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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:STAU2-PAWR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: STAU2-PAWR
FusionPDB ID: 87340
FusionGDB2.0 ID: 87340
HgeneTgene
Gene symbol

STAU2

PAWR

Gene ID

27067

5074

Gene namestaufen double-stranded RNA binding protein 2pro-apoptotic WT1 regulator
Synonyms39K2|39K3PAR4|Par-4
Cytomap

8q21.11

12q21.2

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-binding protein Staufen homolog 2staufen homolog 2staufen, RNA binding protein, homolog 2PRKC apoptosis WT1 regulator proteinPRKC, apoptosis, WT1, regulatorWT1-interacting proteinprostate apoptosis response protein 4prostate apoptosis response protein PAR-4prostate apoptosis response-4transcriptional repressor PAR4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000355780, ENST00000519961, 
ENST00000522509, ENST00000522695, 
ENST00000524104, ENST00000524300, 
ENST00000521210, ENST00000521419, 
ENST00000522962, ENST00000517542, 
ENST00000521451, ENST00000521727, 
ENST00000523558, 		ENST00000547571, 
ENST00000328827, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 20 X 13=676014 X 10 X 7=980
# samples 3416
** MAII scorelog2(34/6760*10)=-4.31341659503185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/980*10)=-2.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: STAU2 [Title/Abstract] AND PAWR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)STAU2(74650519)-PAWR(80014987), # samples:2
Anticipated loss of major functional domain due to fusion event.STAU2-PAWR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
STAU2-PAWR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
STAU2-PAWR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
STAU2-PAWR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
STAU2-PAWR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
STAU2-PAWR seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across STAU2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PAWR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1702-01ASTAU2chr8

74621267

-PAWRchr12

80014987

-
ChimerDB4OVTCGA-29-1702-01ASTAU2chr8

74650519

-PAWRchr12

80014987

-
ChimerDB4OVTCGA-29-1702STAU2chr8

74650518

-PAWRchr12

80014987

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000522695STAU2chr874650519-ENST00000328827PAWRchr1280014987-82844426550174
ENST00000522695STAU2chr874650518-ENST00000328827PAWRchr1280014987-82844426550174
ENST00000519961STAU2chr874621267-ENST00000328827PAWRchr1280014987-843219278698206

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000522695ENST00000328827STAU2chr874650519-PAWRchr1280014987-0.0010991970.9989008
ENST00000522695ENST00000328827STAU2chr874650518-PAWRchr1280014987-0.0010991970.9989008
ENST00000519961ENST00000328827STAU2chr874621267-PAWRchr1280014987-0.0004625450.99953747

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87340_87340_1_STAU2-PAWR_STAU2_chr8_74621267_ENST00000519961_PAWR_chr12_80014987_ENST00000328827_length(amino acids)=206AA_BP=38
MANPKEKTAMCLVNELARFNRVQPQYKLLNERGPAHSKCLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSG
RYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDL

--------------------------------------------------------------

>87340_87340_2_STAU2-PAWR_STAU2_chr8_74650518_ENST00000522695_PAWR_chr12_80014987_ENST00000328827_length(amino acids)=174AA_BP=5
MLQINQCLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDA

--------------------------------------------------------------

>87340_87340_3_STAU2-PAWR_STAU2_chr8_74650519_ENST00000522695_PAWR_chr12_80014987_ENST00000328827_length(amino acids)=174AA_BP=5
MLQINQCLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:74650519/chr12:80014987)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePAWRchr8:74621267chr12:80014987ENST0000032882717186_206172.0341.0Coiled coilOntology_term=ECO:0000255
TgenePAWRchr8:74650518chr12:80014987ENST0000032882717186_206172.0341.0Coiled coilOntology_term=ECO:0000255
TgenePAWRchr8:74650519chr12:80014987ENST0000032882717186_206172.0341.0Coiled coilOntology_term=ECO:0000255
TgenePAWRchr8:74621267chr12:80014987ENST0000032882717300_340172.0341.0RegionNote=Leucine-zipper
TgenePAWRchr8:74650518chr12:80014987ENST0000032882717300_340172.0341.0RegionNote=Leucine-zipper
TgenePAWRchr8:74650519chr12:80014987ENST0000032882717300_340172.0341.0RegionNote=Leucine-zipper

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTAU2chr8:74621267chr12:80014987ENST00000524104-16207_2740106.0DomainDRBM 3
HgeneSTAU2chr8:74621267chr12:80014987ENST00000524104-16307_3750106.0DomainDRBM 4
HgeneSTAU2chr8:74621267chr12:80014987ENST00000524104-168_750106.0DomainDRBM 1
HgeneSTAU2chr8:74621267chr12:80014987ENST00000524104-1695_1810106.0DomainDRBM 2
HgeneSTAU2chr8:74650518chr12:80014987ENST00000524104-36207_2746.0106.0DomainDRBM 3
HgeneSTAU2chr8:74650518chr12:80014987ENST00000524104-36307_3756.0106.0DomainDRBM 4
HgeneSTAU2chr8:74650518chr12:80014987ENST00000524104-368_756.0106.0DomainDRBM 1
HgeneSTAU2chr8:74650518chr12:80014987ENST00000524104-3695_1816.0106.0DomainDRBM 2
HgeneSTAU2chr8:74650519chr12:80014987ENST00000524104-36207_2746.0106.0DomainDRBM 3
HgeneSTAU2chr8:74650519chr12:80014987ENST00000524104-36307_3756.0106.0DomainDRBM 4
HgeneSTAU2chr8:74650519chr12:80014987ENST00000524104-368_756.0106.0DomainDRBM 1
HgeneSTAU2chr8:74650519chr12:80014987ENST00000524104-3695_1816.0106.0DomainDRBM 2
HgeneSTAU2chr8:74621267chr12:80014987ENST00000524104-16273_2910106.0MotifNuclear localization signal 1
HgeneSTAU2chr8:74621267chr12:80014987ENST00000524104-16373_4120106.0MotifNuclear localization signal 2
HgeneSTAU2chr8:74650518chr12:80014987ENST00000524104-36273_2916.0106.0MotifNuclear localization signal 1
HgeneSTAU2chr8:74650518chr12:80014987ENST00000524104-36373_4126.0106.0MotifNuclear localization signal 2
HgeneSTAU2chr8:74650519chr12:80014987ENST00000524104-36273_2916.0106.0MotifNuclear localization signal 1
HgeneSTAU2chr8:74650519chr12:80014987ENST00000524104-36373_4126.0106.0MotifNuclear localization signal 2
HgeneSTAU2chr8:74621267chr12:80014987ENST00000524104-16381_5700106.0RegionRequired for dendritic transport
HgeneSTAU2chr8:74650518chr12:80014987ENST00000524104-36381_5706.0106.0RegionRequired for dendritic transport
HgeneSTAU2chr8:74650519chr12:80014987ENST00000524104-36381_5706.0106.0RegionRequired for dendritic transport
TgenePAWRchr8:74621267chr12:80014987ENST000003288271749_120172.0341.0Compositional biasNote=Ala-rich
TgenePAWRchr8:74650518chr12:80014987ENST000003288271749_120172.0341.0Compositional biasNote=Ala-rich
TgenePAWRchr8:74650519chr12:80014987ENST000003288271749_120172.0341.0Compositional biasNote=Ala-rich
TgenePAWRchr8:74621267chr12:80014987ENST0000032882717145_161172.0341.0MotifNuclear localization signal
TgenePAWRchr8:74621267chr12:80014987ENST000003288271768_72172.0341.0MotifB30.2/SPRY domain-binding motif
TgenePAWRchr8:74650518chr12:80014987ENST0000032882717145_161172.0341.0MotifNuclear localization signal
TgenePAWRchr8:74650518chr12:80014987ENST000003288271768_72172.0341.0MotifB30.2/SPRY domain-binding motif
TgenePAWRchr8:74650519chr12:80014987ENST0000032882717145_161172.0341.0MotifNuclear localization signal
TgenePAWRchr8:74650519chr12:80014987ENST000003288271768_72172.0341.0MotifB30.2/SPRY domain-binding motif
TgenePAWRchr8:74621267chr12:80014987ENST0000032882717145_203172.0341.0RegionNote=Selective for apoptosis induction in cancer cells (SAC)
TgenePAWRchr8:74650518chr12:80014987ENST0000032882717145_203172.0341.0RegionNote=Selective for apoptosis induction in cancer cells (SAC)
TgenePAWRchr8:74650519chr12:80014987ENST0000032882717145_203172.0341.0RegionNote=Selective for apoptosis induction in cancer cells (SAC)


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
STAU2
PAWR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to STAU2-PAWR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to STAU2-PAWR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource