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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:STAT3-RAB5C

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: STAT3-RAB5C
	FusionPDB ID: 87249
	FusionGDB2.0 ID: 87249
		Hgene	Tgene
	Gene symbol	STAT3	RAB5C
	Gene ID	6774	5878
	Gene name	signal transducer and activator of transcription 3	RAB5C, member RAS oncogene family
	Synonyms	ADMIO\|ADMIO1\|APRF\|HIES	L1880\|RAB5CL\|RAB5L\|RABL
	Cytomap	17q21.2	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	signal transducer and activator of transcription 3DNA-binding protein APRFacute-phase response factor	ras-related protein Rab-5CRAB5C, member of RAS oncogene family
	Modification date	20200329	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000389272, ENST00000404395, ENST00000588969, ENST00000264657, ENST00000585517, ENST00000590776,	ENST00000346213, ENST00000393860, ENST00000547517,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 20 X 10=3600	8 X 7 X 6=336
	# samples	23	10
	** MAII score	log2(23/3600*10)=-3.96829114027266 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/336*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: STAT3 [Title/Abstract] AND RAB5C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	STAT3(40475022)-RAB5C(40278866), # samples:1
Anticipated loss of major functional domain due to fusion event.	STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	STAT3	GO:0006355	regulation of transcription, DNA-templated	15664994\|17344214
Hgene	STAT3	GO:0006606	protein import into nucleus	18234692
Hgene	STAT3	GO:0010507	negative regulation of autophagy	26962683
Hgene	STAT3	GO:0010628	positive regulation of gene expression	23820254
Hgene	STAT3	GO:0030522	intracellular receptor signaling pathway	17324931
Hgene	STAT3	GO:0032355	response to estradiol	12552091
Hgene	STAT3	GO:0032870	cellular response to hormone stimulus	12552091
Hgene	STAT3	GO:0033210	leptin-mediated signaling pathway	17344214
Hgene	STAT3	GO:0035278	miRNA mediated inhibition of translation	23820254
Hgene	STAT3	GO:0044320	cellular response to leptin stimulus	17344214
Hgene	STAT3	GO:0044321	response to leptin	17344214
Hgene	STAT3	GO:0045893	positive regulation of transcription, DNA-templated	19390056
Hgene	STAT3	GO:0045944	positive regulation of transcription by RNA polymerase II	17324931\|27050391\|31462771
Hgene	STAT3	GO:0051726	regulation of cell cycle	17344214
Hgene	STAT3	GO:0060396	growth hormone receptor signaling pathway	10925297
Hgene	STAT3	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	12552091
Hgene	STAT3	GO:0070102	interleukin-6-mediated signaling pathway	12359225\|12552091\|17324931\|24429361
Hgene	STAT3	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	19390056\|23820254
Hgene	STAT3	GO:2000637	positive regulation of gene silencing by miRNA	23820254

Fusion gene breakpoints across STAT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAB5C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-7820	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264657	STAT3	chr17	40475022	-	ENST00000346213	RAB5C	chr17	40278866	-	3218	2201	313	2298	661
ENST00000264657	STAT3	chr17	40475022	-	ENST00000393860	RAB5C	chr17	40278866	-	3214	2201	313	2298	661
ENST00000264657	STAT3	chr17	40475022	-	ENST00000547517	RAB5C	chr17	40278866	-	2527	2201	313	2298	661
ENST00000585517	STAT3	chr17	40475022	-	ENST00000346213	RAB5C	chr17	40278866	-	3070	2053	30	2150	706
ENST00000585517	STAT3	chr17	40475022	-	ENST00000393860	RAB5C	chr17	40278866	-	3066	2053	30	2150	706
ENST00000585517	STAT3	chr17	40475022	-	ENST00000547517	RAB5C	chr17	40278866	-	2379	2053	30	2150	706

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264657	ENST00000346213	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.020193728	0.97980624
ENST00000264657	ENST00000393860	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.020207101	0.97979295
ENST00000264657	ENST00000547517	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.020764273	0.9792357
ENST00000585517	ENST00000346213	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.020494651	0.9795053
ENST00000585517	ENST00000393860	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.020526294	0.97947377
ENST00000585517	ENST00000547517	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.021547657	0.9784524

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87249_87249_1_STAT3-RAB5C_STAT3_chr17_40475022_ENST00000264657_RAB5C_chr17_40278866_ENST00000346213_length(amino acids)=661AA_BP=0
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFL
QSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSL
AESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISG

--------------------------------------------------------------

>87249_87249_2_STAT3-RAB5C_STAT3_chr17_40475022_ENST00000264657_RAB5C_chr17_40278866_ENST00000393860_length(amino acids)=661AA_BP=0
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFL
QSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSL
AESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISG

--------------------------------------------------------------

>87249_87249_3_STAT3-RAB5C_STAT3_chr17_40475022_ENST00000264657_RAB5C_chr17_40278866_ENST00000547517_length(amino acids)=661AA_BP=0
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFL
QSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSL
AESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISG

--------------------------------------------------------------

>87249_87249_4_STAT3-RAB5C_STAT3_chr17_40475022_ENST00000585517_RAB5C_chr17_40278866_ENST00000346213_length(amino acids)=706AA_BP=1
MDRHPGLALSLPLGSERPFGLREPRRPSPAHAQPRPLGLCRRNSRMAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAY
AASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAA
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLL
SAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRN
LMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLS
AEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTK
PPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYI

--------------------------------------------------------------

>87249_87249_5_STAT3-RAB5C_STAT3_chr17_40475022_ENST00000585517_RAB5C_chr17_40278866_ENST00000393860_length(amino acids)=706AA_BP=1
MDRHPGLALSLPLGSERPFGLREPRRPSPAHAQPRPLGLCRRNSRMAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAY
AASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAA
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLL
SAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRN
LMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLS
AEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTK
PPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYI

--------------------------------------------------------------

>87249_87249_6_STAT3-RAB5C_STAT3_chr17_40475022_ENST00000585517_RAB5C_chr17_40278866_ENST00000547517_length(amino acids)=706AA_BP=1
MDRHPGLALSLPLGSERPFGLREPRRPSPAHAQPRPLGLCRRNSRMAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAY
AASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAA
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLL
SAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRN
LMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLS
AEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTK
PPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYI

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:40475022/chr17:40278866)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000264657

150_162

629.3333333333334

771.0

Motif

Note=Essential for nuclear import

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000404395

150_162

629.3333333333334

770.0

Motif

Note=Essential for nuclear import

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000588969

150_162

629.3333333333334

771.0

Motif

Note=Essential for nuclear import

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

164_166

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

164_166

147.0

217.0

Nucleotide binding

GTP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000264657

580_670

629.3333333333334

771.0

Domain

SH2

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000404395

580_670

629.3333333333334

770.0

Domain

SH2

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000588969

580_670

629.3333333333334

771.0

Domain

SH2

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

50_58

147.0

217.0

Motif

Effector region

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

50_58

147.0

217.0

Motif

Effector region

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

50_58

180.0

250.0

Motif

Effector region

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

134_137

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

28_36

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

47_53

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

76_80

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

134_137

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

28_36

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

47_53

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

76_80

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

134_137

180.0

250.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

164_166

180.0

250.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

28_36

180.0

250.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

47_53

180.0

250.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

76_80

180.0

250.0

Nucleotide binding

GTP

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
STAT3
RAB5C

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to STAT3-RAB5C

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to STAT3-RAB5C

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source