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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:STRN-HEATR5B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: STRN-HEATR5B
FusionPDB ID: 87738
FusionGDB2.0 ID: 87738
HgeneTgene
Gene symbol

STRN

HEATR5B

Gene ID

6801

54497

Gene namestriatinHEAT repeat containing 5B
SynonymsPPP2R6A|SG2NA|STRN1-
Cytomap

2p22.2

2p22.2

Type of geneprotein-codingprotein-coding
Descriptionstriatinprotein phosphatase 2 regulatory subunit B'''alphastriatin, calmodulin binding proteinHEAT repeat-containing protein 5B
Modification date2020031320200313
UniProtAcc

O43815

Q9P2D3

Ensembl transtripts involved in fusion geneENST idsENST00000263918, ENST00000379213, 
ENST00000233099, ENST00000354531, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 14 X 10=14004 X 7 X 6=168
# samples 158
** MAII scorelog2(15/1400*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: STRN [Title/Abstract] AND HEATR5B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)STRN(37193373)-HEATR5B(37216002), # samples:2
Anticipated loss of major functional domain due to fusion event.STRN-HEATR5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
STRN-HEATR5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
STRN-HEATR5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
STRN-HEATR5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across STRN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HEATR5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0BP-01ASTRNchr2

37121041

-HEATR5Bchr2

37293053

-
ChimerDB4CESCTCGA-HM-A6W2-01ASTRNchr2

37193373

-HEATR5Bchr2

37195744

-
ChimerDB4LUSCTCGA-94-8491-01ASTRNchr2

37096697

-HEATR5Bchr2

37208937

-
ChimerDB4SARCTCGA-KD-A5QS-01ASTRNchr2

37193373

-HEATR5Bchr2

37216002

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263918STRNchr237096697-ENST00000233099HEATR5Bchr237208937-2406150891562517
ENST00000263918STRNchr237096697-ENST00000354531HEATR5Bchr237208937-2293150891562517
ENST00000379213STRNchr237096697-ENST00000233099HEATR5Bchr237208937-2250135201406468
ENST00000379213STRNchr237096697-ENST00000354531HEATR5Bchr237208937-2137135201406468
ENST00000263918STRNchr237121041-ENST00000233099HEATR5Bchr237293053-6572940959781989
ENST00000263918STRNchr237121041-ENST00000354531HEATR5Bchr237293053-6192940957111900
ENST00000379213STRNchr237121041-ENST00000233099HEATR5Bchr237293053-6527895059331977
ENST00000379213STRNchr237121041-ENST00000354531HEATR5Bchr237293053-6147895056661888

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263918ENST00000233099STRNchr237096697-HEATR5Bchr237208937-0.0004268660.9995732
ENST00000263918ENST00000354531STRNchr237096697-HEATR5Bchr237208937-0.0005459290.9994541
ENST00000379213ENST00000233099STRNchr237096697-HEATR5Bchr237208937-0.0004117540.9995883
ENST00000379213ENST00000354531STRNchr237096697-HEATR5Bchr237208937-0.0005290320.999471
ENST00000263918ENST00000233099STRNchr237121041-HEATR5Bchr237293053-0.0003947530.99960524
ENST00000263918ENST00000354531STRNchr237121041-HEATR5Bchr237293053-0.0008019910.999198
ENST00000379213ENST00000233099STRNchr237121041-HEATR5Bchr237293053-0.000369360.9996306
ENST00000379213ENST00000354531STRNchr237121041-HEATR5Bchr237293053-0.0007516060.9992483

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87738_87738_1_STRN-HEATR5B_STRN_chr2_37096697_ENST00000263918_HEATR5B_chr2_37208937_ENST00000233099_length(amino acids)=517AA_BP=500
MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKG
QENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS
KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKK
ALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN
LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALR

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>87738_87738_2_STRN-HEATR5B_STRN_chr2_37096697_ENST00000263918_HEATR5B_chr2_37208937_ENST00000354531_length(amino acids)=517AA_BP=500
MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKG
QENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS
KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKK
ALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN
LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALR

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>87738_87738_3_STRN-HEATR5B_STRN_chr2_37096697_ENST00000379213_HEATR5B_chr2_37208937_ENST00000233099_length(amino acids)=468AA_BP=451
MDEQAGPGVFFSNNHPGAGGAKGLGPLAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRI
KMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSD
VTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTK
EALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSF
IMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAK

--------------------------------------------------------------

>87738_87738_4_STRN-HEATR5B_STRN_chr2_37096697_ENST00000379213_HEATR5B_chr2_37208937_ENST00000354531_length(amino acids)=468AA_BP=451
MDEQAGPGVFFSNNHPGAGGAKGLGPLAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRI
KMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSD
VTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTK
EALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSF
IMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAK

--------------------------------------------------------------

>87738_87738_5_STRN-HEATR5B_STRN_chr2_37121041_ENST00000263918_HEATR5B_chr2_37293053_ENST00000233099_length(amino acids)=1989AA_BP=310
MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKG
QENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS
KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKK
ALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEA
SIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVS
IAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFV
AHCPELLTEDVIRKLMTPIECAMTMMSHIPSVMKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTS
LLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQ
MLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGPLDNPNPILRCAAGEALGRMAQVVGEATFIARM
AQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVL
TLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATTSTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLC
VHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNTGDKESSSANVSPFAPGVSSRTDIHCRHQGVNITETGLEGLLFGMLDRETD
RKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSTATLLSSGKDEEAEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAA
DCLCRIINLCENADQAHFDLALARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQY
QANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVV
AMNIKKEAESKPKRAIKNTDDDDDDCGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARL
HYRNSWAPILHAVALWLNSTGFTCSESTEAAAISGLQKRSTSVNLNQASGAVGSAKSLPEINKDRMHLILGVSIQFLCSPRPEEPIEHVT
ACLQALHTLLDSPYARVHIAEDQLIGVELLSVLHRLLLTWNPSSVQLLVTGVVQQIVRAAQDYLQEKRNTLNEDDMEKEACTVLGEGGDS
GGLIPGKSLVFATMELLMFILVRHMPHLSTKVSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLIARILKDT
AIKSADNQVPPPVSAALQGIKSIVTLSMAKTEAGVQKQWTALIRSTLACILEYSQPEDSVPTPDEVSMLTAIALFLWSASNEIIGVQSLQ
NGCMNRFKNALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPASNIELLAVQEGIKVLETLVALGEEQNRV
QLLALLVPTLISYLLDENSFASASSASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKVRLETAVRASQASKAKAAARQPAPAIHSAP

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>87738_87738_6_STRN-HEATR5B_STRN_chr2_37121041_ENST00000263918_HEATR5B_chr2_37293053_ENST00000354531_length(amino acids)=1900AA_BP=310
MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKG
QENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS
KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKK
ALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEA
SIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVS
IAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFV
AHCPELLTEDVIRKLMTPIECAMTMMSHIPSVMKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTS
LLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQ
MLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGPLDNPNPILRCAAGEALGRMAQVVGEATFIARM
AQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVL
TLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATTSTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLC
VHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNTGDKESSSANVSPFAPGVSSRTDIHCRHQGVNITETGLEGLLFGMLDRETD
RKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSTATLLSSGKDEEAEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAA
DCLCRIINLCENADQAHFDLALARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQY
QANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVV
AMNIKKEAESKPKRAIKNTDDDDDDCGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARL
HYRNSWAPILHAVALWLNSTGFTCSESTEAAAISGLQKRSTSVNLNQASGAVGSAKSLPEINKDRMHLILGVSIQFLCSPRPEEPIEHVT
ACLQALHTLLDSPYARVHIAEDQLIGVELLSVLHRLLLTWNPSSVQLLVTGVVQQIVRAAQDYLQEKRNTLRCMTILPTILFLIARILKD
TAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEAGVQKQWTALIRSTLACILEYSQPEDSVPTPDEVSMLTAIALFLWSASNEIIGVQSL
QNGCMNRFKNALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPASNIELLAVQEGIKVLETLVALGEEQNR
VQLLALLVPTLISYLLDENSFASASSASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKVRLETAVRASQASKAKAAARQPAPAIHSA

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>87738_87738_7_STRN-HEATR5B_STRN_chr2_37121041_ENST00000379213_HEATR5B_chr2_37293053_ENST00000233099_length(amino acids)=1977AA_BP=298
MDEQAGPGVFFSNNHPGAGGAKGLGPLAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRI
KMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSD
VTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTK
EALKEFDFLVTSEEGDNESRSAGDGTDWEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIVTSVL
LHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQN
SRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVI
RKLMTPIECAMTMMSHIPSVMKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSV
LLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQMLDHFAECVKQA
KGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGPLDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSAR
DVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTE
VHQCLGRCLGAIITTVGPELQGNGATTSTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRR
AAVACLRQLAQREAAEVCEYAMSLAKNTGDKESSSANVSPFAPGVSSRTDIHCRHQGVNITETGLEGLLFGMLDRETDRKLCSDIHDTLG
HMLSSLAVEKLSHWLMLCKDVLAASSDMSTATLLSSGKDEEAEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCEN
ADQAHFDLALARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAF
SQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKP
KRAIKNTDDDDDDCGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHA
VALWLNSTGFTCSESTEAAAISGLQKRSTSVNLNQASGAVGSAKSLPEINKDRMHLILGVSIQFLCSPRPEEPIEHVTACLQALHTLLDS
PYARVHIAEDQLIGVELLSVLHRLLLTWNPSSVQLLVTGVVQQIVRAAQDYLQEKRNTLNEDDMEKEACTVLGEGGDSGGLIPGKSLVFA
TMELLMFILVRHMPHLSTKVSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPP
VSAALQGIKSIVTLSMAKTEAGVQKQWTALIRSTLACILEYSQPEDSVPTPDEVSMLTAIALFLWSASNEIIGVQSLQNGCMNRFKNALN
SCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPASNIELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLIS

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>87738_87738_8_STRN-HEATR5B_STRN_chr2_37121041_ENST00000379213_HEATR5B_chr2_37293053_ENST00000354531_length(amino acids)=1888AA_BP=298
MDEQAGPGVFFSNNHPGAGGAKGLGPLAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRI
KMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSD
VTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTK
EALKEFDFLVTSEEGDNESRSAGDGTDWEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIVTSVL
LHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQN
SRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVI
RKLMTPIECAMTMMSHIPSVMKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSV
LLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQMLDHFAECVKQA
KGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGPLDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSAR
DVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTE
VHQCLGRCLGAIITTVGPELQGNGATTSTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRR
AAVACLRQLAQREAAEVCEYAMSLAKNTGDKESSSANVSPFAPGVSSRTDIHCRHQGVNITETGLEGLLFGMLDRETDRKLCSDIHDTLG
HMLSSLAVEKLSHWLMLCKDVLAASSDMSTATLLSSGKDEEAEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCEN
ADQAHFDLALARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAF
SQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKP
KRAIKNTDDDDDDCGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHA
VALWLNSTGFTCSESTEAAAISGLQKRSTSVNLNQASGAVGSAKSLPEINKDRMHLILGVSIQFLCSPRPEEPIEHVTACLQALHTLLDS
PYARVHIAEDQLIGVELLSVLHRLLLTWNPSSVQLLVTGVVQQIVRAAQDYLQEKRNTLRCMTILPTILFLIARILKDTAIKSADNQVPP
PVSAALQGIKSIVTLSMAKTEAGVQKQWTALIRSTLACILEYSQPEDSVPTPDEVSMLTAIALFLWSASNEIIGVQSLQNGCMNRFKNAL
NSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPASNIELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:37193373/chr2:37216002)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STRN

O43815

HEATR5B

Q9P2D3

FUNCTION: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.FUNCTION: Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTRNchr2:37096697chr2:37208937ENST00000263918-111853_120499.6666666666667781.0Coiled coilOntology_term=ECO:0000255
HgeneSTRNchr2:37096697chr2:37208937ENST00000379213-111853_120450.6666666666667732.0Coiled coilOntology_term=ECO:0000255
HgeneSTRNchr2:37121041chr2:37293053ENST00000263918-71853_120310.3333333333333781.0Coiled coilOntology_term=ECO:0000255
HgeneSTRNchr2:37121041chr2:37293053ENST00000379213-81853_120298.3333333333333732.0Coiled coilOntology_term=ECO:0000255
HgeneSTRNchr2:37096697chr2:37208937ENST00000263918-1118149_166499.6666666666667781.0RegionCalmodulin-binding
HgeneSTRNchr2:37096697chr2:37208937ENST00000263918-111855_63499.6666666666667781.0RegionCaveolin-binding
HgeneSTRNchr2:37096697chr2:37208937ENST00000379213-1118149_166450.6666666666667732.0RegionCalmodulin-binding
HgeneSTRNchr2:37096697chr2:37208937ENST00000379213-111855_63450.6666666666667732.0RegionCaveolin-binding
HgeneSTRNchr2:37121041chr2:37293053ENST00000263918-718149_166310.3333333333333781.0RegionCalmodulin-binding
HgeneSTRNchr2:37121041chr2:37293053ENST00000263918-71855_63310.3333333333333781.0RegionCaveolin-binding
HgeneSTRNchr2:37121041chr2:37293053ENST00000379213-818149_166298.3333333333333732.0RegionCalmodulin-binding
HgeneSTRNchr2:37121041chr2:37293053ENST00000379213-81855_63298.3333333333333732.0RegionCaveolin-binding
HgeneSTRNchr2:37193373chr2:37216002ENST00000263918-11855_6378.0781.0RegionCaveolin-binding
HgeneSTRNchr2:37193373chr2:37216002ENST00000379213-21855_6366.0732.0RegionCaveolin-binding
HgeneSTRNchr2:37096697chr2:37208937ENST00000263918-1118461_500499.6666666666667781.0RepeatNote=WD 1
TgeneHEATR5Bchr2:37121041chr2:37293053ENST000002330997361062_1099392.33333333333332072.0RepeatNote=HEAT 2
TgeneHEATR5Bchr2:37121041chr2:37293053ENST000002330997361290_1327392.33333333333332072.0RepeatNote=HEAT 3
TgeneHEATR5Bchr2:37121041chr2:37293053ENST00000233099736848_885392.33333333333332072.0RepeatNote=HEAT 1
TgeneHEATR5Bchr2:37121041chr2:37293053ENST000003545317351062_1099392.33333333333331983.0RepeatNote=HEAT 2
TgeneHEATR5Bchr2:37121041chr2:37293053ENST000003545317351290_1327392.33333333333331983.0RepeatNote=HEAT 3
TgeneHEATR5Bchr2:37121041chr2:37293053ENST00000354531735848_885392.33333333333331983.0RepeatNote=HEAT 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTRNchr2:37193373chr2:37216002ENST00000263918-11853_12078.0781.0Coiled coilOntology_term=ECO:0000255
HgeneSTRNchr2:37193373chr2:37216002ENST00000379213-21853_12066.0732.0Coiled coilOntology_term=ECO:0000255
HgeneSTRNchr2:37193373chr2:37216002ENST00000263918-118149_16678.0781.0RegionCalmodulin-binding
HgeneSTRNchr2:37193373chr2:37216002ENST00000379213-218149_16666.0732.0RegionCalmodulin-binding
HgeneSTRNchr2:37096697chr2:37208937ENST00000263918-1118514_553499.6666666666667781.0RepeatNote=WD 2
HgeneSTRNchr2:37096697chr2:37208937ENST00000263918-1118567_606499.6666666666667781.0RepeatNote=WD 3
HgeneSTRNchr2:37096697chr2:37208937ENST00000263918-1118662_701499.6666666666667781.0RepeatNote=WD 4
HgeneSTRNchr2:37096697chr2:37208937ENST00000263918-1118704_743499.6666666666667781.0RepeatNote=WD 5
HgeneSTRNchr2:37096697chr2:37208937ENST00000263918-1118750_779499.6666666666667781.0RepeatNote=WD 6
HgeneSTRNchr2:37096697chr2:37208937ENST00000379213-1118461_500450.6666666666667732.0RepeatNote=WD 1
HgeneSTRNchr2:37096697chr2:37208937ENST00000379213-1118514_553450.6666666666667732.0RepeatNote=WD 2
HgeneSTRNchr2:37096697chr2:37208937ENST00000379213-1118567_606450.6666666666667732.0RepeatNote=WD 3
HgeneSTRNchr2:37096697chr2:37208937ENST00000379213-1118662_701450.6666666666667732.0RepeatNote=WD 4
HgeneSTRNchr2:37096697chr2:37208937ENST00000379213-1118704_743450.6666666666667732.0RepeatNote=WD 5
HgeneSTRNchr2:37096697chr2:37208937ENST00000379213-1118750_779450.6666666666667732.0RepeatNote=WD 6
HgeneSTRNchr2:37121041chr2:37293053ENST00000263918-718461_500310.3333333333333781.0RepeatNote=WD 1
HgeneSTRNchr2:37121041chr2:37293053ENST00000263918-718514_553310.3333333333333781.0RepeatNote=WD 2
HgeneSTRNchr2:37121041chr2:37293053ENST00000263918-718567_606310.3333333333333781.0RepeatNote=WD 3
HgeneSTRNchr2:37121041chr2:37293053ENST00000263918-718662_701310.3333333333333781.0RepeatNote=WD 4
HgeneSTRNchr2:37121041chr2:37293053ENST00000263918-718704_743310.3333333333333781.0RepeatNote=WD 5
HgeneSTRNchr2:37121041chr2:37293053ENST00000263918-718750_779310.3333333333333781.0RepeatNote=WD 6
HgeneSTRNchr2:37121041chr2:37293053ENST00000379213-818461_500298.3333333333333732.0RepeatNote=WD 1
HgeneSTRNchr2:37121041chr2:37293053ENST00000379213-818514_553298.3333333333333732.0RepeatNote=WD 2
HgeneSTRNchr2:37121041chr2:37293053ENST00000379213-818567_606298.3333333333333732.0RepeatNote=WD 3
HgeneSTRNchr2:37121041chr2:37293053ENST00000379213-818662_701298.3333333333333732.0RepeatNote=WD 4
HgeneSTRNchr2:37121041chr2:37293053ENST00000379213-818704_743298.3333333333333732.0RepeatNote=WD 5
HgeneSTRNchr2:37121041chr2:37293053ENST00000379213-818750_779298.3333333333333732.0RepeatNote=WD 6
HgeneSTRNchr2:37193373chr2:37216002ENST00000263918-118461_50078.0781.0RepeatNote=WD 1
HgeneSTRNchr2:37193373chr2:37216002ENST00000263918-118514_55378.0781.0RepeatNote=WD 2
HgeneSTRNchr2:37193373chr2:37216002ENST00000263918-118567_60678.0781.0RepeatNote=WD 3
HgeneSTRNchr2:37193373chr2:37216002ENST00000263918-118662_70178.0781.0RepeatNote=WD 4
HgeneSTRNchr2:37193373chr2:37216002ENST00000263918-118704_74378.0781.0RepeatNote=WD 5
HgeneSTRNchr2:37193373chr2:37216002ENST00000263918-118750_77978.0781.0RepeatNote=WD 6
HgeneSTRNchr2:37193373chr2:37216002ENST00000379213-218461_50066.0732.0RepeatNote=WD 1
HgeneSTRNchr2:37193373chr2:37216002ENST00000379213-218514_55366.0732.0RepeatNote=WD 2
HgeneSTRNchr2:37193373chr2:37216002ENST00000379213-218567_60666.0732.0RepeatNote=WD 3
HgeneSTRNchr2:37193373chr2:37216002ENST00000379213-218662_70166.0732.0RepeatNote=WD 4
HgeneSTRNchr2:37193373chr2:37216002ENST00000379213-218704_74366.0732.0RepeatNote=WD 5
HgeneSTRNchr2:37193373chr2:37216002ENST00000379213-218750_77966.0732.0RepeatNote=WD 6
TgeneHEATR5Bchr2:37096697chr2:37208937ENST0000023309934361062_10991970.33333333333332072.0RepeatNote=HEAT 2
TgeneHEATR5Bchr2:37096697chr2:37208937ENST0000023309934361290_13271970.33333333333332072.0RepeatNote=HEAT 3
TgeneHEATR5Bchr2:37096697chr2:37208937ENST000002330993436848_8851970.33333333333332072.0RepeatNote=HEAT 1
TgeneHEATR5Bchr2:37096697chr2:37208937ENST0000035453133351062_10991881.33333333333331983.0RepeatNote=HEAT 2
TgeneHEATR5Bchr2:37096697chr2:37208937ENST0000035453133351290_13271881.33333333333331983.0RepeatNote=HEAT 3
TgeneHEATR5Bchr2:37096697chr2:37208937ENST000003545313335848_8851881.33333333333331983.0RepeatNote=HEAT 1
TgeneHEATR5Bchr2:37193373chr2:37216002ENST0000023309933361062_10991899.02072.0RepeatNote=HEAT 2
TgeneHEATR5Bchr2:37193373chr2:37216002ENST0000023309933361290_13271899.02072.0RepeatNote=HEAT 3
TgeneHEATR5Bchr2:37193373chr2:37216002ENST000002330993336848_8851899.02072.0RepeatNote=HEAT 1
TgeneHEATR5Bchr2:37193373chr2:37216002ENST0000035453132351062_10991810.01983.0RepeatNote=HEAT 2
TgeneHEATR5Bchr2:37193373chr2:37216002ENST0000035453132351290_13271810.01983.0RepeatNote=HEAT 3
TgeneHEATR5Bchr2:37193373chr2:37216002ENST000003545313235848_8851810.01983.0RepeatNote=HEAT 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
STRNSTK24, MCC, CTTNBP2, CTTNBP2NL, STRIP1, MOB4, PDCD10, PPP2CA, PPP2R1A, STK26, SIKE1, STK25, STRN3, PPP2R1B, STRN4, STRIP2, SLMAP, CCT2, CCT8, CCT3, TCP1, CCT5, FGFR1OP2, CCT6A, CCT7, CCT4, CCT6B, TRAF3IP3, PPP2CB, ZRANB1, Dynll1, ELAVL1, LNX1, APC, TJP1, DDX1, DYNC1H1, CPSF6, EIF2S1, SF3B5, BRCA1, ECT2, PAXIP1, STK3, STK4, TFIP11, RINT1, PCOLCE2, LYPD3, NR1H3, PPP2R2C, RASSF3, PGAM5, NTRK1, HSPB1, DYNLL1, MAP4K4, EEF1E1, BAG2, SLC43A3, AHNAK, Ppp2ca, Ppp2r1a, Strn3, Arrb2, Strip1, PRDM14, TNFRSF1A, NHSL2, PSMC5, PLP1, ZNF550, SNX24, LRRCC1, ZNF331, PRPF19, SPINK2, EXOC1, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, GIPC1, ESR2, USP15, GOLGA2, KIAA1429, ATG16L1, HOOK3, EP300, ESR1, RMDN3, CUL4A, TULP3, GOLGA1, TMOD1, MINK1, TNIK, SMAD4, DYNLL2, PMF1, RABEP2, ENDOD1, FLII, KIAA1522, GOLGA8G, ISCA2, GOLGA6A, FILIP1, SSUH2, PCM1, CAMK2B, MAP1S,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
STRNall structure
HEATR5B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to STRN-HEATR5B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to STRN-HEATR5B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource