UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SYNPO2-METTL14

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SYNPO2-METTL14
	FusionPDB ID: 88473
	FusionGDB2.0 ID: 88473
		Hgene	Tgene
	Gene symbol	SYNPO2	METTL14
	Gene ID	171024	57721
	Gene name	synaptopodin 2	methyltransferase like 14
	Synonyms	-	hMETTL14
	Cytomap	4q26	4q26
	Type of gene	protein-coding	protein-coding
	Description	synaptopodin-2genethonin-2myopodin	N6-adenosine-methyltransferase non-catalytic subunitN6-adenosine-methyltransferase subunit METTL14methyltransferase-like protein 14
	Modification date	20200313	20200313
	UniProtAcc	.	Q9HCE5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000307142, ENST00000429713, ENST00000434046, ENST00000448416,	ENST00000388822, ENST00000506780,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 5 X 5=175	3 X 3 X 3=27
	# samples	9	3
	** MAII score	log2(9/175*10)=-0.959358015502654 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SYNPO2 [Title/Abstract] AND METTL14 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SYNPO2(119810296)-METTL14(119621705), # samples:3
Anticipated loss of major functional domain due to fusion event.	SYNPO2-METTL14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SYNPO2-METTL14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SYNPO2-METTL14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SYNPO2-METTL14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	METTL14	GO:0080009	mRNA methylation	27281194\|27373337\|27627798

Fusion gene breakpoints across SYNPO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across METTL14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PCPG	TCGA-QR-A707-01A	SYNPO2	chr4	119810296	-	METTL14	chr4	119621705	+
ChimerDB4	PCPG	TCGA-QR-A707-01A	SYNPO2	chr4	119810296	+	METTL14	chr4	119621705	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000307142	SYNPO2	chr4	119810296	+	ENST00000388822	METTL14	chr4	119621705	+	6158	301	196	1026	276
ENST00000307142	SYNPO2	chr4	119810296	+	ENST00000506780	METTL14	chr4	119621705	+	1328	301	196	1026	276
ENST00000448416	SYNPO2	chr4	119810296	+	ENST00000388822	METTL14	chr4	119621705	+	6145	288	183	1013	276
ENST00000448416	SYNPO2	chr4	119810296	+	ENST00000506780	METTL14	chr4	119621705	+	1315	288	183	1013	276
ENST00000429713	SYNPO2	chr4	119810296	+	ENST00000388822	METTL14	chr4	119621705	+	6144	287	182	1012	276
ENST00000429713	SYNPO2	chr4	119810296	+	ENST00000506780	METTL14	chr4	119621705	+	1314	287	182	1012	276
ENST00000434046	SYNPO2	chr4	119810296	+	ENST00000388822	METTL14	chr4	119621705	+	5962	105	0	830	276
ENST00000434046	SYNPO2	chr4	119810296	+	ENST00000506780	METTL14	chr4	119621705	+	1132	105	0	830	276

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000307142	ENST00000388822	SYNPO2	chr4	119810296	+	METTL14	chr4	119621705	+	0.011250936	0.988749
ENST00000307142	ENST00000506780	SYNPO2	chr4	119810296	+	METTL14	chr4	119621705	+	0.07369269	0.9263074
ENST00000448416	ENST00000388822	SYNPO2	chr4	119810296	+	METTL14	chr4	119621705	+	0.011186198	0.9888138
ENST00000448416	ENST00000506780	SYNPO2	chr4	119810296	+	METTL14	chr4	119621705	+	0.06742911	0.93257093
ENST00000429713	ENST00000388822	SYNPO2	chr4	119810296	+	METTL14	chr4	119621705	+	0.011176919	0.98882306
ENST00000429713	ENST00000506780	SYNPO2	chr4	119810296	+	METTL14	chr4	119621705	+	0.06619741	0.93380255
ENST00000434046	ENST00000388822	SYNPO2	chr4	119810296	+	METTL14	chr4	119621705	+	0.010507747	0.9894923
ENST00000434046	ENST00000506780	SYNPO2	chr4	119810296	+	METTL14	chr4	119621705	+	0.04907688	0.9509231

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88473_88473_1_SYNPO2-METTL14_SYNPO2_chr4_119810296_ENST00000307142_METTL14_chr4_119621705_ENST00000388822_length(amino acids)=276AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

--------------------------------------------------------------

>88473_88473_2_SYNPO2-METTL14_SYNPO2_chr4_119810296_ENST00000307142_METTL14_chr4_119621705_ENST00000506780_length(amino acids)=276AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

--------------------------------------------------------------

>88473_88473_3_SYNPO2-METTL14_SYNPO2_chr4_119810296_ENST00000429713_METTL14_chr4_119621705_ENST00000388822_length(amino acids)=276AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

--------------------------------------------------------------

>88473_88473_4_SYNPO2-METTL14_SYNPO2_chr4_119810296_ENST00000429713_METTL14_chr4_119621705_ENST00000506780_length(amino acids)=276AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

--------------------------------------------------------------

>88473_88473_5_SYNPO2-METTL14_SYNPO2_chr4_119810296_ENST00000434046_METTL14_chr4_119621705_ENST00000388822_length(amino acids)=276AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

--------------------------------------------------------------

>88473_88473_6_SYNPO2-METTL14_SYNPO2_chr4_119810296_ENST00000434046_METTL14_chr4_119621705_ENST00000506780_length(amino acids)=276AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

--------------------------------------------------------------

>88473_88473_7_SYNPO2-METTL14_SYNPO2_chr4_119810296_ENST00000448416_METTL14_chr4_119621705_ENST00000388822_length(amino acids)=276AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

--------------------------------------------------------------

>88473_88473_8_SYNPO2-METTL14_SYNPO2_chr4_119810296_ENST00000448416_METTL14_chr4_119621705_ENST00000506780_length(amino acids)=276AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:119810296/chr4:119621705)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	METTL14 Q9HCE5
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:29348140, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). {ECO:0000250\|UniProtKB:Q3UIK4, ECO:0000269\|PubMed:24316715, ECO:0000269\|PubMed:24407421, ECO:0000269\|PubMed:25719671, ECO:0000269\|PubMed:27281194, ECO:0000269\|PubMed:27373337, ECO:0000269\|PubMed:27627798, ECO:0000269\|PubMed:29348140}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

METTL14

chr4:119810296

chr4:119621705

ENST00000388822

409_452

215.0

457.0

Compositional bias

Note=Gly-rich

Tgene

METTL14

chr4:119810296

chr4:119621705

ENST00000388822

245_254

215.0

457.0

Region

Positively charged region required for RNA-binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

400_405

35.0

1262.0

Compositional bias

Note=Poly-Arg

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

423_426

35.0

1262.0

Compositional bias

Note=Poly-Glu

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

591_658

35.0

1262.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

756_818

35.0

1262.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

767_770

35.0

1262.0

Compositional bias

Note=Poly-Ser

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

400_405

35.0

1094.0

Compositional bias

Note=Poly-Arg

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

423_426

35.0

1094.0

Compositional bias

Note=Poly-Glu

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

591_658

35.0

1094.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

756_818

35.0

1094.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

767_770

35.0

1094.0

Compositional bias

Note=Poly-Ser

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

400_405

35.0

1110.0

Compositional bias

Note=Poly-Arg

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

423_426

35.0

1110.0

Compositional bias

Note=Poly-Glu

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

591_658

35.0

1110.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

756_818

35.0

1110.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

767_770

35.0

1110.0

Compositional bias

Note=Poly-Ser

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

6_88

35.0

1262.0

Domain

PDZ

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

6_88

35.0

1094.0

Domain

PDZ

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

6_88

35.0

1110.0

Domain

PDZ

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

398_406

35.0

1262.0

Motif

Nuclear localization signal

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

619_622

35.0

1262.0

Motif

PPPY motif

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

398_406

35.0

1094.0

Motif

Nuclear localization signal

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

619_622

35.0

1094.0

Motif

PPPY motif

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

398_406

35.0

1110.0

Motif

Nuclear localization signal

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

619_622

35.0

1110.0

Motif

PPPY motif

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

534_663

35.0

1262.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

664_803

35.0

1262.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

664_916

35.0

1262.0

Region

F-actin bundling activity

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000307142

751_900

35.0

1262.0

Region

Actin binding

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

534_663

35.0

1094.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

664_803

35.0

1094.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

664_916

35.0

1094.0

Region

F-actin bundling activity

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000429713

751_900

35.0

1094.0

Region

Actin binding

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

534_663

35.0

1110.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

664_803

35.0

1110.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

664_916

35.0

1110.0

Region

F-actin bundling activity

Hgene

SYNPO2

chr4:119810296

chr4:119621705

ENST00000434046

751_900

35.0

1110.0

Region

Actin binding

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SYNPO2
METTL14

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000307142	+	1	5	481_663	35.0	1262.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000307142	+	1	5	664_924	35.0	1262.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000307142	+	1	5	901_1093	35.0	1262.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000429713	+	1	4	481_663	35.0	1094.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000429713	+	1	4	664_924	35.0	1094.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000429713	+	1	4	901_1093	35.0	1094.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000434046	+	1	5	481_663	35.0	1110.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000434046	+	1	5	664_924	35.0	1110.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000434046	+	1	5	901_1093	35.0	1110.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000307142	+	1	5	615_626	35.0	1262.0	BAG3
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000429713	+	1	4	615_626	35.0	1094.0	BAG3
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000434046	+	1	5	615_626	35.0	1110.0	BAG3
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000307142	+	1	5	810_1093	35.0	1262.0	FLNC
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000429713	+	1	4	810_1093	35.0	1094.0	FLNC
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000434046	+	1	5	810_1093	35.0	1110.0	FLNC
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000307142	+	1	5	1_180	35.0	1262.0	VPS18
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000429713	+	1	4	1_180	35.0	1094.0	VPS18
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000434046	+	1	5	1_180	35.0	1110.0	VPS18
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000307142	+	1	5	607_811	35.0	1262.0	YWHAB
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000429713	+	1	4	607_811	35.0	1094.0	YWHAB
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000434046	+	1	5	607_811	35.0	1110.0	YWHAB
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000307142	+	1	5	1000_1019	35.0	1262.0	ZYX
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000429713	+	1	4	1000_1019	35.0	1094.0	ZYX
Hgene	SYNPO2	chr4:119810296	chr4:119621705	ENST00000434046	+	1	5	1000_1019	35.0	1110.0	ZYX
Tgene	METTL14	chr4:119810296	chr4:119621705	ENST00000388822		6	11	135_136	215.0	457.0	METTL3

Top

Related Drugs to SYNPO2-METTL14

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SYNPO2-METTL14

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source