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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SUZ12-LRRC37A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SUZ12-LRRC37A
	FusionPDB ID: 88241
	FusionGDB2.0 ID: 88241
		Hgene	Tgene
	Gene symbol	SUZ12	LRRC37A
	Gene ID	23512	105376839
	Gene name	SUZ12 polycomb repressive complex 2 subunit	uncharacterized LOC105376839
	Synonyms	CHET9\|IMMAS\|JJAZ1	LRRC37A
	Cytomap	17q11.2	17q21.31
	Type of gene	protein-coding	ncRNA
	Description	polycomb protein SUZ12chET 9 proteinchromatin precipitated E2F target 9 proteinjoined to JAZF1 proteinsuppressor of zeste 12 protein homolog	leucine rich repeat containing 37A
	Modification date	20200313	20200313
	UniProtAcc	Q15022	O60309
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000322652, ENST00000580398,	ENST00000320254, ENST00000393465, ENST00000496930,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 12 X 10=1800	7 X 7 X 6=294
	# samples	15	7
	** MAII score	log2(15/1800*10)=-3.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SUZ12 [Title/Abstract] AND LRRC37A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SUZ12(30303633)-LRRC37A(44405757), # samples:1
Anticipated loss of major functional domain due to fusion event.	SUZ12-LRRC37A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SUZ12-LRRC37A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SUZ12-LRRC37A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SUZ12-LRRC37A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SUZ12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LRRC37A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DU-5874	SUZ12	chr17	30303633	+	LRRC37A	chr17	44405757	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000322652	SUZ12	chr17	30303633	+	ENST00000496930	LRRC37A	chr17	44405757	+	3265	1146	37	3195	1052
ENST00000322652	SUZ12	chr17	30303633	+	ENST00000393465	LRRC37A	chr17	44405757	+	3055	1146	37	3000	987
ENST00000322652	SUZ12	chr17	30303633	+	ENST00000320254	LRRC37A	chr17	44405757	+	3267	1146	37	3195	1052
ENST00000580398	SUZ12	chr17	30303633	+	ENST00000496930	LRRC37A	chr17	44405757	+	3147	1028	108	3077	989
ENST00000580398	SUZ12	chr17	30303633	+	ENST00000393465	LRRC37A	chr17	44405757	+	2937	1028	108	2882	924
ENST00000580398	SUZ12	chr17	30303633	+	ENST00000320254	LRRC37A	chr17	44405757	+	3149	1028	108	3077	989

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000322652	ENST00000496930	SUZ12	chr17	30303633	+	LRRC37A	chr17	44405757	+	0.000705379	0.99929464
ENST00000322652	ENST00000393465	SUZ12	chr17	30303633	+	LRRC37A	chr17	44405757	+	0.000943891	0.99905616
ENST00000322652	ENST00000320254	SUZ12	chr17	30303633	+	LRRC37A	chr17	44405757	+	0.000718043	0.99928194
ENST00000580398	ENST00000496930	SUZ12	chr17	30303633	+	LRRC37A	chr17	44405757	+	0.000689777	0.99931026
ENST00000580398	ENST00000393465	SUZ12	chr17	30303633	+	LRRC37A	chr17	44405757	+	0.001085499	0.9989145
ENST00000580398	ENST00000320254	SUZ12	chr17	30303633	+	LRRC37A	chr17	44405757	+	0.000702647	0.9992974

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88241_88241_1_SUZ12-LRRC37A_SUZ12_chr17_30303633_ENST00000322652_LRRC37A_chr17_44405757_ENST00000320254_length(amino acids)=1052AA_BP=369
MRRHFFFPPSFPPLLLPSLPLSSPLSSFPPRSAGACWGERLVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFG
GSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLT
YMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQV
PTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFV
AQMTVFDKNRILPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGI
NLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIR
REQGAQASVENAAEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGTPSTSSPAKALPQVRDRSKDLTHA
ISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQ
ENPFLEVSALSEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEP
KSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKI
ENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRSLQEDEEGFSRGIFRFLPWRGCSSRRESQ

--------------------------------------------------------------

>88241_88241_2_SUZ12-LRRC37A_SUZ12_chr17_30303633_ENST00000322652_LRRC37A_chr17_44405757_ENST00000393465_length(amino acids)=987AA_BP=369
MRRHFFFPPSFPPLLLPSLPLSSPLSSFPPRSAGACWGERLVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFG
GSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLT
YMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQV
PTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFV
AQMTVFDKNRILPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGI
NLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIR
REQGAQASVENAAEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGTPSTSSPAKALPQVRDRSKDLTHA
ISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQ
ENPFLEVSALSEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEP
KSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKI

--------------------------------------------------------------

>88241_88241_3_SUZ12-LRRC37A_SUZ12_chr17_30303633_ENST00000322652_LRRC37A_chr17_44405757_ENST00000496930_length(amino acids)=1052AA_BP=369
MRRHFFFPPSFPPLLLPSLPLSSPLSSFPPRSAGACWGERLVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFG
GSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLT
YMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQV
PTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFV
AQMTVFDKNRILPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGI
NLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIR
REQGAQASVENAAEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGTPSTSSPAKALPQVRDRSKDLTHA
ISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQ
ENPFLEVSALSEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEP
KSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKI
ENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRSLQEDEEGFSRGIFRFLPWRGCSSRRESQ

--------------------------------------------------------------

>88241_88241_4_SUZ12-LRRC37A_SUZ12_chr17_30303633_ENST00000580398_LRRC37A_chr17_44405757_ENST00000320254_length(amino acids)=989AA_BP=306
MVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGA
AVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSPNSENEQ
NSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGE
TNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRILPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFM
KVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNR
QRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPF
SKGTPSTSSPAKALPQVRDRSKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPKVRKKSYLSRLMLANR
LPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSALSEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTA
FNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRT
GHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRSL

--------------------------------------------------------------

>88241_88241_5_SUZ12-LRRC37A_SUZ12_chr17_30303633_ENST00000580398_LRRC37A_chr17_44405757_ENST00000393465_length(amino acids)=924AA_BP=306
MVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGA
AVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSPNSENEQ
NSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGE
TNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRILPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFM
KVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNR
QRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPF
SKGTPSTSSPAKALPQVRDRSKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPKVRKKSYLSRLMLANR
LPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSALSEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTA
FNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRT
GHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRSL

--------------------------------------------------------------

>88241_88241_6_SUZ12-LRRC37A_SUZ12_chr17_30303633_ENST00000580398_LRRC37A_chr17_44405757_ENST00000496930_length(amino acids)=989AA_BP=306
MVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGA
AVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSPNSENEQ
NSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGE
TNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRILPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFM
KVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNR
QRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPF
SKGTPSTSSPAKALPQVRDRSKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPKVRKKSYLSRLMLANR
LPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSALSEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTA
FNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRT
GHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRSL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:30303633/chr17:44405757)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SUZ12 Q15022	LRRC37A O60309
FUNCTION: Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269\|PubMed:12351676, ECO:0000269\|PubMed:12435631, ECO:0000269\|PubMed:15099518, ECO:0000269\|PubMed:15225548, ECO:0000269\|PubMed:15231737, ECO:0000269\|PubMed:15385962, ECO:0000269\|PubMed:15684044, ECO:0000269\|PubMed:16431907, ECO:0000269\|PubMed:16618801, ECO:0000269\|PubMed:17200670, ECO:0000269\|PubMed:17344414, ECO:0000269\|PubMed:18086877, ECO:0000269\|PubMed:18285464, ECO:0000269\|PubMed:28229514, ECO:0000269\|PubMed:29499137, ECO:0000269\|PubMed:31959557}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SUZ12

chr17:30303633

chr17:44405757

ENST00000322652

51_59

305.6666666666667

740.0

Compositional bias

Note=Poly-Ser

Hgene

SUZ12

chr17:30303633

chr17:44405757

ENST00000322652

60_67

305.6666666666667

740.0

Compositional bias

Note=Poly-Ala

Hgene

SUZ12

chr17:30303633

chr17:44405757

ENST00000322652

7_50

305.6666666666667

740.0

Compositional bias

Note=Gly-rich

Tgene

LRRC37A

chr17:30303633

chr17:44405757

ENST00000320254

1604_1700

1017.6666666666666

1701.0

Topological domain

Cytoplasmic

Tgene

LRRC37A

chr17:30303633

chr17:44405757

ENST00000320254

1583_1603

1017.6666666666666

1701.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SUZ12

chr17:30303633

chr17:44405757

ENST00000322652

563_639

305.6666666666667

740.0

Region

Note=VEFS-box

Hgene

SUZ12

chr17:30303633

chr17:44405757

ENST00000322652

448_471

305.6666666666667

740.0

Zinc finger

Note=C2H2-type

Tgene

LRRC37A

chr17:30303633

chr17:44405757

ENST00000320254

866_887

1017.6666666666666

1701.0

Repeat

Note=LRR 1

Tgene

LRRC37A

chr17:30303633

chr17:44405757

ENST00000320254

890_911

1017.6666666666666

1701.0

Repeat

Note=LRR 2

Tgene

LRRC37A

chr17:30303633

chr17:44405757

ENST00000320254

914_935

1017.6666666666666

1701.0

Repeat

Note=LRR 3

Tgene

LRRC37A

chr17:30303633

chr17:44405757

ENST00000320254

938_959

1017.6666666666666

1701.0

Repeat

Note=LRR 4

Tgene

LRRC37A

chr17:30303633

chr17:44405757

ENST00000320254

965_986

1017.6666666666666

1701.0

Repeat

Note=LRR 5

Tgene

LRRC37A

chr17:30303633

chr17:44405757

ENST00000320254

36_1582

1017.6666666666666

1701.0

Topological domain

Extracellular

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SUZ12
LRRC37A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	SUZ12	chr17:30303633	chr17:44405757	ENST00000322652	+	8	16	146_363	305.6666666666667	740.0	AEBP2 and PHF19

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Related Drugs to SUZ12-LRRC37A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SUZ12-LRRC37A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	SUZ12	C0206727	Nerve Sheath Tumors	2	CTD_human
Hgene	SUZ12	C0751689	Peripheral Nerve Sheath Neoplasm	2	CTD_human
Hgene	SUZ12	C0751691	Perineurioma	2	CTD_human
Hgene	SUZ12	C0001430	Adenoma	1	CTD_human
Hgene	SUZ12	C0014170	Endometrial Neoplasms	1	CTD_human
Hgene	SUZ12	C0017636	Glioblastoma	1	CTD_human
Hgene	SUZ12	C0017638	Glioma	1	CTD_human
Hgene	SUZ12	C0025202	melanoma	1	CTD_human
Hgene	SUZ12	C0027809	Neurilemmoma	1	CTD_human
Hgene	SUZ12	C0027830	neurofibroma	1	CTD_human
Hgene	SUZ12	C0027962	Melanocytic nevus	1	CTD_human
Hgene	SUZ12	C0042063	Urogenital Abnormalities	1	GENOMICS_ENGLAND
Hgene	SUZ12	C0205646	Adenoma, Basal Cell	1	CTD_human
Hgene	SUZ12	C0205647	Follicular adenoma	1	CTD_human
Hgene	SUZ12	C0205648	Adenoma, Microcystic	1	CTD_human
Hgene	SUZ12	C0205649	Adenoma, Monomorphic	1	CTD_human
Hgene	SUZ12	C0205650	Papillary adenoma	1	CTD_human
Hgene	SUZ12	C0205651	Adenoma, Trabecular	1	CTD_human
Hgene	SUZ12	C0206630	Endometrial Stromal Sarcoma	1	ORPHANET
Hgene	SUZ12	C0259783	mixed gliomas	1	CTD_human
Hgene	SUZ12	C0265210	Weaver syndrome	1	ORPHANET
Hgene	SUZ12	C0334588	Giant Cell Glioblastoma	1	CTD_human
Hgene	SUZ12	C0476089	Endometrial Carcinoma	1	CTD_human
Hgene	SUZ12	C0545053	Advanced bone age	1	GENOMICS_ENGLAND
Hgene	SUZ12	C0555198	Malignant Glioma	1	CTD_human
Hgene	SUZ12	C0557874	Global developmental delay	1	GENOMICS_ENGLAND
Hgene	SUZ12	C0751374	Schwannomatosis, Plexiform	1	CTD_human
Hgene	SUZ12	C1621958	Glioblastoma Multiforme	1	CTD_human
Hgene	SUZ12	C1842581	Abnormal corpus callosum morphology	1	GENOMICS_ENGLAND
Hgene	SUZ12	C1849265	Overgrowth	1	GENOMICS_ENGLAND
Hgene	SUZ12	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Hgene	SUZ12	C4018871	Abnormality of the respiratory system	1	GENOMICS_ENGLAND
Hgene	SUZ12	C4021664	Abnormality of the abdominal wall	1	GENOMICS_ENGLAND
Hgene	SUZ12	C4021790	Abnormality of the skeletal system	1	GENOMICS_ENGLAND