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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SYS1-SMYD3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SYS1-SMYD3
	FusionPDB ID: 88525
	FusionGDB2.0 ID: 88525
		Hgene	Tgene
	Gene symbol	SYS1	SMYD3
	Gene ID	90196	64754
	Gene name	SYS1 golgi trafficking protein	SET and MYND domain containing 3
	Synonyms	C20orf169\|dJ453C12.4\|dJ453C12.4.1	KMT3E\|ZMYND1\|ZNFN3A1\|bA74P14.1
	Cytomap	20q13.12	1q44
	Type of gene	protein-coding	protein-coding
	Description	protein SYS1 homologSYS1 Golgi-localized integral membrane protein homolog	histone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1
	Modification date	20200313	20200320
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000479779, ENST00000243918, ENST00000372727, ENST00000414310, ENST00000426004,	ENST00000388985, ENST00000490107, ENST00000541742, ENST00000366517, ENST00000403792,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 3 X 3=27	29 X 14 X 17=6902
	# samples	4	47
	** MAII score	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(47/6902*10)=-3.87628181187052 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SYS1 [Title/Abstract] AND SMYD3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SYS1(43994326)-SMYD3(245927451), # samples:2
Anticipated loss of major functional domain due to fusion event.	SYS1-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SYS1-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SYS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SMYD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-2557-01A	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-
ChimerDB4	GBM	TCGA-06-2557	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000372727	SYS1	chr20	43994326	+	ENST00000541742	SMYD3	chr1	245927451	-	907	473	99	683	194
ENST00000372727	SYS1	chr20	43994326	+	ENST00000490107	SMYD3	chr1	245927451	-	905	473	99	683	194
ENST00000372727	SYS1	chr20	43994326	+	ENST00000388985	SMYD3	chr1	245927451	-	684	473	99	683	194
ENST00000414310	SYS1	chr20	43994326	+	ENST00000541742	SMYD3	chr1	245927451	-	878	444	85	654	189
ENST00000414310	SYS1	chr20	43994326	+	ENST00000490107	SMYD3	chr1	245927451	-	876	444	85	654	189
ENST00000414310	SYS1	chr20	43994326	+	ENST00000388985	SMYD3	chr1	245927451	-	655	444	85	654	190
ENST00000243918	SYS1	chr20	43994326	+	ENST00000541742	SMYD3	chr1	245927451	-	955	521	30	731	233
ENST00000243918	SYS1	chr20	43994326	+	ENST00000490107	SMYD3	chr1	245927451	-	953	521	30	731	233
ENST00000243918	SYS1	chr20	43994326	+	ENST00000388985	SMYD3	chr1	245927451	-	732	521	30	731	233
ENST00000426004	SYS1	chr20	43994326	+	ENST00000541742	SMYD3	chr1	245927451	-	844	410	36	620	194
ENST00000426004	SYS1	chr20	43994326	+	ENST00000490107	SMYD3	chr1	245927451	-	842	410	36	620	194
ENST00000426004	SYS1	chr20	43994326	+	ENST00000388985	SMYD3	chr1	245927451	-	621	410	36	620	194

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372727	ENST00000541742	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.013098113	0.9869019
ENST00000372727	ENST00000490107	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.013367028	0.98663294
ENST00000372727	ENST00000388985	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.016539497	0.9834605
ENST00000414310	ENST00000541742	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.019997992	0.9800019
ENST00000414310	ENST00000490107	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.020367648	0.9796323
ENST00000414310	ENST00000388985	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.025100486	0.97489953
ENST00000243918	ENST00000541742	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.035671145	0.9643289
ENST00000243918	ENST00000490107	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.03535491	0.96464515
ENST00000243918	ENST00000388985	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.031569265	0.96843076
ENST00000426004	ENST00000541742	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.019688595	0.9803114
ENST00000426004	ENST00000490107	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.020325003	0.979675
ENST00000426004	ENST00000388985	SYS1	chr20	43994326	+	SMYD3	chr1	245927451	-	0.02274711	0.9772529

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88525_88525_1_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000243918_SMYD3_chr1_245927451_ENST00000388985_length(amino acids)=233AA_BP=164
MLVPGSGGSGRGCTHYACATSAPPLRCFPRKRFFPTQPLLPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLGMAG
QFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMK

--------------------------------------------------------------

>88525_88525_2_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000243918_SMYD3_chr1_245927451_ENST00000490107_length(amino acids)=233AA_BP=164
MLVPGSGGSGRGCTHYACATSAPPLRCFPRKRFFPTQPLLPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLGMAG
QFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMK

--------------------------------------------------------------

>88525_88525_3_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000243918_SMYD3_chr1_245927451_ENST00000541742_length(amino acids)=233AA_BP=164
MLVPGSGGSGRGCTHYACATSAPPLRCFPRKRFFPTQPLLPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLGMAG
QFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMK

--------------------------------------------------------------

>88525_88525_4_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000372727_SMYD3_chr1_245927451_ENST00000388985_length(amino acids)=194AA_BP=125
MPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLGMAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVR
SSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDL

--------------------------------------------------------------

>88525_88525_5_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000372727_SMYD3_chr1_245927451_ENST00000490107_length(amino acids)=194AA_BP=125
MPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLGMAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVR
SSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDL

--------------------------------------------------------------

>88525_88525_6_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000372727_SMYD3_chr1_245927451_ENST00000541742_length(amino acids)=194AA_BP=125
MPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLGMAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVR
SSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDL

--------------------------------------------------------------

>88525_88525_7_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000414310_SMYD3_chr1_245927451_ENST00000388985_length(amino acids)=190AA_BP=120
MPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSL
DQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLE

--------------------------------------------------------------

>88525_88525_8_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000414310_SMYD3_chr1_245927451_ENST00000490107_length(amino acids)=189AA_BP=120
MPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSL
DQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLE

--------------------------------------------------------------

>88525_88525_9_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000414310_SMYD3_chr1_245927451_ENST00000541742_length(amino acids)=189AA_BP=120
MPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSL
DQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLE

--------------------------------------------------------------

>88525_88525_10_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000426004_SMYD3_chr1_245927451_ENST00000388985_length(amino acids)=194AA_BP=125
MPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLGMAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVR
SSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDL

--------------------------------------------------------------

>88525_88525_11_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000426004_SMYD3_chr1_245927451_ENST00000490107_length(amino acids)=194AA_BP=125
MPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLGMAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVR
SSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDL

--------------------------------------------------------------

>88525_88525_12_SYS1-SMYD3_SYS1_chr20_43994326_ENST00000426004_SMYD3_chr1_245927451_ENST00000541742_length(amino acids)=194AA_BP=125
MPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLGMAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVR
SSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:43994326/chr1:245927451)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000243918

13_33

76.66666666666667

157.0

Transmembrane

Helical

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000372727

13_33

76.66666666666667

157.0

Transmembrane

Helical

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000426004

13_33

76.66666666666667

77.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000243918

113_133

76.66666666666667

157.0

Transmembrane

Helical

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000243918

65_85

76.66666666666667

157.0

Transmembrane

Helical

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000243918

91_111

76.66666666666667

157.0

Transmembrane

Helical

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000372727

113_133

76.66666666666667

157.0

Transmembrane

Helical

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000372727

65_85

76.66666666666667

157.0

Transmembrane

Helical

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000372727

91_111

76.66666666666667

157.0

Transmembrane

Helical

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000426004

113_133

76.66666666666667

77.0

Transmembrane

Helical

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000426004

65_85

76.66666666666667

77.0

Transmembrane

Helical

Hgene

SYS1

chr20:43994326

chr1:245927451

ENST00000426004

91_111

76.66666666666667

77.0

Transmembrane

Helical

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000388985

4_240

358.6666666666667

429.0

Domain

SET

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000490107

4_240

299.6666666666667

370.0

Domain

SET

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000541742

4_240

299.6666666666667

370.0

Domain

SET

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000388985

14_16

358.6666666666667

429.0

Region

S-adenosyl-L-methionine binding

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000388985

205_206

358.6666666666667

429.0

Region

S-adenosyl-L-methionine binding

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000490107

14_16

299.6666666666667

370.0

Region

S-adenosyl-L-methionine binding

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000490107

205_206

299.6666666666667

370.0

Region

S-adenosyl-L-methionine binding

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000541742

14_16

299.6666666666667

370.0

Region

S-adenosyl-L-methionine binding

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000541742

205_206

299.6666666666667

370.0

Region

S-adenosyl-L-methionine binding

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000388985

49_87

358.6666666666667

429.0

Zinc finger

MYND-type

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000490107

49_87

299.6666666666667

370.0

Zinc finger

MYND-type

Tgene

SMYD3

chr20:43994326

chr1:245927451

ENST00000541742

49_87

299.6666666666667

370.0

Zinc finger

MYND-type

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>364_SYS1_43994326_SMYD3_245927451_ranked_0.pdb	SYS1	43994326	43994326	ENST00000388985	SMYD3	chr1	245927451	-	MLVPGSGGSGRGCTHYACATSAPPLRCFPRKRFFPTQPLLPPWSLELCLSRPAAPLLHGPVCQRCFGSPPVRPGHAQTLRSSSLSLGMAG QFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTWIFFPGSHPVRGVQVMK	233

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

SYS1_pLDDT.png

SMYD3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SYS1
SMYD3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to SYS1-SMYD3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SYS1-SMYD3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source