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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SYNPO2-SUPT3H

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SYNPO2-SUPT3H
FusionPDB ID: 88476
FusionGDB2.0 ID: 88476
HgeneTgene
Gene symbol

SYNPO2

SUPT3H

Gene ID

171024

8464

Gene namesynaptopodin 2SPT3 homolog, SAGA and STAGA complex component
Synonyms-SPT3|SPT3L
Cytomap

4q26

6p21.1

Type of geneprotein-codingprotein-coding
Descriptionsynaptopodin-2genethonin-2myopodintranscription initiation protein SPT3 homologSPT3-like proteinsuppressor of Ty 3 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000307142, ENST00000429713, 
ENST00000434046, ENST00000448416, 
ENST00000371458, ENST00000459689, 
ENST00000306867, ENST00000371459, 
ENST00000371460, ENST00000371461, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 5 X 5=17519 X 9 X 9=1539
# samples 922
** MAII scorelog2(9/175*10)=-0.959358015502654
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(22/1539*10)=-2.80641780280355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SYNPO2 [Title/Abstract] AND SUPT3H [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SYNPO2(119810296)-SUPT3H(44988369), # samples:1
Anticipated loss of major functional domain due to fusion event.SYNPO2-SUPT3H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SYNPO2-SUPT3H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSUPT3H

GO:0016578

histone deubiquitination

18206972

TgeneSUPT3H

GO:0043966

histone H3 acetylation

11564863


check buttonFusion gene breakpoints across SYNPO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SUPT3H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J7-01ASYNPO2chr4

119810296

+SUPT3Hchr6

44988369

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000307142SYNPO2chr4119810296+ENST00000371460SUPT3Hchr644988369-21533011961068290
ENST00000307142SYNPO2chr4119810296+ENST00000371459SUPT3Hchr644988369-20403011961068290
ENST00000307142SYNPO2chr4119810296+ENST00000371461SUPT3Hchr644988369-10693011961068291
ENST00000307142SYNPO2chr4119810296+ENST00000306867SUPT3Hchr644988369-10693011961068291
ENST00000448416SYNPO2chr4119810296+ENST00000371460SUPT3Hchr644988369-21402881831055290
ENST00000448416SYNPO2chr4119810296+ENST00000371459SUPT3Hchr644988369-20272881831055290
ENST00000448416SYNPO2chr4119810296+ENST00000371461SUPT3Hchr644988369-10562881831055290
ENST00000448416SYNPO2chr4119810296+ENST00000306867SUPT3Hchr644988369-10562881831055290
ENST00000429713SYNPO2chr4119810296+ENST00000371460SUPT3Hchr644988369-21392871821054290
ENST00000429713SYNPO2chr4119810296+ENST00000371459SUPT3Hchr644988369-20262871821054290
ENST00000429713SYNPO2chr4119810296+ENST00000371461SUPT3Hchr644988369-10552871821054291
ENST00000429713SYNPO2chr4119810296+ENST00000306867SUPT3Hchr644988369-10552871821054291
ENST00000434046SYNPO2chr4119810296+ENST00000371460SUPT3Hchr644988369-19571050872290
ENST00000434046SYNPO2chr4119810296+ENST00000371459SUPT3Hchr644988369-18441050872290
ENST00000434046SYNPO2chr4119810296+ENST00000371461SUPT3Hchr644988369-8731050872290
ENST00000434046SYNPO2chr4119810296+ENST00000306867SUPT3Hchr644988369-8731050872290

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000307142ENST00000371460SYNPO2chr4119810296+SUPT3Hchr644988369-0.0013148290.9986852
ENST00000307142ENST00000371459SYNPO2chr4119810296+SUPT3Hchr644988369-0.0013608720.99863917
ENST00000307142ENST00000371461SYNPO2chr4119810296+SUPT3Hchr644988369-0.00309790.9969021
ENST00000307142ENST00000306867SYNPO2chr4119810296+SUPT3Hchr644988369-0.00309790.9969021
ENST00000448416ENST00000371460SYNPO2chr4119810296+SUPT3Hchr644988369-0.0011613430.9988387
ENST00000448416ENST00000371459SYNPO2chr4119810296+SUPT3Hchr644988369-0.0012107810.99878925
ENST00000448416ENST00000371461SYNPO2chr4119810296+SUPT3Hchr644988369-0.0028842960.99711573
ENST00000448416ENST00000306867SYNPO2chr4119810296+SUPT3Hchr644988369-0.0028842960.99711573
ENST00000429713ENST00000371460SYNPO2chr4119810296+SUPT3Hchr644988369-0.0011845880.9988154
ENST00000429713ENST00000371459SYNPO2chr4119810296+SUPT3Hchr644988369-0.0012302460.9987697
ENST00000429713ENST00000371461SYNPO2chr4119810296+SUPT3Hchr644988369-0.0028485210.99715155
ENST00000429713ENST00000306867SYNPO2chr4119810296+SUPT3Hchr644988369-0.0028485210.99715155
ENST00000434046ENST00000371460SYNPO2chr4119810296+SUPT3Hchr644988369-0.0008981750.9991019
ENST00000434046ENST00000371459SYNPO2chr4119810296+SUPT3Hchr644988369-0.0009550550.99904495
ENST00000434046ENST00000371461SYNPO2chr4119810296+SUPT3Hchr644988369-0.0018800380.9981199
ENST00000434046ENST00000306867SYNPO2chr4119810296+SUPT3Hchr644988369-0.0018800380.9981199

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88476_88476_1_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000307142_SUPT3H_chr6_44988369_ENST00000306867_length(amino acids)=291AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_2_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000307142_SUPT3H_chr6_44988369_ENST00000371459_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_3_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000307142_SUPT3H_chr6_44988369_ENST00000371460_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_4_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000307142_SUPT3H_chr6_44988369_ENST00000371461_length(amino acids)=291AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_5_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000429713_SUPT3H_chr6_44988369_ENST00000306867_length(amino acids)=291AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_6_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000429713_SUPT3H_chr6_44988369_ENST00000371459_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_7_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000429713_SUPT3H_chr6_44988369_ENST00000371460_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_8_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000429713_SUPT3H_chr6_44988369_ENST00000371461_length(amino acids)=291AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_9_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000434046_SUPT3H_chr6_44988369_ENST00000306867_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_10_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000434046_SUPT3H_chr6_44988369_ENST00000371459_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_11_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000434046_SUPT3H_chr6_44988369_ENST00000371460_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_12_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000434046_SUPT3H_chr6_44988369_ENST00000371461_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_13_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000448416_SUPT3H_chr6_44988369_ENST00000306867_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_14_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000448416_SUPT3H_chr6_44988369_ENST00000371459_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_15_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000448416_SUPT3H_chr6_44988369_ENST00000371460_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

>88476_88476_16_SYNPO2-SUPT3H_SYNPO2_chr4_119810296_ENST00000448416_SUPT3H_chr6_44988369_ENST00000371461_length(amino acids)=290AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDED
DLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCS
SMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:119810296/chr6:44988369)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15400_40535.01262.0Compositional biasNote=Poly-Arg
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15423_42635.01262.0Compositional biasNote=Poly-Glu
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15591_65835.01262.0Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15756_81835.01262.0Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15767_77035.01262.0Compositional biasNote=Poly-Ser
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14400_40535.01094.0Compositional biasNote=Poly-Arg
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14423_42635.01094.0Compositional biasNote=Poly-Glu
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14591_65835.01094.0Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14756_81835.01094.0Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14767_77035.01094.0Compositional biasNote=Poly-Ser
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15400_40535.01110.0Compositional biasNote=Poly-Arg
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15423_42635.01110.0Compositional biasNote=Poly-Glu
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15591_65835.01110.0Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15756_81835.01110.0Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15767_77035.01110.0Compositional biasNote=Poly-Ser
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+156_8835.01262.0DomainPDZ
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+146_8835.01094.0DomainPDZ
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+156_8835.01110.0DomainPDZ
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15398_40635.01262.0MotifNuclear localization signal
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15619_62235.01262.0MotifPPPY motif
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14398_40635.01094.0MotifNuclear localization signal
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14619_62235.01094.0MotifPPPY motif
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15398_40635.01110.0MotifNuclear localization signal
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15619_62235.01110.0MotifPPPY motif
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15534_66335.01262.0RegionF-actin binding
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15664_80335.01262.0RegionF-actin binding
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15664_91635.01262.0RegionF-actin bundling activity
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15751_90035.01262.0RegionActin binding
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14534_66335.01094.0RegionF-actin binding
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14664_80335.01094.0RegionF-actin binding
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14664_91635.01094.0RegionF-actin bundling activity
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14751_90035.01094.0RegionActin binding
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15534_66335.01110.0RegionF-actin binding
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15664_80335.01110.0RegionF-actin binding
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15664_91635.01110.0RegionF-actin bundling activity
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15751_90035.01110.0RegionActin binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SYNPO2
SUPT3H


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15481_66335.01262.0ACTN2
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15664_92435.01262.0ACTN2
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15901_109335.01262.0ACTN2
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14481_66335.01094.0ACTN2
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14664_92435.01094.0ACTN2
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14901_109335.01094.0ACTN2
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15481_66335.01110.0ACTN2
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15664_92435.01110.0ACTN2
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15901_109335.01110.0ACTN2
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15615_62635.01262.0BAG3
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14615_62635.01094.0BAG3
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15615_62635.01110.0BAG3
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15810_109335.01262.0FLNC
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14810_109335.01094.0FLNC
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15810_109335.01110.0FLNC
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+151_18035.01262.0VPS18
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+141_18035.01094.0VPS18
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+151_18035.01110.0VPS18
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+15607_81135.01262.0YWHAB
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+14607_81135.01094.0YWHAB
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+15607_81135.01110.0YWHAB
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000307142+151000_101935.01262.0ZYX
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000429713+141000_101935.01094.0ZYX
HgeneSYNPO2chr4:119810296chr6:44988369ENST00000434046+151000_101935.01110.0ZYX


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Related Drugs to SYNPO2-SUPT3H


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SYNPO2-SUPT3H


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource