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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:STXBP4-NIPA2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: STXBP4-NIPA2
FusionPDB ID: 87889
FusionGDB2.0 ID: 87889
HgeneTgene
Gene symbol

STXBP4

NIPA2

Gene ID

252983

81614

Gene namesyntaxin binding protein 4NIPA magnesium transporter 2
SynonymsSynipSLC57A2
Cytomap

17q22

15q11.2

Type of geneprotein-codingprotein-coding
Descriptionsyntaxin-binding protein 4STX4-interacting proteinsyntaxin 4 interacting proteinmagnesium transporter NIPA2non imprinted in Prader-Willi/Angelman syndrome 2non-imprinted in Prader-Willi/Angelman syndrome region protein 2
Modification date2020031320200313
UniProtAcc.

Q8N8Q9

Ensembl transtripts involved in fusion geneENST idsENST00000376352, ENST00000434978, 
ENST00000299341, ENST00000398391, 
ENST00000405898, 		ENST00000559571, 
ENST00000337451, ENST00000359727, 
ENST00000398013, ENST00000398014, 
ENST00000539711, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 6 X 3=1262 X 2 X 2=8
# samples 62
** MAII scorelog2(6/126*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: STXBP4 [Title/Abstract] AND NIPA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)STXBP4(53158544)-NIPA2(23014528), # samples:1
Anticipated loss of major functional domain due to fusion event.STXBP4-NIPA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
STXBP4-NIPA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
STXBP4-NIPA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
STXBP4-NIPA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTXBP4

GO:0006974

cellular response to DNA damage stimulus

19451233

HgeneSTXBP4

GO:0061178

regulation of insulin secretion involved in cellular response to glucose stimulus

12855681


check buttonFusion gene breakpoints across STXBP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NIPA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1F2-01ASTXBP4chr17

53158544

+NIPA2chr15

23014528

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376352STXBP4chr1753158544+ENST00000337451NIPA2chr1523014528+412016962072582791
ENST00000376352STXBP4chr1753158544+ENST00000398014NIPA2chr1523014528+412016962072582791
ENST00000376352STXBP4chr1753158544+ENST00000398013NIPA2chr1523014528+345216962072582791
ENST00000376352STXBP4chr1753158544+ENST00000539711NIPA2chr1523014528+265216962072582791
ENST00000376352STXBP4chr1753158544+ENST00000359727NIPA2chr1523014528+258316962072582791
ENST00000434978STXBP4chr1753158544+ENST00000337451NIPA2chr1523014528+404316191962505769
ENST00000434978STXBP4chr1753158544+ENST00000398014NIPA2chr1523014528+404316191962505769
ENST00000434978STXBP4chr1753158544+ENST00000398013NIPA2chr1523014528+337516191962505769
ENST00000434978STXBP4chr1753158544+ENST00000539711NIPA2chr1523014528+257516191962505769
ENST00000434978STXBP4chr1753158544+ENST00000359727NIPA2chr1523014528+250616191962505770

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376352ENST00000337451STXBP4chr1753158544+NIPA2chr1523014528+0.0001200760.99987996
ENST00000376352ENST00000398014STXBP4chr1753158544+NIPA2chr1523014528+0.0001200760.99987996
ENST00000376352ENST00000398013STXBP4chr1753158544+NIPA2chr1523014528+0.0001323070.9998677
ENST00000376352ENST00000539711STXBP4chr1753158544+NIPA2chr1523014528+0.0001718960.9998281
ENST00000376352ENST00000359727STXBP4chr1753158544+NIPA2chr1523014528+0.0002042970.99979573
ENST00000434978ENST00000337451STXBP4chr1753158544+NIPA2chr1523014528+0.0001462540.99985373
ENST00000434978ENST00000398014STXBP4chr1753158544+NIPA2chr1523014528+0.0001462540.99985373
ENST00000434978ENST00000398013STXBP4chr1753158544+NIPA2chr1523014528+0.0001607080.9998393
ENST00000434978ENST00000539711STXBP4chr1753158544+NIPA2chr1523014528+0.0002082950.9997917
ENST00000434978ENST00000359727STXBP4chr1753158544+NIPA2chr1523014528+0.0002569090.99974304

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87889_87889_1_STXBP4-NIPA2_STXBP4_chr17_53158544_ENST00000376352_NIPA2_chr15_23014528_ENST00000337451_length(amino acids)=791AA_BP=497
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII
TGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDE
VNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ
RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSN
LSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDLGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLN
LHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGL
GIAIKELFAGKPVLRHPLAWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTI

--------------------------------------------------------------

>87889_87889_2_STXBP4-NIPA2_STXBP4_chr17_53158544_ENST00000376352_NIPA2_chr15_23014528_ENST00000359727_length(amino acids)=791AA_BP=497
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII
TGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDE
VNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ
RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSN
LSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDLGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLN
LHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGL
GIAIKELFAGKPVLRHPLAWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTI

--------------------------------------------------------------

>87889_87889_3_STXBP4-NIPA2_STXBP4_chr17_53158544_ENST00000376352_NIPA2_chr15_23014528_ENST00000398013_length(amino acids)=791AA_BP=497
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII
TGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDE
VNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ
RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSN
LSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDLGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLN
LHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGL
GIAIKELFAGKPVLRHPLAWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTI

--------------------------------------------------------------

>87889_87889_4_STXBP4-NIPA2_STXBP4_chr17_53158544_ENST00000376352_NIPA2_chr15_23014528_ENST00000398014_length(amino acids)=791AA_BP=497
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII
TGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDE
VNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ
RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSN
LSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDLGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLN
LHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGL
GIAIKELFAGKPVLRHPLAWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTI

--------------------------------------------------------------

>87889_87889_5_STXBP4-NIPA2_STXBP4_chr17_53158544_ENST00000376352_NIPA2_chr15_23014528_ENST00000539711_length(amino acids)=791AA_BP=497
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII
TGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDE
VNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ
RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSN
LSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDLGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLN
LHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGL
GIAIKELFAGKPVLRHPLAWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTI

--------------------------------------------------------------

>87889_87889_6_STXBP4-NIPA2_STXBP4_chr17_53158544_ENST00000434978_NIPA2_chr15_23014528_ENST00000337451_length(amino acids)=769AA_BP=475
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII
TGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDE
VNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKIT
ELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGR
SIPATLALESKELVKSVRALLDMDLGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAP
KEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLAWIL
LLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPV

--------------------------------------------------------------

>87889_87889_7_STXBP4-NIPA2_STXBP4_chr17_53158544_ENST00000434978_NIPA2_chr15_23014528_ENST00000359727_length(amino acids)=770AA_BP=475
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII
TGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDE
VNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKIT
ELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGR
SIPATLALESKELVKSVRALLDMDLGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAP
KEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLAWIL
LLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPV

--------------------------------------------------------------

>87889_87889_8_STXBP4-NIPA2_STXBP4_chr17_53158544_ENST00000434978_NIPA2_chr15_23014528_ENST00000398013_length(amino acids)=769AA_BP=475
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII
TGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDE
VNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKIT
ELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGR
SIPATLALESKELVKSVRALLDMDLGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAP
KEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLAWIL
LLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPV

--------------------------------------------------------------

>87889_87889_9_STXBP4-NIPA2_STXBP4_chr17_53158544_ENST00000434978_NIPA2_chr15_23014528_ENST00000398014_length(amino acids)=769AA_BP=475
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII
TGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDE
VNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKIT
ELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGR
SIPATLALESKELVKSVRALLDMDLGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAP
KEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLAWIL
LLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPV

--------------------------------------------------------------

>87889_87889_10_STXBP4-NIPA2_STXBP4_chr17_53158544_ENST00000434978_NIPA2_chr15_23014528_ENST00000539711_length(amino acids)=769AA_BP=475
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII
TGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDE
VNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKIT
ELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGR
SIPATLALESKELVKSVRALLDMDLGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAP
KEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLAWIL
LLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:53158544/chr15:23014528)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NIPA2

Q8N8Q9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Acts as a selective Mg(2+) transporter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTXBP4chr17:53158544chr15:23014528ENST00000376352+1618291_417496.3333333333333554.0Coiled coilOntology_term=ECO:0000255
HgeneSTXBP4chr17:53158544chr15:23014528ENST00000376352+161819_105496.3333333333333554.0DomainPDZ
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148100_10765.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148129_14965.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148171_17565.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148197_21565.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148237_24665.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148268_27865.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148300_36065.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST000003374514878_7865.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726100_10746.333333333333336342.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726129_14946.333333333333336342.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726171_17546.333333333333336342.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726197_21546.333333333333336342.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726237_24646.333333333333336342.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726268_27846.333333333333336342.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726300_36046.333333333333336342.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST000003597272678_7846.333333333333336342.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326100_10765.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326129_14965.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326171_17565.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326197_21565.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326237_24665.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326268_27865.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326300_36065.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST000003980132678_7865.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437100_10765.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437129_14965.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437171_17565.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437197_21565.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437237_24665.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437268_27865.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437300_36065.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST000003980143778_7865.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115100_10746.333333333333336342.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115129_14946.333333333333336342.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115171_17546.333333333333336342.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115197_21546.333333333333336342.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115237_24646.333333333333336342.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115268_27846.333333333333336342.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115300_36046.333333333333336342.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST000005397111578_7846.333333333333336342.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148108_12865.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148150_17065.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148176_19665.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148216_23665.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148247_26765.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000033745148279_29965.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000003374514879_9965.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726108_12846.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726150_17046.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726176_19646.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726216_23646.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726247_26746.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000035972726279_29946.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000003597272657_7746.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000003597272679_9946.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326108_12865.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326150_17065.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326176_19665.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326216_23665.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326247_26765.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801326279_29965.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000003980132679_9965.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437108_12865.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437150_17065.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437176_19665.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437216_23665.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437247_26765.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000039801437279_29965.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000003980143779_9965.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115108_12846.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115150_17046.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115176_19646.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115216_23646.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115247_26746.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST0000053971115279_29946.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000005397111557_7746.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000005397111579_9946.333333333333336342.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTXBP4chr17:53158544chr15:23014528ENST00000299341+112291_4170246.0Coiled coilOntology_term=ECO:0000255
HgeneSTXBP4chr17:53158544chr15:23014528ENST00000398391+111291_4170246.0Coiled coilOntology_term=ECO:0000255
HgeneSTXBP4chr17:53158544chr15:23014528ENST00000299341+11219_1050246.0DomainPDZ
HgeneSTXBP4chr17:53158544chr15:23014528ENST00000299341+112496_5290246.0DomainWW
HgeneSTXBP4chr17:53158544chr15:23014528ENST00000376352+1618496_529496.3333333333333554.0DomainWW
HgeneSTXBP4chr17:53158544chr15:23014528ENST00000398391+11119_1050246.0DomainPDZ
HgeneSTXBP4chr17:53158544chr15:23014528ENST00000398391+111496_5290246.0DomainWW
TgeneNIPA2chr17:53158544chr15:23014528ENST00000337451481_965.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST000003374514831_5665.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST00000359727261_946.333333333333336342.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST000003597272631_5646.333333333333336342.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST00000398013261_965.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST000003980132631_5665.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST00000398014371_965.33333333333333361.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST000003980143731_5665.33333333333333361.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST00000539711151_946.333333333333336342.0Topological domainExtracellular
TgeneNIPA2chr17:53158544chr15:23014528ENST000005397111531_5646.333333333333336342.0Topological domainCytoplasmic
TgeneNIPA2chr17:53158544chr15:23014528ENST000003374514810_3065.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000003374514857_7765.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000003597272610_3046.333333333333336342.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000003980132610_3065.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000003980132657_7765.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000003980143710_3065.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000003980143757_7765.33333333333333361.0TransmembraneHelical
TgeneNIPA2chr17:53158544chr15:23014528ENST000005397111510_3046.333333333333336342.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
STXBP4
NIPA2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to STXBP4-NIPA2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to STXBP4-NIPA2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource