrX:48123215ENST00000269137-910344_369379.0388.0RegionNote=2 X 13 AA imperfect tandem repeats
HgeneSS18chr18:23612363chrX:48123215ENST00000415083-10112_186410.0419.0RegionNote=Transcriptional activation
HgeneSS18chr18:23612363chrX:48123215ENST00000415083-1011344_369410.0419.0RegionNote=2 X 13 AA imperfect tandem repeats
HgeneSS18chr18:23612363chrX:48123217ENST00000269137-9102_186379.0388.0RegionNote=Transcriptional activation
HgeneSS18chr18:23612363chrX:48123217ENST00000269137-910344_369379.0388.0RegionNote=2 X 13 AA imperfect tandem repeats
HgeneSS18chr18:23612363chrX:48123217ENST00000415083-10112_186410.0419.0RegionNote=Transcriptional activation
HgeneSS18chr18:23612363chrX:48123217ENST00000415083-1011344_369410.0419.0RegionNote=2 X 13 AA imperfect tandem repeats
HgeneSS18chr18:23612362chrX:48123216ENST00000269137-910344_356379.0388.0RepeatNote=1
HgeneSS18chr18:23612362chrX:48123216ENST00000269137-910357_369379.0388.0RepeatNote=2
HgeneSS18chr18:23612362chrX:48123216ENST00000415083-1011344_356410.0419.0RepeatNote=1
HgeneSS18chr18:23612362chrX:48123216ENST00000415083-1011357_369410.0419.0RepeatNote=2
HgeneSS18chr18:23612363chrX:48123215ENST00000269137-910344_356379.0388.0RepeatNote=1
HgeneSS18chr18:23612363chrX:48123215ENST00000269137-910357_369379.0388.0RepeatNote=2
HgeneSS18chr18:23612363chrX:48123215ENST00000415083-1011344_356410.0419.0RepeatNote=1
HgeneSS18chr18:23612363chrX:48123215ENST00000415083-1011357_369410.0419.0RepeatNote=2
HgeneSS18chr18:23612363chrX:48123217ENST00000269137-910344_356379.0388.0RepeatNote=1
HgeneSS18chr18:23612363chrX:48123217ENST00000269137-910357_369379.0388.0RepeatNote=2
HgeneSS18chr18:23612363chrX:48123217ENST00000415083-1011344_356410.0419.0RepeatNote=1
HgeneSS18chr18:23612363chrX:48123217ENST00000415083-1011357_369410.0419.0RepeatNote=2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSS18chr18:23612362chrX:48123216ENST00000269137-910175_418379.0388.0Compositional biasNote=Gln-rich
HgeneSS18chr18:23612362chrX:48123216ENST00000415083-1011175_418410.0419.0Compositional biasNote=Gln-rich
HgeneSS18chr18:23612363chrX:48123215ENST00000269137-910175_418379.0388.0Compositional biasNote=Gln-rich
HgeneSS18chr18:23612363chrX:48123215ENST00000415083-1011175_418410.0419.0Compositional biasNote=Gln-rich
HgeneSS18chr18:23612363chrX:48123217ENST00000269137-910175_418379.0388.0Compositional biasNote=Gln-rich
HgeneSS18chr18:23612363chrX:48123217ENST00000415083-1011175_418410.0419.0Compositional biasNote=Gln-rich
HgeneSS18chr18:23612362chrX:48123216ENST00000269137-910392_401379.0388.0MotifSH3-binding
HgeneSS18chr18:23612362chrX:48123216ENST00000269137-910413_416379.0388.0MotifSH2-binding
HgeneSS18chr18:23612362chrX:48123216ENST00000415083-1011413_416410.0419.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123215ENST00000269137-910392_401379.0388.0MotifSH3-binding
HgeneSS18chr18:23612363chrX:48123215ENST00000269137-910413_416379.0388.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123215ENST00000415083-1011413_416410.0419.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123217ENST00000269137-910392_401379.0388.0MotifSH3-binding
HgeneSS18chr18:23612363chrX:48123217ENST00000269137-910413_416379.0388.0MotifSH2-binding
HgeneSS18chr18:23612363chrX:48123217ENST00000415083-1011413_416410.0419.0MotifSH2-binding
TgeneSSX1chr18:23612362chrX:48123216ENST000003769194820_83110.0347.3333333333333DomainKRAB-related
TgeneSSX1chr18:23612363chrX:48123215ENST000003769194820_83110.0347.3333333333333DomainKRAB-related
TgeneSSX1chr18:23612363chrX:48123217ENST000003769194820_83110.0347.3333333333333DomainKRAB-related


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (94) >>>94.pdbFusion protein BP residue:
CIF file (94) >>>94.cif		SS18chr1823612362-SSX1chrX48121200+
MPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNH
MPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMS
QGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM
GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGP
PEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQ
QDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQG
333
3D view using mol* of 94 (AA BP:)
PDB file (106) >>>106.pdbFusion protein BP residue: 327
CIF file (106) >>>106.cif		SS18chr1823612362-SSX1chrX48123278+
MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSH
NMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNM
PSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQ
GPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPP
YRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQ
DAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQ
344
3D view using mol* of 106 (AA BP:327)
PDB file (167) >>>167.pdbFusion protein BP residue: 326
CIF file (167) >>>167.cif		SS18chr1823612362-SSX1chrX48123216+
MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSH
NMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNM
PSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQ
GPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPP
YRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQ
DAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQ
GQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEDENDSKGVSEASGPQ
NDGKQLHPPGKANISEKINKRSGPKRGKHAWTHRLRERKQLVIYEEISDP
405
3D view using mol* of 167 (AA BP:326)
PDB file (176) >>>176.pdbFusion protein BP residue:
CIF file (176) >>>176.cif		SS18chr1823612362-SSX1chrX48121200+
MTSLPSPGCRDNSGRPLLPGGMLDDNNHLIQCIMDSQNKGKTSECSQYQQ
MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSH
NMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNM
PSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQ
GPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPP
YRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQ
PSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQY
PGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQ
413
3D view using mol* of 176 (AA BP:)
PDB file (190) >>>190.pdbFusion protein BP residue: 410
CIF file (190) >>>190.cif		SS18chr1823612362-SSX1chrX48123278+
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQY
QQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPR
SHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSM
NMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQP
NQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQI
PPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGY
QQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQ
QYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQP
427
3D view using mol* of 190 (AA BP:410)
PDB file (222) >>>222.pdbFusion protein BP residue: 436
CIF file (222) >>>222.cif		SS18chr1823612362-SSX1chrX48123278+
MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLA
DSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGK
TSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQS
GPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQL
NMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPR
PNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNH
MMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPD
GNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGP
QYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQPTKRWETTAPPRKS
453
3D view using mol* of 222 (AA BP:436)
PDB file (280) >>>280.pdbFusion protein BP residue: 409
CIF file (280) >>>280.cif		SS18chr1823612362-SSX1chrX48123216+
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQY
QQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPR
SHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSM
NMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQP
NQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQI
PPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGY
QQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQ
QYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQP
PQQRPYGYDQIMPKKPAEDENDSKGVSEASGPQNDGKQLHPPGKANISEK
488
3D view using mol* of 280 (AA BP:409)
PDB file (324) >>>324.pdbFusion protein BP residue: 435
CIF file (324) >>>324.cif		SS18chr1823612362-SSX1chrX48123216+
MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLA
DSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGK
TSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQS
GPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQL
NMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPR
PNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNH
MMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPD
GNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGP
QYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEDENDSK
GVSEASGPQNDGKQLHPPGKANISEKINKRSGPKRGKHAWTHRLRERKQL
514
3D view using mol* of 324 (AA BP:435)


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SS18_pLDDT.png
all structure
all structure
SSX1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SS18_SSX1_94_PAE.png (AA BP:)
all structure
SS18_SSX1_94_pLDDT.png (AA BP:)
all structure
SS18_SSX1_94_pLDDT_and_active_sites.png (AA BP:)
all structure
SS18_SSX1_94_violinplot.png (AA BP:)
all structure
SS18_SSX1_106_PAE.png (AA BP:327)
all structure
SS18_SSX1_106_pLDDT.png (AA BP:327)
all structure
SS18_SSX1_167_PAE.png (AA BP:326)
all structure
SS18_SSX1_167_pLDDT.png (AA BP:326)
all structure
SS18_SSX1_167_pLDDT_and_active_sites.png (AA BP:326)
all structure
SS18_SSX1_167_violinplot.png (AA BP:326)
all structure
SS18_SSX1_176_PAE.png (AA BP:)
all structure
SS18_SSX1_176_pLDDT.png (AA BP:)
all structure
SS18_SSX1_176_pLDDT_and_active_sites.png (AA BP:)
all structure
SS18_SSX1_176_violinplot.png (AA BP:)
all structure
SS18_SSX1_190_pLDDT.png (AA BP:410)
all structure
SS18_SSX1_190_pLDDT_and_active_sites.png (AA BP:410)
all structure
SS18_SSX1_190_violinplot.png (AA BP:410)
all structure
SS18_SSX1_222_PAE.png (AA BP:436)
all structure
SS18_SSX1_222_pLDDT.png (AA BP:436)
all structure
SS18_SSX1_222_pLDDT_and_active_sites.png (AA BP:436)
all structure
SS18_SSX1_222_violinplot.png (AA BP:436)
all structure
SS18_SSX1_280_pLDDT.png (AA BP:409)
all structure
SS18_SSX1_280_pLDDT_and_active_sites.png (AA BP:409)
all structure
SS18_SSX1_280_violinplot.png (AA BP:409)
all structure
SS18_SSX1_324_pLDDT.png (AA BP:435)
all structure
SS18_SSX1_324_pLDDT_and_active_sites.png (AA BP:435)
all structure
SS18_SSX1_324_violinplot.png (AA BP:435)
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
SS18_SSX1_106.png
all structure
SS18_SSX1_167.png
all structure
SS18_SSX1_176.png
all structure
SS18_SSX1_190.png
all structure
SS18_SSX1_222.png
all structure
SS18_SSX1_280.png
all structure
SS18_SSX1_324.png
all structure

Top

Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
940.432130.33434.9860.8060.540.7420.1171.0070.1160.91Chain A: 58,59,60,61,114,115,116
1670.37270.14422.2950.7940.5650.9460.1161.3620.0860.505Chain A: 217,218,219,220,221,222,223
1760.665340.64365.8560.6670.5750.7670.6480.7690.8440.759Chain A: 1,2,3,4,5,6,50,53,54,57,58,61,62
1900.792520.793187.6210.6810.620.8540.8070.7881.0250.883Chain A: 6,7,8,9,10,11,12,52,55,56,59,60,63,64
2220.89750.932273.7140.7380.5880.7510.7260.7221.0050.763Chain A: 63,64,65,66,67,68,69,70,71,72,73,77,78,80
,81,84,87,88,109,110,112,113,114,116,117,120,121
2800.864700.877205.80.5980.6260.8110.7040.8740.8060.769Chain A: 5,6,7,8,9,10,11,52,55,56,59,60,63
3240.863720.881216.4330.6940.6080.8060.5020.8640.5810.556Chain A: 65,66,68,70,71,72,73,74,77,78,81,84,88,11
0,113,114,116,117,118,121

Top

Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

Top

check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

Top

Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


Top

Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SS18SMARCA2, SMARCB1, EP300, MLLT10, GRB2, Bcl7b, SMARCD1, RBM14, YWHAG, ELAVL1, CUL3, CST11, ATF2, TLE1, SMARCA5, HDAC1, HDAC2, EED, SUZ12, EZH2, SS18, NFKBID, DPF3, DPF2, SMARCE1, ARID1B, ARID1A, PHF10, SMARCC2, SMARCC1, GLTSCR1, SMARCD3, SMARCD2, SMARCA4, ARID2, DPF1, ACTL6A, ACTL6B, BCL7A, BCL7C, BCL7B, BRD9, CDKN1A, NEFM, RAB5C, SYNCRIP, Wash, FUS, DDIT3, FLI1, nsp13ab, BRD3, NR3C1, SS18L1, BRD7, PBRM1, ACTC1, STK11IP, DDX58, UBQLN2, PTPRR, T, ELF5, ERG, ETV4, FOS, GATA2, GCM1, HNF4A, IRF1, IRF4, KLF3, KLF5, LHX2, MYOD1, PAX7, SOX17, SOX2, SP7,
SSX1FUBP3, LHX4, MAGEC2, KDM2B, CDCA7L, MTURN, CFL1, CRIP2, ACO1, NCALD, CPSF7,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SS18all structure
SSX1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to SS18-SSX1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to SS18-SSX1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
SS18SSX1Synovial SarcomaMyCancerGenome
SS18SSX1Pancreatic AdenocarcinomaMyCancerGenome
SS18SSX1Breast Invasive Ductal CarcinomaMyCancerGenome
SS18SSX1Cancer Of Unknown PrimaryMyCancerGenome
SS18SSX1NosMyCancerGenome
SS18SSX1Esophagogastric CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSS18C0039101synovial sarcoma2CTD_human;ORPHANET
TgeneSSX1C0039101synovial sarcoma2CTD_human;ORPHANET
TgeneSSX1C2239176Liver carcinoma1CTD_human