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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ST7-CAV1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ST7-CAV1
FusionPDB ID: 87017
FusionGDB2.0 ID: 87017
HgeneTgene
Gene symbol

ST7

CAV1

Gene ID

93655

857

Gene nameST7 overlapping transcript 3caveolin 1
SynonymsNCRNA00026|ST7|ST7OT3BSCL3|CGL3|LCCNS|MSTP085|PPH3|VIP21
Cytomap

7q31.2

7q31.2

Type of genencRNAprotein-coding
DescriptionST7 overlapping transcript 3 (non-coding RNA)ST7 overlapping transcript 3 (non-protein coding)suppression of tumorigenicity 7caveolin-1caveolin 1, caveolae protein, 22kDacell growth-inhibiting protein 32
Modification date2020031320200329
UniProtAcc.

Q03135

Ensembl transtripts involved in fusion geneENST idsENST00000265437, ENST00000323984, 
ENST00000393446, ENST00000393449, 
ENST00000393451, ENST00000393443, 
ENST00000393444, ENST00000393447, 
ENST00000422922, ENST00000432298, 
ENST00000465133, ENST00000487459, 
ENST00000393468, ENST00000341049, 
ENST00000393467, ENST00000393470, 
ENST00000405348, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 11 X 9=168311 X 9 X 7=693
# samples 2314
** MAII scorelog2(23/1683*10)=-2.87132941038557
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/693*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ST7 [Title/Abstract] AND CAV1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ST7(116593745)-CAV1(116199000), # samples:2
Anticipated loss of major functional domain due to fusion event.ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ST7-CAV1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ST7-CAV1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAV1

GO:0009617

response to bacterium

24625804

TgeneCAV1

GO:0010875

positive regulation of cholesterol efflux

24576892

TgeneCAV1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

25893292

TgeneCAV1

GO:0031295

T cell costimulation

17287217

TgeneCAV1

GO:0031623

receptor internalization

25893292

TgeneCAV1

GO:0032091

negative regulation of protein binding

16890161

TgeneCAV1

GO:0032570

response to progesterone

12388746

TgeneCAV1

GO:0033137

negative regulation of peptidyl-serine phosphorylation

18081315

TgeneCAV1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

18081315

TgeneCAV1

GO:0043627

response to estrogen

12388746

TgeneCAV1

GO:0051480

regulation of cytosolic calcium ion concentration

19052258

TgeneCAV1

GO:0072584

caveolin-mediated endocytosis

19931615

TgeneCAV1

GO:1900027

regulation of ruffle assembly

24625804

TgeneCAV1

GO:2000535

regulation of entry of bacterium into host cell

24625804


check buttonFusion gene breakpoints across ST7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0184-01AST7chr7

116593745

-CAV1chr7

116199000

+
ChimerDB4GBMTCGA-06-0184-01AST7chr7

116593745

+CAV1chr7

116199000

+
ChimerDB4GBMTCGA-06-0184ST7chr7

116593745

+CAV1chr7

116198999

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393446ST7chr7116593745+ENST00000341049CAV1chr7116198999+268545439110495
ENST00000393446ST7chr7116593745+ENST00000393470CAV1chr7116198999+82845439110495
ENST00000393446ST7chr7116593745+ENST00000405348CAV1chr7116198999+268845439110495
ENST00000393446ST7chr7116593745+ENST00000393467CAV1chr7116198999+268545439110495
ENST00000265437ST7chr7116593745+ENST00000341049CAV1chr7116198999+25963653021595
ENST00000265437ST7chr7116593745+ENST00000393470CAV1chr7116198999+7393653021595
ENST00000265437ST7chr7116593745+ENST00000405348CAV1chr7116198999+25993653021595
ENST00000265437ST7chr7116593745+ENST00000393467CAV1chr7116198999+25963653021595
ENST00000393451ST7chr7116593745+ENST00000341049CAV1chr7116198999+2581350287096
ENST00000393451ST7chr7116593745+ENST00000393470CAV1chr7116198999+724350287096
ENST00000393451ST7chr7116593745+ENST00000405348CAV1chr7116198999+2584350287096
ENST00000393451ST7chr7116593745+ENST00000393467CAV1chr7116198999+2581350287096
ENST00000393449ST7chr7116593745+ENST00000341049CAV1chr7116198999+25443132069178893
ENST00000393449ST7chr7116593745+ENST00000393470CAV1chr7116198999+687313250283
ENST00000393449ST7chr7116593745+ENST00000405348CAV1chr7116198999+25473132069178893
ENST00000393449ST7chr7116593745+ENST00000393467CAV1chr7116198999+25443132069178893
ENST00000323984ST7chr7116593745+ENST00000341049CAV1chr7116198999+25443132069178893
ENST00000323984ST7chr7116593745+ENST00000393470CAV1chr7116198999+687313250283
ENST00000323984ST7chr7116593745+ENST00000405348CAV1chr7116198999+25473132069178893
ENST00000323984ST7chr7116593745+ENST00000393467CAV1chr7116198999+25443132069178893
ENST00000393446ST7chr7116593745+ENST00000341049CAV1chr7116199000+268545439110495
ENST00000393446ST7chr7116593745+ENST00000393470CAV1chr7116199000+82845439110495
ENST00000393446ST7chr7116593745+ENST00000405348CAV1chr7116199000+268845439110495
ENST00000393446ST7chr7116593745+ENST00000393467CAV1chr7116199000+268545439110495
ENST00000265437ST7chr7116593745+ENST00000341049CAV1chr7116199000+25963653021595
ENST00000265437ST7chr7116593745+ENST00000393470CAV1chr7116199000+7393653021595
ENST00000265437ST7chr7116593745+ENST00000405348CAV1chr7116199000+25993653021595
ENST00000265437ST7chr7116593745+ENST00000393467CAV1chr7116199000+25963653021595
ENST00000393451ST7chr7116593745+ENST00000341049CAV1chr7116199000+2581350287096
ENST00000393451ST7chr7116593745+ENST00000393470CAV1chr7116199000+724350287096
ENST00000393451ST7chr7116593745+ENST00000405348CAV1chr7116199000+2584350287096
ENST00000393451ST7chr7116593745+ENST00000393467CAV1chr7116199000+2581350287096
ENST00000393449ST7chr7116593745+ENST00000341049CAV1chr7116199000+25443132069178893
ENST00000393449ST7chr7116593745+ENST00000393470CAV1chr7116199000+687313250283
ENST00000393449ST7chr7116593745+ENST00000405348CAV1chr7116199000+25473132069178893
ENST00000393449ST7chr7116593745+ENST00000393467CAV1chr7116199000+25443132069178893
ENST00000323984ST7chr7116593745+ENST00000341049CAV1chr7116199000+25443132069178893
ENST00000323984ST7chr7116593745+ENST00000393470CAV1chr7116199000+687313250283
ENST00000323984ST7chr7116593745+ENST00000405348CAV1chr7116199000+25473132069178893
ENST00000323984ST7chr7116593745+ENST00000393467CAV1chr7116199000+25443132069178893

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393446ENST00000341049ST7chr7116593745+CAV1chr7116198999+0.51688970.48311034
ENST00000393446ENST00000393470ST7chr7116593745+CAV1chr7116198999+0.319877450.6801225
ENST00000393446ENST00000405348ST7chr7116593745+CAV1chr7116198999+0.51022210.48977792
ENST00000393446ENST00000393467ST7chr7116593745+CAV1chr7116198999+0.51688970.48311034
ENST00000265437ENST00000341049ST7chr7116593745+CAV1chr7116198999+0.56079690.4392031
ENST00000265437ENST00000393470ST7chr7116593745+CAV1chr7116198999+0.198805930.8011941
ENST00000265437ENST00000405348ST7chr7116593745+CAV1chr7116198999+0.562547560.43745247
ENST00000265437ENST00000393467ST7chr7116593745+CAV1chr7116198999+0.56079690.4392031
ENST00000393451ENST00000341049ST7chr7116593745+CAV1chr7116198999+0.489411320.5105887
ENST00000393451ENST00000393470ST7chr7116593745+CAV1chr7116198999+0.115909310.8840907
ENST00000393451ENST00000405348ST7chr7116593745+CAV1chr7116198999+0.48844640.5115536
ENST00000393451ENST00000393467ST7chr7116593745+CAV1chr7116198999+0.489411320.5105887
ENST00000393449ENST00000341049ST7chr7116593745+CAV1chr7116198999+0.290030330.7099697
ENST00000393449ENST00000393470ST7chr7116593745+CAV1chr7116198999+0.135520680.8644793
ENST00000393449ENST00000405348ST7chr7116593745+CAV1chr7116198999+0.293689550.70631045
ENST00000393449ENST00000393467ST7chr7116593745+CAV1chr7116198999+0.290030330.7099697
ENST00000323984ENST00000341049ST7chr7116593745+CAV1chr7116198999+0.290030330.7099697
ENST00000323984ENST00000393470ST7chr7116593745+CAV1chr7116198999+0.135520680.8644793
ENST00000323984ENST00000405348ST7chr7116593745+CAV1chr7116198999+0.293689550.70631045
ENST00000323984ENST00000393467ST7chr7116593745+CAV1chr7116198999+0.290030330.7099697
ENST00000393446ENST00000341049ST7chr7116593745+CAV1chr7116199000+0.51688970.48311034
ENST00000393446ENST00000393470ST7chr7116593745+CAV1chr7116199000+0.319877450.6801225
ENST00000393446ENST00000405348ST7chr7116593745+CAV1chr7116199000+0.51022210.48977792
ENST00000393446ENST00000393467ST7chr7116593745+CAV1chr7116199000+0.51688970.48311034
ENST00000265437ENST00000341049ST7chr7116593745+CAV1chr7116199000+0.56079690.4392031
ENST00000265437ENST00000393470ST7chr7116593745+CAV1chr7116199000+0.198805930.8011941
ENST00000265437ENST00000405348ST7chr7116593745+CAV1chr7116199000+0.562547560.43745247
ENST00000265437ENST00000393467ST7chr7116593745+CAV1chr7116199000+0.56079690.4392031
ENST00000393451ENST00000341049ST7chr7116593745+CAV1chr7116199000+0.489411320.5105887
ENST00000393451ENST00000393470ST7chr7116593745+CAV1chr7116199000+0.115909310.8840907
ENST00000393451ENST00000405348ST7chr7116593745+CAV1chr7116199000+0.48844640.5115536
ENST00000393451ENST00000393467ST7chr7116593745+CAV1chr7116199000+0.489411320.5105887
ENST00000393449ENST00000341049ST7chr7116593745+CAV1chr7116199000+0.290030330.7099697
ENST00000393449ENST00000393470ST7chr7116593745+CAV1chr7116199000+0.135520680.8644793
ENST00000393449ENST00000405348ST7chr7116593745+CAV1chr7116199000+0.293689550.70631045
ENST00000393449ENST00000393467ST7chr7116593745+CAV1chr7116199000+0.290030330.7099697
ENST00000323984ENST00000341049ST7chr7116593745+CAV1chr7116199000+0.290030330.7099697
ENST00000323984ENST00000393470ST7chr7116593745+CAV1chr7116199000+0.135520680.8644793
ENST00000323984ENST00000405348ST7chr7116593745+CAV1chr7116199000+0.293689550.70631045
ENST00000323984ENST00000393467ST7chr7116593745+CAV1chr7116199000+0.290030330.7099697

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87017_87017_1_ST7-CAV1_ST7_chr7_116593745_ENST00000265437_CAV1_chr7_116198999_ENST00000341049_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_2_ST7-CAV1_ST7_chr7_116593745_ENST00000265437_CAV1_chr7_116198999_ENST00000393467_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_3_ST7-CAV1_ST7_chr7_116593745_ENST00000265437_CAV1_chr7_116198999_ENST00000393470_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_4_ST7-CAV1_ST7_chr7_116593745_ENST00000265437_CAV1_chr7_116198999_ENST00000405348_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_5_ST7-CAV1_ST7_chr7_116593745_ENST00000265437_CAV1_chr7_116199000_ENST00000341049_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_6_ST7-CAV1_ST7_chr7_116593745_ENST00000265437_CAV1_chr7_116199000_ENST00000393467_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_7_ST7-CAV1_ST7_chr7_116593745_ENST00000265437_CAV1_chr7_116199000_ENST00000393470_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_8_ST7-CAV1_ST7_chr7_116593745_ENST00000265437_CAV1_chr7_116199000_ENST00000405348_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_9_ST7-CAV1_ST7_chr7_116593745_ENST00000323984_CAV1_chr7_116198999_ENST00000341049_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_10_ST7-CAV1_ST7_chr7_116593745_ENST00000323984_CAV1_chr7_116198999_ENST00000393467_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_11_ST7-CAV1_ST7_chr7_116593745_ENST00000323984_CAV1_chr7_116198999_ENST00000393470_length(amino acids)=83AA_BP=

--------------------------------------------------------------

>87017_87017_12_ST7-CAV1_ST7_chr7_116593745_ENST00000323984_CAV1_chr7_116198999_ENST00000405348_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_13_ST7-CAV1_ST7_chr7_116593745_ENST00000323984_CAV1_chr7_116199000_ENST00000341049_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_14_ST7-CAV1_ST7_chr7_116593745_ENST00000323984_CAV1_chr7_116199000_ENST00000393467_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_15_ST7-CAV1_ST7_chr7_116593745_ENST00000323984_CAV1_chr7_116199000_ENST00000393470_length(amino acids)=83AA_BP=

--------------------------------------------------------------

>87017_87017_16_ST7-CAV1_ST7_chr7_116593745_ENST00000323984_CAV1_chr7_116199000_ENST00000405348_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_17_ST7-CAV1_ST7_chr7_116593745_ENST00000393446_CAV1_chr7_116198999_ENST00000341049_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_18_ST7-CAV1_ST7_chr7_116593745_ENST00000393446_CAV1_chr7_116198999_ENST00000393467_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_19_ST7-CAV1_ST7_chr7_116593745_ENST00000393446_CAV1_chr7_116198999_ENST00000393470_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_20_ST7-CAV1_ST7_chr7_116593745_ENST00000393446_CAV1_chr7_116198999_ENST00000405348_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_21_ST7-CAV1_ST7_chr7_116593745_ENST00000393446_CAV1_chr7_116199000_ENST00000341049_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_22_ST7-CAV1_ST7_chr7_116593745_ENST00000393446_CAV1_chr7_116199000_ENST00000393467_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_23_ST7-CAV1_ST7_chr7_116593745_ENST00000393446_CAV1_chr7_116199000_ENST00000393470_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_24_ST7-CAV1_ST7_chr7_116593745_ENST00000393446_CAV1_chr7_116199000_ENST00000405348_length(amino acids)=95AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_25_ST7-CAV1_ST7_chr7_116593745_ENST00000393449_CAV1_chr7_116198999_ENST00000341049_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_26_ST7-CAV1_ST7_chr7_116593745_ENST00000393449_CAV1_chr7_116198999_ENST00000393467_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_27_ST7-CAV1_ST7_chr7_116593745_ENST00000393449_CAV1_chr7_116198999_ENST00000393470_length(amino acids)=83AA_BP=

--------------------------------------------------------------

>87017_87017_28_ST7-CAV1_ST7_chr7_116593745_ENST00000393449_CAV1_chr7_116198999_ENST00000405348_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_29_ST7-CAV1_ST7_chr7_116593745_ENST00000393449_CAV1_chr7_116199000_ENST00000341049_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_30_ST7-CAV1_ST7_chr7_116593745_ENST00000393449_CAV1_chr7_116199000_ENST00000393467_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_31_ST7-CAV1_ST7_chr7_116593745_ENST00000393449_CAV1_chr7_116199000_ENST00000393470_length(amino acids)=83AA_BP=

--------------------------------------------------------------

>87017_87017_32_ST7-CAV1_ST7_chr7_116593745_ENST00000393449_CAV1_chr7_116199000_ENST00000405348_length(amino acids)=93AA_BP=
MSRRNKKLLDIPGSFLYDSGLQVKFLSLSSEEFELIPAKYFNLFITASSPIFFLGKGMLGLGPKLLAGGGAMCHSITDGCKCFTEQGSGL

--------------------------------------------------------------

>87017_87017_33_ST7-CAV1_ST7_chr7_116593745_ENST00000393451_CAV1_chr7_116198999_ENST00000341049_length(amino acids)=96AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_34_ST7-CAV1_ST7_chr7_116593745_ENST00000393451_CAV1_chr7_116198999_ENST00000393467_length(amino acids)=96AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_35_ST7-CAV1_ST7_chr7_116593745_ENST00000393451_CAV1_chr7_116198999_ENST00000393470_length(amino acids)=96AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_36_ST7-CAV1_ST7_chr7_116593745_ENST00000393451_CAV1_chr7_116198999_ENST00000405348_length(amino acids)=96AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_37_ST7-CAV1_ST7_chr7_116593745_ENST00000393451_CAV1_chr7_116199000_ENST00000341049_length(amino acids)=96AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_38_ST7-CAV1_ST7_chr7_116593745_ENST00000393451_CAV1_chr7_116199000_ENST00000393467_length(amino acids)=96AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_39_ST7-CAV1_ST7_chr7_116593745_ENST00000393451_CAV1_chr7_116199000_ENST00000393470_length(amino acids)=96AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

>87017_87017_40_ST7-CAV1_ST7_chr7_116593745_ENST00000393451_CAV1_chr7_116199000_ENST00000405348_length(amino acids)=96AA_BP=
MKNHTVHRYVQDQTMQDLSCSRKPVAASAMFQRSSLLPRLLVSAGMIHRPGGAARAAAAAAARAPPEPARRRGRGLGGKSRGPRARRLFL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116593745/chr7:116199000)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAV1

Q03135

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST7chr7:116593745chr7:116198999ENST00000265437+11615_3550.333333333333336586.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116198999ENST00000393451+11515_3550.333333333333336555.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116199000ENST00000265437+11615_3550.333333333333336586.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116199000ENST00000393451+11515_3550.333333333333336555.0TransmembraneHelical
TgeneCAV1chr7:116593745chr7:116198999ENST0000034104913105_12565.0179.0IntramembraneHelical
TgeneCAV1chr7:116593745chr7:116198999ENST0000039346702105_12534.0148.0IntramembraneHelical
TgeneCAV1chr7:116593745chr7:116198999ENST0000039346813105_12534.0148.0IntramembraneHelical
TgeneCAV1chr7:116593745chr7:116198999ENST0000040534813105_12534.0148.0IntramembraneHelical
TgeneCAV1chr7:116593745chr7:116199000ENST0000034104913105_12565.0179.0IntramembraneHelical
TgeneCAV1chr7:116593745chr7:116199000ENST0000039346702105_12534.0148.0IntramembraneHelical
TgeneCAV1chr7:116593745chr7:116199000ENST0000039346813105_12534.0148.0IntramembraneHelical
TgeneCAV1chr7:116593745chr7:116199000ENST0000040534813105_12534.0148.0IntramembraneHelical
TgeneCAV1chr7:116593745chr7:116198999ENST0000034104913131_14265.0179.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000034104913149_16065.0179.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000034104913167_17865.0179.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000039346702131_14234.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000039346702149_16034.0148.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000039346702167_17834.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000039346813131_14234.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000039346813149_16034.0148.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000039346813167_17834.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000040534813131_14234.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000040534813149_16034.0148.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000040534813167_17834.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000034104913131_14265.0179.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000034104913149_16065.0179.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000034104913167_17865.0179.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000039346702131_14234.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000039346702149_16034.0148.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000039346702167_17834.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000039346813131_14234.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000039346813149_16034.0148.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000039346813167_17834.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000040534813131_14234.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000040534813149_16034.0148.0RegionInteracts with SPRY1%2C SPRY2%2C and SPRY4
TgeneCAV1chr7:116593745chr7:116199000ENST0000040534813167_17834.0148.0RegionInteracts with SPRY1%2C SPRY2%2C SPRY3 and SPRY4
TgeneCAV1chr7:116593745chr7:116198999ENST0000034104913126_17865.0179.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116198999ENST0000039346702126_17834.0148.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116198999ENST0000039346813126_17834.0148.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116198999ENST0000040534813126_17834.0148.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116199000ENST0000034104913126_17865.0179.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116199000ENST0000039346702126_17834.0148.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116199000ENST0000039346813126_17834.0148.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116199000ENST0000040534813126_17834.0148.0Topological domainCytoplasmic

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST7chr7:116593745chr7:116198999ENST00000265437+116512_53250.333333333333336586.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116198999ENST00000265437+11662_8250.333333333333336586.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116198999ENST00000393443+11615_350500.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116198999ENST00000393443+116512_5320500.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116198999ENST00000393443+11662_820500.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116198999ENST00000393451+115512_53250.333333333333336555.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116198999ENST00000393451+11562_8250.333333333333336555.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116199000ENST00000265437+116512_53250.333333333333336586.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116199000ENST00000265437+11662_8250.333333333333336586.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116199000ENST00000393443+11615_350500.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116199000ENST00000393443+116512_5320500.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116199000ENST00000393443+11662_820500.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116199000ENST00000393451+115512_53250.333333333333336555.0TransmembraneHelical
HgeneST7chr7:116593745chr7:116199000ENST00000393451+11562_8250.333333333333336555.0TransmembraneHelical
TgeneCAV1chr7:116593745chr7:116198999ENST00000341049132_9465.0179.0RegionRequired for homooligomerization
TgeneCAV1chr7:116593745chr7:116198999ENST00000393467022_9434.0148.0RegionRequired for homooligomerization
TgeneCAV1chr7:116593745chr7:116198999ENST00000393468132_9434.0148.0RegionRequired for homooligomerization
TgeneCAV1chr7:116593745chr7:116198999ENST00000405348132_9434.0148.0RegionRequired for homooligomerization
TgeneCAV1chr7:116593745chr7:116199000ENST00000341049132_9465.0179.0RegionRequired for homooligomerization
TgeneCAV1chr7:116593745chr7:116199000ENST00000393467022_9434.0148.0RegionRequired for homooligomerization
TgeneCAV1chr7:116593745chr7:116199000ENST00000393468132_9434.0148.0RegionRequired for homooligomerization
TgeneCAV1chr7:116593745chr7:116199000ENST00000405348132_9434.0148.0RegionRequired for homooligomerization
TgeneCAV1chr7:116593745chr7:116198999ENST00000341049132_10465.0179.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116198999ENST00000393467022_10434.0148.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116198999ENST00000393468132_10434.0148.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116198999ENST00000405348132_10434.0148.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116199000ENST00000341049132_10465.0179.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116199000ENST00000393467022_10434.0148.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116199000ENST00000393468132_10434.0148.0Topological domainCytoplasmic
TgeneCAV1chr7:116593745chr7:116199000ENST00000405348132_10434.0148.0Topological domainCytoplasmic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ST7
CAV1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ST7-CAV1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ST7-CAV1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource