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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ST5-DENND5A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ST5-DENND5A
FusionPDB ID: 86969
FusionGDB2.0 ID: 86969
HgeneTgene
Gene symbol

ST5

DENND5A

Gene ID

6764

23258

Gene nameDENN domain containing 2BDENN domain containing 5A
SynonymsHTS1|ST5|p126EIEE49|RAB6IP1
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionsuppression of tumorigenicity 5 proteinDENN/MADD domain containing 2BheLa tumor suppression 1DENN domain-containing protein 5ADENN/MADD domain containing 5ARAB6 interacting protein 1rab6-interacting protein 1
Modification date2020031320200313
UniProtAcc.

Q6IQ26

Ensembl transtripts involved in fusion geneENST idsENST00000313726, ENST00000357665, 
ENST00000526757, ENST00000530438, 
ENST00000534127, ENST00000526099, 
ENST00000530991, ENST00000531237, 
ENST00000534278, 
ENST00000526523, 
ENST00000328194, ENST00000527700, 
ENST00000530044, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 11 X 7=77015 X 15 X 6=1350
# samples 1216
** MAII scorelog2(12/770*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/1350*10)=-3.07681559705083
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ST5 [Title/Abstract] AND DENND5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DENND5A(9163487)-ST5(8772272), # samples:1
ST5(8853103)-DENND5A(9171756), # samples:3
Anticipated loss of major functional domain due to fusion event.ST5-DENND5A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ST5-DENND5A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ST5-DENND5A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ST5-DENND5A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ST5-DENND5A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ST5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DENND5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0X1-01AST5chr11

8772168

-DENND5Achr11

9163655

-
ChimerDB4SKCMTCGA-W3-AA1V-06BST5chr11

8853103

-DENND5Achr11

9171756

-
ChimerDB4SKCMTCGA-W3-AA1V-06BST5chr11

8860857

-DENND5Achr11

9171756

-
ChimerDB4SKCMTCGA-W3-AA1V-06BST5chr11

8892881

-DENND5Achr11

9171756

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000534127ST5chr118772168-ENST00000328194DENND5Achr119163655-16654661267154893
ENST00000534127ST5chr118772168-ENST00000530044DENND5Achr119163655-99746688661191
ENST00000534127ST5chr118772168-ENST00000527700DENND5Achr119163655-98646692064591
ENST00000313726ST5chr118772168-ENST00000328194DENND5Achr119163655-16284291230151193
ENST00000313726ST5chr118772168-ENST00000530044DENND5Achr119163655-96042984957491
ENST00000313726ST5chr118772168-ENST00000527700DENND5Achr119163655-94942988360891
ENST00000357665ST5chr118772168-ENST00000328194DENND5Achr119163655-14392401041132293
ENST00000357665ST5chr118772168-ENST00000530044DENND5Achr119163655-77124066038591
ENST00000357665ST5chr118772168-ENST00000527700DENND5Achr119163655-76024069441991
ENST00000530438ST5chr118772168-ENST00000328194DENND5Achr119163655-18046053740125
ENST00000530438ST5chr118772168-ENST00000530044DENND5Achr119163655-1136605102575091
ENST00000530438ST5chr118772168-ENST00000527700DENND5Achr119163655-11256053740125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534127ENST00000328194ST5chr118772168-DENND5Achr119163655-0.555499260.44450068
ENST00000534127ENST00000530044ST5chr118772168-DENND5Achr119163655-0.299093630.70090634
ENST00000534127ENST00000527700ST5chr118772168-DENND5Achr119163655-0.121675770.8783243
ENST00000313726ENST00000328194ST5chr118772168-DENND5Achr119163655-0.682719350.3172807
ENST00000313726ENST00000530044ST5chr118772168-DENND5Achr119163655-0.45062840.5493716
ENST00000313726ENST00000527700ST5chr118772168-DENND5Achr119163655-0.158943180.8410568
ENST00000357665ENST00000328194ST5chr118772168-DENND5Achr119163655-0.691582140.3084178
ENST00000357665ENST00000530044ST5chr118772168-DENND5Achr119163655-0.2166190.783381
ENST00000357665ENST00000527700ST5chr118772168-DENND5Achr119163655-0.094059610.9059404
ENST00000530438ENST00000328194ST5chr118772168-DENND5Achr119163655-0.93229190.06770802
ENST00000530438ENST00000530044ST5chr118772168-DENND5Achr119163655-0.5154750.48452502
ENST00000530438ENST00000527700ST5chr118772168-DENND5Achr119163655-0.273805860.7261941

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>86969_86969_1_ST5-DENND5A_ST5_chr11_8772168_ENST00000313726_DENND5A_chr11_9163655_ENST00000328194_length(amino acids)=93AA_BP=
MRGKPHAPIKGIFSSASKQAPMSQSHVFSFLSVLFGKETCRDVSSCQIPHFLLAQFHRSKHKHVLTGFSFLFSFLKCFIYLTRHCVFLSI

--------------------------------------------------------------

>86969_86969_2_ST5-DENND5A_ST5_chr11_8772168_ENST00000313726_DENND5A_chr11_9163655_ENST00000527700_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------

>86969_86969_3_ST5-DENND5A_ST5_chr11_8772168_ENST00000313726_DENND5A_chr11_9163655_ENST00000530044_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------

>86969_86969_4_ST5-DENND5A_ST5_chr11_8772168_ENST00000357665_DENND5A_chr11_9163655_ENST00000328194_length(amino acids)=93AA_BP=
MRGKPHAPIKGIFSSASKQAPMSQSHVFSFLSVLFGKETCRDVSSCQIPHFLLAQFHRSKHKHVLTGFSFLFSFLKCFIYLTRHCVFLSI

--------------------------------------------------------------

>86969_86969_5_ST5-DENND5A_ST5_chr11_8772168_ENST00000357665_DENND5A_chr11_9163655_ENST00000527700_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------

>86969_86969_6_ST5-DENND5A_ST5_chr11_8772168_ENST00000357665_DENND5A_chr11_9163655_ENST00000530044_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------

>86969_86969_7_ST5-DENND5A_ST5_chr11_8772168_ENST00000530438_DENND5A_chr11_9163655_ENST00000328194_length(amino acids)=125AA_BP=
MTFRGAPRSQVSRALLAGQAGCHGDPVLARRARAQRRALGLARAQGRSLFLSFSLSLSLSLSLSLSQFWEASMKQHCLLISSVFACIPLL

--------------------------------------------------------------

>86969_86969_8_ST5-DENND5A_ST5_chr11_8772168_ENST00000530438_DENND5A_chr11_9163655_ENST00000527700_length(amino acids)=125AA_BP=
MTFRGAPRSQVSRALLAGQAGCHGDPVLARRARAQRRALGLARAQGRSLFLSFSLSLSLSLSLSLSQFWEASMKQHCLLISSVFACIPLL

--------------------------------------------------------------

>86969_86969_9_ST5-DENND5A_ST5_chr11_8772168_ENST00000530438_DENND5A_chr11_9163655_ENST00000530044_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------

>86969_86969_10_ST5-DENND5A_ST5_chr11_8772168_ENST00000534127_DENND5A_chr11_9163655_ENST00000328194_length(amino acids)=93AA_BP=
MRGKPHAPIKGIFSSASKQAPMSQSHVFSFLSVLFGKETCRDVSSCQIPHFLLAQFHRSKHKHVLTGFSFLFSFLKCFIYLTRHCVFLSI

--------------------------------------------------------------

>86969_86969_11_ST5-DENND5A_ST5_chr11_8772168_ENST00000534127_DENND5A_chr11_9163655_ENST00000527700_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------

>86969_86969_12_ST5-DENND5A_ST5_chr11_8772168_ENST00000534127_DENND5A_chr11_9163655_ENST00000530044_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:9163487/chr11:8772272)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DENND5A

Q6IQ26

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST5chr11:8772168chr11:9163655ENST00000313726-22033_9326.6666666666666681138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000313726-220350_43426.6666666666666681138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000357665-32133_9326.6666666666666681138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000357665-321350_43426.6666666666666681138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000526757-21933_9326.666666666666668718.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000526757-219350_43426.666666666666668718.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000530438-21933_9326.666666666666668718.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000530438-219350_43426.666666666666668718.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000530991-11733_930610.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000530991-117350_4340610.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000534127-52333_9326.6666666666666681138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000534127-523350_43426.6666666666666681138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000313726-2201003_109626.6666666666666681138.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000313726-220698_84626.6666666666666681138.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000313726-220868_100126.6666666666666681138.0DomaincDENN
HgeneST5chr11:8772168chr11:9163655ENST00000357665-3211003_109626.6666666666666681138.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000357665-321698_84626.6666666666666681138.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000357665-321868_100126.6666666666666681138.0DomaincDENN
HgeneST5chr11:8772168chr11:9163655ENST00000526757-2191003_109626.666666666666668718.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000526757-219698_84626.666666666666668718.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000526757-219868_100126.666666666666668718.0DomaincDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530438-2191003_109626.666666666666668718.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530438-219698_84626.666666666666668718.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530438-219868_100126.666666666666668718.0DomaincDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530991-1171003_10960610.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530991-117698_8460610.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530991-117868_10010610.0DomaincDENN
HgeneST5chr11:8772168chr11:9163655ENST00000534127-5231003_109626.6666666666666681138.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000534127-523698_84626.6666666666666681138.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000534127-523868_100126.6666666666666681138.0DomaincDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST0000032819420233_91170.33333333333331288.0Compositional biasNote=Poly-Gly
TgeneDENND5Achr11:8772168chr11:9163655ENST000003281942023593_5981170.33333333333331288.0Compositional biasNote=Poly-Asp
TgeneDENND5Achr11:8772168chr11:9163655ENST0000053004420233_91170.33333333333331242.0Compositional biasNote=Poly-Gly
TgeneDENND5Achr11:8772168chr11:9163655ENST000005300442023593_5981170.33333333333331242.0Compositional biasNote=Poly-Asp
TgeneDENND5Achr11:8772168chr11:9163655ENST0000032819420231134_12821170.33333333333331288.0DomainRUN 2
TgeneDENND5Achr11:8772168chr11:9163655ENST000003281942023278_4141170.33333333333331288.0DomaincDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST000003281942023416_5981170.33333333333331288.0DomaindDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST00000328194202357_2591170.33333333333331288.0DomainuDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST000003281942023787_9501170.33333333333331288.0DomainRUN 1
TgeneDENND5Achr11:8772168chr11:9163655ENST000003281942023954_10621170.33333333333331288.0DomainPLAT
TgeneDENND5Achr11:8772168chr11:9163655ENST0000053004420231134_12821170.33333333333331242.0DomainRUN 2
TgeneDENND5Achr11:8772168chr11:9163655ENST000005300442023278_4141170.33333333333331242.0DomaincDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST000005300442023416_5981170.33333333333331242.0DomaindDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST00000530044202357_2591170.33333333333331242.0DomainuDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST000005300442023787_9501170.33333333333331242.0DomainRUN 1
TgeneDENND5Achr11:8772168chr11:9163655ENST000005300442023954_10621170.33333333333331242.0DomainPLAT


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ST5
DENND5A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneST5chr11:8772168chr11:9163655ENST00000313726-220401_44726.6666666666666681138.0ABL1
HgeneST5chr11:8772168chr11:9163655ENST00000357665-321401_44726.6666666666666681138.0ABL1
HgeneST5chr11:8772168chr11:9163655ENST00000526757-219401_44726.666666666666668718.0ABL1
HgeneST5chr11:8772168chr11:9163655ENST00000530438-219401_44726.666666666666668718.0ABL1
HgeneST5chr11:8772168chr11:9163655ENST00000530991-117401_4470610.0ABL1
HgeneST5chr11:8772168chr11:9163655ENST00000534127-523401_44726.6666666666666681138.0ABL1


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Related Drugs to ST5-DENND5A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ST5-DENND5A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource