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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:STIM1-WT1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: STIM1-WT1
	FusionPDB ID: 87410
	FusionGDB2.0 ID: 87410
		Hgene	Tgene
	Gene symbol	STIM1	WT1
	Gene ID	6786	7490
	Gene name	stromal interaction molecule 1	WT1 transcription factor
	Synonyms	D11S4896E\|GOK\|IMD10\|STRMK\|TAM\|TAM1	AWT1\|GUD\|NPHS4\|WAGR\|WIT-2\|WT33
	Cytomap	11p15.4	11p13
	Type of gene	protein-coding	protein-coding
	Description	stromal interaction molecule 1	Wilms tumor proteinWilms tumor 1
	Modification date	20200329	20200320
	UniProtAcc	.	P19544
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000527484, ENST00000300737, ENST00000527651, ENST00000533977,	ENST00000332351, ENST00000379079, ENST00000448076, ENST00000530998,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 13 X 12=3276	3 X 6 X 5=90
	# samples	23	4
	** MAII score	log2(23/3276*10)=-3.83222959069663 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/90*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: STIM1 [Title/Abstract] AND WT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	STIM1(4076867)-WT1(32421590), # samples:1
Anticipated loss of major functional domain due to fusion event.	STIM1-WT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STIM1-WT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STIM1-WT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. STIM1-WT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	STIM1	GO:0002115	store-operated calcium entry	28219928
Hgene	STIM1	GO:0005513	detection of calcium ion	16005298
Hgene	STIM1	GO:0032237	activation of store-operated calcium channel activity	16005298\|26322679\|28219928
Hgene	STIM1	GO:0045762	positive regulation of adenylate cyclase activity	19171672
Hgene	STIM1	GO:0051924	regulation of calcium ion transport	16005298
Tgene	WT1	GO:0000122	negative regulation of transcription by RNA polymerase II	7585606
Tgene	WT1	GO:0007530	sex determination	9815658
Tgene	WT1	GO:0008285	negative regulation of cell proliferation	9553041\|9765217
Tgene	WT1	GO:0030308	negative regulation of cell growth	9553041\|9765217
Tgene	WT1	GO:0045892	negative regulation of transcription, DNA-templated	1332065\|7585606\|7720589\|8119964\|12802290\|14701728\|19050011
Tgene	WT1	GO:0045893	positive regulation of transcription, DNA-templated	8132626\|9178767\|9553041\|9765217\|12802290\|14701728\|16467207\|21390327
Tgene	WT1	GO:0045944	positive regulation of transcription by RNA polymerase II	23042785
Tgene	WT1	GO:0071371	cellular response to gonadotropin stimulus	15961562

Fusion gene breakpoints across STIM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-23-1028	STIM1	chr11	4076867	+	WT1	chr11	32421590	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000300737	STIM1	chr11	4076867	+	ENST00000379079	WT1	chr11	32421590	-	2893	1066	554	1609	351
ENST00000300737	STIM1	chr11	4076867	+	ENST00000332351	WT1	chr11	32421590	-	2902	1066	554	1618	354
ENST00000300737	STIM1	chr11	4076867	+	ENST00000530998	WT1	chr11	32421590	-	2899	1066	554	1618	354
ENST00000300737	STIM1	chr11	4076867	+	ENST00000448076	WT1	chr11	32421590	-	1989	1066	554	1609	351
ENST00000527651	STIM1	chr11	4076867	+	ENST00000379079	WT1	chr11	32421590	-	2413	586	74	1129	351
ENST00000527651	STIM1	chr11	4076867	+	ENST00000332351	WT1	chr11	32421590	-	2422	586	74	1138	354
ENST00000527651	STIM1	chr11	4076867	+	ENST00000530998	WT1	chr11	32421590	-	2419	586	74	1138	354
ENST00000527651	STIM1	chr11	4076867	+	ENST00000448076	WT1	chr11	32421590	-	1509	586	74	1129	351

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000300737	ENST00000379079	STIM1	chr11	4076867	+	WT1	chr11	32421590	-	0.00281895	0.99718106
ENST00000300737	ENST00000332351	STIM1	chr11	4076867	+	WT1	chr11	32421590	-	0.002580013	0.99741995
ENST00000300737	ENST00000530998	STIM1	chr11	4076867	+	WT1	chr11	32421590	-	0.002614367	0.9973857
ENST00000300737	ENST00000448076	STIM1	chr11	4076867	+	WT1	chr11	32421590	-	0.023239242	0.97676075
ENST00000527651	ENST00000379079	STIM1	chr11	4076867	+	WT1	chr11	32421590	-	0.001381308	0.9986187
ENST00000527651	ENST00000332351	STIM1	chr11	4076867	+	WT1	chr11	32421590	-	0.001304796	0.9986952
ENST00000527651	ENST00000530998	STIM1	chr11	4076867	+	WT1	chr11	32421590	-	0.001309107	0.9986909
ENST00000527651	ENST00000448076	STIM1	chr11	4076867	+	WT1	chr11	32421590	-	0.008601601	0.99139833

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87410_87410_1_STIM1-WT1_STIM1_chr11_4076867_ENST00000300737_WT1_chr11_32421590_ENST00000332351_length(amino acids)=354AA_BP=170
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------

>87410_87410_2_STIM1-WT1_STIM1_chr11_4076867_ENST00000300737_WT1_chr11_32421590_ENST00000379079_length(amino acids)=351AA_BP=170
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------

>87410_87410_3_STIM1-WT1_STIM1_chr11_4076867_ENST00000300737_WT1_chr11_32421590_ENST00000448076_length(amino acids)=351AA_BP=170
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------

>87410_87410_4_STIM1-WT1_STIM1_chr11_4076867_ENST00000300737_WT1_chr11_32421590_ENST00000530998_length(amino acids)=354AA_BP=170
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------

>87410_87410_5_STIM1-WT1_STIM1_chr11_4076867_ENST00000527651_WT1_chr11_32421590_ENST00000332351_length(amino acids)=354AA_BP=170
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------

>87410_87410_6_STIM1-WT1_STIM1_chr11_4076867_ENST00000527651_WT1_chr11_32421590_ENST00000379079_length(amino acids)=351AA_BP=170
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------

>87410_87410_7_STIM1-WT1_STIM1_chr11_4076867_ENST00000527651_WT1_chr11_32421590_ENST00000448076_length(amino acids)=351AA_BP=170
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------

>87410_87410_8_STIM1-WT1_STIM1_chr11_4076867_ENST00000527651_WT1_chr11_32421590_ENST00000530998_length(amino acids)=354AA_BP=170
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:4076867/chr11:32421590)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	WT1 P19544
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). {ECO:0000269\|PubMed:15520190, ECO:0000269\|PubMed:16934801, ECO:0000269\|PubMed:17716689, ECO:0000269\|PubMed:19123921, ECO:0000269\|PubMed:19416806, ECO:0000269\|PubMed:25258363, ECO:0000269\|PubMed:7862533}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

76_87

165.66666666666666

686.0

Calcium binding

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

63_98

165.66666666666666

686.0

Domain

Note=EF-hand

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000379079

236_244

121.66666666666667

303.0

Motif

9aaTAD

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000530998

236_244

104.66666666666667

289.0

Motif

9aaTAD

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000379079

323_347

121.66666666666667

303.0

Zinc finger

C2H2-type 1

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000379079

353_377

121.66666666666667

303.0

Zinc finger

C2H2-type 2

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000379079

383_405

121.66666666666667

303.0

Zinc finger

C2H2-type 3

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000379079

414_438

121.66666666666667

303.0

Zinc finger

C2H2-type 4

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000530998

323_347

104.66666666666667

289.0

Zinc finger

C2H2-type 1

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000530998

353_377

104.66666666666667

289.0

Zinc finger

C2H2-type 2

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000530998

383_405

104.66666666666667

289.0

Zinc finger

C2H2-type 3

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000530998

414_438

104.66666666666667

289.0

Zinc finger

C2H2-type 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

248_442

165.66666666666666

686.0

Coiled coil

Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

270_336

165.66666666666666

686.0

Compositional bias

Note=Glu-rich

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

600_629

165.66666666666666

686.0

Compositional bias

Note=Pro/Ser-rich

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

672_685

165.66666666666666

686.0

Compositional bias

Note=Lys-rich

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

132_200

165.66666666666666

686.0

Domain

SAM

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

642_645

165.66666666666666

686.0

Motif

Note=Microtubule tip localization signal

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

334_444

165.66666666666666

686.0

Region

Note=SOAR/CAD

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

235_685

165.66666666666666

686.0

Topological domain

Cytoplasmic

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

23_213

165.66666666666666

686.0

Topological domain

Extracellular

Hgene

STIM1

chr11:4076867

chr11:32421590

ENST00000300737

214_234

165.66666666666666

686.0

Transmembrane

Helical

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000379079

27_83

121.66666666666667

303.0

Compositional bias

Note=Pro-rich

Tgene

WT1

chr11:4076867

chr11:32421590

ENST00000530998

27_83

104.66666666666667

289.0

Compositional bias

Note=Pro-rich

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
STIM1
WT1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to STIM1-WT1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to STIM1-WT1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	WT1	C0950121	Denys-Drash Syndrome	20	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	WT1	C0027708	Nephroblastoma	8	CGI;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	WT1	C3151568	NEPHROTIC SYNDROME, TYPE 4	6	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	WT1	C0950122	Frasier Syndrome	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	WT1	C1837026	MEACHAM SYNDROME (disorder)	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	WT1	C0023467	Leukemia, Myelocytic, Acute	2	CGI;CTD_human
Tgene	WT1	C0026998	Acute Myeloid Leukemia, M1	2	CTD_human
Tgene	WT1	C0345967	Malignant mesothelioma	2	CTD_human;GENOMICS_ENGLAND
Tgene	WT1	C1879321	Acute Myeloid Leukemia (AML-M2)	2	CTD_human
Tgene	WT1	C2930471	Bilateral Wilms Tumor	2	CTD_human
Tgene	WT1	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	WT1	C0007102	Malignant tumor of colon	1	CTD_human
Tgene	WT1	C0009375	Colonic Neoplasms	1	CTD_human
Tgene	WT1	C0017636	Glioblastoma	1	CTD_human
Tgene	WT1	C0017658	Glomerulonephritis	1	CTD_human
Tgene	WT1	C0018054	Gonadal Dysgenesis, 46,XY	1	ORPHANET
Tgene	WT1	C0019284	Diaphragmatic Hernia	1	CTD_human
Tgene	WT1	C0023418	leukemia	1	CTD_human
Tgene	WT1	C0023473	Myeloid Leukemia, Chronic	1	CTD_human
Tgene	WT1	C0023487	Acute Promyelocytic Leukemia	1	CTD_human
Tgene	WT1	C0024121	Lung Neoplasms	1	CTD_human
Tgene	WT1	C0027809	Neurilemmoma	1	CTD_human
Tgene	WT1	C0029463	Osteosarcoma	1	CTD_human
Tgene	WT1	C0030297	Pancreatic Neoplasm	1	CTD_human
Tgene	WT1	C0031149	Peritoneal Neoplasms	1	CTD_human
Tgene	WT1	C0085215	Ovarian Failure, Premature	1	CTD_human
Tgene	WT1	C0086367	Gonadotropin-Resistant Ovary Syndrome	1	CTD_human
Tgene	WT1	C0206115	WAGR Syndrome	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	WT1	C0235833	Congenital diaphragmatic hernia	1	CTD_human
Tgene	WT1	C0242379	Malignant neoplasm of lung	1	CTD_human
Tgene	WT1	C0265699	Congenital hernia of foramen of Morgagni	1	CTD_human
Tgene	WT1	C0265700	Congenital hernia of foramen of Bochdalek	1	CTD_human
Tgene	WT1	C0334588	Giant Cell Glioblastoma	1	CTD_human
Tgene	WT1	C0346647	Malignant neoplasm of pancreas	1	CTD_human
Tgene	WT1	C0346990	Carcinomatosis of peritoneal cavity	1	CTD_human
Tgene	WT1	C0678222	Breast Carcinoma	1	CTD_human
Tgene	WT1	C0751374	Schwannomatosis, Plexiform	1	CTD_human
Tgene	WT1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	WT1	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	WT1	C1621958	Glioblastoma Multiforme	1	CTD_human
Tgene	WT1	C1704377	Bright Disease	1	CTD_human
Tgene	WT1	C1840452	Hyaloideoretinal degeneration of Wagner	1	GENOMICS_ENGLAND
Tgene	WT1	C1868672	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	1	ORPHANET
Tgene	WT1	C2931803	Deletion 11p13	1	ORPHANET
Tgene	WT1	C2936694	Swyer Syndrome	1	ORPHANET
Tgene	WT1	C3494522	Hypergonadotropic Ovarian Failure, X-Linked	1	CTD_human
Tgene	WT1	C4510744	46,XY partial gonadal dysgenesis	1	ORPHANET
Tgene	WT1	C4552079	Premature Ovarian Failure 1	1	CTD_human
Tgene	WT1	C4704874	Mammary Carcinoma, Human	1	CTD_human